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Background The screening of biological hazards, chemical contaminants and allergens in food products is a major concern of food industry since they can cause serious illnesses and even lead to death. Therefore, there is a significant interest in developing low-cost, robust, and rapid detection methods for food safety and quality analysis. Conventional methods provide accurate analytical characteristics, but require well-equipped laboratories, trained personnel, costly reagents, and complicated sample preparation procedures prior to the detection in order to obtain reliable results. Hence, they are not always ideal for on-site food surveillance. Scope and approach This paper discusses the fundamentals of microfluidic paper-based analytical devices (μPADs) and reviews the recent progress in their usage for screening biological hazards, harmful chemical residues, and allergens in food products to systematically evaluate the strengths and weaknesses of this technology. It then covers future trends and useful strategies that could be employed in μPADs design and fabrication procedures to address the critical challenges in equipment-free food analysis. Key findings and conclusions μPADs offer promising avenues to revolutionize food safety and quality analysis with merits of equipment-free sample preparation and detection at low-cost. Despite the advancement in the microfluidic technology, the manufacturing of user-friendly sample-to-answer μPADs still requires intensive research studies to be employed for robust and sensitive food safety and quality analysis.

Laser-induced graphene (LIG) technology featuring low-cost, high-efficiency and scalability has presented great advantages in micro-supercapacitors (MSCs) fabrication. However, the limited capacitance of LIG based MSCs is still hindering their further development. Herein, we introduce joule heating as a critical in-situ treatment merged with the assembly of laser-induced graphene paper based MSCs (LIGP-MSCs) toward capacitive enhancement. By increasing heating-treatment temperature from ∼20 to 500 °C, the number of nanopores in LIGP continuously increases, attributed to the gradual decomposition of amorphous carbon components. The resulting joule-heated LIGP (J-LIGP) with improved specific surface area (160.97–533.49 m2/g) and pore volume (0.179–0.553 cm3/g) as well as superhydrophilic surface is highly suitable to be employed as J-LIGP-MSCs microelectrodes. By investigating process dependent performance, the J-LIGP-MSCs heated at 500 °C for 60 min delivers a significantly improved specific areal capacitance (CA) of 13.71 mF/cm2 at 10 mV/s, which is approximately six-fold higher than that of unheated LIGP-MSCs. By further exploring and optimizing the process efficiency, J-LIGP-MSCs with a CA of 12.61 mF/cm2 has been achieved by 550 °C heating for only 5 min. Along with superior mechanical flexibility, cyclability and structural modularity, the proposed in-situ joule heating treatment is finally proved to be a universal approach for consistently enhancing the CA of LIG based MSCs processed under various chemical modifications.

Palliative radiation therapy (pRT) is an effective tool for people with incurable cancer, in the treatment of many cancer-related symptoms such as pain, bleeding and dyspnea. As utilization rates for palliative radiation therapy increase, the demands on the healthcare system continue to grow. Radiation Therapists with advanced knowledge, skills and judgements began demonstrating their ability to practice autonomously in 2004, with the development of the Clinical Specialist Radiation Therapist (CSRT) role. Since this time, CSRTs with a specific focus in pRT (pCSRT) have been increasing in both numbers as well as their positive effects on the cancer care system. Integrating a pCSRT into the existing pRT system has resulted in increased access to and quality of pRT being delivered to palliative cancer patients. The benefits of the addition of pCSRTs to the cancer care system include increasing system capacity and increasing quality of care. This white paper provides information related to the improvements that can be realized in a RT program related to the care and treatment of its palliative patients by adding a pCSRT to the interprofessional healthcare team and suggest it as one of many strategies that can be undertaken to make improvements to access and quality of care.

Neonatal and infantile cholestasis (NIC) can represent the onset of a surgically correctable disease and of a genetic or metabolic disorder worthy of medical treatment. Timely recognition of NIC and identification of the underlying etiology are paramount to improve outcomes. Upon invitation by the Italian National Institute of Health (ISS), an expert working grouped was formed to formulate evidence-based positions on current knowledge about the diagnosis of NIC. A systematic literature search was conducted to collect evidence about epidemiology, etiology, clinical aspects and accuracy of available diagnostic tests in NIC. Evidence was scored using the GRADE system. All recommendations were approved by a panel of experts upon agreement of at least 75% of the members. The final document was approved by all the panel components. This position document summarizes the collected statements and defines the best-evidence diagnostic approach to cholestasis in the first year of life.

With the increased awareness of reusing solid wastes for higher sustainability and the concern of water pollution associated with phosphorus over-emission, there are strong interests in developing solid waste based adsorbents for purifying phosphorus-containing wastewater. As a rich calcium resource, paper mill sludge (i.e., a major solid waste from pulping industry) can be used as phosphorus removal adsorbent after calcination. Thus, in this work, a simple and clean thermally treating route has been proposed for preparing calcium-containing biochar from paper mill sludge. The effect of the physicochemical properties of paper mill sludge and its carbonization condition on phosphorus adsorption has been analyzed. Moreover, the influence of some key adsorption parameters, e.g., biochar dosage, initial pH of solution, co-existing anions, initial phosphorus concentration and contact time has also been investigated. The results showed that the phosphorus adsorption data could be fitted well with pseudo-second-order kinetic and Langmuir isothermal models. The calculated maximum adsorption capacity of the as-prepared optimal calcium-containing biochar could reach to 68.49 mg·g−1 at 25 °C. Combined with the characterization results, it can be reasonably inferred that the adsorption process was chemisorption-dominated. Lastly, the application of this spent adsorbent in agriculture field has also been discussed. In brief, this work provided a feasible strategy for converting paper mill solid waste to an environmental functional material (i.e., calcium-rich biochar) for remediation of eutrophic water.

This study optimizes a novel surfactant-assisted green liquor dregs (GLD) pretreatment of paper mill sludge (PMS), both of which are wastes from the kraft pulping industry, using a combined Response Surface Methodology (RSM) design. Optimized conditions give a maximal reducing sugar release of 16.38 g/L. A substantial reduction in heavy metals aluminum, chromium, cobalt, arsenic, lead, and copper after pretreatment illustrates the enhancement of substrate digestibility by reducing toxic elements. Separate hydrolysis and fermentation (SHF) and simultaneous saccharification and fermentation (SSF) for hydrogen production are assessed. SSF produced a hydrogen yield of 3.72 mL/g, displaying a 36.26% increase from pretreated PMS compared to SHF. These findings provide insights into possible methods of reducing process duration, energy input, and costs incurred with waste disposal within the paper industry. Furthermore, improved hydrogen yield using an SSF process demonstrates the potential beneficiation of pulp and paper GLD and PMS wastes.

Paper and pulp mills generate substantial quantities of cellulose-rich sludge materials that are disposed in landfills at a large scale. For sustainability purposes, sludge materials can be bioprocessed to produce renewable fuels and useful chemicals. The enzymatic hydrolysis of cellulose is the process bottleneck that affects the conversion economics directly by using zero-cost raw materials. In order to study and optimize the process, the characteristics of the sludge raw materials should be first evaluated. In this work, sludge samples were obtained from paper mills located at different locations in Wisconsin and Minnesota. Part of the sludge samples was washed (de-ashed) with hydrochloric acid while the other part remained unwashed. The samples were subjected to multiple spectroscopic analyses techniques to evaluate the morphological properties of cellulose fibers and to estimate the total structural carbohydrate content. The results showed that the de-ashing process changed some fiber characteristics and cellulose crystallinity structure in all sludge samples. Sludge sample A (obtained from Kraft pulp and recycled paper mill region) showed a high percentage of fiber, with crystalline cellulose, compared to the other two sludge samples suggesting that sludge A is a valuable source to make value-added products. Aspen Plus mass and energy calculations performed in view of the ‘zero’ cost and the reliable supply of sludge raw materials producing 2 mol H2/mol glucose. Moreover, the results showed that extracting crystalline cellulose from these sludge samples is more profitable than crystalline cellulose made from the other lignocellulosic feedstocks. The results reported here showed that the utilization of these sludge materials would be an economically attractive and promising alternative for the production of hydrogen.

Human trafficking is a pandemic human rights violation with an emerging paradigm shift that reframes an issue traditionally seen through a criminal justice lens to that of a public health crisis, particularly for children. Children and adolescents who are trafficked or are at risk for trafficking should receive evidence-based, trauma-informed, and culturally responsive care from trained health care providers (HCPs). The purpose of this article was to engage and equip pediatric HCPs to respond effectively to human trafficking in the clinical setting, improving health outcomes for affected and at-risk children. Pediatric HCPs are ideally positioned to intervene and advocate for children with health disparities and vulnerability to trafficking in a broad spectrum of care settings and to optimize equitable health outcomes.

In society, there is widespread and growing acceptance of the value of cooperation between industry and universities being collaborative Research and Development (R&D) domain and industrial policy the fuel of knowledge-based economies. In this paper, different domains of cooperation between the University and Industry as well as their generated benefits for each partner are identified. These benefits have been assigned to each domain of cooperation, showing a large number of benefits associated to collaborative R&D. Leading us to make a statement - collaborative R&D is the key cooperation domain for sustainable long-term university-industry partnerships. Suggestions are given about how to continue this research study.

The transperineal approach is preferred to reduce prostate biopsy (PB)-related infections. Fluoroquinolones are suspended for prophylaxis of PB in the European Union; therefore, alternative antibiotics based on local resistance, or targeted prophylaxis, in conjunction with povidone-iodine rectal preparation are recommended for transrectal PB.

Advancements in technology have led to the use of smartphones as biosensor detectors. However, it is difficult to obtain stable color information of colorimetric sensors using multiple smartphones owing to different light conditions and image correction operations. In this study, we attempted color detection of the colorimetric paper chip using smartphone-embedded light-emitting diode (LED) and simple transformation calculation. This method enables the acquisition of stable color information using different smartphones by reducing the influence of external light sources. Moreover, we studied characteristics such as convergence and distinction of detection result details by the manufacturers and smartphones. These findings suggested the necessity of classification criteria for the use of smartphones to achieve optimal detection. In addition, white and black references were used to set the standard for color correction of various light sources. Based on our results, we conclude that this approach presents the possibility of smartphone-based colorimetric detection in practical applications.

Antimicrobial resistance (AMR) continues to threaten global health. Although global and national AMR action plans are in place, infection prevention and control is primarily discussed in the context of healthcare facilities with home and everyday life settings barely addressed.\ud \ud As seen with the recent global SARS-CoV-2 pandemic, everyday hygiene measures can play an important role in containing the threat from infectious microorganisms.\ud \ud This position paper has been developed following a meeting of global experts in London, 2019. It presents evidence that home and community settings are important for infection transmission and also the acquisition and spread of AMR. It also demonstrates that the targeted hygiene approach offers a framework for maximizing protection against colonization and infections, thereby reducing antibiotic prescribing and minimizing selection pressure for the development of antibiotic resistance. If combined with the provision of clean water and sanitation, targeted hygiene can reduce the circulation of resistant bacteria in homes and communities, regardless of a country's Human Development Index (overall social and economic development). Achieving a reduction of AMR strains in healthcare settings requires a mirrored reduction in the community.\ud \ud The authors call upon national and international policy makers, health agencies and healthcare professionals to further recognize the importance of targeted hygiene in the home and everyday life settings for preventing and controlling infection, in a unified quest to tackle AMR.

Unprinting of paper can reduce multiple life-cycle stages in the recycling of paper to yield significant environmental impact. Laser-unprinting has been demonstrated for uncoated paper but causes significant damage to coated paper. This work explores a scalable optical (non-laser) process for unprinting coated paper. Printed coated paper is exposed to pulsed broad-spectrum Intense Pulsed Light (IPL) from a xenon lamp and the toner is then removed by dabbing gently with an ethanol wipe. While black toner is easily unprinted, unprinting of colored prints (red, blue, green) is best realized by incorporating an initial overprint of black toner. An unprinting throughput on the order of mm2/s is achieved. Three distinct regimes of unprinting are identified based on the extent of toner removal and damage of the paper. The optical properties of the unprinted paper, characterized via UV–Visible spectrophotometry, are correlated to these regimes to understand the potential for in-situ optical process monitoring. Scanning Electron Micrography and Fourier-Transform Infrared Spectroscopy are performed to understand the underlying mechanisms that govern the occurrence of the different unprinting regimes. Further, the potential impact of the developed approach on recycling of paper is discussed in the context of the capabilities of current optical unprinting approaches and the potential elimination of life-cycle stages in conventional paper recycling.

Paper based assays are paving the way to automated, simplified, robust and cost-effective point of care testing (POCT). We propose a method for fabricating three dimensional (3D) microfluidic paper based analytical devices (μPADs) via combining thin adhesive films and paper folding, which avoids the use of cellulose powders and the complex folding sequence and simultaneously permits assays in several layers. To demonstrate the effectiveness of this approach, a 3DμPADs was designed to conduct more assays on a small footprint, allowing dual colorimetric and electrochemical detections. More importantly, we further developed a 3D platform for implementing automated and multiplexed ELISA in parallel, since ELISA, a routine and standard laboratory method, has rarely been used in practical analyses outside of the laboratory. In this configuration, complex and multistep diagnostic assays can be carried out with the addition of the sample and buffer in a simple fashion. Using Troponin I as model, the device showed a broad dynamic range of detection with a detection limit of 0.35 ng/mL. Thus, the developed platforms allow for various assays to be cost-effectively carried out on a single 3D device, showing great potential in an academic setting and point of care testing under resource-poor conditions.

The recycling of waste paper has been an effective way to achieve the environmental-friendly growth of papermaking industry. Focusing on the mixed-pulping process which has been generally employed, to ensure the required properties of the deinking pulp (DIP) and minimize the purchase cost of waste paper, an intelligent model scheduling the mixing ratio of waste paper was developed in the study. Primarily, driven by the field data of mixing ratio of waste paper and DIP properties, the prediction models of DIP properties were developed by SVM, GA-SVM, and BP-NN algorithms. Subsequently, based on the best prediction model, the scheduling model for the mixing ratio of waste paper was set up by NSGAII algorithm. The experimental results showed that, based on the obtained best BP-NN prediction model of DIP properties, the developed NSGAII scheduling model for the ratio of waste paper could achieve excellent scheduling results under the rigorous constraints and multi-objective. Compared with the previous study, the developed prediction and scheduling models in this study reduced the purchase cost of waste paper by 2.16%, and improved the acceptable proportion of DIP property from 56.07% to 100%.

The dissemination of emerging electronic devices increases considerably alongside with the Internet of Things (IoT) paradigm. Some key elements considered in these devices (e.g. rare-earth) are becoming critical materials and are associated with serious environmental concerns. Therefore, there is a major requirement for designing differently our electronic technologies at the early stages of the research process. Many reports present the promising properties of paper-based electronics as meant to address this challenge. Through technical and life cycle assessments, this article discusses the main design levers in terms of material and fabrication process choices for the eco-design of paper-electronics water quality sensors. Our results suggest conscientious choices of conductive nanomaterials and additive fabrication techniques.

Paper-based devices are always more gaining a relevant position in the field of sensors. The continuous demand for affordable, simple, sustainable, and portable devices, is making paper as the ideal basis towards the realization of analytical tools for the easy self-testing. In this work, we demonstrate, for the first time, the development of a disposable paper-based printed electroanalytical strip for reliable, rapid, and high-throughput detection of glutathione in blood. The detection is based on the thiol-disulfide exchange reaction, which produces a detectable compound easily oxidizable at a Prussian Blue/carbon black nanocomposite involving a favorable low-interference overpotential. This nanocomposite is mixed within a carbon-based conductive ink and successively screen-printed onto a wax-patterned filter paper. The employment of paper provides a reagent-free device, as a consequence of the reagents pre-loading within the testing area. After the experimental conditions have been optimized, glutathione has been detected up to 10 mM, with a detection limit of 60 μM, and a sensitivity of (0.102 ± 0.005) μA/mM. This sensor showed satisfactory repeatability (relative standard deviation equal to 10%, for detection of glutathione 1 mM), especially by considering the hand-made manufacturing process. The “real-world” applicability of this strip has been evaluated by quantifying blood glutathione at physiological levels and by recovery studies achieving satisfactory values.

The development of renewable energy sources minimizes the burning of fossil fuels for clean and green environment. Electrochemical energy storage/conversion device pays a way towards sustainable development that concludes an emerging field in the trends of the research community. Prominently, the functional materials with suitable structure and property determine the performance and durability of the devices. In recent times, graphene with its tremendous properties play a major role in electrochemical energy device applications. Meanwhile, the graphene-based electrodes were fabricated by various coating techniques on existing electrodes that utilized for energy device fabrication. Apart from these, it is also fabricated in a paper like a form (self-supported or free-standing) with its remarkable high conductivity, flexibility, robustness and electrochemical behavior which have been nominated for fabrication of flexible energy devices. Paper-like electrodes become an emerging field to fabricate a light-weight and flexible electronic devices for future prospects. Thus, we have summarized a synthetic strategy of graphene paper and its properties that potentially focused on flexible device fabrication in both the energy storage and conversion system. Hence, this review boosts up the forthcoming researchers to enhance the device performance with interrelating free-standing graphene and other host material.

In most cases, three-dimensional paper-based microfluidic analytical devices (3D-μPADs) were fabricated manually by stacking or folding methods. For the first time, digital light processing stereolithography (DLP-SLA) 3D printing technology was adopted to automatically make 3D-μPADs. In the fabrication process, a printing pause was set between two layers to allow paper to be placed in the resin tank. The resin on the fresh paper spontaneously bonded to the former cured paper layer during curing, thus realizing the automatic bonding and alignment between different layers of paper and avoiding the human participation and errors as in stacking and folding methods. There was a gap between two vertical aligned flow paths, therefore the liquid did not flow spontaneously from the upper layer to the lower layer. Most of the fluid flow in 3D-μPADs was spontaneous or manually activated, which was not conducive to complex assays that require different regents to be delivered sequentially. Herein, we used an electric field or airflow to trigger the fluid flow and demonstrated the flow controllability by a proof-of-concept colorimetric assay. The limits of detection of glucose and albumin were 0.8 mM and 3.5 μM, respectively, which were sufficient for clinical requirements. Given the characteristic of flow controllability, we believe that the proposed 3D-μPADs have great potential to make paper-based complex assays automated and programmable.

Paper-based microfluidic devices based on electrowetting principle, more specifically electrowetting on dielectric (EWOD), have attracted increasing attention due to their powerful liquid handling capability as compared to continuous-flow paper-based analytical devices (μPAD) that use capillary effects to control liquids. Here, we demonstrate fabrication of paper-based EWOD devices using cellulose paper as substrate and paraffin wax as dielectric hydrophobic layer by a simple pressing treatment for the cellulose paper and melting or spray-coating of paraffin wax. We optimized the key fabrication parameters according to the surface morphology and hydrophobicity of the obtained wax film, including the pressing pressure, thermal annealing temperature and amount of paraffin wax. Moreover, the EWOD devices fabricated by the spray-coating method demonstrate larger contact angle changes but with smaller contact angle hysteresis under DC electric field when compared with the devices fabricated by the melting method. Our study opens up potential fabrication of hybrid paper-based microfluidic device combining advantages of continuous-flow and electrowetting using cellulose paper and paraffin wax.

Adding biochar to paper mill biosolids (PB) amendments may affect PB mineralization rate and nitrogen (N) availability. The objective of this 224-day incubation study was to evaluate the effect of amending two PB types varying in carbon (C)/N ratio (PB1, C/N = 24; and PB2, C/N = 13) with three rates (0%, 2%, and 5%) of pine (Pinus strobus L.) biochar produced at 700 °C on the dynamics of total C, total N, mineral N, N mineralization rate, and microbial biomass C (MBC) and N (MBN) in two agricultural soils (Kamouraska clay and St-Antoine sandy-loam). Two reference treatments were also included, namely, mineral fertilization and unamended soil. Total soil C concentration remained stable over the incubation period, whereas a decrease in total soil N was observed in both soils. In comparison with the unamended soil, the application of PB significantly increased total N, NH4-N, NO3-N, net mineralized N, applied N mineralization rate, and MBC in both soils. In comparison with the application of PB alone, biochar addition increased total C and MBC but decreased NH4-N, NO3-N, net N mineralization, and applied N mineralization rate in both soils. The co-application of biochar and PB1 resulted in the sequestration of mineral N released, which was more pronounced in the Kamouraska clay soil. The co-application of biochar and PB2 resulted in moderate release of mineral N. This study showed that the co-application of biochar and PB can benefit agricultural soils by improving NO3-N retention in agroecosystems while increasing organic matter and promoting microbial biomass.

Improvements in survival among cancer patients have revealed the clinical impact of cardiotoxicity on both cardiovascular and hematological and oncological outcomes, especially when it leads to the interruption of highly effective antitumor therapies. Atrial fibrillation is a common complication in patients with active cancer and its treatment poses a major challenge. These patients have an increased thromboembolic and hemorrhagic risk but standard stroke prediction scores have not been validated in this population. The aim of this expert consensus-based document is to provide a multidisciplinary and practical approach to the prevention and treatment of atrial fibrillation in patients with active cancer. This is a position paper of the Spanish Cardio-Oncology working group and the Spanish Thrombosis working group, drafted in collaboration with experts from the Spanish Society of Cardiology, the Spanish Society of Medical Oncology, the Spanish Society of Radiation Oncology, and the Spanish Society of Hematology.

The development and production of new materials requires advanced analytical characterisation to explain the relation between the physico-chemical structure of the material and its properties. Highly integrated microelectronic structure analysis of surfaces with laser beams and X-ray fluorescence aided devices are found to be helpful for providing important information, including the interrelationships between physical, chemical, mechanical and durability characteristics of the new developed products. In most instances no single technique provides all the needed information and hence simultaneous application of several techniques becomes necessary. This study was aimed for hydration analysis, characterization and evaluation of a new novel non-Portland binder (NPB) with waste paper sludge ash (PSA) using FTIR and TG/DTA. The progressive formation of hydration products within the non-Portland binder was identified and their microstructural characteristics were analysed. The stable and non-expansive nature of secondary ettringite formation was also identified after a period of 365 days curing.

This review paper encompasses the inclusive approach of lime sludge valorization in construction materials. Research studies based on cement and aggregate replacement by lime sludge concludes that 10–30% lime sludge is gainfully utilized in sustainable concrete and mortar. Additional prospect for lime sludge application in construction material is the production of cement and ceramics. Significant use of lime sludge in combination with supplementary cementitious materials such as silica fume, nanosilica and fly ash is recommended for the production of cement components and ceramics. The recommendations are also suggested in accordance with the outcome of the study.

Graphical abstract, Highlights • Detection of cytokine storm biomarkers with mobile biosensors. • Immunosensors are made solely of cellulose modified with antibody-decorated nanoparticles. • Turnaround time under 10 min. • Detection of biomarkers in respiratory samples allows monitoring local inflammation. • Compatible with decentralized health care schemes., Decentralizing COVID-19 care reduces contagions and affords a better use of hospital resources. We introduce biosensors aimed at detecting severe cases of COVID-19 in decentralized healthcare settings. They consist of a paper immunosensor interfaced with a smartphone. The immunosensors have been designed to generate intense colorimetric signals when the sample contains ultralow concentrations of IL-6, which has been proposed as a prognosis biomarker of COVID-19. This is achieved by combining a paper-based signal amplification mechanism with polymer-filled reservoirs for dispensing antibody-decorated nanoparticles and a bespoken app for color quantification. With this design we achieved a low limit of detection (LOD) of 10−3 pg mL-1 and semi-quantitative measurements in a wide dynamic range between 10−3 and 102 pg mL-1 in PBS. The assay time is under 10 min. The low LOD allowed us to dilute blood samples and detect IL-6 with an LOD of 1.3 pg mL-1 and a dynamic range up to 102 pg mL-1. Following this protocol, we were able to stratify COVID-19 patients according to different blood levels of IL-6. We also report on the detection of IL-6 in respiratory samples (bronchial aspirate, BAS) from COVID-19 patients. The test could be easily adapted to detect other cytokines such as TNF-α and IL-8 by changing the antibodies decorating the nanoparticles accordingly. The ability of detecting cytokines in blood and respiratory samples paves the way for monitoring local inflammation in the lungs as well as systemic inflammation levels in the body.

Photonic crystals film that possesses periodic dielectric structure have shown great prospect in developing environmentally friendly paper alternatives due to the unique properties of dye free and non-photobleaching, but their practical application is limited by the weak interaction between colloidal particles. Although some progress has been obtained, it is still a challenge to develop photonic paper with the desired mechanical and optical properties. Herein, multifunctional hard core/soft shell nanoparticles with controlled size are fabricated by semi-continuous seed emulsion polymerization method. Compared with convention colloidal particles, these core/shell nanoparticles can facile self-assemble into large-scale dense ordered structure film via dried at room temperature due to the relatively low glass transition temperature (Tg) of the shell layers. The facile fabrication route enables the continuous high-through put production of the photonic papers. The as-formed papers not only possess the capacity to solvent (water/ethanol) rewritable and multicolor painting, but also can rapidly reversible mechanochromic. Moreover, due to the good compatibility of core/shell interface, these photonic films possess excellent mechanical properties, demonstrating that this multifunctional film makes the fabrication of novel robust rewritable papers possible and enables visual monitoring of deformation degree.

Cancer-related cognitive decline (CRCD) may have particularly significant consequences for older adults, impacting their functional and physical abilities, level of independence, ability to make decisions, treatment adherence, overall quality of life, and ultimately survival. In honor of Dr. Hurria's work we explore and examine multiple types of screening, assessment and non-pharmacologic treatments for CRCD. We then suggest future research and clinical practice questions to holistically appreciate the complexity of older adults with cancer's experiences and fully integrate the team-based approach to best serve this population. (C) 2019 Elsevier Ltd. All rights reserved.

Hematopoietic stem cell transplantation (HSCT) patients can suffer from various musculoskeletal problems resulting in long-term functional incapacity. Physical therapy (PT), as a part of the healthcare team, has been historically advocated for regaining functional capacity and improving quality of life post-HSCT. Because of the nature of this condition and the burden of post-transplant complications, this patient group requires a unique approach toward their rehabilitation that takes into account their complex musculoskeletal presentation ranging from fascia, muscle, tendons, bones, and ligaments. However, to our knowledge there is no universal standardized PT protocol or pathway to help guide rehab specialists to achieve optimal gains for this patient group, and anecdotal evidence suggests that these patients do not always receive the PT care they require. Hence, in collaboration with the Transplant Complications Working Party of the European Society for Blood and Marrow Transplantation, the Survivorship Special Interest Group of the American Society of Blood and Marrow Transplantation, and the Quality of Life Committee of the Eastern Mediterranean Blood and Marrow Transplantation, herein the Physical Therapy Association for Graft Versus Host Disease provides a brief review on role of PT in mitigating musculoskeletal complications in HSCT patients and makes evidence-based recommendations for incorporation of PT into routine HSCT care. ispartof: Biol Blood Marrow Transplant vol:25 issue:6 pages:e191-e198 ispartof: location:United States status: published

In this study, fabrication of microfluidic paper based analytical devices (μPADs) by microembossing was proposed. Different from the embossing methods described in the literature, the filter paper was embossed such that a protruded structure was formed, which subsequently became the channel after heating the wax at the backside of the filter paper. It was found that, when using the Whatman No. 3 filter paper, the embossing pressure needed to be larger than 50 kg/cm2 in conjunction with using a minimal 2-mm wide channel, and the wax heating time ranged from 15 to 45 s in order to obtain a reliable μPAD with repetitive and consistent results. In addition, there was no need of a hydrophobic material as the backside support. The glucose detection was demonstrated using the μPADs as fabricated and a linear relationship was obtained between 5 and 50 mM glucose concentrations. With the proposed method, the processing time of fabricating μPADs can be reduced within approximately 1 min.

Microfluidic paper-based analytical devices (μPADs) have recently emerged as a simple, portable, user-friendly, and affordable alternative to more instrument-intensive analytical approaches for point-of-care testing (POCT), food safety analysis, and environmental monitoring. However, most of the existing methods for the fabrication of μPADs still face a great challenge because of different trade-offs among cost, convenience, and the pattern resolution. In this work, we report a facile one-step approach to prepare a μPAD using an affordable, easy-to-build 3D printer to generate patterns of solid wax on laboratory filter paper. The presented wax printing method did not require the use of predesigned masks and an external heat source to form complete hydrophobic wax barrier through the use of a custom-made extruder. The results revealed a strong linear relationship (R2 = 0.985) between the nominal and the printed widths of the wax barriers. The achievable resolution of the wax barrier printed on filter paper was 468 ± 72 µm, which was lower than previously reported minimum barrier feature sizes achieved by wax printing and other wax patterning techniques, such as stamping and screen-printing. The analytical utility of the fabricated μPADs was evaluated for colorimetric nitrite and glucose detection in artificial solutions. It was found that the fabricated μPADs provided adequate accuracy and reproducibility for quantitative determination of nitrite and glucose within concentration ranges relevant to the disease detection in human saliva and urine. The wax printing approach reported here provides a simple, rapid, and cost-effective fabrication method for paper-based microfluidics and may bring benefits to medical diagnostics in the developing world.

The paper drying process has the highest level of energy consumption in the pulp and paper production process. Analysis and optimization of the energy system during the paper drying process is critical for improving the energy efficiency of the entire paper mill. In the existing model for the paper drying process, the solution requires accurate boundary conditions such as the air temperature and humidity of the pocket area and the cylinder surface temperature, which are very difficult to obtain in the papermaking process. This can result in significant deviations between the model solution and the actual production process. This paper focuses on the single-tier dryer cylinder-based paper drying process that has been widely used with high-speed papermaking machines in recent years. A mathematical model is proposed based on real-time data. The verification via industrial production demonstrates that the proposed model is reliable for the paper drying process. Based on the simulation results, two optimization operations have been proposed. The energy consumption decreases from 1.51 t steam/t paper to 1.44 t steam/t paper, 4.6% of the steam and 1.26 × 106 RMB can be saved for a medium-scale paper mill with the annual production capacity of 105 t paper.

Pulp and paper industry is one of the high priority sectors that generates large amount of solid (sludge) and liquid (paper mill effluent) wastes. Making use of this huge quantity of paper mill sludge (PMS) in an environment friendly manner is challenging and cost involving. Similarly the present wastewater treatment strategies based on physical and chemical methods encounter certain serious setbacks including secondary pollution generation with expensive mode of abatement processes. The present study aims at a “waste treats waste” strategy for the bioremediation of paper mill effluent in fluidized bed reactor (FBR) using another waste of the same industry, PMS as immobilizing matrix for Planococcus sp. TRC1, a wastewater bacterial isolate. This study simultaneously explores this isolate for the yellowish orange pigment it produces (2.3 ± 0.2 mg/gm of dry bacterial biomass) and characterizes it as a member of the pharmacologically important carotenoid pigment family via UV-Vis spectrophotometry, TLC, FT-IR and 13C NMR. The antioxidant potential of this pigment was studied by DPPH assay (IC50 = 33 ± 0.4 μg/ml) and H2O2 assay (IC50 = 147.4 ± 2.2 μg/ml). In FBR, the PMS immobilized bacteria showed removal of phenol, lignin, colour and COD from the effluent by 96%, 74%, 81% and 85% respectively after 60hr of treatment. The experimental data on immobilization fitted well with pseudo second-order (R2 = 0.955) and Freundlich adsorption isotherm (R2 = 0.996) models. The alterations in PMS before and after bacterial immobilization, as revealed by SEM and FT-IR, depicted the success of PMS as immobilization matrix. Phytotoxicity (90% seed germination) and mutagenicity studies confirmed that the treated effluent was substantially less toxic than its raw state. This study highlights a novel utilization possibility of PMS in an eco-friendly and economic way as immobilization matrix for Planococcus sp.TRC1 for paper pulp mill effluent treatment along with production of carotenoid pigment from this potential bacterial isolate as value added product.

Flexible sensing devices have drawn tremendous attention in the past decades due to their potential applications in future hand-held, potable consumer, and wearable electronics. Here, we firstly developed an ultrasensitive wireless potentiometric aptasensor based on flexible freestanding graphene paper for kanamycin detection. Flexible graphene paper made from a simple vacuum filtration method was used as a biocompatible platform for effective immobilization of aptamer. A nuclease-assisted amplification strategy was introduced into this potentiometric biosensing system in order to significantly improve the detection sensitivity through a classic catalytic recycling reaction of target induced by the nuclease (DNase I). As expected, an ultra-low detection limit of 30.0 fg/mL for kanamycin was achieved. Furthermore, the developed potentiometric enzymatic aptasensor exhibits high selectivity, favorable flexibility, excellent stability and reproducibility, which holds great promising for its routine sensing application.

In this study, a waste pickling liquor from a steel mill, which is rich in iron and acid, was used as the main raw material to prepare a composite coagulant: polymeric ferric aluminum sulfate chloride (PFASC). The as-prepared PFASC was used, together with PAM, for the tertiary treatment of papermaking wastewater to decrease its COD and Chroma. The Results from FT-IR and XRD of PFASC, supported the conclusion that polymeric ferric aluminum hydroxide hydrates compounds/ complexes are formed in the synthesized PFASC. When applied to a waste water sample from a paper mill, PFASC, together PAM, leads to decreases in COD and Chroma by 65.3% and 71.2%, respectively (initial pH 7.5, 1 ml/L PFASC, 1.0 ppm PAM). The technology has been implemented at a paper mill, and the obtained results are consistent with those from the laboratory.

To evaluate the effect of brown-rot fungi Oligoporus placenta and earthworm Eisenia fetida on decomposition of paper mill sludge, the paper mill sludge was mixed with cow dung in 0, 25, 50, 75, and 100% proportions and changes in physicochemical quality of waste mixtures was carried out for 28 days. All waste mixtures were treated with: Setup-I (E. fetida), Setup-II (O. placenta) and, Setup-III (E. fetida + O. placenta). A decrease in total organic carbon, C/N ratio and cellulose but an increase in total kjeldhal nitrogen, total phosphorus, total potassium and pH was recorded. The paper mill sludge in 50–75% proportion in feedstock showed the better results and rate of mineralisation were in order: Setup-III > Setup-I > Setup-II. The proportion of CD has direct role in waste mineralisation. The microbial population (bacterial, fungal and actinomycetes) and earthworm biomass were also high in Setup-III, suggesting the influence of brown-rot fungi on paper mill sludge humification. Results indicate that fungal inoculate in vermicomposting was effective in decomposing cellulose-rich industrial sludge.

The non-process-elements (NPE's) in the pulp and paper production, in particular chloride (Cl−) and potassium (K+), eventually accumulate in a sodium sulfate recovery cycle of a paper plant, especially on boiler fly ashes (flue gas cleaning). This accumulation often leads to fouling and corrosion. Thus, in order to reduce such problems, a leaching unit is typically integrated aiming to remove Cl− and K+ and recover sodium sulfate (Na2SO4) from boiler fly ashes. In this context, this research is focused on investigating the effects of temperature, ash concentration and pH on the separation efficiency (Cl− and K+ removal and Na2SO4 recovery) of recovery boiler fly ashes using design of experiments in a devised laboratory setup. As expected from the literature, the results obtained reveals that concentration has the most significant effect on the response variables followed by temperature; whereas pH, not mentioned in this application so far, also has a significant effect. The optimum operating condition, which yields 84 wt% of Na2SO4 recovery and 97 wt% of Cl− and K+ removal, is achieved at 60 °C, 50 wt% of ash and pH 9.0. For practical applications, this optimal condition reduces the accumulation of NPE‘s and mitigates the risks of fouling and corrosion.

Dewatering and handling of pulp and paper mill sludge is challenging and often comprises more than half of the overall wastewater treatment costs at a mill. Primary sludge is usually more dewaterable than biosludge (waste activated sludge), and the ratio between both types of sludge largely determines the dewaterability of the sludge mix. This study has quantified the benefits of adding primary sludge to biosludge to enhance the dewaterability in terms of cake solids and filtrate/pressate solids content. Furthermore, the effects of the particle size distribution and the monovalent to divalent cation ratio of the various types of sludge were investigated. Biosludge and three types of primary sludge from a Canadian pulp and paper mill were mixed at various ratios and tested for dewaterability using a Crown Press®, a bench-scale device which simulates industrial belt press dewatering. Results show that after addition of primary sludge at up to 40% mass proportion (dry solids basis) the dewatered cake solids content increased substantially, from 10.4% to 18.7–19.9%, depending on the type of primary sludge added. Further addition of primary sludge led to comparably only small improvements. Primary sludge addition also resulted in decreased total suspended solids (TSS) concentrations in the combined gravity filtrate / Crown Press pressate. Primary sludge content of only 10% in the sludge mix was sufficient to decrease the TSS concentration from 1.8 g/L to 0.2 – 0.4 g/L. The study shows that only less than half of the sludge mix needs to consist of primary sludge, in order to achieve adequate dewaterability. This opens up the possibility of retaining more primary fiber within the pulping process, without compromising downstream sludge dewatering.

The pulp and paper industry, which provides cellulose pulp and paper, bio-based energy and chemicals, is one of the largest energy consumers, greenhouse gases (GHG) and pollutant emitters among manufacturing industries. Although the environmental impact of the pulp and paper industry has been extensively studied, life cycle assessment (LCA) results have not yet reached a consensus. By means of a systematic review and meta-analysis, this article contributes to the quantification and harmonization of the life cycle environmental impacts of pulp making and paper making systems. Based on the screening of 45 cases of paper making and 18 cases of pulp making, we found that 1 t of paper results in about 950 kg carbon dioxide (CO2) equivalent (CO2-eq) GHG emissions on average. However, there are distinct differences between countries and pulp and paper categories. The dominant factor influencing GHG emissions is energy use. In paper making, the pulp making process is responsible for 62% of energy use, 45% of GHG emissions, 48% of acidification potential, and 49% of eutrophication potential. The kg CO2-eq emissions of three different types of pulp were as follows: Kraft, 508 kg CO2-eq/t; chemi-mechanical, 513 kg CO2-eq/t; and recycled pulp, 408 kg CO2-eq/t. Excluding emissions from electricity and steam production, the convergence of carbon emissions is observed within the same categories of pulp. Straw-based pulp caused far more environmental impact than any other type because of the intensive inputs in agricultural activities as well as in the pulp making process. This research highlighted the inconsistencies in functional units, system boundaries, and methodologies and carbon neutrality assumptions in different LCA studies of pulp and paper making. Future studies should focus on the environmental impact of straw-based pulp making, system boundary unification, and calculation of biogenic carbon emissions.

In remote areas, such as India, Africa and Southeast Asia, typically not connected to the natural gas distribution network, tissue paper production is currently carried out using a Yankee cylinder and two hot air hoods heated with saturated steam produced in conventional boilers. In this way the drying air is heated at medium temperature, around 160-180 °C, with consequent low levels of dried paper production. In this context, the present study intends to evaluate the technical and economic feasibility of using a wood biomass fixed bed downdraft gasification plant for the production of syngas to be used as fuel in gas hoods, in order to reach high drying temperatures (around 500 °C), comparable with those of the current modern hoods powered with natural gas. Using previously developed calculation codes, an evaluation of energy performance of the paper drying system and of the gasification plant has been performed. The present study also evaluates the possibility of applying a CHP plant, powered by biomass, for the production of steam and electric, this last obtained adopting a steam turbine, thus covering all the electrical and thermal needs of the paper mill. Results show that, for a paper mill with a production of about 80 t/day of paper, two gasification reactors with a thermal output of about 1.95 MWt, and a consumption of dry biomass of 0.86 t/h, are required. For the steam system, the net electric power needed to meet the needs of the paper mill is about 3100 kW with a consumption of 4.72 t/h of moist biomass and a net efficiency of 23.9 %.

Primary paper mill sludge (PPMS) is the major waste expelled from the pulp and paper industries contributing soil and water pollution through the recalcitrant organic and inorganic constituents. These pollutants can, however, be transformed into a high-value soil ameliorating material with nominal investment and time. Current study therefore evaluated the potential of rotary drum composting PPMS for 20 days to delineate an environmentally sustainable option. Five trials with proportions of PPMS, cow dung and saw dust: Trial 1 (10:0:0), Trial 2 (8:1:1), Trial 3 (7:2:1), Trial 4 (6:3:1) and Trial 5 (5:4:1) were performed for evaluation of degrading and nutritive ability along with the fate of pollutants for total mass of 150 kg. Trial 4 exhibited highest metabolic activity contributing higher temperature evolution and longer thermophilic phase (10 days) owing to optimum addition of innoculum and nitrogen through the cattle manure. Moreover, degradation of 16.8% organic matter was also best achieved in Trial 4 following up first-order kinetics. Furthermore, BOD, COD and C/N ratio also explains degradation to be maximum in trial 4 (6:3:1) with reduction of 59.3%, 60.1% and C/N ratio from 55.1 to 18 respectively, proving to be the essential determining factors. Phosphorus availability increased by around 67% in trial 4. PPMS can be thus transformed into a potential valued added product and safe for subsequent land application.

Background In Victoria, Australia, public hospitals are administered through a system of devolved governance. Overall, Victoria's public health system has a record of good performance when comparing measurable safety outcomes to the rest of Australia. However, in 2015 a cluster of preventable perinatal deaths were identified at a health service in Melbourne's outer fringes. Questions What were the factors that contributed to these preventable deaths, and what were the outcomes of the four key inquiries commissioned by the Victorian government after the identification of the cluster? What can be learnt by comparing this crisis in one Victorian health service to similar events at other health services in Australia and the United Kingdom? Methods This paper discusses the crisis at the Victorian health service and expands on the factors that contributed to the crisis, the inquiries, subsequent recommendations, and the response from the Victorian state government. Similarities between this case and others in Australia and the United Kingdom are discussed. Findings A common theme in the four inquiries into the crisis at the health service in Victoria was that inadequate clinical governance was a key factor that led to these events. As a result, a number of significant changes were implemented across the state to improve patient safety across all areas of health care. When comparing this Victorian crisis to similar events at other health services across the world, inadequate clinical governance consistently appears as a key contributing factor to poor clinical outcomes. Discussion All cases discussed had a delay in the identification of clusters of poor clinical outcomes. This was found to be a direct result of inadequate clinical governance structures at both a local and government level. Conclusion A robust clinical governance framework that is enacted at both the government and the health organisation level is essential to deliver high quality and safe patient care.

Background Over the last number of years, the healthcare system has become more complex in managing increasing costs and outcomes within a defined budget. To be effective through reform, especially moving forward from the COVID-19 pandemic, healthcare leaders, specifically in nursing, have an increased need for business acumen beyond traditional leadership and management principles. Aim This paper examines the concept of business acumen in the profession of nursing, specifically for managers and higher nurse leaders, establishing whether these skills are optional or essential. Discussion Nurses learn and develop broad skills in leadership and management, but less specifically about business or the broader system. With a contemporary Australian health system aiming to be more effective, nurses may require a greater level of business acumen to adequately understand the mechanics of business decision making in the system when designing care models, as well as representing the business potential of nursing in balance with clinical outcomes through reform. Conclusion The modern nurse, in addition to clinical skills, may need a foundational understanding of business evolving throughout their career, to maximise innovative growth across the system, in meeting the healthcare needs of our community now and into the future. Without a foundation level of business acumen and an understanding of the system across the profession, nurses may not be empowered with their full potential of being a strong voice influencing health system reform.

Triboelectric nanogenerators (TENGs) have been investigated as a promising device to harvest mechanical energy into electricity. At present, paper-based triboelectric nanogenerators (P-TENGs) have been widely researched because paper features with lightweight, low cost, abundance, renewability and biodegradability. In this paper, the operating principles and operation modes of TENGs, the development progress and performance enhancement routes of P-TENGs are comprehensively reviewed. Additionally, the overview, challenges and opportunities of P-TENGs applications are also presented.

L -dopa is a chiral drug that has been extensively used for the treatment of Parkinson’s disease. The concentration of L -dopa plays a vital role in the treatment, and this work emphasizes on designing a versatile platform for the quantitative and selective detection of L -dopa using reduced graphene quantum dot (rGQD). The platform is efficient in three different sensing methods, viz. fluorescence turn-on, filter paper-based sensing, and electronic measurements. The rGQD undergoes a dramatic fluorescence turn-on in the presence of L -dopa in aqueous media and artificial urine with a detection limit as low as 1.307 µM and 1.217 µM respectively. Experimental evidence revealed that the fluorescence enhancement is attributed to aggregation-induced emission mechanism. The system is also applicable for visual detection of L -dopa using filter paper strips treated with rGQD and develops bright fluorescence under ultra-violet irradiation. Apart from this, electrical sensors for L -dopa were also developed by preparing rGQD treated poly-vinyl alcohol films, and the increase in the current conduction with varying concentrations of L -dopa was observed. The films produce 2.5 order higher current conduction at 300 μM of L -dopa with a detection limit of about 13.136 µM. At the final stage, we have designed flexible electronic devices using these materials that develop 1.3 order higher current for L -dopa. The devices exhibit excellent air stability under varied relative humidity conditions as well as high bending stability for potential practical applications.

Highlights •Mechanical stimuli-triggered optical responses of cholesteric liquid crystal devices are realized.•Self-powered bistable smart window and E-paper are demonstrated.•Self-powered optical switch is developed for remote control.Intelligent responsive devices are crucial for a variety of applications ranging from smart electronics to robotics. Electro-responsive cholesteric liquid crystals (CLC) have been widely applied in display panels, smart windows, and so on. In this work, we realize the mechanical stimuli-triggered optical responses of the CLC by integrating it with a triboelectric nanogenerator (TENG), which converts the mechanical motion into alternating current electricity and then tunes the different optical responses of the CLC. When the voltage applied on the CLC is relatively low (15–40 V), the TENG drives the switching between the bistable planar state and focal conic state of the CLC, which shows potential applications in self-powered smart windows or E-paper displays. When the voltage supplied by the TENG is larger than 60 V, a self-powered optical switch is demonstrated by utilizing the transformation between focal conic state and instantons homeotropic state of the CLC. This triboelectric-optical responsive device consumes no extra electric power and suggests a great potential for future smart electronics.

Background We use inkjet printing and film adhesion methods to economically develop paper-based electrowetting-on-dielectric (EWOD) mixing device. Because the periodic shrinking and stretching of droplet contact line induces surface capillary wave, the coalesced droplet on EWOD device vibrates to accelerate solute mixing on the merged spot. Methods An office inkjet printer fabricates pads of conducting silver nanoparticles to compose EWOD activation electrodes on a piece of glossy label paper, covered with one oil-coated dielectric film. Using the triggering relays of each pad, two droplets of thirty microliter individually loaded on the electrode ends are driven to coalesce. Alloy nanorod-catalyzed chemiluminescence assay can be performed on this mixing device. Findings When ac voltage of 100 Hz is applied on the electrode flakes, compared with solute transport efficiency in static condition, solute diffusivity is enhanced by 4 times using this mixing device. Linear relation (R2 = 0.99) between luminescence intensity acquired with smartphone camera and luminol concentration of aforementioned chemiluminescence assay is obtained, demonstrating reproducibility improvement for accurate determination.

In museum lighting, Chinese paper cultural relics are prone to cracking, embrittlement and other photochemical damage after absorbing the spectral energy of light sources. Owing to the different absorption and reflection characteristics of paper for different bands, optimizing the spectrum compositions of light sources can provide effective protection, the basis of which is to clarify the influence rule of spectra on the paper. However, the methods of color difference and Raman spectroscopy, which are widely used in the current research, cannot scientifically measure the lighting damage. In this study, Fourier transform infrared spectroscopy was used as the evaluation method, and 10 kinds of narrow-band lights were used as the experimental light source to conduct a 1440 h irradiation experiment on the samples of the ancient Chinese Xuan paper. The oxidation index was calculated as the evaluation index based on the infrared spectra measured every 240 hours, and a mathematical model for the response rate of paper to spectrum and exposure was established. 610 spectra were obtained with the 10 kinds of narrow-band lights combined and superimposed. The color rendering indexes of the above spectra were calculated, and 9,477 spectra that meet the requirements of viewing indicators were obtained. By calculating the damage degree of the above spectra with the model, the optimal LED spectrum with the minimum damage which met the visual requirements was obtained. Then it was input into the 10-channel spectral simulation system for spectral restoration. Two kinds of lights commonly used in lighting for paper cultural relics were selected to conduct a comparative experiment. The results showed that the optimal LED spectrum reduced damage degree by 49.4% and 59.7% respectively compared with the two kinds of contrast light sources, and was beneficial to energy saving.

Activating flux is made up of inorganic material mixed with a volatile medium. The objective of this study is to identify and review the literature in activating flux, and different type of welding techniques. For that purpose, a structured review method is adopted and the Scopus database is used as a primary source for the selection of papers. The papers were identified using the string term of “Activating flux” OR “Activated flux” in the title of papers. And a total of 238 papers were identified for the study. Besides the above few other papers were also reviewed and the materials used, the type of flux used, and the findings of different combinations were highlighted in the form of tables. The findings of the study provide a comprehensive understanding of the different type of welding techniques focusing on TIG welding, and the different combination of flux used and their impact was summarized.

This paper describes a simple, low-cost, and highly flexible rapid prototyping method to construct electrochemical paper-based analytical device (ePAD) for multiplexed analyte determinations. The ePAD was composed of two electrochemical cell (EC) compartments, separated by hydrophobic barriers of wax, and screen-printed electrodes (SPEs) deposited directly over the surface of the filter paper. The ePAD was entirely constructed using an inexpensive craft cutter printer with no needed of a wax printer. The rapid prototyping method involves two steps: the deposition of the SPEs and the creation of the wax barriers. In this case, the SPEs were screen-printed on filter paper by using adhesive tape as mask by cutting the electrodes pattern with the cutter printer. Following, the wax barriers were created using stamps made of filter paper also cut with the printer and impregnated with wax. In the ePAD, each ECs containing an array of 4-working electrodes, allowing up to 4 replicates in a single measurement. Both ECs shared one counter and one reference electrodes, permitting the simultaneous multianalysis. The ePAD was successfully applied to simultaneous detection of paracetamol (PAR), caffeine (CAF), and ascorbic acid (AA) in drugs. PAR and CAF were detected in a sample using one EC and AA was detected, in a different sample, on the other EC, both with no chemical modifications in the working electrodes. Limits of detection of 0.04 mmol L−1 for PAR, 0.22 mmol L−1 for CAF, and 0.40 mmol L−1 for AA were obtained. The construction process proposed provide an easy way to implement screen-printing electrodes and wax barriers in filter paper to create electrochemical devices for fast and simultaneous multianalysis.

A novel visual and fluorometric-sensor paper is prepared for the monitoring of atmospheric humidity and ethanol. The paper contains a combination of copper nanoclusters (CuNCs) and carbon dots (CDs), immobilized on a filter paper. This makes it a dual-emission system. The visual sensor shows bright fluorescence and has a diameter of ∼8 cm with uniform and homogeneous surface. The detection mechanism of the sensing paper is based on the fluorescence intensity variation of CuNCs in different environments. Desirable linear relationship is observed between fluorescence intensity ratio (red/blue) and humidity. Visible color transformation of this sensor paper is observed in the humidity range ∼40-80%, implying utility for easy and facile atmospheric humidity determination. Furthermore, due to the water and ethanol have different impacts on the spectrum, this paper-based fluorescent probe shows excellent response to ethanol. Therefore dual-emitting sensing paper, when suitably calibrated, shows promise for visual and fluorometric sensing platforms aimed at humidity or ethanol detection.