Back to Search
Start Over
The dementia-associated APOE ε4 allele is not associated with rapid eye movement sleep behavior disorder
- Source :
- Neurobiology of Aging, Neurobiology of Aging, Elsevier, 2017, 49, pp.218.e13-218.e15. ⟨10.1016/j.neurobiolaging.2016.10.002⟩, Gan-Or, Z, Montplaisir, J Y, Ross, J P, Poirier, J, Warby, S C, Arnulf, I, Strong, S, Dauvilliers, Y, Leblond, C S, Hu, M T M, Högl, B, Stefani, A, Monaca, C C, De Cock, V C, Boivin, M, Ferini-Strambi, L, Plazzi, G, Antelmi, E, Young, P, Heidbreder, A, Barber, T R, Evetts, S G, Rolinski, M, Dion, P A, Desautels, A, Gagnon, J-F, Dupré, N, Postuma, R B & Rouleau, G A 2017, ' The dementia-associated APOE ε4 allele is not associated with rapid eye movement sleep behavior disorder ', Neurobiology of Aging, vol. 49, pp. 218.e13-218.e15 . https://doi.org/10.1016/j.neurobiolaging.2016.10.002
- Publication Year :
- 2017
- Publisher :
- Elsevier Inc., 2017.
-
Abstract
- International audience; The present study aimed to examine whether the APOE ε4 allele, associated with dementia with Lewy bodies (DLB), and possibly with dementia in Parkinson's disease (PD), is also associated with idiopathic rapid eye movement sleep behavior disorder (RBD). Two single nucleotide polymorphisms, rs429358 and rs7412, were genotyped in RBD patients (n = 480) and in controls (n = 823). APOE ε4 allele frequency was 0.14 among RBD patients and 0.13 among controls (OR = 1.11, 95% CI: 0.88-1.40, p = 0.41). APOE ε4 allele frequencies were similar in those who converted to DLB (0.14) and those who converted to Parkinson's disease (0.12) or multiple system atrophy (0.14, p = 1.0). The APOE ε4 allele is neither a risk factor for RBD nor it is associated with conversion from RBD to DLB or other synucleinopathies.
- Subjects :
- 0301 basic medicine
Apolipoprotein E
Male
Aging
Parkinson's disease
Dementia with Lewy bodie
[SDV]Life Sciences [q-bio]
Dementia with Lewy bodies
REM sleep behavior disorder
Gastroenterology
0302 clinical medicine
Gene Frequency
Risk Factors
Allele
General Neuroscience
Parkinson Disease
3. Good health
Female
Supranuclear Palsy, Progressive
APOE
Human
Adult
Lewy Body Disease
medicine.medical_specialty
Adolescent
Single-nucleotide polymorphism
Genetic Association Studie
Polymorphism, Single Nucleotide
03 medical and health sciences
Young Adult
Apolipoproteins E
Genetic
Internal medicine
Genetics
medicine
Humans
Dementia
Allele frequency
Alleles
Genetic Association Studies
Synucleinopathies
Neuroscience (all)
business.industry
Risk Factor
Multiple System Atrophy
medicine.disease
030104 developmental biology
Neurology (clinical)
Geriatrics and Gerontology
business
Neuroscience
030217 neurology & neurosurgery
Developmental Biology
Subjects
Details
- Language :
- English
- ISSN :
- 01974580
- Database :
- OpenAIRE
- Journal :
- Neurobiology of Aging, Neurobiology of Aging, Elsevier, 2017, 49, pp.218.e13-218.e15. ⟨10.1016/j.neurobiolaging.2016.10.002⟩, Gan-Or, Z, Montplaisir, J Y, Ross, J P, Poirier, J, Warby, S C, Arnulf, I, Strong, S, Dauvilliers, Y, Leblond, C S, Hu, M T M, Högl, B, Stefani, A, Monaca, C C, De Cock, V C, Boivin, M, Ferini-Strambi, L, Plazzi, G, Antelmi, E, Young, P, Heidbreder, A, Barber, T R, Evetts, S G, Rolinski, M, Dion, P A, Desautels, A, Gagnon, J-F, Dupré, N, Postuma, R B & Rouleau, G A 2017, ' The dementia-associated APOE ε4 allele is not associated with rapid eye movement sleep behavior disorder ', Neurobiology of Aging, vol. 49, pp. 218.e13-218.e15 . https://doi.org/10.1016/j.neurobiolaging.2016.10.002
- Accession number :
- edsair.doi.dedup.....27eebc10e12c3ef8eedfa25cc23bc5ab
- Full Text :
- https://doi.org/10.1016/j.neurobiolaging.2016.10.002⟩