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Protective effects of maternal methyl donor supplementation on adult offspring of high fat diet-fed dams.
- Source :
-
The Journal of nutritional biochemistry [J Nutr Biochem] 2016 Aug; Vol. 34, pp. 42-51. Date of Electronic Publication: 2016 Apr 27. - Publication Year :
- 2016
-
Abstract
- Obesity has become a global public health problem associated with metabolic dysfunction and chronic disorders. It has been shown that the risk of obesity and the DNA methylation profiles of the offspring can be affected by maternal nutrition, such as high-fat diet (HFD) consumption. The aim of this study was to investigate whether metabolic dysregulation and physiological abnormalities in offspring caused by maternal HFD can be alleviated by the treatment of methyl donors during pregnancy and lactation of dams. Female C57BL/6 mice were assigned to specific groups and given different nutrients (control diet, Control+Met, HFD and HFD+Met) throughout gestation and lactation. Offspring of each group were weaned onto a control diet at 3 weeks of age. Physiological (weight gain and adipose composition) and metabolic (plasma biochemical analyses) outcomes were assessed in male and female adult offspring. Expression and DNA methylation profiles of obesogenic-related genes including PPAR γ, fatty acid synthase, leptin and adiponectin were also detected in visceral fat of offspring. The results showed that dietary supplementation with methyl donors can prevent the adverse effects of maternal HFD on offspring. Changes in the expression and DNA methylation of obesogenic-related genes indicated that epigenetic regulation may contribute to the effects of maternal dietary factors on offspring outcomes.<br /> (Copyright © 2016 Elsevier Inc. All rights reserved.)
- Subjects :
- Adiposity
Animals
DNA Methylation
Diet, High-Fat adverse effects
Female
Intra-Abdominal Fat metabolism
Intra-Abdominal Fat pathology
Male
Mice, Inbred C57BL
Obesity etiology
Obesity physiopathology
Pediatric Obesity etiology
Pediatric Obesity metabolism
Pediatric Obesity pathology
Pregnancy
Pregnancy Complications etiology
Pregnancy Complications physiopathology
Random Allocation
Specific Pathogen-Free Organisms
Weaning
Weight Gain
Dietary Supplements
Fetal Development
Gene Expression Regulation, Developmental
Lactation
Maternal Nutritional Physiological Phenomena
Methionine therapeutic use
Pediatric Obesity prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 1873-4847
- Volume :
- 34
- Database :
- MEDLINE
- Journal :
- The Journal of nutritional biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 27183114
- Full Text :
- https://doi.org/10.1016/j.jnutbio.2016.04.005