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Effects of dietary iron restriction on kidney mitochondria function and oxidative stress in streptozotocin-diabetic rats
- Source :
- Mitochondrion. 54:41-48
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Diabetes mellitus is characterized by chronic hyperglycemia causing mitochondrial dysfunction and kidney iron overload has been observed during diabetes. We evaluated the effects of an iron-restricted diet (IRD) on mitochondrial function, oxidative stress, and mitochondrial iron levels in the kidneys of Wistar rats with streptozotocin-induced diabetes. IRD ameliorated mitochondrial dysfunction in diabetic rats by restoring mitochondrial respiration and respiratory complex activity, improving oxidative stress and glutathione status in kidney mitochondria. We also observed mitochondrial iron overload. Our data suggest that elevated iron levels were attenuated by IRD, resulting in modulation of oxidative stress and mitochondrial function in the kidney.
- Subjects :
- Male
0301 basic medicine
medicine.medical_specialty
Iron
Cell Respiration
Mitochondrion
medicine.disease_cause
Streptozocin
Diabetes Mellitus, Experimental
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
Diabetes mellitus
parasitic diseases
medicine
Animals
Rats, Wistar
Respiratory system
Molecular Biology
Kidney
business.industry
Iron Deficiencies
Cell Biology
Glutathione
Streptozotocin
medicine.disease
Mitochondria
Rats
Oxidative Stress
Treatment Outcome
030104 developmental biology
medicine.anatomical_structure
Endocrinology
chemistry
Molecular Medicine
business
Iron, Dietary
030217 neurology & neurosurgery
Function (biology)
Oxidative stress
medicine.drug
Subjects
Details
- ISSN :
- 15677249
- Volume :
- 54
- Database :
- OpenAIRE
- Journal :
- Mitochondrion
- Accession number :
- edsair.doi.dedup.....aea61f02c20cd69531fa4e3716b2c68e