11 results on '"Yuhki Koike"'
Search Results
2. Early first episode of pouchitis after ileal pouch–anal anastomosis for pediatric ulcerative colitis is a risk factor for development of chronic pouchitis
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Yuka Nagano, Yoshiki Okita, Satoru Kondo, Kohei Matsushita, Masato Kusunoki, Yuji Toiyama, Keiichi Uchida, Yuhki Koike, Mikihiro Inoue, and Toshimitsu Araki
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,Pouchitis ,Anastomosis ,Gastroenterology ,Chronic pouchitis ,Young Adult ,Risk Factors ,Internal medicine ,medicine ,Humans ,Risk factor ,Child ,Retrospective Studies ,First episode ,medicine.diagnostic_test ,business.industry ,Proctocolectomy, Restorative ,General Medicine ,medicine.disease ,Ulcerative colitis ,Endoscopy ,Ileal Pouch Anal Anastomosis ,ROC Curve ,Child, Preschool ,Chronic Disease ,Pediatrics, Perinatology and Child Health ,Colitis, Ulcerative ,Female ,Surgery ,business - Abstract
Background The predictive factors for chronic pouchitis after ileal pouch–anal anastomosis (IPAA) in pediatric-onset ulcerative colitis (UC) remain unclear. This study evaluated the predictive factors for chronic pouchitis after IPAA in patients with pediatric UC. Methods The data from 52 patients with pediatric-onset UC who underwent IPAA in Mie University Hospital were retrospectively reviewed. The endoscopy surveillance was performed yearly or at the timing of the symptom. Chronic pouchitis was defined as antibiotic-dependent/-refractory and relapsing cases. Potential predictors of chronic pouchitis were analyzed. Results During the first 5 years after IPAA, pouchitis was identified in 32.7%. Of these patients, 12 (70.6%) developed chronic pouchitis. The predictor of chronic pouchitis was a preoperative history of immunomodulator use before IPAA (p = 0.04). Life table analysis revealed that patients with chronic pouchitis tended to develop pouchitis earlier after IPAA than did patients without chronic pouchitis (p = 0.012). Receiver operating characteristic curve analysis showed that the occurrence of pouchitis within 15 months after IPAA surgery predicted the development of chronic pouchitis (sensitivity, 92%; specificity, 80%). Conclusion In pediatric patients with UC, the predictive factors for chronic pouchitis are immunomodulator use and early occurrence of the first episode of pouchitis within 15 months after IPAA. Level of evidence III
- Published
- 2019
3. Predictors for Pouchitis After Ileal Pouch-Anal Anastomosis for Pediatric-Onset Ulcerative Colitis
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Yuhki Koike, Yoshiki Okita, Yuji Toiyama, Masato Kusunoki, Toshimitsu Araki, Kohei Matsushita, Keiichi Uchida, and Mikihiro Inoue
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Male ,medicine.medical_specialty ,Multivariate analysis ,Adolescent ,Neutrophils ,Population ,Pouchitis ,Anastomosis ,Severity of Illness Index ,Gastroenterology ,Leukocyte Count ,Young Adult ,03 medical and health sciences ,Postoperative Complications ,0302 clinical medicine ,Risk Factors ,Internal medicine ,medicine ,Humans ,Risk factor ,Child ,Perioperative Period ,education ,Glucocorticoids ,Retrospective Studies ,education.field_of_study ,Dose-Response Relationship, Drug ,Receiver operating characteristic ,Proportional hazards model ,business.industry ,Proctocolectomy, Restorative ,medicine.disease ,Ulcerative colitis ,ROC Curve ,Child, Preschool ,030220 oncology & carcinogenesis ,Multivariate Analysis ,Colitis, Ulcerative ,Female ,030211 gastroenterology & hepatology ,Surgery ,business ,Follow-Up Studies - Abstract
Background The predictive factors for the development of pouchitis after ileal pouch-anal anastomosis (IPAA) in pediatric-onset ulcerative colitis (UC) have not been well investigated. The present study aimed to determine the predictive factors for the development of pouchitis after IPAA in the pediatric UC population. Methods The data from 54 patients with pediatric-onset UC who underwent IPAA in Mie University Hospital between 2000 and 2017 were retrospectively reviewed. A modified pouchitis disease activity index of ≥5 was defined as pouchitis. Potential preoperative, intraoperative, and postoperative predictors for pouchitis including various demographic and clinical variables were analyzed using Cox regression analysis, Students’ t-tests, Mann–Whitney U tests, and Kaplan–Meier curves. The optimal cutoff value for continuous variables was determined using the receiver operating characteristic curve analysis. Results Pouchitis was identified in 17 (31.5%) patients within 5 y of follow-up. In multivariable analysis, the independent predictors for pouchitis were preoperative cumulative steroid dose of >10,000 mg (P = 0.0056) and >65% neutrophils just before IPAA (P = 0.032). Multivariate analysis revealed that the independent predictors of pouchitis were a total steroid dose of >10,000 mg (P = 0.0002) and a neutrophil percentage of >65% (P = 0.0078). No patient for whom both of these independent predictors were negative developed pouchitis, whereas >40% of patients who had one or both predictors developed pouchitis. Conclusions In pediatric patients with UC, the predictive factors for pouchitis development are a greater cumulative total dose of steroids and a greater percentage of neutrophils before IPAA.
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- 2019
4. Breast milk-derived exosomes promote intestinal epithelial cell growth
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Augusto Zani, Hiromu Miyake, Pekka Määttänen, Alison Hock, Agostino Pierro, Yuhki Koike, Leonardo Ermini, Yong Chen, Carol Lee, and Bo Li
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0301 basic medicine ,Cell viability ,Breast milk ,Cell Survival ,Proliferation ,Inflammation ,Biology ,Exosomes ,Pediatrics ,Exosome ,Andrology ,03 medical and health sciences ,Immune system ,Enterocolitis, Necrotizing ,medicine ,Animals ,Humans ,Viability assay ,Intestinal Mucosa ,Cell Proliferation ,Enterocolitis ,Infant, Newborn ,Infant ,Epithelial Cells ,General Medicine ,Perinatology and Child Health ,Newborn ,Microvesicles ,Epithelium ,Rats ,Necrotizing enterocolitis (NEC) ,Breast Feeding ,Milk ,030104 developmental biology ,medicine.anatomical_structure ,Pediatrics, Perinatology and Child Health ,Immunology ,Female ,Surgery ,medicine.symptom ,Stem cell ,Necrotizing - Abstract
Background Breast milk administration prevents necrotizing enterocolitis (NEC). However, the mechanism remains unclear. Exosomes are cell-derived vesicles highly present in human milk and regulate intercellular signaling, inflammation, and immune response. We hypothesized that milk-derived exosomes beneficially affect intestinal epithelial cells. Methods Rat milk was collected, and exosomes were isolated using ExoQuick reagent and visualized by Nanoparticle Tracking Analysis. Protein was extracted from encapsulating exosomes, and concentration was measured. 2×10 4 intestinal epithelial cells (IEC-18) were treated for five hours with 0.5-μg/μl exosomes, an equal volume of exosome-free milk, or control solution (PBS). IEC-18 viability was measured using a colorimetric assay (MTT), and gene expression was analyzed by qRT-PCR. Data were compared using one-way ANOVA with Bonferroni post-test. Results Rat milk was collected, and exosome isolation was confirmed. Compared to control, treatment with exosomes significantly increased IEC viability, proliferation, and stem cell activity (all p Conclusions Rat milk-derived exosomes promote IEC viability, enhance proliferation, and stimulate intestinal stem cell activity. These findings provide insight into the mechanism of action of breast milk in the intestines. Exosome administration is a promising prevention method for infants at risk of developing NEC when breastfeeding is not tolerated.
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- 2017
5. Intestinal epithelial injury induced by maternal separation is protected by hydrogen sulfide
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Augusto Zani, Yuhki Koike, Agostino Pierro, Xinpei Li, Zechariah Martin, Alison Hock, Elke Zani-Ruttenstock, Carol Lee, and Bo Li
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Male ,0301 basic medicine ,Thiobarbituric acid ,Crypt ,Inflammation ,Sodium hydrosulfide ,Sulfides ,medicine.disease_cause ,Andrology ,Mice ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,medicine ,Animals ,Intestinal Mucosa ,Goblet cell ,biology ,business.industry ,Maternal Deprivation ,General Medicine ,Intestines ,Mice, Inbred C57BL ,Nitric oxide synthase ,Oxidative Stress ,030104 developmental biology ,medicine.anatomical_structure ,Animals, Newborn ,chemistry ,030220 oncology & carcinogenesis ,Myeloperoxidase ,Models, Animal ,Pediatrics, Perinatology and Child Health ,Immunology ,biology.protein ,Cytokines ,Surgery ,medicine.symptom ,business ,Biomarkers ,Oxidative stress - Abstract
Purpose Oxidative stress has been implicated in the pathogenesis of various neonatal diseases involving the intestine. Hydrogen sulfide (H 2 S) has been shown to protect against oxidative stress. We hypothesized that administration of sodium hydrosulfide (NaHS), an H 2 S donor, to neonatal mice can decrease the intestinal epithelial injury associated with maternal separation (MS). Methods C57BL/6 mice received either intraperitoneal phosphate buffered saline (PBS; n=10) or NaHS (1mg/kg/day; n=10), followed by MS for 3h daily between postnatal day P5 and P9. Control neonatal mice were untreated and were not exposed to MS (n=10). Proximal colon was harvested and analyzed for crypt length, goblet cell number per crypt, oxidative stress and inflammation. Groups were compared using one-way ANOVA with Bonferroni post-test. Results Compared to controls, MS+PBS mice had shorter crypt lengths, fewer goblet cells per crypt, reduced glutathione peroxidase activity, increased expression of thiobarbituric acid reactive substances and inducible nitric oxide synthase mRNA, as well as increased IL-6 , TNFα and myeloperoxidase. Administration of NaHS significantly counteracted these negative effects of MS. Conclusions H 2 S protects the colon from the epithelial damage, oxidative stress and inflammation caused by maternal separation. This study provides insights on the pathogenesis of neonatal bowel diseases and indicates the potential for a pharmacological intervention to rescue the colonic epithelium. Level of evidence n/a – animal and laboratory study.
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- 2017
6. Use of computed tomography-lymphangiography with direct injection of water-soluble contrast medium to identify the origin of chylous ascites
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Keiichi Uchida, Mitsunaga Narushima, Mikihiro Inoue, Kohei Otake, Yuhki Koike, and Masato Kusunoki
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medicine.medical_specialty ,Contrast Media ,Computed tomography ,Chylous ascites ,Lymphatic vessel ,Humans ,Medicine ,Lymphedema ,Laparoscopy ,Chylous Ascites ,Lymphatic Vessels ,medicine.diagnostic_test ,business.industry ,Lymphography ,medicine.disease ,Contrast medium ,Lymphatic system ,medicine.anatomical_structure ,Surgery ,Radiology ,Tomography, X-Ray Computed ,Cardiology and Cardiovascular Medicine ,business ,Ligation - Abstract
Contrast lymphangiography is a useful technique to determine the site of lymphatic leakage in the patient with chylous ascites. Conventional lymphangiography with lipid-soluble contrast material carries the disadvantage of complications, such as oil emboli and lymphedema. The authors report a successful case of computed tomography (CT)-lymphangiography with direct injection of water-soluble contrast medium into a lower limb lymphatic vessel to determine the site of lymphatic leakage in a pediatric patient with refractory primary chylous ascites. The patient subsequently underwent laparoscopic ligation of the leaking site and recovered well. This novel technique offers superior potential for preoperative assessment and the planning of laparoscopic repair.
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- 2015
7. Intraluminal appendiceal fluid is a predictive factor for recurrent appendicitis after initial successful non-operative management of uncomplicated appendicitis in pediatric patients
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Kohei Otake, Yoshihide Tsukamoto, Keiichi Uchida, Kohei Matsushita, Yuhki Koike, Masato Kusunoki, Mikihiro Inoue, and Makoto Nakazawa
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Male ,medicine.medical_specialty ,Adolescent ,Cefoperazone ,Appendix ,Recurrence ,Risk Factors ,medicine ,Appendectomy ,Humans ,Uncomplicated appendicitis ,Child ,Ultrasonography ,First episode ,Univariate analysis ,medicine.diagnostic_test ,business.industry ,Infant ,General Medicine ,Appendicitis ,medicine.disease ,Anti-Bacterial Agents ,Body Fluids ,Predictive factor ,Surgery ,Time to recurrence ,Recurrent appendicitis ,Child, Preschool ,Abdominal ultrasonography ,Pediatrics, Perinatology and Child Health ,Female ,Radiology ,Tomography, X-Ray Computed ,business - Abstract
Background The risk factors for recurrent appendicitis in pediatric patients are unclear. This study aimed to identify the predictive factors for recurrent appendicitis in pediatric patients who initially underwent successful non-operative management of uncomplicated appendicitis. Methods Potential predictive factors for recurrent appendicitis in terms of clinical characteristics, laboratory data, and abdominal ultrasonography and computed tomography findings, were evaluated. Results This study included 125 patients who underwent initial successful non-operative management of appendicitis. The rate of recurrent appendicitis was 19.2%, and the mean time to recurrence was 12.6months. Univariate analyses found that rebound tenderness, muscle guarding, appendicoliths, appendiceal diameter >9mm, and intraluminal appendiceal fluid were associated with recurrent appendicitis. Multivariate analysis identified only intraluminal appendiceal fluid as an independent predictor of recurrent appendicitis. Conclusions Intraluminal appendiceal fluid is a predictive factor for recurrent appendicitis after initial non-operative management. The results of this study provide valuable information that may help to determine the appropriate management during the first episode of appendicitis.
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- 2014
8. Su1966 – Novel Evidence for Serum Mir-203 Levels As a Significant Predictor of Myopenia in Colorectal Cancer Patients
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Yukina Kusunoki, Takahito Kitajima, Toshimitsu Araki, Chengzeng Yin, Kurando Kusunoki, Keun Hur, Akira Yamamoto, Hiroyuki Fujikawa, Yoshiki Okita, Masato Kusunoki, Ajay Goel, Yusuke Omura, Junichiro Hiro, Yuji Toiyama, Yoshinaga Okugawa, Yuhki Koike, Shozo Ide, Hiromi Yasuda, and Shigeyuki Yoshiyama
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Oncology ,medicine.medical_specialty ,Hepatology ,business.industry ,Colorectal cancer ,Internal medicine ,Gastroenterology ,Medicine ,miR-203 ,business ,medicine.disease - Published
- 2019
9. Plasma Redox Imbalance Caused by Albumin Oxidation Promotes Lung-Predominant NETosis and Metastasis in Patients Treated with Definitive Radiation Therapy
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M. Inoue, Xiao Zhao, Mitsuhiko Ikura, John Waldron, Yuhki Koike, Scott V. Bratman, Kenneth W. Yip, M. Di Grappa, Fei-Fei Liu, S.H. Huang, and M. Enomoto
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Cancer Research ,Radiation ,Lung ,business.industry ,Albumin ,medicine.disease ,Definitive Radiation Therapy ,Redox ,Metastasis ,medicine.anatomical_structure ,Oncology ,medicine ,Cancer research ,Radiology, Nuclear Medicine and imaging ,In patient ,business - Published
- 2018
10. Efficacy of Seprafilm for preventing adhesive bowel obstruction and cost–benefit analysis in pediatric patients undergoing laparotomy
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Masato Kusunoki, Yuka Nagano, Shozo Ide, Mikihiro Inoue, Yasuhiko Mohri, Keiichi Uchida, Kohei Matsushita, Kohei Otake, Kiyoshi Hashimoto, and Yuhki Koike
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Male ,medicine.medical_specialty ,Cost-Benefit Analysis ,medicine.medical_treatment ,Adhesion (medicine) ,Tissue Adhesions ,Laparotomy ,ABO blood group system ,medicine ,Humans ,Cumulative incidence ,Prospective Studies ,Hyaluronic Acid ,Child ,Prospective cohort study ,Cost–benefit analysis ,business.industry ,Incidence ,Incidence (epidemiology) ,Infant, Newborn ,Infant ,General Medicine ,medicine.disease ,Surgery ,Bowel obstruction ,Intestinal Diseases ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Female ,business ,Intestinal Obstruction - Abstract
Purpose This aim of the study is to determine whether the use of Seprafilm reduces the incidence and the medical costs of adhesive bowel obstruction (ABO) in children. Methods Pediatric patients undergoing laparotomy were prospectively assigned to the Seprafilm group, n = 441). A historical control group consisted of children without using Seprafilm (n = 409). The incidence of ABO during a 24-month follow-up period was compared between the groups. To clarify the cost–benefit relations, expenses for Seprafilm and medical costs for hospitalization related to ABO in the Seprafilm group were compared with the ABO-associated hospitalization costs in the control group. Results The cumulative incidence rate of ABO in the control group was significantly higher than in the Seprafilm group (4.9% vs. 2.0%, p = 0.015). Nearly all cases that required adhesiolysis had adhesions to areas other than the incision in both groups. In cost–benefit analysis, cost per patient was $105 higher in the control group than in the Seprafilm group, but this did not reach significance (p = 0.63). Conclusions Seprafilm reduces the incidence of ABO in the pediatric patients undergoing laparotomy. Although associated medical costs in the Seprafilm group were not significantly reduced, use of Seprafilm did not lead to an increase in cost. Wider range of Seprafilm application or an additional anti-adhesion device may help in preventing adhesion to areas other than the incision.
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- 2013
11. Intravascular Redox Homeostasis Regulates NETosis and Cancer Metastasis
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S.H. Huang, Mitsuhiko Ikura, Yuhki Koike, Xiao Zhao, Fei-Fei Liu, John Waldron, M. Inoue, M. Enomoto, Kenneth W. Yip, M. Di Grappa, and Scott V. Bratman
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Cancer Research ,Radiation ,Oncology ,Redox homeostasis ,business.industry ,Cancer research ,Cancer metastasis ,Medicine ,Radiology, Nuclear Medicine and imaging ,business - Published
- 2018
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