Myelodysplastic syndrome with t(6;9)(p22;q34.1)/DEK-NUP214 better classified as acute myeloid leukemia? A multicenter study of 107 cases

Authors :: Gang Zheng
Qi Shen
Wei Wang
Lina Shao
Lan Zheng
Ji Yuan
Young L. Kim
Guillermo Garcia-Manero
Yongzhong Yuan
Xiaohui Zhang
Xiaojun Wu
Rong He
L. Jeffrey Medeiros
Yulei Shen
Hong Fang
Sunyi Chi
Mariko Yabe
Sanam Loghavi
Shimin Hu
Peng Wei
Dong Chen
Guiling Tang
Source :: Modern Pathology. 34:1143-1152
Publication Year :: 2021
Publisher :: Elsevier BV, 2021.
Abstract: t(6;9)(p22;q34.1)/DEK-NUP214 is a recurrent genetic abnormality that occurs in 1-2% of patients with acute myeloid leukemia (AML), and rarely in myelodysplastic syndrome (MDS). It has been suggested by others that all myeloid neoplasms with t(6;9)/DEK-NUP214 may be considered as AML, even when blast count is

Subjects :: Adult
Male
0301 basic medicine
Oncology
medicine.medical_specialty
Pathology
Myeloid
Adolescent
Oncogene Proteins, Fusion
Chromosomal Proteins, Non-Histone
medicine.medical_treatment
Hematopoietic stem cell transplantation
Translocation, Genetic
Pathology and Forensic Medicine
Young Adult
03 medical and health sciences
0302 clinical medicine
hemic and lymphatic diseases
Internal medicine
White blood cell
medicine
Humans
Oncogene Fusion
Child
Poly-ADP-Ribose Binding Proteins
Survival analysis
Aged
Aged, 80 and over
Oncogene Proteins
business.industry
Myeloid leukemia
Middle Aged
medicine.disease
Nuclear Pore Complex Proteins
Transplantation
Leukemia, Myeloid, Acute
stomatognathic diseases
030104 developmental biology
medicine.anatomical_structure
Basophilia
Myelodysplastic Syndromes
030220 oncology & carcinogenesis
Chromosomes, Human, Pair 6
Female
Bone marrow
Chromosomes, Human, Pair 9
business

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