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Your search keyword '"Imai, Ryosuke"' showing total 13 results
Start Over Author "Imai, Ryosuke" Publisher elsevier bv
13 results on '"Imai, Ryosuke"'

3. Clinical characteristics and outcomes after extracorporeal cardiopulmonary resuscitation in out-of-hospital cardiac arrest patients with an initial asystole rhythm

Author

Shirasaki, Kasumi, primary, Hifumi, Toru, additional, Goto, Masahiro, additional, Shin, Kijong, additional, Horie, Katsuhiro, additional, Isokawa, Shutaro, additional, Inoue, Akihiko, additional, Sakamoto, Tetsuya, additional, Kuroda, Yasuhiro, additional, Imai, Ryosuke, additional, and Otani, Norio, additional

Published
2023
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4. The Tumor Immune Microenvironment and Frameshift Neoantigen Load Determine Response to PD-L1 Blockade in Extensive-Stage SCLC

Author

Kanemura, Hiroaki, primary, Hayashi, Hidetoshi, additional, Tomida, Shuta, additional, Tanizaki, Junko, additional, Suzuki, Shinichiro, additional, Kawanaka, Yusuke, additional, Tsuya, Asuka, additional, Fukuda, Yasushi, additional, Kaneda, Hiroyasu, additional, Kudo, Keita, additional, Takahama, Takayuki, additional, Imai, Ryosuke, additional, Haratani, Koji, additional, Chiba, Yasutaka, additional, Otani, Tomoyuki, additional, Ito, Akihiko, additional, Sakai, Kazuko, additional, Nishio, Kazuto, additional, and Nakagawa, Kazuhiko, additional

Published
2022
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5. MO4-4 Safety of immune checkpoint blockade in lung cancer and pre-existing autoimmune diseases: NEJ047 multi-center study

Author

Kitadai, Rui, primary, Asao, Tetsuhiko, additional, Shukuya, Takehito, additional, Yamamoto, Gaku, additional, Mouri, Atsuto, additional, Imai, Ryosuke, additional, Tsukita, Yoko, additional, Isobe, Kazutoshi, additional, Watanabe, Satoshi, additional, Kamimura, Mitsuhiro, additional, Morita, Ryo, additional, Kudo, Keita, additional, Inomata, Minehiko, additional, Tateishi, Kazunari, additional, Kakinuma, Kazutaka, additional, Yoshioka, Hiroshige, additional, Namba, Yukiko, additional, Nakagawa, Taku, additional, Kobayashi, Kunihiko, additional, and Takahashi, Kazuhisa, additional

Published
2022
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6. Clinical Characteristics and Outcomes after Extracorporeal Cardiopulmonary Resuscitation in Out-of-Hospital Cardiac Arrest Patients with an Initial Asystole Rhythm

Author

Shirasaki, Kasumi, primary, Hifumi, Toru, additional, Goto, Masahiro, additional, Shin, Kijong, additional, Horie, Katsuhiro, additional, Isokawa, Shutaro, additional, Inoue, Akihiko, additional, Sakamoto, Tetsuya, additional, Kuroda, Yasuhiro, additional, Imai, Ryosuke, additional, and Otani, Norio, additional

Published
2022
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10. A Transient Rise in Free Mg 2+ Ions Released from ATP-Mg Hydrolysis Contributes to Mitotic Chromosome Condensation

Author

20422545, Maeshima, Kazuhiro, Matsuda, Tomoki, Shindo, Yutaka, Imamura, Hiromi, Tamura, Sachiko, Imai, Ryosuke, Kawakami, Syoji, Nagashima, Ryosuke, Soga, Tomoyoshi, Noji, Hiroyuki, Oka, Kotaro, Nagai, Takeharu, 20422545, Maeshima, Kazuhiro, Matsuda, Tomoki, Shindo, Yutaka, Imamura, Hiromi, Tamura, Sachiko, Imai, Ryosuke, Kawakami, Syoji, Nagashima, Ryosuke, Soga, Tomoyoshi, Noji, Hiroyuki, Oka, Kotaro, and Nagai, Takeharu

Abstract

For cell division, negatively charged chromatin, in which nucleosome fibers (10 nm fibers) are irregularly folded [ 1–5 ], must be condensed into chromosomes and segregated. While condensin and other proteins are critical for organizing chromatin into the appropriate chromosome shape [ 6–17 ], free divalent cations such as Mg2+ and Ca2+, which condense chromatin or chromosomes in vitro [ 18–28 ], have long been considered important, especially for local condensation, because the nucleosome fiber has a net negative charge and is by itself stretched like “beads on a string” by electrostatic repulsion. For further folding, other positively charged factors are required to decrease the charge and repulsion [ 29 ]. However, technical limitations to measure intracellular free divalent cations, but not total cations [ 30 ], especially Mg2+, have prevented us from elucidating their function. Here, we developed a Förster resonance energy transfer (FRET)-based Mg2+ indicator that monitors free Mg2+ dynamics throughout the cell cycle. By combining this indicator with Ca2+ [ 31 ] and adenosine triphosphate (ATP) [ 32 ] indicators, we demonstrate that the levels of free Mg2+, but not Ca2+, increase during mitosis. The Mg2+ increase is coupled with a decrease in ATP, which is normally bound to Mg2+ in the cell [ 33 ]. ATP inhibited Mg2+-dependent chromatin condensation in vitro. Chelating Mg2+ induced mitotic cell arrest and chromosome decondensation, while ATP reduction had the opposite effect. Our results suggest that ATP-bound Mg2+ is released by ATP hydrolysis and contributes to mitotic chromosome condensation with increased rigidity, suggesting a novel regulatory mechanism for higher-order chromatin organization by the intracellular Mg2+-ATP balance.

Published
2018

11. A Transient Rise in Free Mg2+ Ions Released from ATP-Mg Hydrolysis Contributes to Mitotic Chromosome Condensation

Author

Maeshima, Kazuhiro, primary, Matsuda, Tomoki, additional, Shindo, Yutaka, additional, Imamura, Hiromi, additional, Tamura, Sachiko, additional, Imai, Ryosuke, additional, Kawakami, Syoji, additional, Nagashima, Ryosuke, additional, Soga, Tomoyoshi, additional, Noji, Hiroyuki, additional, Oka, Kotaro, additional, and Nagai, Takeharu, additional

Published
2018
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12. Dynamic Organization of Chromatin Domains Revealed by Super-Resolution Live-Cell Imaging

Author

Nozaki, Tadasu, primary, Imai, Ryosuke, additional, Tanbo, Mai, additional, Nagashima, Ryosuke, additional, Tamura, Sachiko, additional, Tani, Tomomi, additional, Joti, Yasumasa, additional, Tomita, Masaru, additional, Hibino, Kayo, additional, Kanemaki, Masato T., additional, Wendt, Kerstin S., additional, Okada, Yasushi, additional, Nagai, Takeharu, additional, and Maeshima, Kazuhiro, additional

Published
2017
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