1. Effects of dietary iron restriction on kidney mitochondria function and oxidative stress in streptozotocin-diabetic rats
- Author
-
Donovan J. Peña-Montes, Xóchitl Trujillo, Miguel Huerta, Maribel Huerta-Cervantes, Mónica Ríos-Silva, Alfredo Saavedra-Molina, and Christian Cortés-Rojo
- Subjects
Male ,0301 basic medicine ,medicine.medical_specialty ,Iron ,Cell Respiration ,Mitochondrion ,medicine.disease_cause ,Streptozocin ,Diabetes Mellitus, Experimental ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Internal medicine ,Diabetes mellitus ,parasitic diseases ,medicine ,Animals ,Rats, Wistar ,Respiratory system ,Molecular Biology ,Kidney ,business.industry ,Iron Deficiencies ,Cell Biology ,Glutathione ,Streptozotocin ,medicine.disease ,Mitochondria ,Rats ,Oxidative Stress ,Treatment Outcome ,030104 developmental biology ,medicine.anatomical_structure ,Endocrinology ,chemistry ,Molecular Medicine ,business ,Iron, Dietary ,030217 neurology & neurosurgery ,Function (biology) ,Oxidative stress ,medicine.drug - Abstract
Diabetes mellitus is characterized by chronic hyperglycemia causing mitochondrial dysfunction and kidney iron overload has been observed during diabetes. We evaluated the effects of an iron-restricted diet (IRD) on mitochondrial function, oxidative stress, and mitochondrial iron levels in the kidneys of Wistar rats with streptozotocin-induced diabetes. IRD ameliorated mitochondrial dysfunction in diabetic rats by restoring mitochondrial respiration and respiratory complex activity, improving oxidative stress and glutathione status in kidney mitochondria. We also observed mitochondrial iron overload. Our data suggest that elevated iron levels were attenuated by IRD, resulting in modulation of oxidative stress and mitochondrial function in the kidney.
- Published
- 2020