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Focal lesions within the subchondral bone, termed subchondral bone cysts (SBCs), are clinically accepted radiographic markers of advanced osteoarthritis (OA), but their etiology in the hip is not well understood.This study used micro-computed tomography (μCT), and histological and immunocytological analysis to examine the prevalence, size, location, and morphological and cellular features of SBCs found within 34 femoral heads (14 male, 20 female; age range = 43-80 years) obtained from total hip arthroplasty procedures.SBCs were common-present in 91% of the femoral heads examined-and frequently commuted with the surface of the femoral head, but otherwise showed no preferred anatomical location. Few associations were found between SBC features and patient characteristics such as BMI, age and sex. SBCs were also heterogenous in composition, ranging from fibrous (most common) to predominantly fatty (least common) and often containing vasculature, nerve fibers, cartilage islands, and bony spicules. Despite this heterogeneity, focal abnormalities in bone density and cartilage thickness were consistently observed. Bone adjacent to SBCs was denser than that in the primary compressive group, and cartilage thickness in regions overlying SBCs was lower than in non-overlying regions. In contrast to these local bony changes, μCT-based finite element analyses indicated that the stiffness of the primary compressive group was only mildly affected by SBCs.These findings indicate that SBCs in the femoral head involve extensive perturbations in cellular activity, culminating in myriad skeletal tissue types and spatially heterogenous changes in bone and cartilage morphology that are likely to affect OA progression.

Background Walch B2 glenoid morphology with glenohumeral osteoarthritis is a difficult degenerative pattern to manage for shoulder surgeons. Anatomic total shoulder arthroplasty (TSA) in combination with eccentric reaming or bone grafting are the traditional methods of treatment. Newer approaches such as TSA with posteriorly augmented glenoid components and reverse shoulder arthroplasty (RSA) may offer better stability for the posteriorly subluxated biconcave B2 wear pattern. The aim of this systematic review is to compare mid-term surgical and functional outcomes of Walch B2 glenoids without significant rotator cuff pathology treated with TSA and RSA. Methods The review was performed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines by searching the MEDLINE (PubMed) and Embase (Elsevier) databases. Inclusion criteria were clinical studies that evaluated the outcomes and complications of TSA or RSA in the setting of B2 glenoid morphology without significant rotator cuff pathology. Data relevant to TSA and RSA surgical outcomes were extracted and compiled, and outcomes were compared. A meta-analysis of proportions of complication and revision rates among TSA and RSA groups was performed. Results Overall, 16 articles were included with 414 TSAs and 78 RSAs. The average follow-up duration was 54.1 ± 14.8 months for patients undergoing TSA and 44.8 ± 10.1 months for patients undergoing RSA. The TSA group was further subdivided based on the use of eccentric reaming (135 TSAs), an augmented glenoid component (84 TSAs), or bone grafting (11 TSAs) or was unspecified (184 TSAs). Overall, patients undergoing TSA and RSA demonstrated mean improvements of 50.1 ± 8.5° and 64.7 ± 5.2° in active flexion, 58.5 ± 10.3° and 68.9 ± not reported° in active abduction, and 31.3 ± 5.7° and 29.0 ± 10.2° in active external rotation, respectively. In regard to functional outcome scores, patients undergoing TSA and RSA showed mean Constant score improvements of 38.8 ± 5.3 and 46.6 ± 3.1 points and American Shoulder and Elbow Surgeons score improvements of 48.2 ± 1.0 and 49.2 ± 25.3 points, respectively. Results of the meta-analysis with mid-term follow-up data demonstrated pooled complication rates of 9% (95% confidence interval [CI], 1%-22%) for TSA and 6% (95% CI, 0%-28%) for RSA and pooled revision rates of 2% (95% CI, 0%-8%) for TSA and 1% (95% CI, 0%-15%) for RSA. Conclusion In the setting of Walch B2 glenoid morphology, TSA with eccentric reaming or an augmented component yields comparable outcomes to RSA. Based on the patient's age, activity level, and expectations, both TSA and RSA can be considered a reasonable option to treat Walch B2 glenoid morphology.

In the era of Photonics, design and development of novel rare earth ion-doped quantum dots (QDs) for optoelectronic applications has gained significant interest owing to their outstanding characteristics. Simultaneously, the creation of a new class of photocatalytic materials on the nanoscale is also imperative for environmental purification. Thus, we report on wet chemical synthesis, the structural, morphological, and optical characteristics, fluorescence, and hydrogen evolution of ZnS:Eu (0, 2, 4, and 6 at%) QDs for optoelectronic and photocatalytic applications. Comprehensive structural studies depicted that Eu3+ ions were efficiently substituted into the host matrix and altered the original structure of the ZnS compound. The emission spectra of the ZnS:Eu QDs exhibited distinctive red fluorescence owing to the transition of dopant ions in 5D0 - 7F1, 5D0 - 7F2, 5D0 - 7F3, and 5D0 - 7F4 energy levels of the 4f orbital of the Eu3+ ions. Moreover, the photocatalytic properties of ZnS:Eu (6 at%) QDs possess better catalytic efficiency toward hydrogen evolution through a water splitting mechanism under simulated sunlight irradiation. The observed photocatalytic phenomenon in the synthesized samples agreed well with the luminescence properties exhibited by the QDs.

In the present study, we fabricate the ZnS: V (0, 2, 4, and 6 at%) nanoparticles (NPs) using the chemical-refluxing technique. We analyzed these samples based on structural, optical, magnetic, degradation, and hydrogen evolution properties. Comprehensive analyses of the chemical, structural, and optical measurements show that the vanadium (V) ions occupied the Zn host site without altering their original structure and without forming new phases. We confirmed the paramagnetic nature of the doped samples via magnetic measurements. We examined the photocatalytic properties of the fabricated NPs by the degrading Rhodamine-B (RhB) dye in an aqueous solution under the ultraviolet (UV) light, and the ZnS: V of 2 at% displayed higher degradation efficiency than the other samples. Moreover, 2 at% ZnS: V (sample showed a higher H2 evolution rate (1140 μmolg−1h−1) than the other samples and was 17 times greater than that of pure ZnS lattice. The observed efficient photocatalytic organic pollutant degradation and better hydrogen fuel evolution in 2 at% ZnS: V sample could be due to the presence of a large surface area, creation of more defect sites, dislocation sites of the prepared compound, generation, and the presence of a huge number of charge carriers due to the substitution of V-dopant in the Zn host site and non-recombination rate of charges.

The design and production of co-doped diluted magnetic semiconductor nanostructures for the development of spin-related operating electronic devices have gained considerable attention owing to their formidable characteristics. In this study, we strived to fabricate ZnO, Zn0.98Ni0.02O, Zn0.97Ni0.02Er0.01O, and Zn0.96Ni0.02Er0.02O nanoparticles. The successful penetration of Ni and Er ions into the ZnO host material was confirmed through wide-ranging structural analyses. A slight change in the bandgap of ZnO was obtained by doping and co-doping. The photoluminescence spectra revealed that doping and co-doping induced various emissions as well as structural defects in the fabricated nanoparticles. Magnetic hysteresis loops revealed that the ZnO and Zn0.98Ni0.02O nanoparticles possessed a paramagnetic nature. However, the Zn0.97Ni0.02Er0.01O and Zn0.96Ni0.02Er0.02O nanoparticles exhibited robust ferromagnetism with clear hysteresis loops. Bound magnetic polaron behavior is well-anticipated to describe the ferromagnetism in the synthesized nanoparticles. Hence, (Ni + Er) co-doping is a promising approach for extending the ferromagnetic nature of the ZnO system for spin-based electronic devices.

Irritability is a common reason why children and adolescents are brought for psychiatric care. Although research is advancing what is known about the underlying brain and behavior mechanisms of irritability, clinicians often are shut out of that research. This article explains some of these research methods, providing brief summaries of what is known about brain/behavior mechanisms in disorders involving irritability, including bipolar disorder, disruptive mood dysregulation disorder, attention-deficit/hyperactivity disorder, and autism spectrum disorder. Greater access to these methods may help clinicians now and in the future, with such mechanisms translated into improved care, as occurs in the treatment of childhood leukemia.

Diluted magnetic semiconductors related to II–VI-based compounds are of significant interest for the development of spin-based operating electronic devices such as magneto-optical instruments, spintronics, and nonvolatile memory devices. Thus, studies of electron paramagnetic resonance, magnetic characteristics, and the photocatalytic properties of transition metal-doped II–VI-based semiconductors are of great importance. We therefore comprehensively studied the structural, electron spin resonance, magnetic hysteresis, and photocatalytic characteristics of CdS:V4+ nanoparticles (NPs) fabricated by the rapid microwave route for the first time. The structural analyses revealed the authentic substitution of V4+ dopant ions into the CdS matrix. The widening of the optical band gap and relevant quantum confinement phenomenon are discussed in terms of the inclusion of V4+ ions into the CdS matrix. The electron paramagnetic resonance (EPR) spectroscopy results were corroborated by the increase in the number of magnetic spins with increasing V4+ dopant concentration. The assessed number of magnetic spins was nearly equal to 3.601597 × 106 and 7.254048 × 106 for the CdS:V (2 and 4 at%) NPs, respectively. Room-temperature magnetic hysteresis loops also revealed the existence of a large number of magnetic spins through the formation of clear paramagnetism in the CdS:V (2 and 4 at%) NPs. The CdS:V (4 at%) system displayed enriched visible light-driven photocatalytic degradation efficiency compared to bare CdS through the degradation of RhB dye in contaminated water.

t(6;9)(p22;q34.1)/DEK-NUP214 is a recurrent genetic abnormality that occurs in 1-2% of patients with acute myeloid leukemia (AML), and rarely in myelodysplastic syndrome (MDS). It has been suggested by others that all myeloid neoplasms with t(6;9)/DEK-NUP214 may be considered as AML, even when blast count is

Upper tract urothelial carcinoma is a rare malignancy for which surgery provides definitive management. Open radical nephroureterectomy was the gold standard treatment, but laparoscopic and robot-assisted approaches are alternative options. Kidney-sparing approaches are feasible for carefully selected patients with ureteral cancer. This article discusses the evaluation of patients with upper tract urothelial carcinoma and definitive management using robot-assisted surgical approaches. Patients with urothelial carcinoma of the upper tract can be treated with robot-assisted nephroureterectomy, distal ureterectomy, and segmental ureterectomy.

Evaluate the effect of intravenous golimumab on health-related quality of life (HRQoL) in patients with ankylosing spondylitis (AS) through week 28 of the phase III, multicenter, randomized, double-blind, placebo-controlled GO-ALIVE study.Adult patients (n = 208) were randomized to IV golimumab 2 mg/kg (n = 105) at weeks 0, 4, and 12 and every 8 weeks or placebo (n = 103) at weeks 0, 4, and 12, with crossover to golimumab 2mg/kg at weeks 16, 20, and every 8 weeks. General HRQoL was evaluated using the Short Form Health Survey (SF-36) Physical Component Summary/Mental Component Summary (PCS/MCS), and the EQ VAS, and AS disease-specific HRQoL was assessed using the Ankylosing Spondylitis Quality of Life (ASQoL) instrument.Mean improvements from baseline in SF-36 PCS were greater in the golimumab group versus the placebo group at weeks 8 and 16 (6.8 vs 2.1 and 8.5 vs 2.9, respectively; P.001); similar results were observed for SF-36 MCS (5.6 vs 1.7 and 6.5 vs 0.8, respectively; P.001). Mean improvement in each of 8 subscale scores of the SF-36 were also greater for golimumab-treated patients versus placebo at weeks 8 and 16. Mean improvements in EQ VAS and ASQoL were greater in the golimumab group versus placebo at week 8 and week 16. Greater proportions of golimumab-treated patients had clinically meaningful improvement in SF-36 PCS, SF-36 MCS, EQ VAS, and ASQoL at weeks 8 and 16; improvements in SF-36 PCS/MCS, EQ VAS, and ASQoL were maintained through week 28.Golimumab-treated patients had greater mean improvements in HRQoL measures compared with placebo through week 16. Clinically meaningful improvements were observed as early as week 8 and continued through week 28.

Objective To measure effects of ED crowding on lung-protective ventilation (LPV) utilization in critically ill ED patients. Methods This is a retrospective cohort study of adult mechanically ventilated ED patients admitted to the medical intensive care unit (MICU), over a 3.5-year period at a single academic tertiary care hospital. Clinical data, including reason for intubation, severity of illness (MPM0-III), acute respiratory distress syndrome (ARDS) risk score (EDLIPS), and ventilator settings were extracted via electronic query of electronic health record and standardized chart abstraction. Crowding metrics were obtained at 5-min intervals and averaged over the ED stay, stratified by acuity and disposition. Multivariate logistic regression was used to predict likelihood of LPV prior to ED departure. Results Mechanical ventilation was used in 446 patients for a median ED duration of 3.7 h (interquartile ratio, IQR, 2.3, 5.6). Mean MPM0-III score was 32.5 ± 22.7, with high risk for ARDS (EDLIPS ≥5) seen in 373 (82%) patients. Initial and final ED ventilator settings differed in 134 (30.0%) patients, of which only 47 (35.1%) involved tidal volume changes. Higher percentages of active ED patients (workup in-progress) and those requiring eventual admission were associated with lower odds of LPV utilization by ED departure (OR 0.97, 95%CI 0.94–1.00; OR 0.97, 95%CI 0.94–1.00, respectively). In periods of high volume, ventilator adjustments to settings other than the tidal volume were associated with higher odds of LPV utilization. Reason for intubation, MPM0-III, and EDLIPS were not associated with LPV utilization, with no interactions detected in times of crowding. Conclusions ED patients remain on suboptimal tidal volume settings with infrequent ventilator adjustments during the ED stay. Hospitals should focus on both systemic factors and bedside physician and/or respiratory therapist interventions to increase LPV utilization in times of ED boarding and crowding for all patients.

The complex 16p11.2 Deletion Syndrome (16pdel) is accompanied by neurological disorders, including epilepsy, autism spectrum disorder and intellectual disability. We demonstrated that 16pdel iPSC differentiated neurons show augmented local field potential activity and altered ceramide-related lipid species relative to unaffected. FAM57B, a poorly characterized gene in the 16p11.2 interval, has emerged as a candidate tied to symptomatology. We found that FAM57B modulates ceramide synthase (CerS) activity, but is not a CerS per se. In FAM57B mutant human neuronal cells and zebrafish brain, composition and levels of sphingolipids and glycerolipids associated with cellular membranes are disrupted. Consistently, we observed aberrant plasma membrane architecture and synaptic protein mislocalization, which were accompanied by depressed brain and behavioral activity. Together, these results suggest that haploinsufficiency of FAM57B contributes to changes in neuronal activity and function in 16pdel Syndrome, through a crucial role for the gene in lipid metabolism.

We develop a method to explore the mechanical response of particles on a liquid-air interface under biaxial tension. Particles were laser cut with designed 2D geometries that interact in a predictable manner through capillary effects. When such particles were arranged into a raft on the water-air interface in a funnel, raising the water level induced deformation and ultimately failure of the raft. While particles that strongly attract one another can be strained further before they fracture, weakly interacting particles are able to move to heal fractures in a manner that is reminiscent of crack healing in ductile materials. Anisotropic particles delay the onset of failure but prevent rearrangement owing to particles locking into fixed orientations relative to their neighbors. These results illustrate the importance of interparticle interactions in determining the emergent mechanical properties of particle rafts.

Currently available smoothened targeted therapies in patients with basal cell nevus syndrome are associated with substantial tumor recurrence and clinical resistance. Strategies bypassing smoothened and/or identifying additional downstream components of the Hedgehog pathway could provide novel antitumor targets with a better therapeutic index. Sry-related high mobility group box 9 (SOX9) is a Hedgehog/glioma-associated oncogene homolog-regulated transcription factor known to be overexpressed in basal cell carcinomas (BCCs). A sequence motif search for SOX9-responsive elements identified three motifs in the promoter region of mammalian target of rapamycin (mTOR). In murine BCC cells, SOX9 occupies the mTOR promoter and induces its transcriptional activity. Short hairpin RNA (shRNA)-mediated knockdown of SOX9 , as well as smoothened inhibition by itraconazole and vismodegib, reduces mTOR expression and the phosphorylation of known downstream mTOR targets. These effects culminate in diminishing the proliferative capacity of BCC cells, demonstrating a direct mechanistic link between the Hedgehog and mTOR pathways capable of driving BCC growth. Furthermore, rapamycin, a pharmacologic mTOR inhibitor, suppressed the growth of UV-induced BCCs in Ptch1 +/– /SKH-1 mice, a model that closely mimics the accelerated BCC growth pattern of patients with basal cell nevus syndrome. Our data demonstrate that Hedgehog signaling converges on mTOR via SOX9, and highlight the SOX9-mTOR axis as a viable additional target downstream of smoothened that could enhance tumor elimination in patients with BCC.

Double-hit lymphomas (DHLs) and double-expressor lymphomas (DELs) are associated with resistance to frontline and salvage immunochemotherapy, as well as autologous stem cell transplantation (SCT). We hypothesized that allogeneic SCT (alloSCT) could overcome the chemoresistance associated with DEL/DHL. We retrospectively studied the impact of DEL/DHL status in a multicenter cohort of patients who underwent alloSCT for relapsed/refractory (rel/ref) aggressive B cell non-Hodgkin lymphoma (B-NHL). Seventy-eight patients transplanted at 3 centers in whom tumor tissue was available for immunohistochemistry and fluorescence in situ hybridization were enrolled; 47% had DEL and 13% had DHL. There were no significant differences in 4-year progression-free (PFS) or overall survival (OS) between patients with DEL compared with patients without DEL (PFS 30% versus 39%, P = .24; OS 31% versus 49%, P = .17) or between patients with DHL compared with patients without DHL (PFS 40% versus 34%, P = .62; OS 50% versus 38%, P = .46). The lack of association between DEL or DHL and outcome was confirmed in multivariable models, although inadequate sample size may have limited our ability to detect significant differences. In our cohort alloSCT produced durable remissions in patients with rel/ref aggressive B-NHL irrespective of DEL and DHL status, justifying its consideration in the treatment of patients with rel/ref DEL/DHL.

Trials SWOG 8949 and EORTC 30947 had the same eligibility criteria and established the role of cytoreductive nephrectomy for metastatic renal cell carcinoma. The more recently published CARMENA trial calls into question the need for cytoreductive nephrectomy. A systematic comparison of CARMENA and SWOG 8949 suggests that cytoreductive nephrectomy may be beneficial for patients receiving immunotherapy but not targeted therapy. The approval of immune checkpoint inhibitors for previously untreated metastatic renal cell carcinoma underlines the need for another randomized phase 3 trial of cytoreductive nephrectomy for patients receiving powerful modern immunotherapies.

Nowadays, diluted magnetic semiconductors with improved ferromagnetic feature is utterly seeking for use in modern spintronic applications.We describe the optical as well as magnetic properties of CdS, CdS:Cr, CdS:(Cr + Al), and CdS:(Cr + Mn) co-doped samples. The substitution of Cr dopant and co-dopant ions (Al and Mn) in the host sites were confirmed through structural analysis. Declining of energy band gap with the incorporation of Cr dopant and co-dopant ions (Al and Mn) into the CdS host lattice was estimated through optical studies. Room-temperature magnetic hysteresis curves revealed that pure CdS exhibited paramagnetic nature due to its surface defects, whereas CdS:Cr, CdS:(Cr + Al), and CdS:(Cr + Mn) co-doped nanoparticles showed better ferromagnetic characteristics. Among all synthesized nanoparticles, CdS:(Cr + Al) semiconductor sample exhibited enhanced ferromagnetic nature and may benficial for spintronic applications.

Scaffolds of tetrahydrocarbazoles are an important class of biologically active compounds found abundant in nature. In the present investigation, functionalized polycyclic tetrahydrocarbazoles were synthesized using Diels-Alder cycloaddition between fused 5-, 6- and 7-membered ring 2-vinylindoles and various dienophiles. The dienophiles used were N -phenylmaleimides, 1,4-naphthoquinone, and dimethyl acetylenedicarboxylate (DMAD). When 1,4-naphthoquinone was used as a dienophile, the 5-membered ring Diels-Alder adduct was obtained in the oxidized form, but this form was not observed in the case of 6- and 7-membered ring Diels-Alder adducts. The desired product yields ranged from 60–70% and the structure of final compounds were determined using 1D and 2D NMR analysis. 1 H NMR studies confirmed excellent diastereoselectivity (>99% de).

Electronic skin, which has pixels composed of various functional sensors and can be applied to robots and various medical devices by mimicking the human skin, requires flexible, multi-mode, high-sensitivity, and low-interference sensors. In this study, we used a flexible electrode material comprised of organic conductor-elastomer-metal nanoparticles, as the core material and the inkjet printing method as the core process. These were used to form a flexible sensor for electronic skin applications, which involved vertically laminated sensors that utilize different sensing principles, thus enabling the realization of a flexible bimodal sensor with negligible interference. The pressure sensor with low resistivity and a flexible electrode, which was implemented using the sophisticated synthesis method, performed well under low-voltage (0.5 mV) operation conditions, exhibited pressure sensitivity over a wide range (3 Pa to 5 kPa), and showed excellent reliability characteristics (100,000 cycles) that can withstand severe mechanical stress. The temperature sensor, which was formed by a long bent organic conductor-metal line, changes its resistance with temperature, has a resistance change sensitivity of 0.32% per degree of temperature change, and exhibits a hysteresis-free temperature sensing capability. In particular, this device has maintained its robustness even over 5000 bending cycles. The 25 pixels temperature-pressure bimodal sensor array demonstrates very fast response rates, high sensitivity, and negligible interference performance. The low-resistivity/high-flexibility conducting electrode, inkjet printing process, device architecture, and integration scheme proposed in this study are expected to be widely used for electronic skin, multi-mode sensors, and flexible devices.

The Korea Heavy Ion Medical Accelerator (KHIMA) project has been developed for cancer therapy. The injector system consists of a low energy beam transport (LEBT) line, a radio-frequency quadrupole, a drift tube linac with two tanks, and a medium energy beam transport (MEBT) line with a charge stripper section. The injector system transports and accelerates the 12 C 4 + beam that is produced from electron cyclotron resonance ion source up to 7 MeV/u, respectively. The 12 C 6 + beam, which is transformed by a charge stripper from the 12 C 4 + beam, is injected into a synchrotron and accelerated up to 430 MeV/u. The lattice for the injector system was designed to optimize the beam parameters and to meet beam requirements for the synchrotron. We performed start-to-end simulations from the LEBT line to the MEBT line to confirm that the required design goals of the beam and injector system were met. Our simulation results indicate that our design achieves the required performance and a good transmission efficiency of 90%. We present the lattice design and beam dynamics for the injector system in the KHIMA project.

How can the business maximize revenue while providing discounts? This research suggests that hospitality operators may stimulate add-on purchases with the adoption of surprise discounts. Two experiments investigated factors that influence hospitality consumers’ ancillary spending. Study 1 tested the discount and product type effects on additional spending intentions for a cruise booking. Study 2 identified how the depth of surprise discount and add-on product type influence consumers' add-on purchase decisions for an online hotel booking. The findings indicate that a surprise discount and hedonic items induce consumers' unplanned purchases. A hedonic add-on item is preferred over a utilitarian item when a low discount is offered. Impulse buying mediates the effect of surprise discount and product type on unplanned purchase intentions. This research extends the traditional discount role, by demonstrating that a discount promotion can induce consumers' additional purchases. The findings provide guidance for effective pricing strategies and add-on marketing mix.

Introduction Tacrolimus has several cardiovascular adverse events. We report case of tacrolimus-induced severe cerebral and coronary vasospasm after heart transplantation. Case Report A 62-year-old female underwent orthotropic heart transplantation due to dialted cardiomyopathy. Her postoperative course was benign. At 2 months, she complained of severe pulsatile headache. CTA of the brain showed diffuse cerebral artery constriction with multifocal beaded features at nearly all distal cranial arteries and scant SAH in the right parietal area (Figure 1). We diagnosed reversible cerebral vasospasm syndrome (RCVS) induced by tacrolimus and planned to switch tacrolimus to sirolimus using the vasodilator. She inevitably maintained a low level of tacrolimus due to sirolimus induced diarrhea. Using nimodipine, her symptoms disappeared, and follow-up CTA of the brain showed relieved cerebral vasoconstriction and absorption of hemorrhage (Figure 1). At 5 months after surgery, she was admitted from acute rejection. After 2 weeks of treatment, she was stabilized with biopsy improvement. We maintained a triple regimen. She soon complained of chest pain. Telemetry revealed transient ST segment elevation (Figure 2). We assumed that this event was associated with elevated tacrolimus levels; thus, tacrolimus was reduced, and oral diltiazem was administered. Using a vasodilator, a coronary vasospasm provocation test was performed. During the test, severe coronary spasm was noted. Intracoronary and intravascular nitroglycerin was administered aggressively. The study was completed after confirming a normalized coronary artery(Figure 3). Twenty minutes later, she collapsed with squeezing chest pain. On-site CPR and ECMO insertion were performed. Two days later, she died of cardiogenic shock even with ECMO support. Summary Early detection of disease and withholding tacrolimus are important strategies.

The creation of oxide based magnetic materials has attracted a great deal of scientific attention, owing to their novel applications in optoelectronic, memory, and spintronic device applications. In this study, the authors report upon the structural, optical, and magnetic properties of Co-substituted CeO2 nanocrystals synthesized via the wet chemical precipitation method. The obtained nanoparticles show good crystallinity as well as an FCC structure with an Fm3m space group of host CeO2 lattice, as confirmed by an X-ray diffraction results. It is noted that Co substitution at low concentrations enhances the photoluminescence characteristics of CeO2 nanoparticles, while higher concentrations significantly reduce the intensity of PL emission, as revealed by PL studies. The estimated M − H loops illustrate that pristine CeO2 shows a paramagnetic nature, while all Co-substituted samples were ferromagnetic in nature. Furthermore, magnetic parameters such as saturation magnetization (MS) and residual magnetization (MR) increased with the inclusion of Co content, reaching a maximum at 4 at% Co and quenching at 6 at% and 8 at% of Co-substitution. In particular, Ce1-xCoxO2 (x = 0.04) nanoparticles show better luminescence and magnetic characteristics than the remaining concentrations.