1. Light-responsive polymeric nanoparticles based on a novel nitropiperonal based polyester as drug delivery systems for photosensitizers in PDT
- Author
-
Klaus Langer, Dirk Kuckling, Timo Schoppa, Dennis Mulac, Tarik Rust, and Dimitri Jung
- Subjects
Drug ,Polyesters ,medicine.medical_treatment ,media_common.quotation_subject ,Pharmaceutical Science ,Nanoparticle ,Nanotechnology ,Photodynamic therapy ,02 engineering and technology ,030226 pharmacology & pharmacy ,03 medical and health sciences ,chemistry.chemical_compound ,Drug Delivery Systems ,0302 clinical medicine ,medicine ,Photosensitizer ,media_common ,Active ingredient ,Photosensitizing Agents ,021001 nanoscience & nanotechnology ,PLGA ,Photochemotherapy ,chemistry ,Targeted drug delivery ,Drug delivery ,Nanoparticles ,Triazenes ,0210 nano-technology - Abstract
Although nanoparticles (NPs) bear a great potential in tumour therapy, just a few nanosized drug delivery systems are commercially available. Besides their advantages like passive drug targeting and stable embedment of lipophilic active pharmaceutical ingredients, targeted drug release is a major challenge for a safe therapy. While drug release of commonly used materials depends on physiological factors, nanoparticles prepared by using stimuli responsive polymers offer a promising approach. External irradiation of light-sensitive nanoparticles enables local drug release, resulting in selective accumulation and consequently more effective treatment with less side effects. In this study light-responsive nanoparticles based on a new innovative light-responsive polyester (Nip-SLrPE) combined with poly(DL-lactide-co-glycolide) (PLGA) were prepared and examined for their physicochemical characteristics and light-triggered properties. As model drug the photosensitizer 5,10,15,20-tetrakis(m-hydroxyphenyl)chlorine (mTHPC) was incorporated and light-depending drug release was investigated. Furthermore, cytotoxic potential of selected formulations for PDT and intracellular accumulation of mTHPC were evaluated. In conclusion, nanoparticles based on the new light-sensitive Nip-SLrPE showed auspicious light-responsive properties, resulting in promising results for a smart drug delivery system.
- Published
- 2021