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1. Allele-specific CRISPR-Cas9 editing of dominant epidermolysis bullosa simplex in human epidermal stem cells

Author

Cattaneo, C., primary, Enzo, E., additional, De Rosa, L., additional, Sercia, L., additional, Consiglio, F., additional, Forcato, M., additional, Bicciato, S., additional, Paiardini, A., additional, Basso, G., additional, Tagliafico, E., additional, Paganelli, A., additional, Fiorentini, C., additional, Magnoni, C., additional, Latella, M.C., additional, and De Luca, M., additional

Published
2024
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2. DIAGNOSIS OF DENGUE VIRUS INFECTIONS IN ITALY FROM NOVEMBER 2015 TO NOVEMBER 2021: A NATIONAL REFERENCE LABORATORY SURVEILLANCE REPORT

Author

Merakou, C., primary, Fortuna, C., additional, Amendola, A., additional, Marsili, G., additional, Argentini, C., additional, Fiorentini, C., additional, Benedetti, E., additional, Riccardo, F., additional, Del Manso, M., additional, Bella, A., additional, Caporali, M.G., additional, Pezzotti, P., additional, and Venturi, G., additional

Published
2023
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4. Metabolic exercise data combined with cardiac and kidney indexes: MECKI score. Predictive role in cardiopulmonary exercise testing with low respiratory exchange ratio in heart failure

Author

Corrà, U, Agostoni, P, Piepoli, Mf, Giordano, A, Mezzani, A, Giannuzzi, P, Cattadori, G, Fiorentini, C, Salvioni, E, Giovannardi, M, Veglia, F, Apostolo, A, Palermo, P, Contini, M, Vignati, C, Farina, S, Bovis, F, Cicoira, M, Vassanelli, C, La Gioia, R, Scrutinio, D, Passantino, A, Santoro, D, Campanale, S, Caputo, D, Scardovi, Ab, Ricci, R, Emdin, Michele, Metra, M, Dei Cas, L, Sinagra, G, Berton, E, Limongelli, G, Iorio, Am, Roselli, T, Buono, A, Calabrò, R, Raimondo, R, Vaninetti, R, Bertipaglia, D, Re, F, Guazzi, M, Belardinelli, R, Pietrucci, F, Parati, G, Magrì, D, Di Lenarda, A, Paolillo, S, Perrone Filardi, P, Passino, Claudio, Pastormerlo, Luigi Emilio, Malfatto, G, Caravita, S., Corrà, Ugo, Agostoni, Piergiuseppe, Piepoli, Massimo F., Giordano, Andrea, Mezzani, Alessandro, Giannuzzi, Pantaleo, Cattadori, Gaia, Fiorentini, Cesare, Salvioni, Elisabetta, Giovannardi, Marta, Veglia, Fabrizio, Apostolo, Anna, Palermo, Pietro, Contini, Mauro, Vignati, Carlo, Farina, Stefania, Bovis, Francesca, Cicoira, Mariantonietta, Vassanelli, Corrado, La Gioia, Rocco, Scrutinio, Domenico, Passantino, Andrea, Santoro, Daniela, Campanale, Saba, Caputo, Domenica, Scardovi, Angela B., Ricci, Roberto, Emdin, Michele, Metra, Marco, Dei Cas, Livio, Sinagra, Gianfranco, Berton, Emanuela, Limongelli, Giuseppe, Iorio, Anna Maria, Roselli, Teo, Buono, Andrea, Calabro', Raffaele, Raimondo, Rosa, Vaninetti, Raffaella, Bertipaglia, Donatella, Re, Federica, Guazzi, Marco, Belardinelli, Milano Romualdo, Pietrucci, Francesca, Parati, Gianfranco, Magrì, Damiano, Di Lenarda, Andrea, Paolillo, Stefania, Perrone Filardi, Pasquale, Passino, Claudio, Pastormerlo, Luigi E., Malfatto, Gabriella, Corrà, U, Agostoni, P, Piepoli, M, Giordano, A, Mezzani, A, Giannuzzi, P, Cattadori, G, Fiorentini, C, Salvioni, E, Giovannardi, M, Veglia, F, Apostolo, A, Palermo, P, Contini, M, Vignati, C, Farina, S, Bovis, F, Cicoira, M, Vassanelli, C, La Gioia, R, Scrutinio, D, Passantino, A, Santoro, D, Campanale, S, Caputo, D, Scardovi, A, Ricci, R, Emdin, M, Metra, M, Dei Cas, L, Sinagra, G, Berton, E, Limongelli, G, Iorio, A, Roselli, T, Buono, A, Calabrò, R, Raimondo, R, Vaninetti, R, Bertipaglia, D, Re, F, Guazzi, M, Belardinelli, M, Pietrucci, F, Parati, G, Magrì, D, Di Lenarda, A, Paolillo, S, Perrone Filardi, P, Passino, C, Pastormerlo, L, Malfatto, G, Calabrò, Raffaele, and DI LENARDA, Andrea

Subjects
Male, medicine.medical_specialty, Cardiopulmonary exercise, Heart failure, Oxygen consumption, Prognosis, Respiratory quotient, Prognosi, Renal function, Respiratory physiology, Kidney Function Tests, Severity of Illness Index, Predictive Value of Tests, Internal medicine, Severity of illness, medicine, Humans, Respiratory exchange ratio, Aged, Kidney, business.industry, Medicine (all), Middle Aged, medicine.disease, medicine.anatomical_structure, Predictive value of tests, Exercise Test, Respiratory Mechanics, Cardiology, Female, Energy Metabolism, Cardiology and Cardiovascular Medicine, business, cardiopulmonary exercise, heart failure, oxygen consumption, prognosis, respiratory quotient, aged, energy metabolism, exercise test, female, humans, kidney function tests, male, middle aged, predictive value of tests, respiratory mechanics, severity of illness index, cardiology and cardiovascular medicine
Abstract

n/a

Published
2015

5. Circulation of West Nile virus lineage 1 and 2 during an outbreak in Italy

Author

Magurano, F., primary, Remoli, M.E., additional, Baggieri, M., additional, Fortuna, C., additional, Marchi, A., additional, Fiorentini, C., additional, Bucci, P., additional, Benedetti, E., additional, Ciufolini, M.G., additional, Rizzo, C., additional, Piga, S., additional, Salcuni, P., additional, Rezza, G., additional, and Nicoletti, L., additional

Published
2012
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6. Feasibility and diagnostic accuracy of a low radiation exposure protocol for prospective ECG-triggering coronary MDCT angiography

Author

Pontone, G., primary, Andreini, D., additional, Bartorelli, A.L., additional, Bertella, E., additional, Mushtaq, S., additional, Foti, C., additional, Formenti, A., additional, Chiappa, L., additional, Annoni, A., additional, Cortinovis, S., additional, Baggiano, A., additional, Conte, E., additional, Bovis, F., additional, Veglia, F., additional, Ballerini, G., additional, Agostoni, P., additional, Fiorentini, C., additional, and Pepi, M., additional

Published
2012
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8. Markers of inflammation, thrombosis and endothelial activation correlate with carotid IMT regression in stable coronary disease after atorvastatin treatment

Author

Baldassarre, D., primary, Porta, B., additional, Camera, M., additional, Amato, M., additional, Arquati, M., additional, Brusoni, B., additional, Fiorentini, C., additional, Montorsi, P., additional, Romano, S., additional, Veglia, F., additional, Tremoli, E., additional, and Cortellaro, M., additional

Published
2009
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24. The deconfining phase transition in lattice gauge SU(3)

Author

Bacilieri, P., primary, Remiddi, E., additional, Todesco, G.M., additional, Bernaschi, M., additional, Cabasino, S., additional, Cabibbo, N., additional, Fernández, L.A., additional, Marinari, E., additional, Paolucci, P., additional, Parisi, G., additional, Salina, G., additional, Tarancón, A., additional, Coppola, F., additional, Lombardo, M.P., additional, Simeone, E., additional, Tripiccione, R., additional, Fiorentini, C., additional, Lai, A., additional, Marchesini, P.A., additional, Marzano, F., additional, Rapuano, F., additional, Tross, W., additional, and Rusack, R., additional

Published
1989
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27. The metabolic exercise test data combined with Cardiac And Kidney Indexes (MECKI) score and prognosis in heart failure. A validation study

Author

Corrà, Ugo, Agostoni, Piergiuseppe, Giordano, Andrea, Cattadori, Gaia, Battaia, Elisa, La Gioia, Rocco, Scardovi, Angela B., Emdin, Michele, Metra, Marco, Sinagra, Gianfranco, Limongelli, Giuseppe, Raimondo, Rosa, Federica, Re, Guazzi, Marco, Belardinelli, Romualdo, Parati, Gianfranco, Magri', Damiano, Fiorentini, Cesare, Cicoira, Mariantonietta, Salvioni, Elisabetta, Giovannardi, Marta, Veglia, Fabrizio, Mezzani, Alessandro, Scrutinio, Domenico, Di Lenarda, Andrea, Ricci, Roberto, Apostolo, Anna, Iorio, Anna Maria, Paolillo, Stefania, Palermo, Pietro, Contini, Mauro, Vassanelli, Corrado, Passino, Claudio, Giannuzzi, Pantaleo, Piepoli, Massimo F., MECKI ScoreResearch Group, Other Members of the MECKI Score research Group, Antonioli, L., Segurini, C., Bertella, E., Farina, S., Bovis, F., Pietrucci, F., Malfatto, G., Roselli, T., Buono, A., Calabrò, R., De Maria, R., Santoro, D., Campanale, S., Caputo, D., Bertipaglia, D., Berton, E., Corrà, Ugo, Agostoni, Piergiuseppe, Giordano, Andrea, Cattadori, Gaia, Battaia, Elisa, La Gioia, Rocco, Scardovi, Angela B., Emdin, Michele, Metra, Marco, Sinagra, Gianfranco, Limongelli, Giuseppe, Raimondo, Rosa, Re, Federica, Guazzi, Marco, Belardinelli, Romualdo, Parati, Gianfranco, Magrì, Damiano, Fiorentini, Cesare, Cicoira, Mariantonietta, Salvioni, Elisabetta, Giovannardi, Marta, Veglia, Fabrizio, Mezzani, Alessandro, Scrutinio, Domenico, DI LENARDA, Andrea, Ricci, Roberto, Apostolo, Anna, Iorio, Anna Maria, Paolillo, Stefania, Palermo, Pietro, Contini, Mauro, Vassanelli, Corrado, Passino, Claudio, Giannuzzi, Pantaleo, Piepoli, Massimo F., Corra, U., Agostoni, P., Giordano, A., Cattadori, G., Battaia, E., La Gioia, R., Scardovi, A. B., Emdin, M., Metra, M., Sinagra, G., Limongelli, G., Raimondo, R., Re, F., Guazzi, M., Belardinelli, R., Parati, G., Magri, D., Fiorentini, C., Cicoira, M., Salvioni, E., Giovannardi, M., Veglia, F., Mezzani, A., Scrutinio, D., Di Lenarda, A., Ricci, R., Apostolo, A., Iorio, A. M., Paolillo, S., Palermo, P., Contini, M., Vassanelli, C., Passino, C., Giannuzzi, P., Piepoli, M. F., Corrà, U, Agostoni, P, Giordano, A, Cattadori, G, Battaia, E, La Gioia, R, Scardovi, A, Emdin, M, Metra, M, Sinagra, G, Limongelli, G, Raimondo, R, Re, F, Guazzi, M, Belardinelli, R, Parati, G, Magrì, D, Fiorentini, C, Cicoira, M, Salvioni, E, Giovannardi, M, Veglia, F, Mezzani, A, Scrutinio, D, Di Lenarda, A, Ricci, R, Apostolo, A, Iorio, A, Paolillo, S, Palermo, P, Contini, M, Vassanelli, C, Passino, C, Giannuzzi, P, and Piepoli, M

Subjects
Male, medicine.medical_treatment, Predictive Value of Test, 030204 cardiovascular system & hematology, Kidney Function Tests, Severity of Illness Index, 0302 clinical medicine, score, 030212 general & internal medicine, Heart transplantation, education.field_of_study, Ejection fraction, Heart Function Test, Stroke volume, Middle Aged, Prognosis, Predictive value of tests, Heart Function Tests, Cardiology, Female, Cardiology and Cardiovascular Medicine, Human, medicine.medical_specialty, Prognosi, Population, Renal function, Heart failure, Prognosis, score, Lower risk, Follow-Up Studie, 03 medical and health sciences, Oxygen Consumption, Predictive Value of Tests, Internal medicine, medicine, Humans, medicine (all), education, Aged, Kidney Function Test, business.industry, heart failure, prognosis, score, aged, exercise test, female, follow-up studies, heart function tests, heart transplantation, humans, kidney function tests, male, middle aged, oxygen consumption, predictive value of tests, prognosis, severity of illness index, stroke volume, cardiology and cardiovascular medicine, Stroke Volume, medicine.disease, Exercise Test, Follow-Up Studies, Heart Failure, Heart Transplantation, business
Abstract

Background The Metabolic Exercise test data combined with Cardiac and Kidney Indexes (MECKI) score is a prognostic model to identify heart failure (HF) patients at risk for cardiovascular mortality (CVM) and urgent heart transplantation (uHT) based on 6 routine clinical parameters: hemoglobin, sodium, kidney function by the Modification of Diet in Renal Disease (MDRD) equation, left ventricle ejection fraction (LVEF), percentage of predicted peak oxygen consumption (VO2) and VE/VCO2 slope. Objectives MECKI score must be generalizable to be considered useful: therefore, its performance was validated in a new sequence of HF patients. Methods Both the development (MECKI-D) and the validation (MECKI-V) cohorts were composed of consecutive HF patients with LVEF < 40% able to perform a symptom-limited cardiopulmonary exercise testing. The CVM or uHT rates were analyzed at one, two and three years in both cohorts: all patients with a censoring time shorter than the scheduled follow-up were excluded, while those with events occurring after 1, 2 and 3 years were considered as censored. Results MECKI-D and MECKI-V consisted of 2009 and 992 patients, respectively. MECKI-V patients had a higher LVEF, higher peak VO2 and lower VE/VCO2 slope, higher prescription of beta-blockers and device therapy: after the 3-year follow-up, CVM or uHT occurred in 206 (18%) MECKI-D and 44 (13%) MECKI-V patients (p < 0.000), respectively. MECKI-V AUC values at one, two and three years were 0.81 ± 0.04, 0.76 ± 0.04, and 0.80 ± 0.03, respectively, not significantly different from MECKI-D. Conclusions MECKI score preserves its predictive ability in a HF population at a lower risk.

Published
2016

28. Severe heart failure prognosis evaluation for transplant selection in the era of beta-blockers: Role of peak oxygen consumption

Author

Marco Metra, Angela Beatrice Scardovi, Marco Guazzi, Giuseppe Pacileo, Rocco La Gioia, Romualdo Belardinelli, Annamaria Iorio, Alessandro Mezzani, Cesare Fiorentini, Claudio Passino, Anna Apostolo, Massimo F Piepoli, Elisabetta Salvioni, Gaia Cattadori, Ugo Corrà, Gianfranco Sinagra, Pantaleo Giannuzzi, Pietro Palermo, Mauro Contini, Andrea Di Lenarda, Domenico Scrutinio, Stefania Paolillo, Gianfranco Parati, Piergiuseppe Agostoni, Giuseppe Limongelli, Federica Re, Elisa Battaia, Fabrizio Veglia, Michele Emdin, Rosa Raimondo, Mariantonietta Cicoira, Damiano Magrì, Cattadori, G, Agostoni, P, Corrà, U, DI LENARDA, Andrea, Sinagra, Gianfranco, Veglia, F, Salvioni, E, La Gioia, R, Scardovi, Ab, Emdin, M, Metra, M, Limongelli, G, Raimondo, R, Re, F, Guazzi, M, Belardinelli, R, Parati, G, Magrì, D, Fiorentini, C, Mezzani, A, Scrutinio, D, Pacileo, G, Apostolo, A, Iorio, A, Paolillo, S, Palermo, P, Contini, M, Giannuzzi, P, Battaia, E, Cicoira, M, Passino, C, Piepoli, Mf, MECKI score research, Group, Cattadori, G., Agostoni, P., Corra, U., Di Lenarda, A., Sinagra, G., Veglia, F., Salvioni, E., La Gioia, R., Scardovi, A. B., Emdin, M., Metra, M., Limongelli, G., Raimondo, R., Re, F., Guazzi, M., Belardinelli, R., Parati, G., Magri, D., Fiorentini, C., Mezzani, A., Scrutinio, D., Pacileo, G., Apostolo, A., Iorio, A., Paolillo, S., Palermo, P., Contini, M., Giannuzzi, P., Battaia, E., Cicoira, M., Passino, C., Piepoli, M. F., Di Lenarda, A, Sinagra, G, Scardovi, A, and Piepoli, M

Subjects
Male, medicine.medical_treatment, chronic, heart, failure, Severity of Illness Index, Beta-blockers, Aortic valve replacement, Heart transplantation, Ejection fraction, exercise, Middle Aged, Prognosis, failure, chronic, Survival Rate, Exercise, Heart failure, Oxygen consumption, Adrenergic beta-Antagonists, Aged, Female, Follow-Up Studies, Heart Failure, Heart Transplantation, Humans, Oxygen Consumption, Patient Selection, cardiovascular system, Cardiology, Cardiology and Cardiovascular Medicine, Human, medicine.medical_specialty, Prognosi, heart, Follow-Up Studie, Internal medicine, Severity of illness, medicine, Beta-blocker, Intensive care medicine, Beta (finance), Survival rate, business.industry, Exercise, Oxygen consumption, Beta-blockers, Heart failure, Prognosis, Adrenergic beta-Antagonist, beta-blockers, heart failure, oxygen consumption, prognosis, MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE, medicine.disease, Stenosis, business
Abstract

fraction. Rev Esp Cardiol 2013;66:261–8. [9] Herrmann HC, Pibarot P, Hueter I, et al. Predictors of mortality and outcomes of therapy in low-flow severe aortic stenosis: a Placement of Aortic Transcatheter Valves (PARTNER) Trial analysis. Circulation 2013;127:2316–26. [10] Ozkan A, Hachamovitch R, Kapadia SR, Tuzcu EM,Marwick TH. Impact of aortic valve replacement on outcome of symptomatic patients with severe aortic stenosis with low gradient and preserved left ventricular ejection fraction. Circulation 2013;128(6):622–31.

Published
2013

29. Low-Dose Coronary CT Angiography in Patients with Atrial Fibrillation: Comparison of Image Quality and Radiation Exposure with Two Different Approaches

Author

Andrea Annoni, Marco Guglielmo, Giuseppe Muscogiuri, Luca Di Odoardo, Alberto Formenti, Eleonora Melotti, Daniele Andreini, Edoardo Conte, Saima Mushtaq, Antonio L. Bartorelli, Andrea Baggiano, Maria Elisabetta Mancini, Cesare Fiorentini, Elisa Consiglio, Gianluca Pontone, Margarida Oliveira, Mauro Pepi, Marco Magatelli, Mushtaq, S, Pontone, G, Conte, E, Guglielmo, M, Consiglio, E, Magatelli, M, Oliveira, M, Muscogiuri, G, Annoni, A, Baggiano, A, Formenti, A, Mancini, M, Di Odoardo, L, Melotti, E, Fiorentini, C, Bartorelli, A, Pepi, M, and Andreini, D

Subjects
Male, medicine.medical_specialty, Scanner, Image quality, Computed Tomography Angiography, Coronary Disease, Iterative reconstruction, Coronary Angiography, Radiation Dosage, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Radiology, Nuclear Medicine and imaging, Prospective Studies, Coronary CT angiography, Image resolution, Interpretability, Aged, business.industry, Radiation exposure, Atrial fibrillation, Coronary ct angiography, Middle Aged, medicine.disease, Image Enhancement, 030220 oncology & carcinogenesis, Female, Radiology, business
Abstract

Rationale and Objectives: To evaluate image quality, coronary interpretability and radiation exposure of coronary CT angiography (CCTA)performed in patients with atrial fibrillation (AF)with the latest scanner generation, comparing two different technical approaches. A new scanner that combines a 0.23 mm spatial resolution, a new generation of iterative reconstruction, fast gantry rotation time and the intracycle motion-correction algorithm to improve the temporal resolution was recently introduced in the clinical field. Materials and Methods: We enrolled 105 consecutive patients with chronic AF who performed CCTA with a whole-heart coverage high-definition CT scanner (16-cm z-axis coverage with 256 detector rows, 0.28 s gantry rotation time). Five of them were excluded for impaired renal function. Patients were randomized between a double acquisition protocol (50 patients, group 1)or a single acquisition protocol (50 patients, group 2). The image quality, coronary segment interpretability and effective dose (ED)of CCTA were assessed. Results: The mean HR during the scan was 85.6±21 bpm in group 1 vs. 83.7±23 bpm in Group 2, respectively (p < ns). In group 2, overall image quality was high and comparable with that of group 1 (Likert scale =3.2 ± 1.4 vs. 3.3 ± 1.2, p = ns, in group 1 and 2, respectively). Coronary interpretability was high and similar between the two groups (97.5% and 97.1% in group 1 and 2, p = ns, respectively). Mean ED was significantly higher in group 1 than in group 2 (5.3 ± 1.8 mSv vs. 2.7 ± 0.7 mSv, p < 0.001). Conclusion: The novel whole-heart coverage CT scanner allows to perform CCTA with a single-acquisition protocol with high image quality and low radiation exposure in AF patients.

Published
2019

30. ESBC: an application for computing stabilization bounds

Author

Alessandro Avellone, Ugo Moscato, Guido Fiorino, Camillo Fiorentini, Mauro Ferrari, Avellone, A, Ferrari, M, Fiorentini, C, Fiorino, G, and Moscato, U

Subjects
combinatorial circuits, harware verification, logic, timing analysis, General Computer Science, Semantics (computer science), Classical logic, INF/01 - INFORMATICA, Static timing analysis, Theoretical Computer Science, Valuation (logic), Computer Science::Hardware Architecture, Computer Science::Emerging Technologies, intermediate logics, Arithmetic, Valuation form semantics, Algorithm, constructive logics, logical synthesis, Computer Science(all), Hardware_LOGICDESIGN, Mathematics
Abstract

We describe the application ESBC to perform the timing analysis of a combinatorial circuit. The circuit is described by formulas of Classical Logic and the delays of propagation of the signals in a gate are represented by a kind of valuation form semantics. ESBC computes the exact stabilization times at which the output signals stabilize. © 2006 Elsevier B.V. All rights reserved.

Published
2006

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