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40 results on '"Zhou, Bao"'

13. Molecular characterization of Haemaphysalis longicornis-borne rickettsiae, Republic of Korea and China

Author

Heung-Chul Kim, Ju Jiang, Sung-Tae Chong, Monica L. O’Guinn, Allen L. Richards, Roxanne G. Burrus, John S. Lee, Hui-juan An, Terry A. Klein, Yan-min Zhang, Yu-zhou Bao, and Dan Song

Subjects
Male, Nymph, 0301 basic medicine, China, Ixodidae, 030231 tropical medicine, Zoology, Tick, Microbiology, 03 medical and health sciences, 0302 clinical medicine, Rickettsiaceae, Phylogenetics, Rickettsia heilongjiangensis, Republic of Korea, Animals, Phylogeny, biology, Phylogenetic tree, Sequence Analysis, DNA, biology.organism_classification, 030104 developmental biology, Infectious Diseases, Rickettsia, Genes, Bacterial, Larva, Insect Science, Candidatus, Multilocus sequence typing, Female, Parasitology, Haemaphysalis longicornis
Abstract

Haemaphysalis longicornis, the cattle tick or bush tick, has an extended distribution throughout Asia and the Pacific region, including China, Russia, the Republic of Korea (ROK), Japan, Australia, New Zealand, and the South Pacific islands. It is an obligate ectoparasite found commonly on medium to large sized wild and domestic animals, with humans as an accidental host. Haemaphysalis longicornis transmits a number of pathogens, including severe fever with thrombocytopenia syndrome and tick-borne encephalitis viruses, bacteria, helminths, and protozoans, that impact on veterinary (wild and domestic animals) and human health. Surveys of rickettsial pathogens associated with H. longicornis from China, the ROK, and Japan have resulted in the discovery of more than 35 incompletely characterized molecular isolates of Rickettsia. In response to the increased global threat of tick-borne rickettsial diseases, H. longicornis collected in the ROK and China were assessed in our laboratory and two additional Rickettsia spp. isolates (ROK-HL727 and XinXian HL9) were identified. These agents were fully characterized by multilocus sequence typing using partial gene fragment sequences of rrs, gltA, ompA, ompB, and sca4. Phylogenetic comparisons of these Rickettsia isolates with known Rickettsia species and other molecular isolates identified from H. longicornis were performed to better understand their interrelationships. Phylogenetic analysis of the sequences from these 5 gene fragments showed that ROK-HL727 was closely related to rickettsial isolates of H. longicornis previously reported from China, the ROK and Japan, but distinct from any currently recognized Rickettsia species. It therefore qualifies genetically as a new species, introduced herein as Candidatus Rickettsia longicornii. The XinXian-HL9 isolate detected from China was determined to be genetically similar to the human pathogen Rickettsia heilongjiangensis. People living and working in areas where H. longicornis is endemic should be aware of the potential for rickettsial diseases.

Published
2018

14. Synthesis of C 3 -Neoglycosides of digoxigenin and their anticancer activities

Author

Jin Shan Tang, Youwei Zhang, Yu zhou Bao, Jie Liu, Xin sheng Yao, Xiao-kun Zhang, Xue-Long Sun, Yi chang Ren, and Xiao san Li

Subjects
Pharmacology, chemistry.chemical_classification, 010405 organic chemistry, Chemistry, Sodium periodate, Organic Chemistry, Glycoside, Biological activity, General Medicine, 01 natural sciences, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, Biochemistry, Apoptosis, Cytoplasm, Drug Discovery, Digoxigenin, Glycosyl, Cytotoxicity
Abstract

Cardiac glycosides exhibit significant anticancer effects and the glycosyl substitution at C3 position of digoxigenin is pivotal for their biological activity. In order to study the structure-activity relationship (SAR) of cardiac glycosides toward cancers and explore more potent anticancer agents, a series of C3-O-neoglycosides and C3-MeON-neoglycosides of digoxigenin were synthesized by the Koenigs-Knorr and neoglycosylation method, respectively. In addition, digoxigenin bisdigitoxoside and monodigitoxoside were prepared from digoxin by sodium periodate (NaIO4) oxidation and 6-aminocaproic acid hydrolysis. The SAR analysis revealed that C3-O-neoglycosides of digoxigenin exhibited stronger cytotoxicity and induction of Nur77 expression of tumor cells than C3-MeON-neoglycosides. Also, 3β-O-glycosides exhibited stronger anticancer effects than 3α-O-glycosides. Among them, 3β-O-(β-l-fucopyranosyl)-digoxigenin (3i) showed the highest activity on induction of Nur77 expression and translocation from the nucleus to cytoplasm, leading to cancer cell apoptosis.

Published
2018

18. Characterization of low-N responses in maize (Zea mays L.) cultivars with contrasting nitrogen use efficiency in the North China Plain

Author

LI, Xiang-ling, primary, GUO, Li-guo, additional, ZHOU, Bao-yuan, additional, TANG, Xiang-ming, additional, CHEN, Cong-cong, additional, ZHANG, Lei, additional, ZHANG, Shao-yun, additional, LI, Chong-feng, additional, XIAO, Kai, additional, DONG, Wei-xin, additional, YIN, Bao-zhong, additional, and ZHANG, Yue-chen, additional

Published
2019
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20. Void fraction of dispersed bubbly flow in a narrow rectangular channel under rolling conditions

Author

Dianchuan Xing, Changqi Yan, Licheng Sun, Zhou Bao, and Guangyuan Jin

Subjects
Materials science, Drift velocity, Energy Engineering and Power Technology, Reynolds number, Slip (materials science), Mechanics, Physics::Classical Physics, Physics::Fluid Dynamics, symbols.namesake, Flow system, Amplitude, Temperature and pressure, Classical mechanics, Nuclear Energy and Engineering, symbols, Influence coefficient, Safety, Risk, Reliability and Quality, Porosity, Waste Management and Disposal
Abstract

Rolling motion, as a typical ocean condition, can induce additional force and change the states of a two-phase flow system. Visualized experiments was carried out on void fraction of air–water flow in a narrow rectangular channel (40 × 3 mm 2 ) under ambient temperature and pressure as well as rolling conditions of 5°-8s, 10°-8s, 15°-8s, 15°-12s, 15°-16s (rolling amplitude-rolling period). The results showed that the void fraction oscillates periodically in rolling motions due to the induced changes in phase distribution and the slip of the interface. In addition, rolling motion gives rise to the reduction of the time-averaged void fraction. The fluctuation amplitude of the void fraction increased with the increase in rolling amplitude and the decrease in rolling period. The distribution parameter under rolling condition was obtained and compared with that under steady state. The influence coefficient K was defined by taking the rolling Reynolds number and gas Reynolds number into consideration. A new correlation for predicting the void fraction was given based on the experimental data.

Published
2014

24. Standard Gibbs energies of transfer of potassium tetraphenylborate from water to (water+t -butyl alcohol) mixtures and the primary medium effect

Author

Zhou Bao-Xue, Zhang Pi-Jian, Wang Feng-Ge, Wang Xiao-Ling, Zou Li-zhuang, and Yu Qingjiang

Subjects
Aqueous solution, Butanol, Inorganic chemistry, Alcohol, Mole fraction, Atomic and Molecular Physics, and Optics, Gibbs free energy, Solvent, chemistry.chemical_compound, symbols.namesake, chemistry, symbols, Ionic conductivity, General Materials Science, Physical and Theoretical Chemistry, Potassium tetraphenylborate
Abstract

Standard Gibbs energies of transfer of potassium tetraphenylborate from water to (water + t -butyl alcohol) (TBA) mixtures at T = 298.15 K have been studied. The mole fractions of TBA in the mixed solvent are 0.00, 0.01, 0.02, 0.03, 0.04, 0.045, 0.05, 0.06, 0.07, 0.08, 0.09, 0.10, 0.20, 0.40, 0.60, 0.80, and 1.00, respectively. The primary medium effect of potassium tetraphenylborate in the mixed solvent is discussed.

Published
1999

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