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Light-responsive polymeric nanoparticles based on a novel nitropiperonal based polyester as drug delivery systems for photosensitizers in PDT
- Source :
- International Journal of Pharmaceutics. 597:120326
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Although nanoparticles (NPs) bear a great potential in tumour therapy, just a few nanosized drug delivery systems are commercially available. Besides their advantages like passive drug targeting and stable embedment of lipophilic active pharmaceutical ingredients, targeted drug release is a major challenge for a safe therapy. While drug release of commonly used materials depends on physiological factors, nanoparticles prepared by using stimuli responsive polymers offer a promising approach. External irradiation of light-sensitive nanoparticles enables local drug release, resulting in selective accumulation and consequently more effective treatment with less side effects. In this study light-responsive nanoparticles based on a new innovative light-responsive polyester (Nip-SLrPE) combined with poly(DL-lactide-co-glycolide) (PLGA) were prepared and examined for their physicochemical characteristics and light-triggered properties. As model drug the photosensitizer 5,10,15,20-tetrakis(m-hydroxyphenyl)chlorine (mTHPC) was incorporated and light-depending drug release was investigated. Furthermore, cytotoxic potential of selected formulations for PDT and intracellular accumulation of mTHPC were evaluated. In conclusion, nanoparticles based on the new light-sensitive Nip-SLrPE showed auspicious light-responsive properties, resulting in promising results for a smart drug delivery system.
- Subjects :
- Drug
Polyesters
medicine.medical_treatment
media_common.quotation_subject
Pharmaceutical Science
Nanoparticle
Nanotechnology
Photodynamic therapy
02 engineering and technology
030226 pharmacology & pharmacy
03 medical and health sciences
chemistry.chemical_compound
Drug Delivery Systems
0302 clinical medicine
medicine
Photosensitizer
media_common
Active ingredient
Photosensitizing Agents
021001 nanoscience & nanotechnology
PLGA
Photochemotherapy
chemistry
Targeted drug delivery
Drug delivery
Nanoparticles
Triazenes
0210 nano-technology
Subjects
Details
- ISSN :
- 03785173
- Volume :
- 597
- Database :
- OpenAIRE
- Journal :
- International Journal of Pharmaceutics
- Accession number :
- edsair.doi.dedup.....9c36794466fb83e81ffd5bff38b90fa6