88 results on '"Niels Fertig"'
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2. Pharmacology of P2X3 and P2X2/3 receptors: An automated patch clamp study
3. High-content multi-frequency impedance cell monitoring for label-free and time-resolved cell toxicity analysis of various cell types
4. Identification of cardiac liability in drug discovery using automated patch clamp: experimental and technical considerations for high throughput recordings of NaV1.5 and hERG
5. Accessing intracellular membrane transport proteins: a novel electrophysiological approach for lysosomal and mitochondrial channels and transporters
6. SSM-based electrophysiology, a label-free real-time method reveals sugar binding & transport events in SGLT1
7. Tackling chronic compound responses of hiPSC-CMs for preclinical cardiac risk evaluation: defined serum-free medium and long-term culture on the FLEXcyte 96
8. Mechanical stimulation in a 2D high-throughput contractility system induces functional changes in human induced pluripotent stem cell-derived cardiomyocytes
9. Drug effects on human Na+/Ca2+ exchanger and implications for testing new drug candidates
10. High throughput chronic cardiotoxicity evaluation of human iPSC-derived cardiomyocytes in a pro-maturation environment
11. Reliable identification of heart disease in drug discovery using automated patch clamps: Benchmarking best practices and calibration criteria for improved proarrhythmic assessment
12. Cell monitoring using multi-frequency impedance recordings for label-free and time-resolved cell response analysis
13. The NaV1.5 late current in WT and Nav1.5-ΔKPQ mutant channels: An automated patch clamp LQT3 electrophysiological assay comparison
14. A Novel Approach to Detect Electrogenic Transporter Activity in Intact Cells Applied to Investigate IPSC Derived Cardiomyocytes and Neurons
15. Reliable Identification of hERG Liability in Drug Discovery by Automated Patch Clamp
16. Kinetic and Pharmacological Properties of P2X3 and P2X2/3 Receptors
17. Automated Patch Clamp Meets High-Throughput Screening: 384 Cells Recorded in Parallel on a Planar Patch Clamp Module
18. Drug Effects On Human Na(+)/Ca(2+)Exchanger and Implications for Drug Development
19. Activation and Inhibition of Assay-Ready TRPA1 and TRPV Cells: An Automated Patch Clamp Study
20. Functional monitoring approaches for cardiac safety assessments and toxicity
21. A higher-throughput approach to investigate cardiac contractility in vitro under physiological mechanical conditions
22. Reliable identification of hERG liability in drug discovery by automated patch clamp
23. Reliable identification of cardiac liability in drug discovery using automated patch clamp: Benchmarking best practices and calibration standards for improved proarrhythmic assessment
24. Automated patch clamp system introducing simulated Ik1 into human iPSC-cardiomycoytes using dynamic clamp
25. Combining Physiological Relevance and Throughput for in vitro Cardiac Contractility Measurement
26. Automated Patch Clamp System Introducing Simulated IK1 into Stem Cell-Derived Cardiomyocytes using Dynamic Clamp
27. A Novel Gain of Function Mutation of Piezo-1 is Investigated in Red Blood Cells by High-Throughput Patch Clamp
28. New Easy-to-Use Hybrid System for Extracellular Potential and Impedance Recordings
29. Membrane assembly of the functional KcsA potassium channel in a vesicle-based eukaryotic cell-free translation system
30. A novel, label-free system to interrogate the function and 3D phenotype of iPSC cardiomyocyte co-culture spheroids for discovery applications
31. Coupled impedance and field potential data analysis of in vitro cardiomyocyte assays
32. High-throughput pharmacology of cardiac L-type Ca2+ channels in overexpressing cell lines and iPSC-cardiomyocytes
33. EAAT3 Investigated using SSM-Based HTS Electrophysiology on the SURFE2R 96SE
34. A sensor based technique for pharmacological safety testing of cardiac transport proteins NCX, NaKATPase and respiratory chain complexes
35. Bridging HTS Ion channel and myocyte data
36. Introducing simulated IK1 into human iPSC-cardiomyocytes using dynamic clamp on an automated patch clamp system
37. Bridging HTS Ion Channel and Myocyte Data
38. Na+/Ca2+ Exchanger in Human iPSC Derived Cardiomyocytes: Functional Evidence and Relevance for Beating Behavior
39. Introducing Simulated IK1 into Human iPSC-Cardiomyocytes using Dynamic Clamp on an Automated Patch Clamp System
40. Comprehensive Cardiac Safety Screening: Pharmacology of Stem Cell-Derived Cardiomyocytes using High-Throughput Automated Patch Clamp
41. Molecular Bases Basis of Antibiotic Translocation Across Outer Membrane Porins of Enterobacter Aerogenes
42. Green Fluorescent Protein Changes the Conductance of Connexin 43 (Cx43) Hemichannels Reconstituted in Planar Lipid Bilayers
43. Automated Patch Clamp on mESC-Derived Cardiomyocytes for Cardiotoxicity Prediction
44. High content cell monitoring of cancer and cancer treatment-related cardiomyopathy
45. Integrating dynamic clamping with automated patch clamping devices: Adding virtual IK1 channels to iPSC-CM
46. Cytotoxicity monitoring for safety assessments: iPS cardiomyocytes and cancer cells
47. Next level toxicity screening: From single channel to overall cell behavior
48. Characterization of Photoswitchable Sodium Channel Inhibitors by Planar Patch Clamp
49. Optogenetic Technologies Enable High Throughput Ion Channel Drug Discovery and Toxicity Screening
50. Introducing Simulated IK1 into Human iPSC-Cardiomyocytes using Dynamic Clamp on an Automated Patch Clamp Platform
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