2,3-Dimercaptosuccinic-acid chelates—2. Renal localization

Using DMSA labeled with 117 m Sn, 14 C, 95 m Tc and 99 m Tc the renal kinetic and receptor identification by autoradiography and subcellular studies was performed. The half-life was found to be 6.5 days in the kidney. The binding receptors of the Tc-(DMSA) 2 are assumed to be in the microsomes of the proximal tubular cells and they are limited in number. The Tc-(DMSA) 2 is assumed to split in the cell where the Tc-DMSA moiety is bound to the protein receptors, and the remaining DMSA is excreted to urine.