16 results on '"Xiaorong Fu"'
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2. Novel dual inhibitor for targeting PIM1 and FGFR1 kinases inhibits colorectal cancer growth in vitro and patient-derived xenografts in vivo
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Fanxiang Yin, Ran Zhao, Dhilli Rao Gorja, Xiaorong Fu, Ning Lu, Hai Huang, Beibei Xu, Hanyong Chen, Jung-Hyun Shim, Kangdong Liu, Zhi Li, Kyle Vaughn Laster, Zigang Dong, and Mee-Hyun Lee
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General Pharmacology, Toxicology and Pharmaceutics - Published
- 2022
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Catalog
3. Inhibition of FGFR1 Activity and Expression by Treatment of β, β-Dimethylacrylalkannin Suppresses Colorectal Cancer Growth in Cells and Patient-Derived Xenograft Mice
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Ran Zhao, Fanxiang Yin, Mangaladoss Fredimoses, Xiaorong Fu, Beibei Xu, Jianhua Zhao, Hanyong Chen, Kangdong Liu, Zhi Li, Joydeb Kumar Kundu, Kyle Vaughn Laster, Zigang Dong, and Mee-Hyun Lee
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- 2023
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4. Ambidextrous balance and channel innovation ability in Chinese business circles: The mediating effect of knowledge inertia and guanxi inertia
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Xiaorong Fu, Rui Luan, Wenting Zhu, Heng-Hui Wu, and Jing Pang
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Marketing ,business.industry ,media_common.quotation_subject ,05 social sciences ,Sample (statistics) ,Inertia ,Preference ,Balance (accounting) ,0502 economics and business ,Organizational learning ,Survey data collection ,050211 marketing ,Business ,Guanxi ,050203 business & management ,Industrial organization ,Communication channel ,media_common - Abstract
Drawing on organizational learning theory and literature on guanxi, this study examines how and why ambidextrous learning balance influences firm innovation capability in Chinese business circles. We propose a U-shaped relation between ambidextrous learning balance and firm innovation capability which is mediated by guanxi inertia and knowledge inertia in different ways. Specifically, ambidextrous learning balance has an inverted U-shaped impact on guanxi inertia and further influences firm innovation capability. Whereas, ambidextrous learning balance has a linear positive influence on innovation capability through a decreased level of knowledge inertia. Based on survey data collected from, The results obtained from a sample of 197 Chinese channel enterprises using SEMs analysis provide strong support for our hypotheses. In addition, the findings based on firms with unbalanced ambidextrous learning indicate that as opposed to exploratory learning, higher level of exploitative learning leads to an increase in guanxi inertia and a decrease in knowledge inertia. These conclusions reveal how ambidextrous learning balance influence innovation capability for a firm with inherent learning preference which is not discussed by the extant research. At the same time, this study fills the gap of ambidextrous learning balance by considering the influence of culture. Our work also informs foreign practitioners of the optimal ways of learning for innovation in China. more...
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- 2021
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5. Hepatic mTORC1 Opposes Impaired Insulin Action to Control Mitochondrial Metabolism in Obesity
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Xiaorong Fu, Joao A.G. Duarte, Christopher B. Newgard, Shawn C. Burgess, Blanka Kucejova, Santhosh Satapati, Olga Ilkayeva, and James Brugarolas
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Male ,0301 basic medicine ,medicine.medical_specialty ,medicine.medical_treatment ,Citric Acid Cycle ,Mice, Transgenic ,Mitochondria, Liver ,mTORC1 ,Mechanistic Target of Rapamycin Complex 1 ,Biology ,Mitochondrion ,Diet, High-Fat ,Tuberous Sclerosis Complex 1 Protein ,Article ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,chemistry.chemical_compound ,Insulin resistance ,Internal medicine ,Ketogenesis ,medicine ,Animals ,Obesity ,Glycogen synthase ,lcsh:QH301-705.5 ,Glycogen ,Tumor Suppressor Proteins ,Insulin ,Gluconeogenesis ,medicine.disease ,Receptor, Insulin ,Enzyme Activation ,Mice, Inbred C57BL ,Insulin receptor ,030104 developmental biology ,Endocrinology ,lcsh:Biology (General) ,Liver ,chemistry ,biology.protein ,Insulin Resistance ,biological phenomena, cell phenomena, and immunity ,Oxidation-Reduction - Abstract
SummaryDysregulated mitochondrial metabolism during hepatic insulin resistance may contribute to pathophysiologies ranging from elevated glucose production to hepatocellular oxidative stress and inflammation. Given that obesity impairs insulin action but paradoxically activates mTORC1, we tested whether insulin action and mammalian target of rapamycin complex 1 (mTORC1) contribute to altered in vivo hepatic mitochondrial metabolism. Loss of hepatic insulin action for 2 weeks caused increased gluconeogenesis, mitochondrial anaplerosis, tricarboxylic acid (TCA) cycle oxidation, and ketogenesis. However, activation of mTORC1, induced by the loss of hepatic Tsc1, suppressed these fluxes. Only glycogen synthesis was impaired by both loss of insulin receptor and mTORC1 activation. Mice with a double knockout of the insulin receptor and Tsc1 had larger livers, hyperglycemia, severely impaired glycogen storage, and suppressed ketogenesis, as compared to those with loss of the liver insulin receptor alone. Thus, activation of hepatic mTORC1 opposes the catabolic effects of impaired insulin action under some nutritional states. more...
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- 2016
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6. Hepatic Mitochondrial Pyruvate Carrier 1 Is Required for Efficient Regulation of Gluconeogenesis and Whole-Body Glucose Homeostasis
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Erin E. Lane, Lalita Oonthonpan, James E. Cox, Shawn C. Burgess, Jared Rutter, Ashley Dohlman, Matthew J. Potthoff, Lawrence R. Gray, Sean C. Tompkins, Adam J. Rauckhorst, Jianxin Xie, Arpit Sharma, Ren Miao, Kathryn S. Brown, Andrew W. Norris, Alvin D. Pewa, Eric B. Taylor, Diana Zepeda-Orozco, Xiaorong Fu, and Mst Rasheda Sultana more...
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medicine.medical_specialty ,endocrine system diseases ,Glycogen ,Physiology ,nutritional and metabolic diseases ,Cell Biology ,Biology ,Glutamine ,Citric acid cycle ,chemistry.chemical_compound ,Endocrinology ,chemistry ,Gluconeogenesis ,immune system diseases ,Mitochondrial matrix ,Internal medicine ,Urea cycle ,medicine ,Glucose homeostasis ,Pyruvic acid ,Molecular Biology - Abstract
SummaryGluconeogenesis is critical for maintenance of euglycemia during fasting. Elevated gluconeogenesis during type 2 diabetes (T2D) contributes to chronic hyperglycemia. Pyruvate is a major gluconeogenic substrate and requires import into the mitochondrial matrix for channeling into gluconeogenesis. Here, we demonstrate that the mitochondrial pyruvate carrier (MPC) comprising the Mpc1 and Mpc2 proteins is required for efficient regulation of hepatic gluconeogenesis. Liver-specific deletion of Mpc1 abolished hepatic MPC activity and markedly decreased pyruvate-driven gluconeogenesis and TCA cycle flux. Loss of MPC activity induced adaptive utilization of glutamine and increased urea cycle activity. Diet-induced obesity increased hepatic MPC expression and activity. Constitutive Mpc1 deletion attenuated the development of hyperglycemia induced by a high-fat diet. Acute, virally mediated Mpc1 deletion after diet-induced obesity decreased hyperglycemia and improved glucose tolerance. We conclude that the MPC is required for efficient regulation of gluconeogenesis and that the MPC contributes to the elevated gluconeogenesis and hyperglycemia in T2D. more...
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- 2015
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7. Comment on 'Further improvement on delay-range-dependent robust absolute stability for Lur׳e uncertain systems with interval time-varying delays' by P. Liu [ISA Trans. 58(2015)58–66]
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Wenyong Duan, Xiaorong Fu, Zhengfan Liu, and Xiaodong Yang
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0209 industrial biotechnology ,Engineering ,business.industry ,Applied Mathematics ,020208 electrical & electronic engineering ,Uncertain systems ,02 engineering and technology ,Interval (mathematics) ,Upper and lower bounds ,Computer Science Applications ,Stability conditions ,020901 industrial engineering & automation ,Control and Systems Engineering ,Control theory ,0202 electrical engineering, electronic engineering, information engineering ,Range (statistics) ,Table (database) ,Point (geometry) ,Electrical and Electronic Engineering ,Absolute stability ,business ,Instrumentation - Abstract
In a recent paper (ISA Transactions (2015)58: 58–66), an integral inequality has been proposed to reduce the conservativeness of stability conditions for Lur׳e uncertain systems. We point out that there exist some errors in Theorems 1–8, and the correct theorems are presented. Finally, the allowable maximum admissible upper bound (MAUB) listed in Table 1 , Table 2 , Table 3 , Table 4 , Table 5 have been recalculated by using the correct results. more...
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- 2016
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8. Mitochondrial Pyruvate Carrier 2 Hypomorphism in Mice Leads to Defects in Glucose-Stimulated Insulin Secretion
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Kyle S. McCommis, Rolf F. Kletzien, Brian N. Finck, Xiaorong Fu, Patrick A. Vigueira, Shawn C. Burgess, Serena L. Cole, Jerry R. Colca, Kari T. Chambers, William G. McDonald, George G. Schweitzer, and Maria S. Remedi more...
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Monocarboxylic Acid Transporters ,Pyruvate decarboxylation ,medicine.medical_specialty ,Pyruvate dehydrogenase kinase ,Anion Transport Proteins ,Pyruvate transport ,Mice, Transgenic ,PKM2 ,Biology ,Mitochondrial Membrane Transport Proteins ,Article ,General Biochemistry, Genetics and Molecular Biology ,Mice ,Internal medicine ,Insulin Secretion ,medicine ,Animals ,Insulin ,Lactic Acid ,Inner mitochondrial membrane ,lcsh:QH301-705.5 ,Mitochondrial pyruvate carrier 2 ,Membrane Transport Proteins ,Pyruvate carboxylase ,Mice, Inbred C57BL ,Glucose ,Endocrinology ,Gluconeogenesis ,lcsh:Biology (General) ,Female ,Secretory Rate - Abstract
SummaryCarrier-facilitated pyruvate transport across the inner mitochondrial membrane plays an essential role in anabolic and catabolic intermediary metabolism. Mitochondrial pyruvate carrier 2 (Mpc2) is believed to be a component of the complex that facilitates mitochondrial pyruvate import. Complete MPC2 deficiency resulted in embryonic lethality in mice. However, a second mouse line expressing an N-terminal truncated MPC2 protein (Mpc2Δ16) was viable but exhibited a reduced capacity for mitochondrial pyruvate oxidation. Metabolic studies demonstrated exaggerated blood lactate concentrations after pyruvate, glucose, or insulin challenge in Mpc2Δ16 mice. Additionally, compared with wild-type controls, Mpc2Δ16 mice exhibited normal insulin sensitivity but elevated blood glucose after bolus pyruvate or glucose injection. This was attributable to reduced glucose-stimulated insulin secretion and was corrected by sulfonylurea KATP channel inhibitor administration. Collectively, these data are consistent with a role for MPC2 in mitochondrial pyruvate import and suggest that Mpc2 deficiency results in defective pancreatic β cell glucose sensing. more...
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- 2014
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9. Chitosan derivatives with dual-antibacterial functional groups for antimicrobial finishing of cotton fabrics
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Xiaorong Fu, Yun Shen, Dan Huang, Xue Jiang, and Yiqi Yan
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Schiff base ,Polymers and Plastics ,Chemistry ,Organic Chemistry ,Antimicrobial ,Chloride ,Polyelectrolyte ,Chitosan ,chemistry.chemical_compound ,Materials Chemistry ,medicine ,Organic chemistry ,Antibacterial activity ,Citric acid ,Antibacterial agent ,medicine.drug - Abstract
The three water-soluble chitosan derivatives bearing double functional groups were synthesized with 2,3-epoxypropyltrimethylammonium chloride and benzaldehyde as modifiers through formation of Schiff base, reduction, N-methylation and O-quaternization. The synthesized chitosan derivatives were applied to cotton fabrics together with citric acid (CA) as the crosslinking agent to evaluate their use as durable antimicrobial textile finishing agents. The optimal finishing conditions were investigated and antibacterial activities of finished fabrics were tested with “Shake-Flask Test”. The fabrics finished showed strong antimicrobial activities and fairly good durability. The antibacterial efficiency of S. aureus and E. coli was more than 99% and 96% respectively, when crosslinked with CA (14%, o.w.f) through a two-bath process. The order of antimicrobial activities of the chitosan derivatives was O-quaternized-N,N-biethyl-N-benzyl ammonium chitosans chloride (O-QCTS-DEBn) ≥ O-quaternized-N-chitosan Schiff bases (O-QCTSS) > O-quaternized-N-benzyl-chitosans (O-QCTS-Bn). The antibacterial activity of using O-QCTSS finishing fabric was still more than 75% after 20 consecutive home launderings. more...
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- 2011
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10. Improved synthesis of sucrose fatty acid monoesters under ultrasonic irradiation
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Kangrong Zhong, Xiaorong Fu, Xue Jiang, Dan Huang, Weidong Gao, and Hao Zhu
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Sucrose ,Time Factors ,Spectrophotometry, Infrared ,Acoustics and Ultrasonics ,Catalysis ,Inorganic Chemistry ,chemistry.chemical_compound ,Column chromatography ,Spectroscopy, Fourier Transform Infrared ,Pressure ,Chemical Engineering (miscellaneous) ,Environmental Chemistry ,Ultrasonics ,Radiology, Nuclear Medicine and imaging ,chemistry.chemical_classification ,Chromatography ,Esterification ,Silica gel ,Fatty Acids ,Organic Chemistry ,Fatty acid ,Esters ,Transesterification ,Chemistry ,Models, Chemical ,chemistry ,Yield (chemistry) ,Solvents ,Anhydrous - Abstract
Sucrose fatty acid esters were synthesized by the transesterification of sucrose with aliphatic esters under ultrasound irradiation in good yield (⩾73%). The optimum reaction conditions for the transesterification reaction include a molar ratio of sucrose to fatty acid ethyl ester of 2:1 and the use of a 13% mol anhydrous K2CO3 catalyst. The optimum reaction temperature was set at 70 °C, the optimum reaction time was 2 h, and the optimum reaction pressure was 11 kPa. The reaction had excellent monoester selectivity. The proportion of monoester (6-monoester + 6′-monoester) in the purified products was up to 92–95% via flash column chromatography over silica gel, the ratios of 6-monoester/6′-monoester are 2.1–2.7, and the sucrose monoesters were identified by HPLC–MS, NMR and IR. more...
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- 2010
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11. FGF19, FGF21, and an FGFR1/β-Klotho-Activating Antibody Act on the Nervous System to Regulate Body Weight and Glycemia
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Junichiro Sonoda, Tian Lan, Xiaorong Fu, William L. Holland, Shawn C. Burgess, David J. Mangelsdorf, Steven A. Kliewer, Donald A. Morgan, and Kamal Rahmouni
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Blood Glucose ,0301 basic medicine ,medicine.medical_specialty ,FGF21 ,Physiology ,medicine.medical_treatment ,Mice, Obese ,Adipose tissue ,030209 endocrinology & metabolism ,Biology ,Nervous System ,Mice ,03 medical and health sciences ,0302 clinical medicine ,Weight loss ,Internal medicine ,Diabetes mellitus ,Weight Loss ,medicine ,Animals ,Receptor, Fibroblast Growth Factor, Type 1 ,Klotho Proteins ,Molecular Biology ,Glycemic ,Mice, Knockout ,Neurons ,Insulin ,Antibodies, Monoclonal ,Membrane Proteins ,FGF19 ,Cell Biology ,medicine.disease ,Fibroblast Growth Factors ,Mice, Inbred C57BL ,030104 developmental biology ,Endocrinology ,Adipose Tissue ,Liver ,Insulin Resistance ,medicine.symptom ,Hormone - Abstract
Summary Despite the different physiologic functions of FGF19 and FGF21 as hormonal regulators of fed and fasted metabolism, their pharmacologic administration causes similar increases in energy expenditure, weight loss, and enhanced insulin sensitivity in obese animals. Here, in genetic loss-of-function studies of the shared co-receptor β-Klotho, we show that these pharmacologic effects are mediated through a common, tissue-specific pathway. Surprisingly, FGF19 and FGF21 actions in liver and adipose tissue are not required for their longer-term weight loss and glycemic effects. In contrast, β-Klotho in neurons is essential for both FGF19 and FGF21 to cause weight loss and lower glucose and insulin levels. We further show an FGF21 mimetic antibody that activates the FGF receptor 1/β-Klotho complex also requires neuronal β-Klotho for its metabolic effects. These studies highlight the importance of the nervous system in mediating the beneficial weight loss and glycemic effects of endocrine FGF drugs. more...
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- 2017
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12. Microstructural and electrical properties in textured lead calcium lanthanum titanate thin films deposited on a Pt/Ti/SiO2/Si substrate
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Zhitang Song, Jianxia Gao, Lianwei Wang, Chenglu Lin, Xiaorong Fu, S. X. Wang, and Lumin Wang
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Materials science ,Mechanical Engineering ,Mineralogy ,Dielectric ,Condensed Matter Physics ,Microstructure ,Ferroelectricity ,Calcium titanate ,chemistry.chemical_compound ,chemistry ,Chemical engineering ,Mechanics of Materials ,Transmission electron microscopy ,General Materials Science ,Texture (crystalline) ,Thin film ,Sol-gel - Abstract
Textured Ca modified (Pb,La)TiO 3 (PLCT) films were deposited on Pt/Ti/SiO 2 /Si substrates using a metal-organic decomposition (MOD) process. The microstructure of the PLCT thin film was investigated by X-ray diffraction (XRD), atomic force microscopy (AFM), and transmission electron microscopy (TEM). Electric properties were measured using the Pt/PLCT/Pt capacitor structure. The PLCT films exhibit good ferroelectric and dielectric properties. more...
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- 2001
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13. Growth of highly (100)-oriented Zr-rich PZT thin films on Pt/Ti/SiO2/Si substrates by a simple sol–gel process
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Xiaorong Fu, Zhitang Song, Chenglu Lin, and Jinhua Li
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Analytical chemistry ,Mineralogy ,Dielectric ,Coercivity ,Condensed Matter Physics ,Lead zirconate titanate ,Ferroelectricity ,Pyroelectricity ,Inorganic Chemistry ,chemistry.chemical_compound ,chemistry ,Materials Chemistry ,Texture (crystalline) ,Thin film ,Sol-gel - Abstract
Zr-rich lead zirconate titanate thin films with highly preferential (1 0 0) orientation, PZT80/20 and PZT85/15, and randomly oriented PZT70/30 thin films have been successfully prepared on (1 1 1)Pt-coated Si substrates using the sol–gel process with rapid thermal annealing (RTA) at 700°C for 200 s. The results of X-ray diffraction, including rocking curve measurements, suggest that PZT80/20 and PZT85/15 have a single (1 0 0) orientation with the rocking curve FWHM of around 0.5°. The dielectric properties of each film have been measured as well. The results show that highly (1 0 0)-oriented PZT85/15 films exhibit higher remnant polarization (2Pr=41.4 μC/cm2) and higher coercive field (2Ec=111 kV/cm) than randomly oriented PZT70/30 films (2Pr=33.4 μC/cm2 and 2Ec=106 kV/cm, respectively). more...
- Published
- 2000
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14. Variation of strain/defects in H+-implanted single crystal silicon
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Xinzhong Duo, Chenglu Lin, Weili Liu, Miao Zhang, Jipo Huang, and Xiaorong Fu
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Nuclear and High Energy Physics ,Materials science ,Silicon ,Annealing (metallurgy) ,Analytical chemistry ,chemistry.chemical_element ,Atmospheric temperature range ,Crystallographic defect ,Elastic recoil detection ,symbols.namesake ,Ion implantation ,chemistry ,symbols ,Rutherford scattering ,Instrumentation ,Diffractometer - Abstract
Single crystal silicon samples were implanted with H + ions at an energy of 30 KeV, and a dose of 4×10 16 /cm 2 . These samples were annealed in the temperature range from 100°C to 500°C. Four-crystal X-ray diffractometer (FCXRD), cross-sectional transmission electron microscopy (XTEM), Rutherford backscattering spectroscopy and channeling (RBS/C) were used to characterize the distribution and magnitude of the strain and extended defects in the samples. Elastic recoil detection analysis (ERDA) was used to measure the redistribution of hydrogen in Si samples during annealing. Strain distributions in the samples were simulated from the rocking curves by computer. The results help to understand the evolution of the strain and defects during annealing in the high dose H + -implanted silicon samples. more...
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- 2000
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15. Preparation of highly (100)-oriented PLCT thin films on Pt/Ti/SiO2/Si substrates by a simple sol–gel process
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Chenglu Lin, Xiaorong Fu, Xiangrong Zhu, Jinhua Li, and Zhitang Song
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Materials science ,Annealing (metallurgy) ,Mechanical Engineering ,Analytical chemistry ,Mineralogy ,chemistry.chemical_element ,Condensed Matter Physics ,Ferroelectricity ,law.invention ,chemistry.chemical_compound ,Calcium titanate ,chemistry ,Mechanics of Materials ,law ,Lanthanum ,General Materials Science ,Lead titanate ,Crystallization ,Thin film ,Sol-gel - Abstract
Highly (100)-oriented lanthanum- and calcium-modified PbTiO 3 (PLCT68/17/15 and PLCT80/10/10) ferroelectric thin films were successfully prepared on Pt/Ti/SiO 2 /Si substrates by a simple sol–gel spin-on process. The effects of thin film composition, film thickness and annealing temperature on the (100) orientation were reported. Highly (100)-oriented PLCT80/10/10 and PLCT68/17/15 thin films with pure perovskite could be obtained with around 0.3 and 0.45 μm thicknesses, respectively, when annealed at 600°C for 1 h. The films' crystallization and orientation were studied using the techniques of X-ray diffraction (XRD) and atomic force microscopy (AFM). more...
- Published
- 2000
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16. Preparation and characterization of MgO thin films by a simple nebulized spray pyrolysis technique
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Zhitang Song, Xinzhong Duo, Shigeng Song, Chenglu Lin, Xiaorong Fu, and Guangming Wu
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Diffraction ,Materials science ,Spreading resistance profiling ,Magnesium ,General Physics and Astronomy ,Mineralogy ,Magnesium acetate ,chemistry.chemical_element ,Surfaces and Interfaces ,General Chemistry ,Chemical vapor deposition ,Condensed Matter Physics ,Surfaces, Coatings and Films ,chemistry.chemical_compound ,Chemical engineering ,chemistry ,Transmission electron microscopy ,Thin film ,Pyrolysis - Abstract
A simple nebulized spray pyrolysis method has been applied to prepare MgO thin films with (200) preferential orientation on (100) Si substrates by using magnesium acetate as starting reactants. The experimental results revealed that the substrates temperature and the oxygen flow played important roles in the formation of (200) oriented MgO film. The surface morphology and some properties of the prepared MgO thin films were examined by atomic force microscopy, transmission electron microscopy, X-ray diffraction and spread resistance processing technique. more...
- Published
- 1999
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