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270 results on '"Ekblad A"'

1. Biochar and peat amendments affect nitrogen retention, microbial capacity and nitrogen cycling microbial communities in a metal and polycyclic aromatic hydrocarbon contaminated urban soil

Author

Rijk, Ingrid, primary, Ekblad, Alf, additional, Dahlin, A. Sigrun, additional, Enell, Anja, additional, Larsson, Maria, additional, Leroy, Prune, additional, Kleja, Dan B., additional, Tiberg, Charlotta, additional, Hallin, Sara, additional, and Jones, Christopher, additional

Published
2024
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7. Head-to-head comparison of plasma p-tau181, p-tau231 and glial fibrillary acidic protein in clinically unimpaired elderly with three levels of APOE4-related risk for Alzheimer's disease

Author

Snellman, Anniina, primary, Ekblad, Laura L., additional, Ashton, Nicholas J., additional, Karikari, Thomas K., additional, Lantero-Rodriguez, Juan, additional, Pietilä, Elina, additional, Koivumäki, Mikko, additional, Helin, Semi, additional, Karrasch, Mira, additional, Zetterberg, Henrik, additional, Blennow, Kaj, additional, and Rinne, Juha O., additional

Published
2023
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10. Neutralising antibody potency against SARS-CoV-2 wild-type and omicron BA.1 and BA.4/5 variants in patients with inflammatory bowel disease treated with infliximab and vedolizumab after three doses of COVID-19 vaccine (CLARITY IBD): an analysis of a prospective multicentre cohort study

Author

Liu, Zhigang, primary, Le, Kaixing, additional, Zhou, Xin, additional, Alexander, James L, additional, Lin, Simeng, additional, Bewshea, Claire, additional, Chanchlani, Neil, additional, Nice, Rachel, additional, McDonald, Timothy J, additional, Lamb, Christopher A, additional, Sebastian, Shaji, additional, Kok, Klaartje, additional, Lees, Charlie W, additional, Hart, Ailsa L, additional, Pollok, Richard C, additional, Boyton, Rosemary J, additional, Altmann, Daniel M, additional, Pollock, Katrina M, additional, Goodhand, James R, additional, Kennedy, Nicholas A, additional, Ahmad, Tariq, additional, Powell, Nick, additional, Islam, Madiha, additional, Croft, Nick, additional, Cipriano, Bessie, additional, Francia, Caroline, additional, Khalid, Nosheen, additional, Kingston, Ashley, additional, Lee, Irish, additional, Lehmann, Anouk, additional, Naik, Kinnari, additional, Samuels, Kevin, additional, Plaatjies, Nicolene, additional, Khatun, Hafiza, additional, Bokth, Farjana, additional, Pabriaga, Elise, additional, Saich, Rebecca, additional, Cousins, Hayley, additional, Fraser, Wendy, additional, Thomas, Rachel, additional, Brown, Matthew, additional, White, Benjamin, additional, Kirkineziadis, Nikolaos, additional, Tilley, Bernadette, additional, Porter, Pennie, additional, Bryant, Rachel, additional, Robaczewska, Natalia, additional, Muhammed, Rafeeq, additional, Bi, Rehana, additional, Cotter, Catherine, additional, Grove, Jayne, additional, Hong, Kate, additional, Howman, Ruth, additional, Mitchell, Monica, additional, Clayton, Sophie, additional, Rogers, Louise, additional, Sultan, Sugrah, additional, Rooney, Melanie, additional, Cottrill, Charlotte, additional, Singh, Salil, additional, Dawe, Chris, additional, Hull, Robert, additional, Silva, Natalie, additional, Chadwick, Julie, additional, Robertson, Laura, additional, Manning, Jonathan, additional, Finlayson, Lauren, additional, Roebuck, Allison, additional, Dawson, Joy, additional, Sonwalkar, Sunil, additional, Chambers, Naomi, additional, Robinson, Matthew, additional, Haigh, Andrew, additional, Matapure, Lear, additional, Raine, Tim, additional, George, Varun, additional, Kapizioni, Christina, additional, Strongili, Konstantina, additional, Thompson, Tina, additional, Ahmed, Mohamed, additional, Kontos, Christos, additional, Dawson, Claire, additional, Bourges, Christophe, additional, Barbutti, Isabella, additional, Gozzard, Megan E, additional, Hendy, Philip, additional, Bull, Rhian, additional, Costa, Patricia, additional, Davey, Lisa, additional, Hannington, Hayley, additional, Nundlall, Kribashnie, additional, Martins, Catarina, additional, Avanzi, Laura, additional, Carungcong, Jaime, additional, Barr, Sabrina, additional, Appleby, Richard, additional, Johnson, Emma, additional, Shakweh, Eathar, additional, Phillis, Kath, additional, Gascoyne, Rachel, additional, Crowder, Amanda, additional, Whileman, Amanda, additional, London, Ian, additional, Grounds, Jenny, additional, Martin, Emmeline, additional, Pajak, Susie, additional, Price, Jude, additional, Cawley, Kathryn, additional, Powell, Sandra, additional, Kearsley, Nichola, additional, Dhar, Anjan, additional, Brown, Ellen, additional, Cowton, Amanda, additional, Stamp, Kimberley, additional, Warner, Ben, additional, Stuart, Carmel, additional, Lacey, Louise, additional, de Silva, Shanika, additional, Allcock, Clare, additional, Harvey, Philip, additional, Jones, Lesley, additional, Cooke, Elise, additional, Slater, Jayne, additional, King, Dominic, additional, Brooks, Johanne, additional, Baker, Pearl, additional, Beadle, Hannah, additional, Cruz, Carina, additional, Potter, Debbie, additional, Collum, Joe, additional, Masters, Farzana, additional, Kumar, Aashish, additional, Coetzee, Samantha, additional, Peiu, Mihaela, additional, Icke, Becky, additional, Williams, Jill, additional, Raj, Meena, additional, Gaynor, Edward, additional, Chadokufa, Sibongile, additional, Huggett, Bonita, additional, Meghari, Hamza, additional, El-Khouly, Sara, additional, Kiparissi, Fevronia, additional, Girshab, Waffa, additional, Russell-Walker, Lynda, additional, Jackson, Christopher, additional, Sidler, Sara, additional, Claridge, Andrew, additional, Fowler, Emily, additional, McCafferty, Laura, additional, Haxton, Lesley, additional, Irving, Peter, additional, Christodoulides, Karolina, additional, Clifford, Angela, additional, Dawson, Patrick, additional, Honap, Sailish, additional, Lim, Samuel, additional, Luber, Raphael, additional, Mahiouz, Karina, additional, Meade, Susanna, additional, Raymode, Parizade, additional, Reynolds, Rebecca, additional, Stanton, Anna, additional, Tripoli, Sherill, additional, Hare, Naomi, additional, Odukwe, Sopuluchukwu, additional, Balachandran, Senthuran, additional, North, Emma, additional, North, Jessica, additional, Browne, Bria, additional, Cordle, Jessica, additional, Jameson, Ella, additional, Siaw, Yih Harn, additional, Manzano, Lane, additional, Segal, Jonathan, additional, Al-Bakir, Ibrahim, additional, Khakoo, Imran, additional, Portukhay, Sofiya, additional, Thoua, Nora, additional, Davidson, Katherine, additional, Miah, Jagrul, additional, Canclini, Lisa, additional, Hall, Alex, additional, Furreed, Hassina, additional, Mitchell-Inwang, Christine, additional, Hayes, Melony, additional, Myers, Sally, additional, Talbot, Alison, additional, Turnbull, Jack, additional, Whitehead, Emma, additional, Stamp, Katie, additional, Pattinson, Alison, additional, Mathew, Verghese, additional, Sherris, Leanne, additional, Wilcox, Julie, additional, Ramachandran, Sankaranarayanan, additional, Robertson, Hayley, additional, Harvey, Angela, additional, Hicks, Lucy, additional, Byrne, Tara-Marie, additional, Cabreros, Leilani, additional, Downing-Wood, Hannah, additional, Hunter, Sophie, additional, Saifuddin, Mohammad Aamir, additional, Prabhudev, Hemanth, additional, Balarajah, Sharmili, additional, Krucznski, Jan, additional, Driva, Kalliopi, additional, D'Mello, Andrea, additional, Shah, Parith, additional, Castro-Seoane, Rocio, additional, Ibraheim, Hajir, additional, Constable, Laura E, additional, Lo, Jonathan W, additional, Torkizadeh, Melissa, additional, Hermangild, Sherine K, additional, Sutherland, Helen, additional, Wilhelmsen, Elva, additional, Mackintosh, Katherine, additional, Verma, Ajay M, additional, Sebastian, Juliemol, additional, Peerally, Mohammad Farhad, additional, Guerdette, Anne-marie, additional, Coburn, Susan, additional, Novem lam, Ching Yee, additional, Durrant, Donna, additional, Schaefer, Belinda, additional, Serna, Solange, additional, Shahzad, Muhammad, additional, Kent, Alexandra, additional, Choong, Lee Meng, additional, Pantaloni, Benedetta, additional, Ravdas, Pantelis, additional, Vadamalayan, Babu, additional, Foley, Stephen, additional, Arnold, Becky, additional, Heeley, Cheryl, additional, Lovegrove, Wayne, additional, Sowton, Donna, additional, Allsop, Lynne, additional, Gregory, Heidi, additional, Gill, Mandy, additional, Holmes, Megan, additional, Balan, Valeria, additional, Smith, Susan, additional, Turner, Sarah, additional, Smith, Philip J, additional, Steel, Alan, additional, Bretland, Giovanna, additional, King, Sarah, additional, Lofthouse, Martina, additional, Rigby, Lindsey, additional, Subramanian, Sreedhar, additional, Tyrer, David, additional, Martin, Kate, additional, Probert, Christopher, additional, Kamperidis, Nikolaos, additional, Adedoyin, Temi, additional, Baden, Manisha, additional, Brown, Jeannette, additional, Chacko, Feba, additional, Young, Lisa, additional, Cicchetti, Michela, additional, Saifuddin, Mohammad, additional, Yesupatham, Priya, additional, Gowda, Rohit, additional, Williams, Maureen, additional, Kemp, Karen, additional, Akhand, Rima, additional, Gray, Glaxy, additional, John, Anu, additional, John, Maya, additional, Mohammed, Tasnim, additional, Sathe, Diamond, additional, Jones, Natasha, additional, Soren, Jennifer, additional, Sprakes, Michael, additional, Burton, Julie, additional, Kane, Patricia, additional, Lupton, Stephanie, additional, Bartholomew, Jacqueline, additional, Denis, Elizabeth, additional, Daniels, Alison, additional, MacFaul, George, additional, Scaletta, Diane, additional, Siamia, Loria, additional, Williams, Felicity, additional, Green, Chloe, additional, Ver, Zeljka, additional, Lamb, Chris, additional, Doona, Mary, additional, Hogg, Ashleigh, additional, Jeffrey, Lesley, additional, King, Andrew, additional, Speight, R Alexander, additional, Doyle, Jennifer, additional, Owen, Ruth, additional, Haworth, Jenny, additional, Patterson, Linda, additional, Varnaulasingam, Vithusa, additional, Mowat, Craig, additional, Rice, Debbie, additional, MacFarlane, Susan, additional, MacLeod, Anne, additional, Mohammed, Samera, additional, Murray, Shona, additional, Elliott, Anne, additional, Anne Morris, Mary, additional, Coke, Louise, additional, Hindle, Grace, additional, Kolokouri, Eirini, additional, Wright, Catherine, additional, Lee, Claire, additional, Ward, Nicola, additional, Dann, Adele, additional, Lockett, Melanie, additional, Cranfield, Charlotte, additional, Jennings, Louise, additional, Srivastava, Ankur, additional, Ward, Lana, additional, Jeynes, Nouf, additional, Ranga, Poonam, additional, Rajasekhar, Praveen, additional, Gallagher, Lisa, additional, Ward, Jill, additional, Basnett, Rae, additional, Murphy, Judy, additional, Parking, Lauren, additional, Lawson, Emma, additional, Short, Stacey, additional, Devadason, David, additional, Moran, Gordon, additional, Khan, Neelam, additional, Tarr, Lauren, additional, Olivia, Charmaine, additional, Warbarton, Samantha, additional, Kelly, Sian, additional, Limdi, Jimmy, additional, Goulden, Kay, additional, Javed, Asad, additional, McKenzie, Lauren, additional, Melville, Julie, additional, Liu, Eleanor, additional, Sabine, Joseph, additional, Jacob, Patricia, additional, McSorland, Denise, additional, Schofield, Nick, additional, Cornwall, Lisa, additional, Quirke, James, additional, Crook, Emma, additional, Turner, Anne, additional, Bhandari, Pradeep, additional, Baker-Moffatt, Michelle, additional, Dash, Joanne, additional, Le Poidevin, Alison, additional, Downe, Hayley, additional, Bombeo, Lucille, additional, Blackman, Helen, additional, Smith, Rebecca, additional, Wiles, Alan, additional, Bloxham, Hannah, additional, Dias, Jose, additional, Nadar, Evelyn, additional, Curgenven, Hollie, additional, Gilham, Ellie, additional, Macdonald, Jonathan, additional, Finan, Shona, additional, McMeeken, Faye, additional, Mahmood, Misbah, additional, Shields, Stephanie, additional, Seenan, John Paul, additional, DeSilva, Des, additional, Malkakorpi, Susanna, additional, Carson, Rachel, additional, Lawrence, Holly, additional, Boateng, Ofori, additional, Kpodo, Felix, additional, Whiteoak, Simon, additional, Edger-Earley, Kelli, additional, Vamplew, Luke, additional, Samways, Joanna, additional, Roffe, Sue, additional, Ingram, Sarah, additional, James, Joel, additional, Botfield, Sharon, additional, Hammonds, Fiona, additional, James, Clare, additional, Berry, Zoe, additional, Aspinall, Gemma, additional, Hawkins, Sarah, additional, Parkinson, Marian, additional, Gardner-Thorpe, Helen, additional, Marriott, Suzie, additional, Redstone, Clare, additional, Windak, Halina, additional, Adam, Ana-Marie, additional, Mabb, Hannah, additional, Stevenson, Emma, additional, Record, Jessica, additional, Murray, Charles, additional, Diaba, Cynthia, additional, Joseph, Fexy, additional, Pakou, Glykeria, additional, Gleeson, Yvonne, additional, Nunag, Annalyn, additional, Berrill, James, additional, Stroud, Natalie, additional, Pothecary, Carla, additional, Roche, Lisa, additional, Turner, Keri, additional, Deering, Lisa, additional, Israel, Lynda, additional, Baker, Evelyn, additional, Nash, Maxine, additional, Fagbemi, Andrew, additional, Jennings, Felicia, additional, Mayor, Imelda, additional, Wilson, Jill, additional, Wheeler, Alice, additional, Phillips, Nicola, additional, Gordon, John, additional, Levell, Emma, additional, Zagalo, Silvia, additional, Hoad, Ina, additional, Anil, Bindu, additional, Russell, Richard, additional, Henderson, Paul, additional, Millar, Margaret, additional, Alexakis, Christopher, additional, Michalak, Natalia, additional, Marriott, Cheryl, additional, Stone, Sarah, additional, Pristopan, Veronika, additional, Saunders, John, additional, Burton, Helen, additional, Cambridge, Vanessa, additional, Clark, Tonia, additional, Ekblad, Charlotte, additional, Hierons, Sarah, additional, Katebe, Joyce, additional, Saunsbury, Emma, additional, Perry, Rachel, additional, Brookes, Matthew, additional, Davies, Kathryn, additional, Green, Marie, additional, Plumbe, Ann, additional, Ormerod, Clare, additional, Christensen, Helen, additional, Howlett, Hannah, additional, Keen, Anne, additional, Ogor, Jonathan, additional, Greenhaigh, Marie, additional, Knowles, Karen, additional, Yin, Shanzi, additional, Poulaka, Maria, additional, Anthony, Alpha, additional, Newitt, Emily, additional, Trim, Fiona, additional, Casey, Ruth, additional, Seymour, Katherine, additional, Reed, Catherine, additional, Joy, Lijo, additional, Fogden, Edward, additional, Russell, Kalisha, additional, Hussain, Samia, additional, Phillips, Anne, additional, Abdulla, Muaad, additional, Butterworth, Jeff, additional, Adams, Colene, additional, Carnahan, Mandy, additional, Buckingham, Elizabeth, additional, Childs, Danielle, additional, Magness, Alison, additional, Stickley, Jo, additional, Motherwell, Nichola, additional, Tonks, Louise, additional, Gibson, Hannah, additional, Wistance, Kate, additional, Thomas, Caradog, additional, Brinkworth, Elaine, additional, Connor, Lynda, additional, Cook, Amanda, additional, Rees, Tabitha, additional, Harford, Rachel, additional, Farley, Sean, additional, Jones, Marie, additional, Wesley, Emma, additional, Moss, Alison, additional, Lucas, Jacob, additional, Lorimer, Claire, additional, Oleary, Maria, additional, Dixon, Maxine, additional, Goodchild, Fiona, additional, Twenlow, Rebecca, additional, Pawley, Corinne, additional, Ramadas, Arvind, additional, Tregonning, Julie, additional, Okeke, Olaku, additional, Jackson, Wendy, additional, Koumoutsos, Ioannis, additional, George, Viji, additional, Kunhunny, Swapna, additional, Laverick, Sophie, additional, Anderson, Isla, additional, Smith, Sophie, additional, Joyce, Joan, additional, Janarthan, Sarala, additional, Patel, Kamal, additional, Ali, Mariam, additional, Mhandu, Hilda, additional, Rana, Aleem, additional, Spears, Katherine, additional, Teixeira, Joana, additional, Mencias, Mark, additional, Seaward, Abigail, additional, Sousa, Jessica, additional, Said, Nooria, additional, Soomaroo, Mark, additional, Raspa, Valentina, additional, Tacouri, Asha, additional, Reps, Nicholas, additional, Martin, Rebecca, additional, Samakomva, Tinashe, additional, Selinger, Christian, additional, Carbonell, Jenelyn, additional, Onovira, Felicia, additional, Quartey, Doris, additional, L'Anson, Alice, additional, Ashworth, Andrew, additional, Bailey, Jessica, additional, Dunn, Angie, additional, Bespaloi, Gjuzel, additional, Rasalan, Harold, additional, Mahmood, Zahid, additional, Campbell, Racheal, additional, Marsh, Liane, additional, Coughlan, Tricia, additional, Jafar, Wisam, additional, Marrs, Janet, additional, McPheat, Christopher, additional, Rahman, Monira, additional, Davies, Sarah, additional, Habibi, Ruth, additional, Jessup-Dunton, Ellen, additional, Joefield, Teishel, additional, Layug, Reina, additional, Patel, Vinod, additional, Vere, Joanne, additional, Turner, Victoria, additional, Kilroy, Susan, additional, Coulding, Martina, additional, Clark, Martyn, additional, McCormick, Jacqueline, additional, Nisar, Attiya, additional, Walker, Gareth, additional, Atkins, Stacey, additional, Growdon, Jasmine, additional, George, Becky, additional, McNeill, Charlotte, additional, Reed, Bryony, additional, Foulds, Angela, additional, Marshall, Catherine, additional, Allison, Michele, additional, Dillon, Briony, additional, Cooney, Rachel, additional, Bennett, Lillie, additional, Bowlas, Louise, additional, Shariff, Sharafaath, additional, Fraser, Aileen, additional, Punnette, Dwayne, additional, Lambert, Rebecca, additional, Bishop-Hurman, Charlotte, additional, Undrell, Elizabeth, additional, Belfield, Katherine, additional, Din, Said, additional, Addleton, Catherine, additional, Appleby, Marie, additional, Brown, Johanna, additional, Holding, Kathleen, additional, Fraser, Catherine, additional, Birkenshaw, Janice, additional, Williams, Jodie, additional, Maulion, Kamille, additional, Lane, Meg, additional, Kravale, Arita, additional, Smith, Claud, additional, Hooper, Patricia, additional, deCaestecker, John, additional, Watchorn, Olivia, additional, Clarke, Ellie, additional, Hayward, Chris, additional, Inniss, Susan, additional, Pritchard, Lucy, additional, Rudge, Karen, additional, Carney, Amanda, additional, Griffee, Sarah, additional, Andreyev, Jervoise, additional, Babu, Sathish, additional, Hayhurst, Caroline, additional, Lockwood, Carol, additional, Osborne, Lynn, additional, Roper, Amanda, additional, Warner, Karen, additional, Hindle, Julia, additional, Lawrence, Tara, additional, Netherton, Kimberley, additional, Watt, Caroline, additional, Szymiczek, Kinga, additional, Mehta, Shameer, additional, Bell, James, additional, Blad, William, additional, Whitley, Lisa, additional, Jastrub, Roman, additional, Durai, Dhamaraj, additional, Baker, Mark, additional, John Sivamurugan, Elizabeth, additional, Evans, Mim, additional, Cummings, Fraser, additional, Harris, Clare, additional, Jones, Amy, additional, Krauze, Liga, additional, Rahmany, Sohail, additional, Earl, Michelle, additional, Vowles, Jenny, additional, Torokwa, Audrey, additional, Petrova, Mirela, additional, Procter, Andrew, additional, Stanley, Jo, additional, Silvamoniz, Claudia, additional, Bettey, Marion, additional, Wahid, Amar, additional, Morrison, Zoe, additional, Thomas-Turner, Rhian, additional, Yendle, Louise, additional, Muller, Jennifer, additional, Mitchell, Marcus, additional, Kirkwood, John, additional, Barnes, Anna, additional, Chaudhary, Rakesh, additional, Claridge, Melanie, additional, Ellis, Chiara, additional, Kemp, Cheryl, additional, Tobi, Ogwa, additional, Milton, Jentus, additional, Johnston, Emma, additional, Oblak, Metod, additional, Winpenny, Carmen, additional, Svensson, Marie-Louise, additional, Godden, Jo, additional, Ashhar, Marium, additional, Alexander, Debbie, additional, Covil, Kate, additional, Derikx, Lauranne, additional, Siakavellas, Sryros, additional, Baxter, Helen, additional, Robertson, Scott, additional, Smith, Linda, additional, Poulose, Beena, additional, Colemam, Anne, additional, Balint, Margareta, additional, Rhys-Jones, Gareth, additional, Watters, Helen, additional, Begg, Susan, additional, Grosalcalde, Beatriz, additional, Coyle, Judy, additional, Johns, Kerrie, additional, Hughes, Rachel, additional, Phipps, Janet, additional, Taylor, Abigail, additional, MacPhee, Catherine, additional, Brooks, Suzanne, additional, John, Jolene, additional, Edwards, Michelle, additional, Smith, Katie, additional, Howard, Linda, additional, Wood, Dianne, additional, Muddu, Ajay, additional, Barman, Laura, additional, Mallinson, Janine, additional, Neale, Tania, additional, Ionita, Diana, additional, Elliot, Kerry, additional, Turnball, Alison, additional, Thomas, Iola, additional, Thomas, Alice, additional, Andrews, Kelly, additional, Sutton, Jonathon, additional, Mulvaney Jones, Caroline, additional, Roberts, Julia, additional, and Bishop, Jeannie, additional

Published
2023
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12. Proteomic correlates of cortical thickness in cognitively normal individuals with normal and abnormal cerebrospinal fluid beta-amyloid1-42

Author

Betty M. Tijms, Pieter Jelle Visser, Laura L. Ekblad, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, Psychiatrie & Neuropsychologie, Neurology, Amsterdam Neuroscience - Neurodegeneration, and Amsterdam Neuroscience - Brain Imaging

Subjects
Proteomics, Aging, Pathology, medicine.medical_specialty, Amyloid, BIOMARKERS, Inflammation, Biology, CEREBRAL AMYLOID ANGIOPATHY, ATROPHY, HIPPOCAMPAL NEUROGENESIS, Cerebrospinal fluid, Atrophy, Cognitively normal, Cortex (anatomy), medicine, Cingulum (brain), Biological pathway, BRAIN, DEMENTIA, General Neuroscience, SIGNATURE, MILD, medicine.disease, NEUROIMAGING INITIATIVE ADNI, ALZHEIMERS-DISEASE, medicine.anatomical_structure, cortical atrophy, Neurology (clinical), Cerebral amyloid angiopathy, Geriatrics and Gerontology, medicine.symptom, Developmental Biology
Abstract

Cortical atrophy is an early feature of Alzheimers acute accent disease (AD). The biological processes associated with variability in cortical thickness remain largely unknown. We studied 220 cerebrospinal fluid (CSF) proteins to evaluate biological pathways associated with cortical thickness in 34 brain regions in 79 cognitively normal older individuals with normal (>192 ng/L, n = 47), and abnormal (

Published
2021

14. Performance in Hand Coordination Tasks and Concurrent Functional MRI Findings in 13-Year-Olds Born Very Preterm

Author

Uusitalo, Karoliina, primary, Haataja, Leena, additional, Saunavaara, Virva, additional, Lind, Annika, additional, Vorobyev, Victor, additional, Tilli, Joni, additional, Parkkola, Riitta, additional, Setänen, Sirkku, additional, Ekblad, Mikael, additional, Ekblad, Satu, additional, Ekholm, Eeva, additional, Grönroos, Linda, additional, Huhtala, Mira, additional, Jaakkola, Jere, additional, Joensuu, Eveliina, additional, Kero, Pentti, additional, Korja, Riikka, additional, Lahti, Katri, additional, Lapinleimu, Helena, additional, Lehtonen, Liisa, additional, Lehtonen, Tuomo, additional, Leppänen, Marika, additional, Matomäki, Jaakko, additional, Maunu, Jonna, additional, Munck, Petriina, additional, Määttänen, Laura, additional, Niemi, Pekka, additional, Nyman, Anna, additional, Palo, Pertti, additional, Ripatti, Liisi, additional, Rautava, Päivi, additional, Saarinen, Katriina, additional, Saarinen, Tiina, additional, Sillanpää, Matti, additional, Stolt, Suvi, additional, Tuomikoski-Koiranen, Päivi, additional, Tuovinen, Timo, additional, Uusitalo, Karoliina, additional, Väliaho, Anniina, additional, and Ylijoki, Milla, additional

Published
2021
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15. Editorial

Author

Bjartell, Anders, primary, Ekblad, Eva, additional, Mulder, Hindrik, additional, and Wierup, Nils, additional

Published
2022
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18. Safety and immunogenicity of concomitant administration of COVID-19 vaccines (ChAdOx1 or BNT162b2) with seasonal influenza vaccines in adults in the UK (ComFluCOV): a multicentre, randomised, controlled, phase 4 trial

Author

Lazarus, Rajeka, primary, Baos, Sarah, additional, Cappel-Porter, Heike, additional, Carson-Stevens, Andrew, additional, Clout, Madeleine, additional, Culliford, Lucy, additional, Emmett, Stevan R, additional, Garstang, Jonathan, additional, Gbadamoshi, Lukuman, additional, Hallis, Bassam, additional, Harris, Rosie A, additional, Hutton, David, additional, Jacobsen, Nick, additional, Joyce, Katherine, additional, Kaminski, Rachel, additional, Libri, Vincenzo, additional, Middleditch, Alex, additional, McCullagh, Liz, additional, Moran, Ed, additional, Phillipson, Adrian, additional, Price, Elizabeth, additional, Ryan, John, additional, Thirard, Russell, additional, Todd, Rachel, additional, Snape, Matthew D, additional, Tucker, David, additional, Williams, Rachel Lauren, additional, Nguyen-Van-Tam, Jonathan S, additional, Finn, Adam, additional, Rogers, Chris A, additional, Adams, Kirsty, additional, Alaee, Seema, additional, Aley, Parvinder K., additional, Allum, Emma, additional, Anthony, Sally, additional, Ashton, Kate, additional, Awal, Tanya, additional, Barnett, Liz, additional, Barratt, Alison, additional, Barron, Charlotte, additional, Baum, Holly, additional, Beard, Chloe, additional, Bennett, Lorna, additional, Bird, Samuel, additional, Bishop, Sarah, additional, Bisset, Jess, additional, Bodalia, Pritesh, additional, Bowles, Jane, additional, Bowyer, Catherine, additional, Bradburn, Kirstie, additional, Bray, Jonathan J.H., additional, Bressington, Catherine, additional, Brimfield, Matthew, additional, Broad, Lauren, additional, Brown, Pauline, additional, Brydon-Hill, Ruth, additional, Burge, Sharon, additional, Carmichael, David, additional, Chohan, Gurjit, additional, Clark, Tonia, additional, Close, Adrianne, additional, Coleman, Tom, additional, Cowley, Claire, additional, Cranfield, Charlotte, additional, Cross, Eleanor, additional, D'Agostino, Alyssa, additional, D'Arcangelo, Silvia, additional, David Otter, Ashley, additional, Davies, Kate, additional, Davies, Catrin, additional, Davies, Ru, additional, Davies, Louisa, additional, Driver, Kimberley, additional, Eglinton, Charlotte, additional, Ekblad, Charlotte, additional, Eldridge, Emma, additional, Evans, Teriann, additional, Evans, Mim, additional, Evans, Isabel, additional, F Mujadidi, Yama, additional, Farrow, Amanda, additional, Faulkner, Beverley, additional, Feltham, Sally, additional, Figueirido, Susan, additional, Ford, Jamie, additional, Foxwell, David, additional, Frayling, Sharon, additional, Gardiner, Sophie, additional, Gooch, Karen E., additional, Goodwin, Jayne, additional, Halliday, Alice, additional, Hamal, Shama, additional, Harrhy, Sarah, additional, Harris, Andrew, additional, Haxton, Lesley, additional, Haynes, Matthew, additional, Hazell, Mae, additional, Hembrough, Tracey, additional, Hewson, Jacqueline, additional, Hicks, Bethany, additional, Higgins, Thomas, additional, Hill, Michelle, additional, Hills, Alex, additional, Hilton, Zoe, additional, Hitchings, Benjamin, additional, Hua, Cheryl, additional, Iftikhar, Hina, additional, Iqbal, Attya, additional, Jones, Laura, additional, Jones, Nicola, additional, Kellett Wright, Johanna, additional, Kidd, Sarah, additional, Kirby, Alison, additional, Knibbs, Lucy, additional, Lamb, Jenny, additional, Langton, Helen, additional, Leach, Rwth, additional, Lewis-Clarke, Phoebe, additional, Lloyd, Amy, additional, Maclean, Kirsty, additional, Manning, Nicola, additional, Marriott, Anthony, additional, McFadzean, Isobel Joy, additional, McLaughlin, Maeve, additional, McQueen, Alison, additional, Mills, Bianca, additional, Naik, Gurudutt, additional, Nicholls, Lisa, additional, Norman, Chris, additional, Northcott, Keren, additional, Nyland, Kerry, additional, Oliver, Catherine, additional, Oliver, Elizabeth, additional, Oliver, Jennifer, additional, Owen, Diana, additional, Paterson, Jemma, additional, Pearce, Lauren, additional, Pegler, Suzannah, additional, Price, Zoe, additional, Pynsent, William B., additional, Ramos, Lidia, additional, Rampling, Tommy, additional, Rea, David, additional, Regan, Karen, additional, Riaz, Tawassal, additional, Ricamara, Marivic, additional, Rice, Danielle, additional, Rich, Melody, additional, Roots, Marianne, additional, Ryan, Kathryn Ann, additional, Sakagami, Yukari, additional, Salem, Ahmed, additional, Salter-Hewitt, Jade, additional, Samuels, Michelle, additional, Santoloce, Silvia, additional, Seaman, Siwan, additional, Seneviratne, Michael, additional, Shankland, Sara, additional, Silva, Louise, additional, Smart, Katie, additional, Smith, Rachel M., additional, Smith, Joyce, additional, Stringer, Rebecca, additional, Talbot, Helen, additional, Tarling, Teresa, additional, Taylor, Sarah Louise, additional, Thomas, Amy, additional, Tilzey, Grace, additional, Townley, Gina, additional, Trembath, Lisa, additional, Turkentine, Kate, additional, Turner, Kelly, additional, Tyler, Jenny, additional, Ugoji, Jacinta, additional, Wale, Katharine, additional, Walker-Smith, Terrie, additional, Walton, Maggie, additional, Warnes, Barbara, additional, Whittley, Sarah, additional, Williams, Jennie, additional, Williams, Gail, additional, Williamson, Kevin, additional, Yim, Yee Ting Nicole, additional, and Youlden, Nicola, additional

Published
2021
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22. Is dissolved COD a suitable design parameter for ozone oxidation of organic micropollutants in wastewater?

Author

Maja Ekblad, Per Falås, M. Hagman, Kai Bester, Fredrik Nilsson, Haitham El-taliawy, and Michael Cimbritz

Subjects
Environmental Engineering, Ozone, 010504 meteorology & atmospheric sciences, Transferability, COD, DOC, Wastewater, 010501 environmental sciences, Waste Disposal, Fluid, 01 natural sciences, Nitrogen removal, chemistry.chemical_compound, Ozonation, Environmental Chemistry, Organic Chemicals, Waste Management and Disposal, Effluent, Activated sludge system, 0105 earth and related environmental sciences, Biological Oxygen Demand Analysis, Emerging contaminants, Pollution, Activated sludge, Linear prediction model, chemistry, Environmental chemistry, Pharmaceuticals, Oxidation-Reduction, Water Pollutants, Chemical
Abstract

Ozone oxidation of organic micropollutants in biologically treated wastewater was investigated in pilot-scale after a high- and a low loaded activated sludge process. Higher ozone doses were required to remove organic micropollutants in the effluent wastewater from the high loaded activated sludge process. Further comparison of the micropollutant removal was based on normalized ozone doses, expressed as g O3/g DOC and g O3/g soluble COD (sCOD). A clear difference was noted for the two effluents when the micropollutant removal was normalized by DOC. This difference disappeared almost completely when the removal was linked to ozone doses normalized by sCOD. The dose-response curves for the organic micropollutants were practically linear in the removal range up to 95%. A linear prediction model was developed and compared with literature values to test the transferability of the obtained results. Results from this comparison indicated that the slope of the dose-response functions could be used to predict the removal efficiency of organic micropollutants at a third plant with an average uncertainty of 10%. The modeled ozone requirements were then set in relation to the COD concentrations in the discharged water from approximately 90 Swedish activated sludge treatment plants with and without nitrogen removal. This comparison highlighted the need for a well-functioning biological treatment for an effective ozone oxidation of organic micropollutants. The results in this study suggest that soluble COD should be further explored for design and modeling of ozone oxidation of organic micropollutants in biologically treated wastewater.

Published
2019

23. Seed priming enhances early growth and improves area of soil exploration by roots

Author

Craig J. Sturrock, Ali Hafeez Malik, Martine I. de Heer, Sacha J. Mooney, Tobias Ekblad, Sebastian Blunk, and Kenneth Fredlund

Subjects
0106 biological sciences, 0301 basic medicine, Lateral root, food and beverages, Plant Science, Root system, Priming (agriculture), Biology, 01 natural sciences, Seed priming, 03 medical and health sciences, 030104 developmental biology, Nutrient, Agronomy, Germination, Seedbed, Agronomy and Crop Science, Ecology, Evolution, Behavior and Systematics, Management practices, 010606 plant biology & botany
Abstract

Introduction Seed priming has been conducted for centuries with growth advantages reported for a variety of different crops. Previous work has suggested priming does not offer a yield advantage despite an increased early growth if grown under ideal conditions. However, how these advantages unfold in regards to early root development is largely unknown. Results We observed accelerated germination speed in primed seeds regardless of applied seed enhancement technology i.e. coating or pelleting. Additionally, we found significant differences in lateral root development in primed seeds vs non-primed seeds. Furthermore, we recorded an increase in volume and surface of embryo and perisperm indicating a distinct morphological change during the germination process of primed seeds compared to non-primed seeds. Conclusions We attribute the enhanced early plant development in primed seeds to increased root development and thus enhanced volume of the soil resource mined for nutrients. This improvement can be detected four days after emergence within the root system throughout the early plant development despite an early transition from seed reserves to soil based growth. The understanding of belowground root architecture characteristics can improve the selection of appropriate seed enhancement technologies and seedbed management practices.

Published
2019

24. In memoriam: Frank Sundler 1943–2021

Author

Anders Bjartell, Eva Ekblad, Hindrik Mulder, and Nils Wierup

Subjects
Cellular and Molecular Neuroscience, Endocrinology, Physiology, Biochemistry
Published
2022

26. Visual Perceptual Skills in Very Preterm Children: Developmental Course and Associations With Neural Activation

Author

Lind, Annika, primary, Parkkola, Riitta, additional, Laasonen, Marja, additional, Vorobyev, Victor, additional, Haataja, Leena, additional, Ekblad, Mikael, additional, Ekblad, Satu, additional, Ekholm, Eeva, additional, Grönroos, Linda, additional, Huhtala, Mira, additional, Jaakkola, Jere, additional, Karukivi, Max, additional, Kero, Pentti, additional, Korja, Riikka, additional, Lahti, Katri, additional, Lapinleimu, Helena, additional, Lehtonen, Liisa, additional, Lehtonen, Tuomo, additional, Leppänen, Marika, additional, Lind, Annika, additional, Koivisto, Mari, additional, Mattsson, Mira, additional, Maunu, Jonna, additional, Munck, Petriina, additional, Määttänen, Laura, additional, Niemi, Pekka, additional, Nyman, Anna, additional, Ripatti, Liisi, additional, Rautava, Päivi, additional, Saarinen, Katriina, additional, Saarinen, Tiina, additional, Salomäki, Susanna, additional, Saunavaara, Virva, additional, Setänen, Sirkku, additional, Sillanpää, Matti, additional, Stolt, Suvi, additional, Tuomikoski, Päivi, additional, Uusitalo, Karoliina, additional, and Ylijoki, Milla, additional

Published
2020
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28. High throughput generation of a resource of the human secretome in mammalian cells

Author

Tegel, Hanna, Dannemeyer, Melanie, Kanje, Sara, Sivertsson, Åsa, Berling, Anna, Svensson, Anne-Sophie, Hober, Andreas, Enstedt, Henric, Volk, Anna-Luisa, Lundqvist, Magnus, Moradi, Mona, Afshari, Delaram, Ekblad, Siri, Xu, LanLan, Vestin, Malin, Bidad, Faranak, Schiavone, Lovisa Holmberg, Davies, Rick, Mayr, Lorenz M., Knight, Sinead, Gopel, Sven O., Voldborg, Bjorn G., Edfors, Fredrik, Forsström, Björn, von Feilitzen, Kalle, Zwahlen, Martin, Rockberg, Johan, Takanen, Jenny Ottosson, Uhlén, Mathias, Hober, Sophia, Tegel, Hanna, Dannemeyer, Melanie, Kanje, Sara, Sivertsson, Åsa, Berling, Anna, Svensson, Anne-Sophie, Hober, Andreas, Enstedt, Henric, Volk, Anna-Luisa, Lundqvist, Magnus, Moradi, Mona, Afshari, Delaram, Ekblad, Siri, Xu, LanLan, Vestin, Malin, Bidad, Faranak, Schiavone, Lovisa Holmberg, Davies, Rick, Mayr, Lorenz M., Knight, Sinead, Gopel, Sven O., Voldborg, Bjorn G., Edfors, Fredrik, Forsström, Björn, von Feilitzen, Kalle, Zwahlen, Martin, Rockberg, Johan, Takanen, Jenny Ottosson, Uhlén, Mathias, and Hober, Sophia

Abstract

The proteins secreted by human tissues and blood cells, the secretome, are important both for the basic understanding of human biology and for identification of potential targets for future diagnosis and therapy. Here, a high-throughput mammalian cell factory is presented that was established to create a resource of recombinant full-length proteins covering the majority of those annotated as 'secreted' in humans. The full-length DNA sequences of each of the predicted secreted proteins were generated by gene synthesis, the constructs were transfected into Chinese hamster ovary (CHO) cells and the recombinant proteins were produced, purified and analyzed. Almost 1,300 proteins were successfully generated and proteins predicted to be secreted into the blood were produced with a success rate of 65%, while the success rates for the other categories of secreted proteins were somewhat lower giving an overall one-pass success rate of ca. 58%. The proteins were used to generate targeted proteomics assays and several of the proteins were shown to be active in a phenotypic assay involving pancreatic beta-cell dedifferentiation. Many of the proteins that failed during production in CHO cells could be rescued in human embryonic kidney (HEK 293) cells suggesting that a cell factory of human origin can be an attractive alternative for production in mammalian cells. In conclusion, a high-throughput protein production and purification system has been successfully established to create a unique resource of the human secretome., QC 20200729

Published
2020
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29. 200,000 years of monsoonal history recorded on the lower Bengal Fan - strong response to insolation forcing

Author

Philipp Wolfgramm, Carsten Meyer-Jacob, Brendan T Reilly, Michael E Weber, Jürgen Titschack, Sandip Agrahari, Hendrik Lantzsch, Alf Ekblad, Yasmina M. Martos, Petra S Dekens, Beth Holmes, and Supriyo Kumar Das

Subjects
Marine isotope stage, Global and Planetary Change, 010504 meteorology & atmospheric sciences, Orbital forcing, Intertropical Convergence Zone, Westerlies, 010502 geochemistry & geophysics, Oceanography, Monsoon, 01 natural sciences, Ice core, Stadial, Glacial period, Geology, 0105 earth and related environmental sciences
Abstract

We conducted a multidisciplinary study to provide the stratigraphic and palaeoclimatic context of monsoonal rainfall dynamics and their responses to orbital forcing for the Bay of Bengal. Using sediment lightness we established an age model at orbital resolution for International Ocean Discovery Programme (IODP) Core U1452C-1H that covers the last 200 ka in the lower Bengal Fan. The low-resolution δ18O of G. sacculifer is consistent with global δ18O records, at least for major glacial-to-interglacial transitions. The variability of total organic carbon, total nitrogen, and the δ13C composition of organic matter indicate the marine origin of organic matter. Marine primary productivity likely increased during insolation minima, indicative for an enhanced NE monsoon during glacials and stadials. Pristine insolation forcing is also documented for wet-bulk density, red-green color variability, and grain-size variations, indicating that darker and coarser-grained material deposited at higher sedimentation rates during insolation minima. Stronger NE monsoon likely amplified ocean-atmosphere interactions over the Indian Ocean, leading to stronger upwelling through shoaling the thermocline, and higher delivery of sediment to the Bay of Bengal due to higher soil erosion on land. In addition, lower glacial and stadial sea levels as well as stronger westward surface circulation favored delivery of coarser-grained fluvial material to the lower Bengal Fan. At the same time the stronger NE monsoon might have increased the aeolian supply. Total inorganic carbon, the Ca/Ti ratio, and biogenic silica vary dominantly on obliquity frequencies, suggesting mobilization and transport of lithogenic material primarily during lowered sea levels and/or higher influence of the Northern Hemisphere westerlies on the dust transport from the Tibetan Plateau. The close resemblance of sediment lightness and the climate record of Antarctic ice cores over multiple glacial cycles indicate close relationship between high southern latitude and tropical Asian climate through shifts in position of the Intertropical Convergence Zone. The Bengal Fan monsoonal record shows very clear and strict responses to insolation forcing in the lower part from ~200 ka to the Younger Toba Tuff during Marine Isotope Stage (MIS) 7 – 5, and less distinct response patterns after deposition of the ash during MIS 4 – 2, consistent with low-amplitude changes in insolation.

Published
2018

30. Spatial and dietary sources of elevated mercury exposure in white-tailed eagle nestlings in an Arctic freshwater environment

Author

Igor Eulaers, Toni Laaksonen, Torsten Stjernberg, Jens Søndergaard, Camilla Ekblad, Ralf Schulz, Jochen P. Zubrod, Finnish Museum of Natural History, Zoology, and Biosciences

Subjects
0106 biological sciences, FEATHERS, Eagles, Health, Toxicology and Mutagenesis, PREY, Fresh Water, METHYLMERCURY, 010501 environmental sciences, Toxicology, 01 natural sciences, chemistry.chemical_compound, Predatory fish, Methylmercury, Apex predator, Trophic level, PANDION-HALIAETUS, education.field_of_study, biology, Ecology, BIOACCUMULATION, General Medicine, Stable isotope, Pollution, 1181 Ecology, evolutionary biology, Environmental Pollutants, FOOD-WEB, Environmental Monitoring, Population, chemistry.chemical_element, FISH, HALIAEETUS-ALBICILLA, biology.animal, STABLE-ISOTOPES, Animals, Humans, 14. Life underwater, education, Ecosystem, Esox, Reservoir, 0105 earth and related environmental sciences, Haliaeetus albicilla, 010604 marine biology & hydrobiology, Mercury, biology.organism_classification, Mercury (element), Lapland, chemistry, 13. Climate action, Evolutionary trap, WILD BIRDS, Environmental science, Bird of prey
Abstract

Human-induced mercury (Hg) contamination is of global concern and its effects on wildlife remain of high concern, especially in environmental hotspots such as inland aquatic ecosystems. Mercury biomagnifies through the food web resulting in high exposure in apex predators, such as the white-tailed eagle (Haliaeetus albicilla), making them excellent sentinel species for environmental Hg contamination. An expanding population of white-tailed eagles is inhabiting a sparsely populated inland area in Lapland, northern Finland, mainly around two large reservoirs flooded 50 years ago. As previous preliminary work revealed elevated Hg levels in this population, we measured Hg exposure along with dietary proxies (δ13C and δ15N) in body feathers collected from white-tailed eagle nestlings in this area between 2007 and 2018. Mercury concentrations were investigated in relation to territory characteristics, proximity to the reservoirs and dietary ecology as potential driving factors of Hg contamination. Mercury concentrations in the nestlings (4.97–31.02 μg g−1 dw) were elevated, compared to earlier reported values in nestlings from the Finnish Baltic coast, and exceeded normal background levels (≤5.00 μg g−1) while remaining below the tentative threshold of elevated risk for Hg exposure mediated health effect (>40.00 μg g−1). The main drivers of Hg contamination were trophic position (proxied by δ15N), the dietary proportion of the predatory fish pike (Esox lucius), and the vicinity to the Porttipahta reservoir. We also identified a potential evolutionary trap, as increased intake of the preferred prey, pike, increases exposure. All in all, we present results for poorly understood freshwater lake environments and show that more efforts should be dedicated to further unravel potentially complex pathways of Hg exposure to wildlife.

Published
2021

31. Modern analogue to past coseismic ground uplift in North Andaman, India

Author

Alf Ekblad, Kohki Yoshida, Subham Chatterjee, Priyank Pravin Patel, Supriyo Kumar Das, and Sumit Kumar Ray

Subjects
Flora, Peat, 010504 meteorology & atmospheric sciences, Subduction, Intertidal zone, 04 agricultural and veterinary sciences, Megathrust earthquake, 01 natural sciences, Debris, law.invention, Paleontology, law, 040103 agronomy & agriculture, 0401 agriculture, forestry, and fisheries, Radiocarbon dating, Mangrove, Geology, 0105 earth and related environmental sciences, Earth-Surface Processes
Abstract

Dynamics of surface geological processes, triggered by coseismic ground uplift following the 2004 Sumatra-Andaman earthquake (Mw > 9.2), provide a modern analogue for assessing the paleoseismic significance of an enigmatic subsurface peat occurrence within beach sands in the western coast of North Andaman Island. The megathrust earthquake uplifted vast stretches of coastal intertidal zones to supratidal levels. As a result, intertidal flora, including mangroves, desiccated and perished. Mass mortality of the flora continued even three years after the earthquake and generated a large volume of forest debris. Coastal waves pushed the debris to the high tide line where the accumulated debris would be gradually buried, and would subsequently transform into linear peat bodies keeping a record of the seismic event in 2004. Accordingly, we have interpreted a linear strand-parallel peat occurrence in beach sand as a record of earlier mass mortality of plants likely associated with a coseismic ground uplift. Stable isotope studies indicate that local intertidal flora is the source of the peat organic matter. Moreover, the 1817 CE calibrated mean AMS radiocarbon age of the peat suggests recurrence of a megathrust earthquake in the Andaman subduction zone about 200 years ago.

Published
2021

32. High throughput generation of a resource of the human secretome in mammalian cells

Author

Tegel, Hanna, primary, Dannemeyer, Melanie, additional, Kanje, Sara, additional, Sivertsson, Åsa, additional, Berling, Anna, additional, Svensson, Anne-Sophie, additional, Hober, Andreas, additional, Enstedt, Henric, additional, Volk, Anna-Luisa, additional, Lundqvist, Magnus, additional, Moradi, Mona, additional, Afshari, Delaram, additional, Ekblad, Siri, additional, Xu, LanLan, additional, Westin, Malin, additional, Bidad, Faranak, additional, Schiavone, Lovisa Holmberg, additional, Davies, Rick, additional, Mayr, Lorenz M., additional, Knight, Sinead, additional, Göpel, Sven O., additional, Voldborg, Björn G., additional, Edfors, Fredrik, additional, Forsström, Björn, additional, von Feilitzen, Kalle, additional, Zwahlen, Martin, additional, Rockberg, Johan, additional, Takanen, Jenny Ottosson, additional, Uhlén, Mathias, additional, and Hober, Sophia, additional

Published
2020
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36. Ozonation efficiency in removing organic micro pollutants from wastewater with respect to hydraulic loading rates and different wastewaters

Author

M. Hagman, Fredrik Nilsson, Maja Ekblad, Haitham El-taliawy, Michael Cimbritz, Karin Jönsson, N. Paxeus, J. la Cour Jansen, and Kai Bester

Subjects
Pollutant, Pollution, Ozone, General Chemical Engineering, media_common.quotation_subject, 0208 environmental biotechnology, Environmental engineering, 02 engineering and technology, General Chemistry, 010501 environmental sciences, 01 natural sciences, Industrial and Manufacturing Engineering, 020801 environmental engineering, chemistry.chemical_compound, Waste treatment, Pilot plant, chemistry, Wastewater, Environmental Chemistry, Environmental science, Sewage treatment, Water treatment, 0105 earth and related environmental sciences, media_common
Abstract

Organic micro pollutants can be removed from water by ozonation. In this article we studied the performance of ozonation under real life conditions and compared results of the same ozonation pilot plant installed at different wastewater treatment plants (WWTPs) thus operating with different waters. The comparability of the removal and reaction rate constants from one waste water treatment plant were low in respect to reaction rate, removal as well as to response to the specific ozone dose. Neither pH-value nor residual nitrite concentrations were the driving force considering these differences. Further tests with different loadings were conducted at the same WWTP under different weather conditions. For the different hydraulic loading of the biological plant, the ozonation was running with rather similar removal rates concerning the same specific (TOC normalized) ozone dose. The compounds that were removed quantitatively under dry weather were still removed well with three times dry weather flow. Using a dataset from one WWTP to optimize operation in another one is thus questionable.

Published
2017

37. Stable carbon isotope labelled carbon dioxide as tracer gas for air change rate measurement in a ventilated single zone

Author

Robin Nyström, Thomas Olofsson, Christoffer Boman, K. E. Anders Ohlsson, Bin Yang, and Alf Ekblad

Subjects
Environmental Engineering, 010504 meteorology & atmospheric sciences, Geography, Planning and Development, Building and Construction, Single zone, 010501 environmental sciences, 01 natural sciences, Cavity ring-down spectroscopy, chemistry.chemical_compound, chemistry, Rate measurement, Air change, Isotopes of carbon, Environmental chemistry, TRACER, Carbon dioxide, Environmental science, 0105 earth and related environmental sciences, Civil and Structural Engineering
Abstract

Carbon dioxide (CO2) has often been used as tracer gas for measurement of the air change rate l (h1 ) in buildings. In such measurements, a correction is required for the presence of indoor CO2, wh ...

Published
2017

38. Gut Microbiota Richness and Composition and Dietary Intake of Overweight Pregnant Women Are Related to Serum Zonulin Concentration, a Marker for Intestinal Permeability1–3

Author

Kati Mokkala, Henna Röytiö, Eveliina Munukka, Asta Laiho, Sami Pietilä, Tapani Rönnemaa, Ulla Ekblad, Erkki Eerola, and Kirsi Laitinen

Subjects
0301 basic medicine, medicine.medical_specialty, Nutrition and Dietetics, Intestinal permeability, biology, business.industry, Medicine (miscellaneous), Zonulin, Faecalibacterium prausnitzii, Overweight, Gut flora, medicine.disease, Micronutrient, biology.organism_classification, Obesity, 03 medical and health sciences, 030104 developmental biology, Endocrinology, Internal medicine, medicine, Median body, medicine.symptom, business
Abstract

BACKGROUND Increased intestinal permeability may precede adverse metabolic conditions. The extent to which the composition of the gut microbiota and diet contribute to intestinal permeability during pregnancy is unknown. OBJECTIVE The aim was to investigate whether the gut microbiota and diet differ according to serum zonulin concentration, a marker of intestinal permeability, in overweight pregnant women. METHODS This cross-sectional study included 100 overweight women [mean age: 29 y; median body mass index (in kg/m(2)): 30] in early pregnancy (

Published
2016

39. Comparison of PFASs contamination in the freshwater and terrestrial environments by analysis of eggs from osprey ( Pandion haliaetus ), tawny owl ( Strix aluco ), and common kestrel ( Falco tinnunculus )

Author

Ylva Lind, Anna Kärrman, Alf Ekblad, Ulrika Eriksson, Anna Roos, and Kjell Hope

Subjects
Hydrocarbons, Fluorinated, 010504 meteorology & atmospheric sciences, Eggs, Zoology, Kestrel, 010501 environmental sciences, Biology, 01 natural sciences, Biochemistry, Falco tinnunculus, Bird egg, Predation, biology.animal, Animals, Soil Pollutants, Fluorotelomer, Falconiformes, 0105 earth and related environmental sciences, General Environmental Science, Sweden, Ecology, Bird of prey, Environmental Exposure, Environmental exposure, Strigiformes, biology.organism_classification, Strix aluco, Environmental Pollutants, Water Pollutants, Chemical, Environmental Monitoring
Abstract

The level of PFAS (per- and polyfluorinated alkyl substances) contamination in freshwater and terrestrial Swedish environments in 2013/2014 was assessed by analyzing a range of perfluorinated alkyl acids, fluorotelomer acids, sulfonamides, sulfonamidoethanols and polyfluoralkyl phosphate diesters (diPAPs) in predator bird eggs. Stable isotopes ((13)C and (15)N) were analyzed to elucidate the dietary source. The tawny owl (Strix aluco, n=10) and common kestrel (Falco tinnunculus, n=40), two terrestrial species, and the osprey (Pandion haliaetus, n=30), a freshwater specie were included. In addition, a temporal trend (1997-2001, 2008-2009, 2013) in osprey was studied as well. The PFAS profile was dominated by perfluorooctane sulfonic acid (PFOS) in eggs from osprey and tawny owl, while for common kestrel perfluorinated carboxylic acids (∑PFCA) exceeded the level of PFOS. PFOS concentration in osprey eggs remained at the same level between 1997 and 2001 and 2013. For the long-chained PFCAs, there were a significant increase in concentrations in osprey eggs between 1997 and 2001 and 2008-2009. The levels of PFOS and PFCAs were about 10 and five times higher, respectively, in osprey compared to tawny owl and common kestrel. Evidence of direct exposure from PFCA precursor compounds to birds in both freshwater and terrestrial environment was observed. Low levels of diPAPs were detected in a few samples of osprey (

Published
2016

40. Resilient properties of binary granular mixtures: A numerical investigation

Author

Ricardo de Frias Lopez, Johan Silfwerbrand, and Jonas Ekblad

Subjects
Bulk modulus, Materials science, business.industry, 0211 other engineering and technologies, Aggregate modulus, Binary number, Resilient modulus, 02 engineering and technology, Structural engineering, Geotechnical Engineering and Engineering Geology, 01 natural sciences, Discrete element method, Computer Science Applications, 0103 physical sciences, Dynamic modulus, SPHERES, 010306 general physics, business, Elastic modulus, 021101 geological & geomatics engineering
Abstract

The effect of stress level on the resilient modulus for binary mixtures of elastic spheres under triaxial loading is investigated using the discrete element method. The secant modulus during the fi ...

Published
2016

41. Interactions of a class IIb bacteriocin with a model lipid bilayer, investigated through molecular dynamics simulations

Author

Panagiota K. Kyriakou, Per Eugen Kristiansen, Bie Ekblad, and Yiannis N. Kaznessis

Subjects
0301 basic medicine, Lipid Bilayers, 030106 microbiology, Antimicrobial peptides, Mutant, Biophysics, Molecular Dynamics Simulation, Biology, Biochemistry, Cell membrane, 03 medical and health sciences, Bacteriocins, Bacteriocin, medicine, Humans, Amino Acids, Lipid bilayer, chemistry.chemical_classification, Cell Membrane, Cell Biology, Anti-Bacterial Agents, Amino acid, 030104 developmental biology, medicine.anatomical_structure, Membrane, Mechanism of action, chemistry, medicine.symptom, Antimicrobial Cationic Peptides
Abstract

The emergence of antibiotic resistant microorganisms poses an alarming threat to global health. Antimicrobial peptides (AMPs) are considered a possible effective alternative to conventional antibiotic therapies. An understanding of the mechanism of action of AMPs is needed in order to better control and optimize their bactericidal activity. Plantaricin EF is a heterodimeric AMP, consisting of two peptides Plantaricin E (PlnE) and Plantaricin F (PlnF). We studied the behavior of these peptides on the surface of a model lipid bilayer. We identified the residues that facilitate peptide-peptide interactions. We also identified residues that mediate interactions of the dimer with the membrane. PlnE interacts with the membrane through amino acids at both its termini, while only the N terminus of PlnF approaches the membrane. By comparing the activity of single-site mutants of the two-peptide bacteriocin and the simulations of the bacteriocin on the surface of a model lipid bilayer, structure activity relationships are proposed. These studies allow us to generate hypotheses that relate biophysical interactions observed in simulations with the experimentally measured activity. We find that single-site amino acid substitutions result in markedly stronger antimicrobial activity when they strengthen the interactions between the two peptides, while, concomitantly, they weaken peptide-membrane association. This effect is more pronounced in the case of the PlnE mutant (G20A), which interacts the strongest with PlnF and the weakest with the membrane while displaying the highest activity.

Published
2016

42. Luteinizing hormone receptors are expressed in rat myenteric neurons and mediate neuronal loss

Author

Eva Ekblad, Elin Sand, Bodil Ohlsson, and Ulrikke Voss

Subjects
Male, endocrine system, medicine.medical_specialty, Cell Survival, Immunocytochemistry, Myenteric Plexus, Cell Count, Gonadotropin-releasing hormone, Biology, Buserelin, Gonadotropin-Releasing Hormone, Rats, Sprague-Dawley, Cellular and Molecular Neuroscience, Ileum, Internal medicine, medicine, Animals, Receptor, Cells, Cultured, Myenteric plexus, Neurons, Dose-Response Relationship, Drug, Endocrine and Autonomic Systems, Enteric neuropathy, luteinizing hormone/choriogonadotropin receptor, Luteinizing Hormone, Receptors, LH, medicine.disease, Immunohistochemistry, Hormones, Endocrinology, nervous system, Female, Neurology (clinical), Luteinizing hormone, Receptors, LHRH, hormones, hormone substitutes, and hormone antagonists, medicine.drug
Abstract

Background Clinical observations have suggested repeated gonadotropin-releasing hormone (GnRH) exposure to cause intestinal dysfunction and loss of enteric neurons. This has been further studied and confirmed in a rat in vivo model involving iterated GnRH treatments. Mechanisms behind are enigmatic since no GnRH receptors are found to be expressed in enteric neurons neither in man nor rat. Both species, however, harbor substantial subpopulations of luteinizing hormone (LH) receptor-immunoreactive myenteric neurons which suggests that intestinal GnRH-induced neuropathy may be mediated by LH release. Aims To reveal if exposures of GnRH or LH to rat myenteric neurons in vitro cause neuronal loss. Methods Primary cultured adult rat myenteric neurons were exposed to single or repeated treatments of the GnRH analog buserelin or the LH analog lutrotropin alpha, and neuronal survival was determined by cell counting. Possible presence of GnRH- or LH receptor -immunoreactive neurons was determined by immunocytochemistry. Results Exposure to the LH, but not the GnRH, analog caused significantly reduced neuronal survival. LH, but not GnRH, receptors were found to be expressed on cultured myenteric neurons. Conclusion Myenteric neurons express LH receptors in vitro and LH exposure causes reduced neuronal survival. This suggests that GnRH-induced enteric neuropathy in vivo is mediated by way of LH release and activation of enteric neuronal LH receptors.

Published
2015

43. The influence of soil warming on organic carbon sequestration of arbuscular mycorrhizal fungi in a sub-arctic grassland

Author

Håkan Wallander, Jing Zhang, Alf Ekblad, and Bjarni D. Sigurdsson

Subjects
Total organic carbon, geography, Biomass (ecology), geography.geographical_feature_category, Soil Science, chemistry.chemical_element, 04 agricultural and veterinary sciences, Soil carbon, Arbuscular mycorrhizal fungi, Microbiology, Grassland, Agronomy, chemistry, 040103 agronomy & agriculture, 0401 agriculture, forestry, and fisheries, Environmental science, Carbon, Mycelium, Soil warming
Abstract

A substantial portion of grassland photosynthates is allocated belowground to arbuscular mycorrhizal fungi (AMF), but controversy remains about whether this carbon (C) contributes to soil organic carbon (SOC) under warming. The goal of this study was to investigate how AMF biomass and C sequestered by AMF (CNew) are influenced by soil warming. We estimated the AMF biomass and CNew, assumed to be mostly AMF necromass, in mycelial ingrowth bags buried for 1, 2, or 3 years in soil under warming (~+0.5–16.4 °C). The AMF biomass had a positive, curvilinear response to warming gradients after one year of burial. About 107 g C m−2 of CNew accumulated over the three years and ~12% of this C was from glomalin-related soil protein. Modelling suggested the production rate of AMF biomass was 153 g C m−2 yr−1 with a rapid (36–75 days) turnover while AMF necromass turnover was much slower (1.4 ± 0.2 yr−1). Warming duration (7–9 years vs. > 50 years) did not have significant influence on AMF biomass or CNew (P > 0.05). Our results suggest that AMF are more tolerant to increases in temperature than other microbes or fine roots. The dramatic loss of soil C and stable soil aggregates under warming found earlier at this site were not attributed to a decrease in AMF biomass or CNew. Despite a low AMF standing biomass, its contribution to SOC may be substantial.

Published
2020

44. Multi-proxy approach on the hydrocarbon generation perspective of Barjora Basin, India

Author

M.S. Kalpana, Satabdi Misra, Alf Ekblad, Sanki Biswas, Devleena Mani, Atul Kumar Varma, and Supriyo Kumar Das

Subjects
chemistry.chemical_classification, Total organic carbon, Stable isotope ratio, Stratigraphy, Mineralogy, chemistry.chemical_element, Geology, Oceanography, Isotopic signature, chemistry.chemical_compound, Geophysics, chemistry, Liptinite, Kerogen, Economic Geology, Organic matter, Carbon, Oil shale
Abstract

Barjora Basin in India is a small basin characterized by a high organic richness of early mature nature. The present study aims to find the source of organic matter (OM) and hydrocarbon generation potential of Barjora Basin. Systematically collected coal and shale samples from R-II seam of the basin were used for proximate and ultimate analyses, Rock Eval pyrolysis along with total organic carbon (TOC) content, organo-micropetrographic framework, thermal maturity, carbon isotopic signature, biomarker composition, functional group studies and estimation of relative aliphaticity and aromaticity through Fourier Transform infrared spectroscopy (FTIR). The novelty of the present work lies in the application of multiple proxies such as stable isotope ratio of organic carbon (δ13C), biomarker signatures, thermal maturity parameters, organo-micropetrography and estimation and quantification of functional groups for palaeoenvironmental reconstruction and to assess the hydrocarbon productivity of the basin. A dominant terrestrial OM input in Barjora Basin is indicated by the TOC to total nitrogen ratio (C/N), δ13C and biomarker compositions. High gelification index (GI), tissue preservation index (TPI), and carbon preference index (CPI) values indicate that coals are deposited in wet swamp forest regime under high rainwater conditions and shales are formed in upper delta plain regime under high groundwater activity. In addition, large liptinite content, TPI and GI designate short transportation of the OM before burial leading to organic richness of the Barjora Basin. Moreover, high liptinite content, type II-III admixed kerogen input, S2/S3 ratio, TPI and index for hydrocarbon generation (IHG) signify higher potential of the basin for hydrocarbon generation.

Published
2020

48. Hepatic arterial therapy with oxaliplatin and systemic capecitabine for patients with liver metastases from breast cancer

Author

Lindgaard, S.C., primary, Brinch, C.M., additional, Jensen, B.K., additional, Nørgaard, H.H., additional, Hermann, K.L., additional, Theile, S., additional, Larsen, F.O., additional, Jensen, B.V., additional, Michelsen, H., additional, Nelausen, K.M., additional, Holm, V.H., additional, Ekblad, L., additional, Soerensen, Peter G., additional, and Nielsen, D.L., additional

Published
2019
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49. Contribution of roots and amendments to soil carbon accumulation within the soil profile in a long-term field experiment in Sweden

Author

Thomas Kätterer, Lorenzo Menichetti, and Alf Ekblad

Subjects
Total organic carbon, Ecology, Field experiment, Soil organic matter, Soil science, Soil carbon, Soil type, complex mixtures, Humus, Agronomy, Environmental science, Soil horizon, Animal Science and Zoology, Agronomy and Crop Science
Abstract

The contribution of different C inputs to organic carbon accumulation within the soil profile in the Ultuna long-term continuous soil organic matter experiment, established in 1956, was determined. ...

Published
2015

50. Successful Airtraq Use in an Air Medical Transport System

Author

Glenn Ekblad, Kyle English, William Selde, Jan Eichel, and Matthew Heffelfinger

Subjects
Medical Audit, medicine.diagnostic_test, business.industry, medicine.medical_treatment, Laryngoscopy, Crew, Human trial, Air Ambulances, Emergency Nursing, Device use, Airtraq, medicine.disease, Anesthesia, Chart review, Intubation, Intratracheal, Emergency Medicine, medicine, Humans, Intubation, Medical emergency, business, Transport system, Retrospective Studies
Abstract

Introduction There is a large body of literature that shows that the AirTraq device achieves equal or superior rates of successful intubation in all classes of user. A recent prospective human trial of the device questioned the first pass success rate and whether effective training could occur outside the Operating Room (OR). The purpose of this study was to investigate the first pass success rate for intubation with the AirTraq (AT) device utilizing only mannequin training in an air ambulance setting from Aug. 1 2009 to Aug. 1 2012 and compare it to direct laryngoscopy (DL). Hypothesis We hypothesize that the AirTraq device will be as effective overall as direct laryngoscopy, and that this requires no OR training to achieve. Methods A retrospective chart review of 161 intubations by air ambulance flight nurses from Aug. 1, 2009 to Aug. 1, 2012 was conducted. Data regarding date of service, devices used, number of attempts, rescue device use, and complications was gathered and analyzed. The generalized estimating equation and the chi-squared test were used to evaluate the data. Results 161 intubations were reviewed. 135 met inclusion criteria. Overall first pass success rate for AT was 82% (68/83) and DL was 74% (35/47). Overall first use success rate for AT was 79% (71/90) and DL was 70% (43/61). The overall success rate of intubation for any patient in which either AT or DL was attempted is 96% (130/135). Conclusion AirTraq was shown to be as effective as direct laryngoscopy. All air crew training for the AirTraq device was performed on mannequins. The successof the device compared to DL shows that mannequin training is sufficient to implement the AirTraq device for pre-hospital intubation.

Published
2014

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