11 results on '"Huitao Zhang"'
Search Results
2. Hemodialysis Arteriovenous Fistula Dysfunction: Retrospective Comparison of Post-thrombotic Percutaneous Endovascular Interventions with Pre-emptive Angioplasty
- Author
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Xinyan Hu, Bing Li, Junjie Mao, Xiaojun Hu, Jingjing Zhang, Hui Guo, Dashuai Wang, Yongyu Zhang, Jianan He, Ni Zhao, Huitao Zhang, and Pengfei Pang
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Angioplasty ,Graft Occlusion, Vascular ,Thrombosis ,General Medicine ,Urokinase-Type Plasminogen Activator ,Arteriovenous Shunt, Surgical ,Treatment Outcome ,Renal Dialysis ,Arteriovenous Fistula ,Humans ,Surgery ,Cardiology and Cardiovascular Medicine ,Angioplasty, Balloon ,Vascular Patency ,Retrospective Studies - Abstract
We aimed to compare the clinical outcomes of pre-emptive angioplasty versus post-thrombotic percutaneous endovascular restoration of dysfunctional arteriovenous fistula (AVF).This retrospective study reviewed the data from 80 patients who underwent 114 endovascular interventions for a malfunctioning AVF from July 2016 to August 2019. Stenotic AVFs were treated with pre-emptive angioplasty. Thrombosed AVFs were treated with percutaneous pharmacomechanical fibrinolysis with urokinase used only during the operation or continuously infused. The differences in patency rates were evaluated using the Kaplan-Meier method. In addition, univariate and multivariate regression Cox models were used to determine influential factors on the postintervention primary patency.Post-thrombotic interventions and pre-emptive angioplasty yielded statistically similar rates in clinical success (100 vs. 100%), anatomic success (94 vs. 89%; P = 0.52), complication (4 vs. 11%; P = 0.29), as well as postintervention primary, assisted primary and secondary patency (P = 0.80; 0.57; 0.57). The use of pre-emptive angioplasty was associated with reduced total cost (¥25,108 vs. ¥30,833, P 0.001). The patients who used urokinase only during the operation prolonged both the primary and assisted primary patency (P = 0.02; 0.002), while those with continuous infusion of urokinase had worst patency rates and high costs (¥39,275 vs. ¥25,108 vs. ¥27,140, P 0.001). Compared with the other locations, dysfunction in the anastomotic or juxta-anastomotic segment (HR = 0.41, P = 0.001) was associated with prolonged postintervention primary patency.No clinical outcome differences were found between the post-thrombotic percutaneous endovascular interventions and pre-emptive angioplasty. However, pre-emptive angioplasty decreased access expenditure.
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- 2022
3. Analysis of Spatial Structure and Filling Mechanism of Paleokarst Conduit Against a Background of Denudation: A Case Study in the Tahe Oilfield, Tarim Basin
- Author
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Chenhe Zhang, Zhiqian Gao, Tailiang Fan, Duan Wei, Jun Wua, Debin Yang, Jinxian Liu, Huitao Zhang, Bo Li, Zhe Chang, Yu Gu, Ming Jiang, Ze Gao, Aolin Wang, and Qianxi Zou
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- 2023
4. Protein Post-translational Modification Site Prediction using Deep Learning
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Yujuan Deng, Yunfang Fu, Huitao Zhang, Xin Liu, and Zhiguo Liu
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General Earth and Planetary Sciences ,General Environmental Science - Published
- 2022
5. Mechanical stimulation on a microfluidic device to highly enhance small extracellular vesicle secretion of mesenchymal stem cells
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Rui Hao, Shi Hu, Huitao Zhang, Xi Chen, Zitong Yu, Jingyi Ren, Hang Guo, and Hui Yang
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Biomaterials ,Biomedical Engineering ,Bioengineering ,Cell Biology ,Molecular Biology ,Biotechnology - Abstract
Small extracellular vesicles (sEVs) are recognized as promising detection biomarkers and attractive delivery vehicles, showing great potential in diagnosis and treatment of diseases. However, the applications of sEVs are usually restricted by their poor secretion amount from donor cells under routine cell culture conditions, which is especially true for mesenchymal stem cells (MSCs) due to their limited expansion and early senescence. Here, a microfluidic device is proposed for boosting sEV secretion from MSCs derived from human fetal bone marrow (BM-MSCs). As the cells rapidly pass through a microfluidic channel with a series of narrow squeezing ridges, mechanical stimulation permeabilizes the cell membrane, thus promoting them to secrete more sEVs into extracellular space. In this study, the microfluidic device demonstrates that mechanical-squeezing effect could increase the secretion amount of sEVs from the BM-MSCs by approximately 4-fold, while maintaining cellular growth state of the stem cells. Further, the secreted sEVs are efficiently taken up by immortalized human corneal epithelial cells and accelerate corneal epithelial wound healing
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- 2023
6. Mediation effect of AhR expression between polycyclic aromatic hydrocarbons exposure and oxidative DNA damage among Chinese occupational workers
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Yanli Liu, Jisheng Nie, Ye Fu, Jinzhu Zhao, Yingying Niu, Hongjie Zhang, Huitao Zhang, Jin Yang, and Aimin Yang
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Adult ,Male ,China ,Mediation (statistics) ,medicine.medical_specialty ,Health, Toxicology and Mutagenesis ,Urinary system ,Naphthols ,010501 environmental sciences ,Toxicology ,01 natural sciences ,law.invention ,Oxidative dna damage ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Asian People ,Naphthalenesulfonates ,law ,Occupational Exposure ,Internal medicine ,medicine ,Humans ,Deoxyguanosine ,Polycyclic Aromatic Hydrocarbons ,Coke ,Chromatography, High Pressure Liquid ,Polymerase chain reaction ,Carcinogen ,0105 earth and related environmental sciences ,Aspartic Acid ,Fluorenes ,Pyrenes ,biology ,Chemistry ,General Medicine ,Aryl hydrocarbon receptor ,030210 environmental & occupational health ,Pollution ,Reverse transcriptase ,Oxidative Stress ,Endocrinology ,Receptors, Aryl Hydrocarbon ,8-Hydroxy-2'-Deoxyguanosine ,Carcinogens ,biology.protein ,Environmental Pollutants ,DNA Damage - Abstract
Polycyclic aromatic hydrocarbons (PAH) are well-known to be carcinogenic and the mechanisms that it contributes to oxidative DNA damage and aryl hydrocarbon receptor (AhR)-dependent induction are also well understood. However, little is known about the associations between PAH exposure, AhR expression, and oxidative DNA damage. We investigated their associations of AhR expression and oxidative DNA damage related to PAH exposure among 310 workers from a coke-oven plant in China. Urine biomarkers of PAH exposure (2-hydroxynaphthalene, 2-NAP; 2-hydroxyfluorene, 2-FLU; 9-hydroxyphenanthren, 9-PHE; and 1-hydroxypyrene, 1-OHP) and a marker of oxidative damage (8-hydroxy- 2′- deoxyguanosine, 8-OHdG) were measured by high performance liquid chromatography. AhR expression in venous blood was measured by reverse transcription -polymerase chain reaction. The results showed that increasing levels of urinary 1-OHP was positively associated with high 8-OHdG (OR (95% CI) was 4.01 (1.41–11.45) for 4th quartile, compared with 1st quartile, P for trend = 0.013). The similar associations were also found between urinary 1-OHP and high-AhR expressions (4th vs. 1st quartile = 3.50, 95% CI: 1.24–9.87, P for trend = 0.029). A significant association between AhR expression and high 8-OHdG was also found (4th vs. 1st quartile = 2.44, 95% CI: 1.05–5.70, P for trend = 0.027). In addition, mediation analysis showed the AhR expression could explain 35.9% of the association of oxidative DNA damage related to PAH exposure. Our findings implicated that the association between PAH exposure and oxidative DNA damage may be mediated by AhR expression among Chinese occupational workers.
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- 2018
7. Population Pharmacokinetic Analysis of Mizoribine in Chinese Renal Transplant Recipients
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Qing-Ling Fu, Huitao Zhang, B. Ren, Long-shan Liu, Su-xiong Deng, Jiajia Jiang, Ji-guang Fei, C. Wang, Likun Chen, Jiang Qiu, Guanghao Chen, and J. Li
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Adult ,Male ,medicine.medical_specialty ,Population ,030232 urology & nephrology ,Urology ,Renal function ,Absorption (skin) ,030204 cardiovascular system & hematology ,Models, Biological ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Asian People ,Pharmacokinetics ,Humans ,Medicine ,education ,Aged ,Distribution Volume ,Transplantation ,education.field_of_study ,Mizoribine ,business.industry ,Bayes Theorem ,Middle Aged ,Kidney Transplantation ,Transplant Recipients ,Confidence interval ,Female ,Surgery ,Ribonucleosides ,business ,Immunosuppressive Agents ,medicine.drug - Abstract
Background We calculated the population pharmacokinetics of mizoribine in adult Chinese patients and compared the parameters with those of Japanese patients to determine whether there are any ethnic differences in blood concentration transition between these 2 populations. Methods The blood concentrations of mizoribine in 21 Chinese patients who were administered mizoribine after renal transplantation were measured at 304 time points. The absorption lag time, absorption rate constant, apparent distribution volume, and oral clearance were thereafter calculated and compared with the respective Japanese references. Results The absorption lag time, absorption rate constant, and apparent distribution volume calculated in this study were, respectively, 0.353 hour, 0.856 hour−1, and 0.776 L/kg. The oral clearance was calculated as 2.18 times the creatinine clearance using creatinine clearance as a function. The absorption rate constant, apparent distribution volume, and oral clearance are determinants of the maximum blood concentration, trough, and area under the blood concentration time curve. The relative absorption rate constant, apparent distribution volume, and oral clearance were 0.9-, 0.9-, and 1.2-fold, respectively, in Chinese patients compared with those in Japanese patients. These values are within the confidence limit, suggesting that there is no significant PK difference between the 2 ethnic groups. Conclusions Results of this study showed no ethnic difference in blood mizoribine concentration transition between Chinese and Japanese patients. In addition, the population pharmacokinetic parameters obtained in this study are useful in determining the initial dosage or in the Bayesian analysis of mizoribine concentrations using scarce time points.
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- 2018
8. Effect of Early Immunosuppression Therapy on De Novo Anti–Human-Leukocyte-Antigen Antibody After Kidney Transplantation
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Huitao Zhang, Gan Huang, Yuxin Zheng, Shuang Wang, Wuguo Deng, Qing-Ling Fu, Chun-Zhi Wang, Ronghai Deng, J. Li, Long-shan Liu, and Huiting Huang
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Adult ,Graft Rejection ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,030232 urology & nephrology ,030230 surgery ,Gastroenterology ,Mycophenolic acid ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,HLA Antigens ,Internal medicine ,medicine ,Humans ,Transplantation, Homologous ,Dosing ,Prospective cohort study ,Kidney transplantation ,Autoantibodies ,Retrospective Studies ,Transplantation ,business.industry ,Graft Survival ,Hazard ratio ,Retrospective cohort study ,Immunosuppression ,Mycophenolic Acid ,medicine.disease ,Kidney Transplantation ,Calcineurin ,Female ,Surgery ,business ,Immunosuppressive Agents ,medicine.drug - Abstract
The aim of the study was to investigate the effect of immunosuppression therapy early after kidney transplantation, particularly exposure of mycophenolic acid (MPA) and calcineurin inhibitor (CNI), on posttransplantation de novo HLA antibody production. Methods A single-center retrospective cohort study was performed at the First Affiliated Hospital of Sun Yat-sen University, enrolling the kidney transplant or pancreas-kidney transplant recipients who had surgery between January 2010 and February 2016. Results A total of 214 recipients were included in the study with a median follow-up period of 1.06 years. A total of 30 recipients (14.0%) were positive in HLA antibody detection posttransplant with a median follow-up period of 1.46 years. Ten recipients (4.7%) lost their allograft function during follow-up, and 6 of them (60%) developed de novo HLA antibody after graft failure. Multivariate analysis showed that acute rejection significantly increased the risk of de novo HLA antibody (hazard ratio [HR], 2.732). Intensified MPA dosing therapy reduced the risk by 59.8% (HR, 0.402); low-dose CNI therapy increased the risk by 33.3% (HR, 1.333), and the effect of extremely low-dose CNI therapy was even larger (HR, 2.242). Conclusion The risk of de novo HLA antibody can be decreased by reducing the risk of acute rejection. A tendency was seen in low-dose CNI therapy to increase the risk of de novo HLA antibody, but intensified MPA dosing therapy may provide an umbrella protection effect by reducing the risk. Prospective study was required to confirm the effects.
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- 2018
9. Urinary 1-hydroxypyrene and smoking are determinants of LINE-1 and AhRR promoter methylation in coke oven workers
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Huitao Zhang, Wubin Wang, Hongjie Zhang, Yanfeng Fan, Yanli Liu, and Jin Yang
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Adult ,Male ,0301 basic medicine ,Coke oven ,Health, Toxicology and Mutagenesis ,Urinary system ,Aryl hydrocarbon receptor repressor ,complex mixtures ,Epigenesis, Genetic ,Water Purification ,Young Adult ,03 medical and health sciences ,Occupational Exposure ,Basic Helix-Loop-Helix Transcription Factors ,Genetics ,Humans ,Epigenetics ,Food science ,Promoter Regions, Genetic ,Coke ,Chromatography, High Pressure Liquid ,Carcinogen ,Pyrenes ,Chemistry ,Smoking ,technology, industry, and agriculture ,Sequence Analysis, DNA ,Methylation ,DNA Methylation ,Middle Aged ,Repressor Proteins ,Logistic Models ,Long Interspersed Nucleotide Elements ,030104 developmental biology ,Case-Control Studies ,DNA methylation ,Pyrosequencing - Abstract
Coke oven emissions (COE) containing polycyclic aromatic hydrocarbons (PAHs) are predominant toxic constituents of particulate air pollution that have been linked to increased risk of lung cancer. Aberrant DNA methylation is one of the best known epigenetic changes in human cancers and healthy subjects exposed to carcinogens. The purpose of this study is to explore the factors influencing the methylation of long interspersed nuclear element-1 (LINE-1) and aryl-hydrocarbon receptor repressor (AhRR) in coke oven workers. The study population is composed by coke oven workers (348) and water treatment workers (131). And their urinary PAH metabolites were analyzed by high performance liquid chromatography; DNA methylation were measured by pyrosequencing. The urinary PAHs metabolites were significantly elevated in coke oven workers (P 0.01). The results from multivariate logistic regression analysis showed that a high level of urinary 1-hydroxypyrene was associated with a significantly increased risk of hypomethylation of LINE-1 (OR: 1.80; 95% CI: 1.25, 2.60), and heavy smoking was associated with a significantly increased risk of hypomethylation of AhRR (OR: 1.44; 95% CI: 1.04, 2.00). Our findings demonstrate that urinary 1-hydroxypyrene may be a useful biomarker for evaluating the role of PAHs exposure on hypomethylation of LINE-1 among coke oven workers and that smoking may be an important factor affecting hypomethylation of AhRR.
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- 2018
10. Understanding working conditions for Entererococcus sp. L1 on methane production: A low temperature condition-based biogas production experiment
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Wang Xiaou, Yang Xinping, Aihemati Guli, Wang Zhifang, Huitao Zhang, Jingping Dai, Xie Yuqing, Feng Lei, Jiang Li, and Jing Chen
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biology ,Strain (chemistry) ,Renewable Energy, Sustainability and the Environment ,Chemistry ,Forestry ,biology.organism_classification ,chemistry.chemical_compound ,Biogas ,Fermentation ,Food science ,Methane production ,Citric acid ,Waste Management and Disposal ,Agronomy and Crop Science ,Cow dung ,Bacteria ,Biogas production - Abstract
To provide an elaborate understanding on the performance of Entererococcus sp. L1 in biogas production at different fermentation periods under controlled low temperature, biogas optimization experiments was undertaken. Specifically, microscopic and culture techniques, physiological and biochemical studies, and measurement of optical densities at 600 wavelengths (OD600) were undertaken to identify and characterize the Entererococcus sp. L1. The aim was to identify the strain and determine its optimum working conditions in biogas production at different fermentation periods under controlled low temperature. The result confirmed the strain as hydrogen-producing bacteria (Enteroccus sp. L1). It was also confirmed that the organic nitrogen source was significantly better than the inorganic nitrogen source in supporting the growth of the bacteria. The optimal pH and temperature for the growth and biogas production performance of the Entererococcus sp. L1 was 7 and 15 °C respectively. The Na2HPO4 concentration of 0.2% was confirmed to be best for the optimum growth of the bacteria, and addition of citric acid resulted to significant inhibitory effect on the growth of the Entererococcus sp. L1. The effect of adding different concentrations (0, 1%, 5%, 10%) of the L1 bacteria inoculum on cow dung at simulated low temperature (15 °C) biogas fermentation showed that 10% treatment had the highest gas production of 3121 ml, which was 89% higher than the control (0 concentration). The daily gas production rate was 0.02 m3/(m−3d−1), which was 90% higher than the control. This showed that 10% treatment provided the best gas production result, with highest gas production occurring at 10% treatment within 31–60 days of fermentation (p
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- 2021
11. BPF-based reconstruction algorithm for multiple rotation–translation scan mode
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Peng Zhang, Ming Chen, and Huitao Zhang
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business.industry ,Process (computing) ,Reconstruction algorithm ,Industrial computed tomography ,Translation (geometry) ,Feature (computer vision) ,General Materials Science ,Computer vision ,Artificial intelligence ,business ,General ,Rotation (mathematics) ,Image resolution ,Interpolation ,Mathematics - Abstract
In industrial CT, it is often required to inspect large objects using short line-detectors. To acquire the complete CT data for the scanning slice of large objects using short line-detectors, some multi-scan modes have been developed. But the existing methods reconstructing an image from the data scanned by multi-scan modes have to rebin the data into fan-beam or parallel-beam form via data interpolation. The data rebinning process not only increases great computational cost, but also degrades image resolution. In this paper, we propose a backprojection-filtration (BPF)-based reconstruction algorithm for rotation–translation (RT) multi-scan mode. An important feature of the proposed algorithm is that data rebinning process is not introduced. The simulation results have verified the validity of the proposed algorithm.
- Published
- 2008
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