1. White adipose tissue dysfunction in obesity and aging.
- Author
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Reyes-Farias M, Fos-Domenech J, Serra D, Herrero L, and Sánchez-Infantes D
- Subjects
- Adipocytes, White metabolism, Adipocytes, White pathology, Adipose Tissue, White metabolism, Adipose Tissue, White pathology, Aging metabolism, Aging pathology, Animals, Humans, Intra-Abdominal Fat immunology, Intra-Abdominal Fat metabolism, Intra-Abdominal Fat pathology, Obesity metabolism, Obesity pathology, Adipocytes, White immunology, Adipose Tissue, White immunology, Aging immunology, Body Fat Distribution methods, Obesity immunology
- Abstract
Both obesity and aging are associated with the development of metabolic diseases such as type 2 diabetes and cardiovascular disease. Chronic low-grade inflammation of adipose tissue is one of the mechanisms implicated in the progression of these diseases. Obesity and aging trigger adipose tissue alterations that ultimately lead to a pro-inflammatory phenotype of the adipose tissue-resident immune cells. Obesity and aging also share other features such as a higher visceral vs. subcutaneous adipose tissue ratio and a decreased lifespan. Here, we review the common characteristics of obesity and aging and the alterations in white adipose tissue and resident immune cells. We focus on the adipose tissue metabolic derangements in obesity and aging such as inflammation and adipose tissue remodeling., (Copyright © 2021 Elsevier Inc. All rights reserved.)
- Published
- 2021
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