1. Systemic lupus erythematosus is associated with poor outcome after acute myocardial infarction
- Author
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Yen-Wen Wu, Jeng-Wei Lin, Ren-Hao Pan, K. Robert Lai, Cheng-Wei Liu, Chiung-Yi Wu, Chien-Lung Chan, and Shin-Rong Ke
- Subjects
Adult ,Male ,medicine.medical_specialty ,Time Factors ,Databases, Factual ,Endocrinology, Diabetes and Metabolism ,Myocardial Infarction ,Taiwan ,Medicine (miscellaneous) ,030209 endocrinology & metabolism ,Disease ,030204 cardiovascular system & hematology ,Risk Assessment ,Young Adult ,03 medical and health sciences ,Sex Factors ,0302 clinical medicine ,Risk Factors ,immune system diseases ,Internal medicine ,medicine ,Humans ,Lupus Erythematosus, Systemic ,Hospital Mortality ,Myocardial infarction ,Significant risk ,Renal Insufficiency, Chronic ,skin and connective tissue diseases ,Aged ,Discharge diagnosis ,Nutrition and Dietetics ,business.industry ,Mortality rate ,Age Factors ,Hospital level ,Length of Stay ,Middle Aged ,Prognosis ,medicine.disease ,National health insurance ,Female ,Cardiology and Cardiovascular Medicine ,business ,Kidney disease - Abstract
Background Systemic lupus erythematosus (SLE) is associated with a higher risk of cardiovascular disease. However, it is not clear whether or not SLE is associated with poor outcomes after acute myocardial infarction (AMI). Methods and results Using the Taiwan National Health Insurance Database, we identified the SLE group as patients with AMI who have a concurrent discharge diagnosis of SLE. We also selected an age-, sex-, hospital level-, and admission calendar year-matched non-SLE group at a ratio of 1:3 from the total non-SLE group. One hundred fifty-one patients with SLE, 113,791 patients without SLE, and 453 matched patients without SLE were admitted with a diagnosis of AMI. Patients with SLE were significantly younger, predominantly female, and more likely to have chronic kidney disease than those without SLE. The in-hospital mortality rates were 12.6%, 9.0%, and 4.2% in the SLE, total non-SLE, and matched non-SLE groups, respectively. The in-hospital mortality was significantly higher in the SLE group than in the total non-SLE group (OR = 1.98; 95% CI = 1.2–3.26) and the matched non-SLE group (mortality OR = 2.20; 95% CI = 1.06–4.58). In addition, the SLE group was associated with a borderline significant risk of prolonged hospitalization when compared with the non-SLE group. Conclusion SLE is associated with a higher risk of in-hospital mortality and a borderline significantly higher risk of prolonged hospitalization after AMI.
- Published
- 2019