1. How Does Preexisting Hypertension Affect Patients with Intracerebral Hemorrhage?
- Author
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Jose Torres, Jonathan Rosenthal, Jennifer A. Frontera, Ariane Lewis, Thomas Calahan, Fred Lee, David Valentine, Barry M. Czeisler, Koto Ishida, and Aaron Lord
- Subjects
Male ,medicine.medical_specialty ,genetic structures ,Blood Pressure ,Affect (psychology) ,Severity of Illness Index ,Disability Evaluation ,Electrocardiography ,03 medical and health sciences ,Patient Admission ,0302 clinical medicine ,Risk Factors ,Internal medicine ,medicine ,Humans ,In patient ,Antihypertensive Agents ,Aged ,Cerebral Hemorrhage ,Ohio ,Retrospective Studies ,Intracerebral hemorrhage ,business.industry ,Rehabilitation ,Middle Aged ,Bleed ,Prognosis ,medicine.disease ,Blood pressure ,Echocardiography ,Hypertension ,Cardiology ,Female ,Hypertrophy, Left Ventricular ,New York City ,Surgery ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine ,business ,030217 neurology & neurosurgery - Abstract
Patients with intracerebral hemorrhage (ICH) frequently present with hypertension, but it is unclear if this is due to pre-existing hypertension (prHTN) or to the bleed itself or associated pain. We sought to assess the relationship between prHTN and admission systolic blood pressure (aBP) and bleed severity.We retrospectively assessed the relationship between prHTN and aBP and NIHSS in patients with ICH at 3 institutions.Of 251 patients, 170 (68%) had prHTN based on history of hypertension/antihypertensive use. Median aBP was significantly higher in those with prHTN (155 mm Hg (IQR 135-181) versus 139 mm Hg (IQR 124-158), P.001). Patients with left ventricular hypertrophy (LVH) on electrocardiogram (ECG) or transthoracic echocardiogram (TTE) had significantly higher aBP than those without LVH (median aBP 195 mm Hg (IQR 155-216) for patients with LVH on ECG versus 147 mm Hg (IQR 129-163) for patients with no LVH on ECG, P.001; median aBP 181 mm Hg (IQR 153-214) for patients with LVH on TTE versus 152 mm Hg (IQR 137-169) for patients with no LVH on TTE, P = .01). prHTN was associated with a higher median NIHSS (11 (IQR 3-20) for patients with history of hypertension/antihypertensive use versus 6 (IQR 1-14) for patients without this history (P = .02); 9 (IQR 3-19) versus 5 (IQR 2-13) for patients with/without LVH on ECG (P = .085); and 10 (IQR 5-18) versus 5 (IQR 1-13) for patients with/without LVH on TTE (P = .046).Patients with ICH who have prHTN have higher aBP and NIHSS, suggesting that prHTN may worsen reactive hypertension in the setting of ICH.
- Published
- 2019