1. The dementia-associated APOE ε4 allele is not associated with rapid eye movement sleep behavior disorder
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Christelle Charley Monaca, Isabelle Arnulf, Guy A. Rouleau, Yves Dauvilliers, Elena Antelmi, Stephanie Strong, Ambra Stefani, Michel Boivin, Patrick A. Dion, Birgit Högl, Alex Desautels, Michele T.M. Hu, Luigi Ferini-Strambi, Valérie Cochen De Cock, Peter Young, Giuseppe Plazzi, Claire S. Leblond, Nicolas Dupré, Michal Rolinski, Anna Heidbreder, Thomas R Barber, Ronald B. Postuma, Ziv Gan-Or, Jay P. Ross, Jacques Montplaisir, Samuel Evetts, Judes Poirier, Simon C. Warby, Jean-François Gagnon, Gan-Or, Ziv, Montplaisir, Jacques Y., Ross, Jay P., Poirier, Jude, Warby, Simon C., Arnulf, Isabelle, Strong, Stephanie, Dauvilliers, Yve, Leblond, Claire S., Michele T. M., Hu, Högl, Birgit, Stefani, Ambra, Monaca, Christelle Charley, De Cock, Valérie Cochen, Boivin, Michel, Ferini-Strambi, Luigi, Plazzi, Giuseppe, Antelmi, Elena, Young, Peter, Heidbreder, Anna, Barber, Thomas R., Evetts, Samuel G., Rolinski, Michal, Dion, Patrick A., Desautels, Alex, Gagnon, Jean-Françoi, Dupré, Nicola, Postuma, Ronald B., Rouleau, Guy A., McGill University = Université McGill [Montréal, Canada], Hôpital du Sacré-Coeur de Montréal, Service des Pathologies du sommeil [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Neuropsychiatrie : recherche épidémiologique et clinique (PSNREC), Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), University of Oxford [Oxford], Department of Neurology, Innsbruck Medical University [Austria] (IMU), Centre Hospitalier Universitaire de Lille (CHU de Lille), Euromov (EuroMov), Université de Montpellier (UM), Faculté de médecine de l'Université Laval [Québec] (ULaval), Universita Vita Salute San Raffaele = Vita-Salute San Raffaele University [Milan, Italie] (UniSR), University of Bologna, University of Münster, Centre hospitalier universitaire de Québec (CHUQ), Centre Hospitalier Universitaire de Québec, Montplaisir, Jacques Y, Ross, Jay P, Warby, Simon C, Leblond, Claire S, Hu, Michele T M, Barber, Thomas R, Evetts, Samuel G, Dion, Patrick A, Postuma, Ronald B, and Rouleau, Guy A
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0301 basic medicine ,Apolipoprotein E ,Male ,Aging ,Parkinson's disease ,Dementia with Lewy bodie ,[SDV]Life Sciences [q-bio] ,Dementia with Lewy bodies ,REM sleep behavior disorder ,Gastroenterology ,0302 clinical medicine ,Gene Frequency ,Risk Factors ,Allele ,General Neuroscience ,Parkinson Disease ,3. Good health ,Female ,Supranuclear Palsy, Progressive ,APOE ,Human ,Adult ,Lewy Body Disease ,medicine.medical_specialty ,Adolescent ,Single-nucleotide polymorphism ,Genetic Association Studie ,Polymorphism, Single Nucleotide ,03 medical and health sciences ,Young Adult ,Apolipoproteins E ,Genetic ,Internal medicine ,Genetics ,medicine ,Humans ,Dementia ,Allele frequency ,Alleles ,Genetic Association Studies ,Synucleinopathies ,Neuroscience (all) ,business.industry ,Risk Factor ,Multiple System Atrophy ,medicine.disease ,030104 developmental biology ,Neurology (clinical) ,Geriatrics and Gerontology ,business ,Neuroscience ,030217 neurology & neurosurgery ,Developmental Biology - Abstract
International audience; The present study aimed to examine whether the APOE ε4 allele, associated with dementia with Lewy bodies (DLB), and possibly with dementia in Parkinson's disease (PD), is also associated with idiopathic rapid eye movement sleep behavior disorder (RBD). Two single nucleotide polymorphisms, rs429358 and rs7412, were genotyped in RBD patients (n = 480) and in controls (n = 823). APOE ε4 allele frequency was 0.14 among RBD patients and 0.13 among controls (OR = 1.11, 95% CI: 0.88-1.40, p = 0.41). APOE ε4 allele frequencies were similar in those who converted to DLB (0.14) and those who converted to Parkinson's disease (0.12) or multiple system atrophy (0.14, p = 1.0). The APOE ε4 allele is neither a risk factor for RBD nor it is associated with conversion from RBD to DLB or other synucleinopathies.
- Published
- 2017
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