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The Hodgkin associated monoclonal antibody (Mab) HRS-1 reacts with Hodgkin and Reed-Sternberg cells (HR-S) in all HD subtypes. HRS-1 Mab was labelled with radioiodine and injected into 10 patients for immunoscintigraphy (IS). Seven patients were injected with HRS-1 Mab radiolabelled with 131I and three patients were injected with HRS-1 Mab labelled with 123I. A control anti-alpha-fetoprotein (anti-AFP) Mab was radiolabelled with another iodine isotope and was injected simultaneously in five cases. Six out of eight patients with proven HD had a true positive scan (nodal, splenic and bony involvement). Imaging was equivocal or failed in the two other patients. In the last two patients IS imaging was truly negative due to the absence of residual HD in one patient and to an erroneous histological diagnosis of HD in another patient. These results, although preliminary, demonstrate that IS with radioiodine-labelled HRS-1 Mab is feasible and may prove to be informative in the staging of HD.

Ortho substituted porphyrins are able to complex copper (+II) in a neutral aqueous medium containing an excess of bovine albumine.

Using DMSA labeled with 117 m Sn, 14 C, 95 m Tc and 99 m Tc the renal kinetic and receptor identification by autoradiography and subcellular studies was performed. The half-life was found to be 6.5 days in the kidney. The binding receptors of the Tc-(DMSA) 2 are assumed to be in the microsomes of the proximal tubular cells and they are limited in number. The Tc-(DMSA) 2 is assumed to split in the cell where the Tc-DMSA moiety is bound to the protein receptors, and the remaining DMSA is excreted to urine.