1. Chromosomal congenital anomalies and residence near hazardous waste landfill sites
- Author
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Martine Vrijheid, R Ide, I Fazarinc, Vera Nelen, Helen Dolk, Ben Armstrong, E. Garne, J. E. S. Scott, Fabrizio Bianchi, David H. Stone, Lenore Abramsky, Romano Tenconi, and Elisabeth Robert
- Subjects
Chromosome Aberrations ,Male ,Hazardous Waste ,Infant, Newborn ,Abnormalities, Drug-Induced ,General Medicine ,Odds ratio ,Risk Assessment ,Infant newborn ,Europe ,Geography ,Pregnancy ,Hazardous waste ,Odds Ratio ,Humans ,Female ,Residence ,Down Syndrome ,Risk factor ,Risk assessment ,Demography - Abstract
Previous findings of the EUROHAZCON study showed a 33% increase in risk of non-chromosomal anomalies near hazardous waste landfill sites. Here, we studied 245 cases of chromosomal anomalies and 2412 controls who lived near 23 such sites in Europe. After adjustment for confounding by maternal age and socioeconomic status, we noted a higher risk of chromosomal anomalies in people who lived close to sites (0-3 km) than in those who lived further away (3-7 km; odds ratio 1.41, 95% CI 1.00-1.99). Our results suggest an increase in risk of chromosomal anomalies similar to that found for non-chromosomal anomalies.
- Published
- 2002