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• The frequency following response (FFR) can measure binaural neural synchrony. • FFR bilateral advantage = larger amplitudes to bilateral than unilateral input. • Children with bilateral hearing loss showed reduced FFR bilateral advantage. • Many children with hearing loss have reduced sensitivity to interaural timing cues. • Reduced binaural neural synchrony is associated with reduced binaural hearing. In prior work using non-speech stimuli, children with hearing loss show impaired perception of binaural cues and no significant change in cortical responses to bilateral versus unilateral stimulation. Aims of the present study were to: 1) identify bilateral responses to envelope and spectral components of a speech syllable using the frequency-following response (FFR), 2) determine if abnormalities in the bilateral FFR occur in children with hearing loss, and 3) assess functional consequences of abnormal bilateral FFR responses on perception of binaural timing cues. A single-syllable speech stimulus (/dα/) was presented to each ear individually and bilaterally. Participants were 9 children with normal hearing (M Age = 12.1 ± 2.5 years) and 6 children with bilateral hearing loss who were experienced bilateral hearing aid users (M Age = 14.0 ± 2.6 years). FFR temporal and spectral peak amplitudes were compared between listening conditions and groups using linear mixed model regression analyses. Behavioral sensitivity to binaural cues were measured by lateralization responses as coming from the right or left side of the head. Both temporal and spectral peaks in FFR responses increased in amplitude in the bilateral compared to unilateral listening conditions in children with normal hearing. These measures of "bilateral advantage" were reduced in the group of children with bilateral hearing loss and associated with decreased sensitivity to interaural timing differences. This study is the first to show that bilateral responses in both temporal and spectral domains can be measured in children using the FFR and is altered in children with hearing loss with consequences to binaural hearing. [ABSTRACT FROM AUTHOR]

• The specialized sound localization system of the barn owl has provided knowledge and theories towards fundamental brain mechanisms and coding schemes underlying optimal sound localization. • The barn owl system is an excellent model system to test mathematical computations and theories underlying sound localization. • Mechanisms described in the barn owl has provided a rich foundation for comparative investigations into conserved mechanisms across species. The barn owl, a nocturnal raptor with remarkably efficient prey-capturing abilities, has been one of the initial animal models used for research of brain mechanisms underlying sound localization. Some seminal findings made from their specialized sound localizing auditory system include discoveries of a midbrain map of auditory space, mechanisms towards spatial cue detection underlying sound-driven orienting behavior, and circuit level changes supporting development and experience-dependent plasticity. These findings have explained properties of vital hearing functions and inspired theories in spatial hearing that extend across diverse animal species, thereby cementing the barn owl's legacy as a powerful experimental system for elucidating fundamental brain mechanisms. This concise review will provide an overview of the insights from which the barn owl model system has exemplified the strength of investigating diversity and similarity of brain mechanisms across species. First, we discuss some of the key findings in the specialized system of the barn owl that elucidated brain mechanisms toward detection of auditory cues for spatial hearing. Then we examine how the barn owl has validated mathematical computations and theories underlying optimal hearing across species. And lastly, we conclude with how the barn owl has advanced investigations toward developmental and experience dependent plasticity in sound localization, as well as avenues for future research investigations towards bridging commonalities across species. Analogous to the informative power of Astrophysics for understanding nature through diverse exploration of planets, stars, and galaxies across the universe, miscellaneous research across different animal species pursues broad understanding of natural brain mechanisms and behavior. [ABSTRACT FROM AUTHOR]

An experiment was performed with 10 young normal-hearing listeners that attempted to determine if envelope modulations affected binaural processing in bandlimited pulse trains. Listeners detected an interaurally out-of-phase carrier pulse train in the presence of different amplitude modulations. The peaks of the pulses were constant (called "flat" or F), followed envelope modulations from an interaurally correlated 50-Hz bandwidth noise (called CM), or followed modulations from an interaurally uncorrelated noise (called UM). The pulse rate was varied from 50 to 500 pulses per second (pps) and the center frequency (CF) was 4 or 8 kHz. It was hypothesized that CM would cause no change or an increase in performance compared to F; UM would cause a decrease because of the blurring of the binaural detection cue. There was a small but significant decrease from F to CM (inconsistent with the hypothesis) and a further decrease from CM to UM (consistent with the hypothesis). Critically, there was a significant envelope by rate interaction caused by a decrease from F to CM for the 200–300 pps rates. The data can be explained by a subject-based factor, where some listeners experienced interaural envelope decorrelation when the sound was encoded by the auditory system that reduced performance when the modulations were present. Since the decrease in performance between F and CM conditions was small, it seems that most young normal-hearing listeners have very similar encoding of modulated stimuli across the ears. This type of task, when further optimized, may be able to assess if hearing-impaired populations experience interaural decorrelation from encoding modulated stimuli and therefore could help better understand the limited spatial hearing in populations like cochlear-implant users. • Modulated stimuli can cause decreases in binaural performance in listeners with normal hearing. • Most audiometrically normal-hearing listeners show small amounts of interaural asymmetry, but some show more. • There is no effect of center frequency on binaural performance if the stimuli have a constant spatial bandwidth and constant sensation level. [ABSTRACT FROM AUTHOR]

Many users of bilateral cochlear implants (BiCIs) localize sound sources less accurately than do people with normal hearing. This may be partly due to using two independently functioning CIs with fixed compression, which distorts and/or reduces interaural level differences (ILDs). Here, we investigate the potential benefits of using binaurally coupled, dynamic compression inspired by the medial olivocochlear reflex; an approach termed "the MOC strategy" (Lopez-Poveda et al., 2016, Ear Hear 37:e138-e148). Twelve BiCI users were asked to localize wideband (125–6000 Hz) noise tokens in a virtual horizontal plane. Stimuli were processed through a standard (STD) sound processing strategy (i.e., involving two independently functioning sound processors with fixed compression) and three different implementations of the MOC strategy: one with fast (MOC1) and two with slower contralateral control of compression (MOC2 and MOC3). The MOC1 and MOC2 strategies had effectively greater inhibition in the higher than in the lower frequency channels, while the MOC3 strategy had slightly greater inhibition in the lower than in the higher frequency channels. Localization was most accurate with the MOC1 strategy, presumably because it provided the largest and less ambiguous ILDs. The angle error improved slightly from 25.3° with the STD strategy to 22.7° with the MOC1 strategy. The improvement in localization ability over the STD strategy disappeared when the contralateral control of compression was made slower, presumably because stimuli were too short (200 ms) for the slower contralateral inhibition to enhance ILDs. Results suggest that some MOC implementations hold promise for improving not only speech-in-noise intelligibility, as shown elsewhere, but also sound source lateralization. • Sound lateralization for bilateral cochlear-implant users was tested using virtual acoustics. • Binaural sound coding inspired by the medial olivocochlear reflex can enhance inter-aural level differences. • The use of binaurally coupled compression can improve sound lateralization. [ABSTRACT FROM AUTHOR]

Bimodal fitting (BF) allows children with cochlear implant to benefit from binaural hearing advantages. Three major binaural hearing advantages, which enhance hearing function of people with normal hearing, are head shadow effect (HSE), binaural squelch effect (BSQ) and binaural summation effect (BSU). This study in pediatric patients attempting to measure the auditory benefits of bimodal stimulation in children with long-standing use of a cochlear implant (CI), and residual hearing on the contralateral side. This cross-sectional study investigated binaural advantages in 24 children of 8–12 years who had undergone cochlear implantation in a cochlear implant center in Tehran and continuously used BF. Improved score of speech perception in noise (SPiN) under BF condition, as compared to the application of cochlear implant alone, was a binaural advantage found in this study. Each binaural advantage was measured by obtaining the SPiN score under different listening and noise conditions, using relevant formulas. The measured value of each advantage reflects the improved score of SPiN, caused by that certain advantage. In this study, improved mean SPiN score caused by the HSE, BSQ and BSU was, respectively, 3.13, 1.42 and 2.04 dB, indicating greater binaural advantages and hence improved SPiN, under BF condition in comparison with cochlear implant alone. Children with unilateral cochlear implant and measurable residual hearing in non-implanted ear can benefit from binaural advantages and better SPiN when hearing aid is used in the unaided ear. [ABSTRACT FROM AUTHOR]

Conventional signal processing implemented on clinical cochlear implant (CI) sound processors is based on envelope signals extracted from overlapping frequency regions. Conventional strategies do not encode temporal envelope or temporal fine-structure cues with high fidelity. In contrast, several research strategies have been developed recently to enhance the encoding of temporal envelope and fine-structure cues. The present study examines the salience of temporal envelope cues when encoded into vocoder representations of CI signal processing. Normal-hearing listeners were evaluated on measures of speech reception, speech quality ratings, and spatial hearing when listening to vocoder representations of CI signal processing. Conventional vocoder techniques using envelope signals with noise- or tone-excited reconstruction were evaluated in comparison to a novel approach based on impulse-response reconstruction. A variation of this impulse-response approach was based on a research strategy, the Fundamentally Asynchronous Stimulus Timing (FAST) algorithm, designed to improve temporal precision of envelope cues. The results indicate that the introduced impulse-response approach, combined with the FAST algorithm, produces similar results on speech reception measures as the conventional vocoder approaches, while providing significantly better sound quality and spatial hearing outcomes. This novel approach for stimulating how temporal envelope cues are encoded into CI stimulation has potential for examining diverse aspects of hearing, particularly in aspects of musical pitch perception and spatial hearing. [ABSTRACT FROM AUTHOR]

Abstract The main impairment associated with single-sided deafness (SSD) is the loss of binaural hearing. Currently, the most effective treatment to compensate for this deficit is to supply patients suffering from SSD with a cochlear implant (CI) in the deaf ear. With this approach binaural hearing abilities can be restored to a certain extent, which is expressed in an improvement in such patients with regard to sound source localization and speech comprehension in noise after receipt of a CI. However, binaural performance of these listeners does not reach the level of normal-hearing listeners. One of the reasons for this might be that the electrical stimulation via CI and the physiological stimulation via the intact ear are not synchronized: the CI transmits the information to the auditory nerve with different timing than does the intact inner ear. As a result, there is a timing mismatch of the information transfer between the left and the right side, which may account for the limited binaural performance. The effective mismatch in timing depends on the CI system because of different stimulation strategies implemented in devices from different manufacturers. For the particular CI device used in this study (MED-EL Mi1000/Mi1200) electrical stimulation led to faster activation of the auditory nerve than natural for a wide frequency range. In particular, electrical stimulation was about 1 to up to 2 ms ahead of time for frequencies above 1.5 kHz. Hence, it was hypothesized that information transfer between the left and the right ear can be tuned by delaying the CI signal. The goal of the present study was to investigate whether such a delay in the CI signal affects binaural performance of CI users with SSD. For this purpose, sound source localization and speech perception in noise were tested in a sample of 12 CI users with SSD (mean age 51 ± 12 years). The tests were performed for four different delay times of the CI signal applied spontaneously (0.5, 1, 2 and 4 ms) and for the base line condition "no delay" in the CI signal (i.e. everyday use). It was found that delaying the signal had a significant impact on sound source localization. Speech perception in noise was affected, but less pronounced than was sound localization. Regarding sound source localization, a signal delay of 1 ms applied to this particular CI device produced the best performance in our patients. It is concluded that improving the synchronisation between the CI-transferred signal and the naturally transferred signal could increase binaural hearing performance in CI users with SSD. Highlights • Compensation of timing differences of cochlear implant systems and normal hearing improves sound localization in patients with single sided deafness • Signal delays of electrical stimulation in cochlear implants yielding best binaural performance in patients with single sided deafness are in line with latency differences found in auditory brainstem responses • Synchronisation of natural hearing and electrical stimulation via cochlear implant impacts on binaural hearing abilities [ABSTRACT FROM AUTHOR]

Abstract Interaural time and intensity differences (ITD and IID) are important cues in binaural hearing and allow for sound localization, improving speech understanding in noise and reverberation, and integrating sound sources in the auditory scene. Whereas previous research showed that the upper-frequency limit for ITD detection in the fine structure of sound declines in aging, the processing of envelope ITD in low-frequency amplitude modulated (AM) sound and the related brain responses are less understood. This study investigated the cortical processing of envelope ITD and compared the results with previous findings about the fine-structure ITD. In two experiments, participants listened to 40-Hz AM tones containing sudden changes in the envelope ITD. Multiple MEG responses were analyzed, including the auditory evoked N1 responses, elicited both by sound onsets and ITD changes, and 40-Hz responses, elicited by the AM. The first experiment with healthy young adults revealed a substantial decline in the magnitudes of the ITD change N1 response, and the 40-Hz phase resets at higher carrier frequencies, suggesting a similar frequency characteristic as observed for fine structure ITD. The amplitude of the 40-Hz ASSR declined only gradually with increasing carrier frequency, and it was excluded as a confounding factor in the decline in the ITD response. Larger responses to outward ITD changes than inward changes, here first reported for envelope ITD, were another characteristics that were similar to fine-structure ITD. A second experiment with groups of young and older listeners examined the effects of aging and concurrent noise on the cortical envelope ITD responses. One important research question was, whether binaural cues are accessible in noise. Behavioural tests showed an age-related hearing loss in the older group and decreased performance in envelope ITD detection and speech-in-noise (SIN) understanding. Binaural hearing and SIN performance were correlated with one other, but not with hearing loss. The frequency limit for envelope ITD was reduced in older listeners similarly as previously found for fine structure ITD, and older listeners were more susceptible to concurrent multi-talker noise. The similarities between responses to envelope ITD and to fine structure ITD suggest that a common cortical code exists for the envelope and fine structure ITD. The dependency on the carrier frequency suggests that envelope ITD processing at the subcortical level requires stimulus phase locking, which might be reduced in aging. Highlights • First report of 40-Hz phase resets and N1 change responses to envelope ITD changes. • Aging affects cortical envelope ITD responses similar to fine structure ITD. • Envelope ITD discrimination correlated with speech-in-noise understanding. • Multi-talker noise attenuated ITD responses stronger than sensory evoked responses. • ITD responses in older listeners were more affected by masking than in young adults. [ABSTRACT FROM AUTHOR]

Abstract Different amplification options are available for listeners with congenital unilateral conductive hearing loss (UCHL). For example, bone-conduction devices (BCDs) and middle ear implants. The present study investigated whether intervention with an active BCD, the Bonebridge, or a middle ear implant, the Vibrant Soundbridge (VSB), affected sound-localization performance of listeners with congenital UCHL. Listening with a Bonebridge or VSB might provide access to binaural cues. However, when fitted with the Bonebridge, but not with a VSB, binaural processing might be affected through cross stimulation of the contralateral normal hearing ear, and could interfere with processing of binaural cues. In the present study twenty-three listeners with congenital UCHL were included. To assess processing of binaural cues, we investigated localization abilities of broadband (BB, 0.5–20 kHz) filtered noise presented at varying sound levels. Sound localization abilities were analyzed separately for stimuli presented at the side of the normal-hearing ear, and for stimuli presented at the side of the hearing-impaired ear. Twenty-six normal hearing children and young adults were tested as control listeners. Sound localization abilities were measured under open-loop conditions by recording head-movement responses. We demonstrate improved sound localization abilities of children with congenital UCHL, when listening with a Bonebridge or VSB, predominantly for stimuli presented at the impaired (aided) side. Our results suggest that the improvement is not related to accurate processing of binaural cues. When listening with the Bonebridge, despite cross stimulation of the contralateral cochlea, localization performance was not deteriorated compared to listening with a VSB. Highlights • Improved sound localization abilities of children with congenital UCHL, when listening with a Bonebridge or VSB. • Improvement is not related to accurate processing of binaural cues. • Cross stimulation of the contralateral cochlea did not deteriorate localization performance. • Spectral cues can provide location information for horizontal sound localization. • Normal-hearing plugged listeners demonstrate deteriorated localization at the side of the open ear and of the plugged ear. [ABSTRACT FROM AUTHOR]

Speech intelligibility prediction methods have recently gained popularity in the speech processing community as supplements to time consuming and costly listening experiments. Such methods can be used to objectively quantify and compare the advantage of different speech enhancement algorithms, in a way that correlates well with actual speech intelligibility. One such method is the short-time objective intelligibility (STOI) measure. In a recent publication, we proposed a binaural version of the STOI measure, based on a modified version of the equalization cancellation (EC) model. This measure was shown to retain many of the advantageous properties of the STOI measure, while at the same time being able to predict intelligibility correctly in conditions involving both binaural advantage and non-linear signal processing. The biggest prediction errors were found for conditions involving multiple spatially distributed interferers. In this paper, we report results for a new listening experiment including different mixtures of isotropic and point source noise. This exposes that the binaural STOI measure has a tendency to overestimate the intelligibility in conditions with spatially distributed interferes at low signal to noise ratios (SNRs). This condition-dependent error can make it difficult to compare intelligibility across different acoustical conditions. We investigate the cause of this upward bias, and propose a correction which alleviates the problem. The modified method is evaluated with five datasets of measured intelligibility, spanning a wide range of realistic acoustic conditions. Within the tested conditions, the modified method yields very accurate predictions, and entirely alleviates the aforementioned tendency to overestimate intelligibility in conditions with spatially distributed interferers. [ABSTRACT FROM AUTHOR]

Using a well-established binaural-listening paradigm the ability to intentionally switch auditory selective attention was examined under anechoic, low reverberation (0.8 s) and high reverberation (1.75 s) conditions. Twenty-three young, normal-hearing subjects were tested in a within-subject design to analyze influences of the reverberation times. Spoken word pairs by two speakers were presented simultaneously to subjects from two of eight azimuth positions. The stimuli consisted of a single number word, (i.e., 1 to 9), followed by either the direction “UP” or “DOWN” in German. Guided by a visual cue prior to auditory stimulus onset indicating the position of the target speaker, subjects were asked to identify whether the target number was numerically smaller or greater than five and to categorize the direction of the second word. Switch costs, (i.e. reaction time differences between a position switch of the target relative to a position repetition), were larger under the high reverberation condition. Furthermore, the error rates were highly dependent on reverberant energy and reverberation interacted with the congruence effect, (i.e. stimuli spoken by target and distractor may evoke the same answer (congruent) or different answers (incongruent)), indicating larger congruence effects under higher reverberation times. [ABSTRACT FROM AUTHOR]

Both harmonic and binaural signal properties are relevant for auditory processing. To investigate how these cues combine in the auditory system, detection thresholds for an 800-Hz tone masked by a diotic (i.e., identical between the ears) harmonic complex tone were measured in six normal-hearing subjects. The target tone was presented either diotically or with an interaural phase difference (IPD) of 180° and in either harmonic or “mistuned” relationship to the diotic masker. Three different maskers were used, a resolved and an unresolved complex tone (fundamental frequency: 160 and 40 Hz) with four components below and above the target frequency and a broadband unresolved complex tone with 12 additional components. The target IPD provided release from masking in most masker conditions, whereas mistuning led to a significant release from masking only in the diotic conditions with the resolved and the narrowband unresolved maskers. A significant effect of mistuning was neither found in the diotic condition with the wideband unresolved masker nor in any of the dichotic conditions. An auditory model with a single analysis frequency band and different binaural processing schemes was employed to predict the data of the unresolved masker conditions. Sensitivity to modulation cues was achieved by including an auditory-motivated modulation filter in the processing pathway. The predictions of the diotic data were in line with the experimental results and literature data in the narrowband condition, but not in the broadband condition, suggesting that across-frequency processing is involved in processing modulation information. The experimental and model results in the dichotic conditions show that the binaural processor cannot exploit modulation information in binaurally unmasked conditions. [ABSTRACT FROM AUTHOR]

Hearing aid (HA) users can differ markedly in their benefit from directional processing (or beamforming) algorithms. The current study therefore investigated candidacy for different bilateral directional processing schemes. Groups of elderly listeners with symmetric ( N = 20) or asymmetric ( N = 19) hearing thresholds for frequencies below 2 kHz, a large spread in the binaural intelligibility level difference (BILD), and no difference in age, overall degree of hearing loss, or performance on a measure of selective attention took part. Aided speech reception was measured using virtual acoustics together with a simulation of a linked pair of completely occluding behind-the-ear HAs. Five processing schemes and three acoustic scenarios were used. The processing schemes differed in the tradeoff between signal-to-noise ratio (SNR) improvement and binaural cue preservation. The acoustic scenarios consisted of a frontal target talker presented against two speech maskers from ±60° azimuth or spatially diffuse cafeteria noise. For both groups, a significant interaction between BILD, processing scheme, and acoustic scenario was found. This interaction implied that, in situations with lateral speech maskers, HA users with BILDs larger than about 2 dB profited more from preserved low-frequency binaural cues than from greater SNR improvement, whereas for smaller BILDs the opposite was true. Audiometric asymmetry reduced the influence of binaural hearing. In spatially diffuse noise, the maximal SNR improvement was generally beneficial. N 0 S π detection performance at 500 Hz predicted the benefit from low-frequency binaural cues. Together, these findings provide a basis for adapting bilateral directional processing to individual and situational influences. Further research is needed to investigate their generalizability to more realistic HA conditions (e.g., with low-frequency vent-transmitted sound). [ABSTRACT FROM AUTHOR]

We investigated speech recognition in noise in subjects with mild to profound levels of unilateral hearing loss. Thirty-five adults were evaluated using an adaptive signal-to-noise ratio (SNR50) sentence recognition threshold test in three spatial configurations. The results revealed a significant correlation between pure-tone average audiometric thresholds in the poorer ear and SNR thresholds in the two conditions where speech and noise were spatially separated: dichotic – with speech presented to the poorer ear and reverse dichotic – with speech presented to the better ear. This first result suggested that standard pure-tone air-conduction thresholds can be a reliable predictor of speech recognition in noise for binaural conditions. However, a subgroup of 14 subjects was found to have poorer-than-expected speech recognition scores, especially in the reverse dichotic listening condition. In this subgroup 9 subjects had been diagnosed with vestibular schwannoma at stage III or IV likely affecting the lower brainstem function. These subjects showed SNR thresholds in the reverse dichotic condition on average 4 dB poorer (higher) than for the other 21 normally-performing subjects. For the 7 of 9 subjects whose vestibular schwannoma was removed, the deficit was no longer apparent on average 5 months following the surgical procedure. These results suggest that following unilateral hearing loss the capacity to use monaural spectral information is supported by the lower brainstem. [ABSTRACT FROM AUTHOR]

Using a binaural-listening paradigm, age-related differences in the ability to intentionally switch auditory selective attention between two speakers, defined by their spatial location, were examined. Therefore 40 normal-hearing participants (20 young, Ø 24.8 years; 20 older Ø 67.8 years) were tested. The spatial reproduction of stimuli was provided by headphones using head-related-transfer-functions of an artificial head. Spoken number words of two speakers were presented simultaneously to participants from two out of eight locations on the horizontal plane. Guided by a visual cue indicating the spatial location of the target speaker, the participants were asked to categorize the target's number word into smaller vs. greater than five while ignoring the distractor's speech. Results showed significantly higher reaction times and error rates for older participants. The relative influence of the spatial switch of the target-speaker (switch or repetition of speaker's direction in space) was identical across age groups. Congruency effects (stimuli spoken by target and distractor may evoke the same answer or different answers) were increased for older participants and depend on the target's position. Results suggest that the ability to intentionally switch auditory attention to a new cued location was unimpaired whereas it was generally harder for older participants to suppress processing the distractor's speech. [ABSTRACT FROM AUTHOR]

Treatment with cochlear implants (CIs) in single-sided deaf individuals started less than a decade ago. CIs can successfully reduce incapacitating tinnitus on the deaf ear and allow, so some extent, the restoration of binaural hearing. Until now, systematic evaluations of subjective CI benefit in post-lingually single-sided deaf individuals and analyses of speech intelligibility outcome for the CI in isolation have been lacking. For the prospective part of this study, the Bern Benefit in Single-Sided Deafness Questionnaire (BBSS) was administered to 48 single-sided deaf CI users to evaluate the subjectively perceived CI benefit across different listening situations. In the retrospective part, speech intelligibility outcome with the CI up to 12 month post-activation was compared between 100 single-sided deaf CI users and 125 bilaterally implanted CI users (2nd implant). The positive median ratings in the BBSS differed significantly from zero for all items suggesting that most individuals with single-sided deafness rate their CI as beneficial across listening situations. The speech perception scores in quiet and noise improved significantly over time in both groups of CI users. Speech intelligibility with the CI in isolation was significantly better in bilaterally implanted CI users (2nd implant) compared to the scores obtained from single-sided deaf CI users. Our results indicate that CI users with single-sided deafness can reach open set speech understanding with their CI in isolation, encouraging the extension of the CI indication to individuals with normal hearing on the contralateral ear. Compared to the performance reached with bilateral CI users’ second implant, speech reception threshold are lower, indicating an aural preference and dominance of the normal hearing ear. The results from the BBSS propose good satisfaction with the CI across several listening situations. [ABSTRACT FROM AUTHOR]

• Contralateral sound field attenuation can be easily implemented as pre-processing with bilateral hearing aids. • Contralateral sound field attenuation can improve speech-in-noise intelligibility and increase spatial release from masking for bilateral hearing-aid users. • Those benefits are present for people with different types of hearing loss. • Contralateral sound field attenuation can help bilateral hearing-aid users communicate in cocktail-party listening environments. We have recently proposed a binaural sound pre-processing method to attenuate sounds contralateral to each ear and shown that it can improve speech intelligibility for normal-hearing (NH) people in simulated "cocktail party" listening situations (Lopez-Poveda et al., 2022, Hear Res 418:108,469). The aim here was to evaluate if this benefit remains for hearing-impaired listeners when the method is combined with two independently functioning hearing aids, one per ear. Twelve volunteers participated in the experiments; five of them had bilateral sensorineural hearing loss and seven were NH listeners with simulated bilateral conductive hearing loss. Speech reception thresholds (SRTs) for sentences in competition with a source of steady, speech-shaped noise were measured in unilateral and bilateral listening, and for (target, masker) azimuthal angles of (0°, 0°), (270°, 45°), and (270°, 90°). Stimuli were processed through a pair of software-based multichannel, fast-acting, wide dynamic range compressors, with and without binaural pre-processing. For spatially collocated target and masker sources at 0° azimuth, the pre-processing did not affect SRTs. For spatially separated target and masker sources, the pre-processing improved SRTs when listening bilaterally (improvements up to 10.7 dB) or unilaterally with the acoustically better ear (improvements up to 13.9 dB), while it worsened SRTs when listening unilaterally with the acoustically worse ear (decrements of up to 17.0 dB). Results show that binaural pre-processing for contralateral sound attenuation can improve speech-in-noise intelligibility in laboratory tests also for bilateral hearing-aid users. [ABSTRACT FROM AUTHOR]

Major criteria for a successful binaural reproduction are not only a suitable localization performance, but also the authenticity and plausibility of the presented scene. It is therefore interesting to examine whether the binaural reproduction can be perceptually distinguished from a real source. The aim of the presented investigation is to compare the quality of the binaural reproduction via headphones with two different microphone setups (miniature microphone in Open-Dome and ear plug) for individual head-related-transfer-function (HRTF) and headphone-transfer-function (HpTF) measurements. Listening tests with a total of 80 subjects were carried out focusing on plausibility and authenticity. In the examination of plausibility detection rates showed that subjects were not able to match the reproduced pink noise to its reproduction system (real source vs. binaural reproduction via headphones). The authenticity of the static binaural reproduction was highly dependent on the stimulus. Pink noise could often be distinguished due to coloration in higher frequencies and small differences in location. A difference between microphone setups could not be found in neither of the listening tests. [ABSTRACT FROM AUTHOR]

For bilateral cochlear implant users, the left and right arrays are typically not physically aligned, resulting in a degradation of binaural fusion, which can be detrimental to binaural abilities. Perceptually aligning the two arrays can be accomplished by disabling electrodes in one ear that do not have a perceptually corresponding electrode in the other side. However, disabling electrodes at the edges of the array will cause compression of the input frequency range into a smaller cochlear extent, which may result in reduced spectral resolution. An alternative approach to overcome this mismatch would be to only align one edge of the array. By aligning either only the apical or basal end of the arrays, fewer electrodes would be disabled, potentially causing less reduction in spectral resolution. The goal of this study was to determine the relative effect of aligning either the basal or apical end of the electrode with regards to binaural fusion. A vocoder was used to simulate cochlear implant listening conditions in normal hearing listeners. Speech signals were vocoded such that the two ears were either predominantly aligned at only the basal or apical end of the simulated arrays. The experiment was then repeated with a spectrally inverted vocoder to determine whether the detrimental effects on fusion were related to the spectral-temporal characteristics of the stimuli or the location in the cochlea where the misalignment occurred. In Experiment 1, aligning the basal portion of the simulated arrays led to significantly less binaural fusion than aligning the apical portions of the simulated array. However, when the input was spectrally inverted, aligning the apical portion of the simulated array led to significantly less binaural fusion than aligning the basal portions of the simulated arrays. These results suggest that, for speech, with its predominantly low frequency spectral-temporal modulations, it is more important to perceptually align the apical portion of the array to better preserve binaural fusion. By partially aligning these arrays, cochlear implant users could potentially increase their ability to fuse speech sounds presented to the two ears while maximizing spectral resolution. [ABSTRACT FROM AUTHOR]

The effect of interaural time difference (ITD) and interaural level difference (ILD) on wave 4 of the binaural and summed monaural auditory brainstem responses (ABRs) as well as on the DN1 component of the binaural interaction component (BIC) of the ABR in young and old Mongolian gerbils ( Meriones unguiculatus ) was investigated. Measurements were made at a fixed sound pressure level (SPL) and a fixed level above visually detected ABR threshold to compensate for individual hearing threshold differences. In both stimulation modes (fixed SPL and fixed level above visually detected ABR threshold) an effect of ITD on the latency and the amplitude of wave 4 as well as of the BIC was observed. With increasing absolute ITD values BIC latencies were increased and amplitudes were decreased. ILD had a much smaller effect on these measures. Old animals showed a reduced amplitude of the DN1 component. This difference was due to a smaller wave 4 in the summed monaural ABRs of old animals compared to young animals whereas wave 4 in the binaural-evoked ABR showed no age-related difference. In old animals the small amplitude of the DN1 component was correlated with small binaural-evoked wave 1 and wave 3 amplitudes. This suggests that the reduced peripheral input affects central binaural processing which is reflected in the BIC. [ABSTRACT FROM AUTHOR]

• Speech intelligibility measured with maskers ranging from noise to speech. • Behavioral data compared to predictions from speech intelligibility models. • No strong evidence for harmonicity-based effects with speech maskers. • Harmonic cancellation not a crucial component of speech intelligibility models. This study investigated the role of harmonic cancellation in the intelligibility of speech in "cocktail party" situations. While there is evidence that harmonic cancellation plays a role in the segregation of simple harmonic sounds based on fundamental frequency (F0), its utility for mixtures of speech containing non-stationary F0s and unvoiced segments is unclear. Here we focused on the energetic masking of speech targets caused by competing speech maskers. Speech reception thresholds were measured using seven maskers: speech-shaped noise, monotonized and intonated harmonic complexes, monotonized speech, noise-vocoded speech, reversed speech and natural speech. These maskers enabled an estimate of how the masking potential of speech is influenced by harmonic structure, amplitude modulation and variations in F0 over time. Measured speech reception thresholds were compared to the predictions of two computational models, with and without a harmonic cancellation component. Overall, the results suggest a minor role of harmonic cancellation in reducing energetic masking in speech mixtures. [ABSTRACT FROM AUTHOR]

• A binaural non-stationary harmonic-cancellation speech intelligibility model. • Predictions of SRTs for speech masked by a harmonic complex. • Accounts for spatial separation, intonation and amplitude modulation of the masker. • Harmonic cancellation and binaural unmasking might be mutually exclusive mechanisms. The aim of this study was to extend the harmonic-cancellation model proposed by Prud'homme et al. [J. Acoust. Soc. Am. 148 (2020) 3246-–3254] to predict speech intelligibility against a harmonic masker, so that it takes into account binaural hearing, amplitude modulations in the masker and variations in masker fundamental frequency (F0) over time. This was done by segmenting the masker signal into time frames and combining the previous long-term harmonic-cancellation model with the binaural model proposed by Vicente and Lavandier [Hear. Res. 390 (2020) 107937]. The new model was tested on the data from two experiments involving harmonic complex maskers that varied in spatial location, temporal envelope and F0 contour. The interactions between the associated effects were accounted for in the model by varying the time frame duration and excluding the binaural unmasking computation when harmonic cancellation is active. Across both experiments, the correlation between data and model predictions was over 0.96, and the mean and largest absolute prediction errors were lower than 0.6 and 1.5 dB, respectively. [ABSTRACT FROM AUTHOR]

• Adventitious sounds, produced by animal locomotion, are an important class of zoogenic sounds. • High-frequency transients appear to be a core component of adventitious sounds. • The lateral superior olive is hypothesized to be adapted for localization of adventitious sounds. Study of the characteristics, neural processing, and behavioral effects of communication sounds are an important focus of hearing research. The goal of this paper is to bring attention to another, rather neglected class of sounds that are omnipresent and that are arguably at least equally important for the daily survival of many species and have been in the evolution of the mammalian auditory system. All terrestrial mammals produce adventitious sounds when they locomote. The handful of studies that examined the characteristics of such sounds suggests that high-frequency transients are an important component. Acoustic propagation of such sounds is limited in distance, particularly for sources and receivers on a vegetated ground plane. It follows that the presence of such sounds is an indication of a nearby animal, and that detection and localization of high-frequency transients is vital for both prey and predator. It is suggested that consideration of adventitious sounds is important in grasping the importance of auditory morphological and physiological features. As an illustration, a hypothesis on the relationship of one binaural brainstem circuit to adventitious sounds is briefly discussed. [ABSTRACT FROM AUTHOR]

Highlights: [•] Across species, interaural time differences are detected by different mechanisms. [•] The detection stage serves as a database for higher auditory areas. [•] ITD representation is remodeled along the ascending auditory pathway. [•] Across species, ITD is represented in few broadly tuned channels in the forebrain. [•] Forebrain ITD representations likely subserve spatial unmasking. [Copyright &y& Elsevier]

• Binaural weighted subtraction is effective in attenuating the contralateral sound field. • Subtraction weights are best when calculated using head-related transfer functions. • Binaural weighted subtraction is simple to implement in bilateral hearing devices. • Binaural weighted subtraction can improve speech intelligibility in complex, free-field listening scenarios. Understanding speech presented in competition with other sounds can be challenging. Here, we reason that in free-field settings, this task can be facilitated by attenuating the sound field contralateral to each ear and propose to achieve this by linear subtraction of the weighted contralateral stimulus. We mathematically justify setting the weight equal to the ratio of ipsilateral to contralateral head-related transfer functions (HRTFs) averaged over an appropriate azimuth range. The algorithm is implemented in the frequency domain and evaluated technically and experimentally for normal-hearing listeners in simulated free-field conditions. Results show that (1) it can substantially improve the signal-to-noise ratio (up to 30 dB) and the short-term objective intelligibility in the ear ipsilateral to the target source, particularly for maskers with speech-like spectra; (2) it can improve speech reception thresholds (SRTs) for sentences in competition with speech-shaped noise by up to 8.5 dB in bilateral listening and 10.0 dB in unilateral listening; (3) for sentences in competition with speech maskers and in bilateral listening, it can improve SRTs by 2 to 5 dB, depending on the number and location of the masker sources; (4) it hardly affects virtual sound-source lateralization; and (5) the improvements, and the algorithm's directivity pattern depend on the azimuth range used to calculate the weights. Contralateral HRTF-weighted subtraction may prove valuable for users of binaural hearing devices. [ABSTRACT FROM AUTHOR]

Abstract: Interaural level difference (ILD) is one of the basic binaural clues in the spatial localization of a sound source. Due to the acoustic shadow cast by the head, a sound source out of the medial plane results in an increased sound level at the nearer ear and a decreased level at the distant ear. In the mammalian auditory brainstem, the ILD is processed by a neuronal circuit of binaural neurons in the lateral superior olive (LSO). These neurons receive major excitatory projections from the ipsilateral side and major inhibitory projections from the contralateral side. As the sound level is encoded predominantly by the neuronal discharge rate, the principal function of LSO neurons is to estimate and encode the difference between the discharge rates of the excitatory and inhibitory inputs. Two general mechanisms of this operation are biologically plausible: (1) subtraction of firing rates integrated over longer time intervals, and (2) detection of coincidence of individual spikes within shorter time intervals. However, the exact mechanism of ILD evaluation is not known. Furthermore, given the stochastic nature of neuronal activity, it is not clear how the circuit achieves the remarkable precision of ILD assessment observed experimentally. We employ a probabilistic model and complementary computer simulations to investigate whether the two general mechanisms are capable of the desired performance. Introducing the concept of an ideal observer, we determine the theoretical ILD accuracy expressed by means of the just-noticeable difference (JND) in dependence on the statistics of the interacting spike trains, the overall firing rate, detection time, the number of converging fibers, and on the neural mechanism itself. We demonstrate that the JNDs rely on the precision of spike timing; however, with an appropriate parameter setting, the lowest theoretical values are similar or better than the experimental values. Furthermore, a mechanism based on excitatory and inhibitory coincidence detection may give better results than the subtraction of firing rates. This article is part of a Special Issue entitled Neural Coding 2012. [Copyright &y& Elsevier]

Abstract: Hosoi (2004) found a pathway for clear sound transmission via aural cartilage. Our research group is developing a new hearing aid using this mechanism. The cartilage conduction hearing aid can be used in patients who cannot insert the earplugs of conventional hearing aids. The cartilage conduction hearing aid (model HD-GX) is composed of a main unit, a transducer, and a fitting part. The ring-shaped fitting part is placed in the entrance of the ear canal, and the vibration at the cartilage then generates sound in the external auditory canal. The cartilage conduction sound remains in the canal and reduces the risk of acoustical feedback. Considering this advantage, we designed it to wear behind the ear (BTE) (model HD-GX2). As binaural cartilage conduction can present sound directivity equivalent to that of air conduction, we then developed a binaural cartilage conduction hearing aid (model HD-GX3) by combining two BTE hearing aids. [Copyright &y& Elsevier]

Abstract: provided an overview of data on the evolutionary pressures on sound localization acuity in mammals. Her most important finding was that sound localization acuity was most strongly correlated with width of field of best vision. This correlation leaves unexplained the mechanism through which evolutionary pressures affect localization acuity in different mammals. A review of the neurophysiology of binaural sound localization cue coding, and the behavioural performance it supports, led us to two hypotheses. First, there is little or no evidence that the neural mechanisms for coding binaural sound location cues, or the dynamic range of the code, vary across mammals. Rather, the neural coding mechanism is remarkably constant both across species, and within species across frequency. Second, there is no need to postulate that evolutionary pressures are exerted on the cue coding mechanism itself. We hypothesize instead that the evolutionary pressure may be on the organism''s ability to exploit a ‘lower envelope principle’ (after ). [Copyright &y& Elsevier]

Abstract: Bilateral cochlear implantation has recently been introduced with the aim of improving both speech perception in background noise and sound localization. Although evidence suggests that binaural perception is possible with two cochlear implants, results in humans are variable. To explore potential contributing factors to these variable outcomes, we have developed a behavioral animal model of bilateral cochlear implantation in a novel species, the ferret. Although ferrets are ideally suited to psychophysical and physiological assessments of binaural hearing, cochlear implantation has not been previously described in this species. This paper describes the techniques of deafening with aminoglycoside administration, surgical implantation of an intracochlear array and chronic intracochlear electrical stimulation with monitoring for electrode integrity and efficacy of stimulation. Experiments have been presented elsewhere to show that the model can be used to study behavioral and electrophysiological measures of binaural hearing in chronically implanted animals. This paper demonstrates that cochlear implantation and chronic intracochlear electrical stimulation are both safe and effective in ferrets, opening up the possibility of using this model to study potential protective effects of bilateral cochlear implantation on the developing central auditory pathway. Since ferrets can be used to assess psychophysical and physiological aspects of hearing along with the structure of the auditory pathway in the same animals, we anticipate that this model will help develop novel neuroprosthetic therapies for use in humans. [Copyright &y& Elsevier]

Abstract: The article reports the experience gained from two implementations of the “Simulated Open-Field Environment” (SOFE), a setup that allows sounds to be played at calibrated levels over a wide frequency range from multiple loudspeakers in an anechoic chamber. Playing sounds from loudspeakers in the free-field has the advantage that each participant listens with their own ears, and individual characteristics of the ears are captured in the sound they hear. This makes an easy and accurate comparison between various listeners with and without hearing devices possible. The SOFE uses custom calibration software to assure individual equalization of each loudspeaker. Room simulation software creates the spatio-temporal reflection pattern of sound sources in rooms which is played via the SOFE loudspeakers. The sound playback system is complemented by a video projection facility which can be used to collect or give feedback or to study auditory–visual interaction. The article discusses acoustical and technical requirements for accurate sound playback against the specific needs in hearing research. An introduction to software concepts is given which allow easy, high-level control of the setup and thus fast experimental development, turning the SOFE into a “Swiss army knife” tool for auditory, spatial hearing and audio–visual research. [Copyright &y& Elsevier]

Abstract: Objective: To assess the advantage of binaural and bimodal hearing for subjects with cochlear implant (CI) using auditory event-related potentials as well as speech perception tests. Subjects and methods: The subjects comprised four binaural CI users (CI/CI group) and eleven bimodal CI users, who wore a hearing aid (HA) contralaterally (CI/HA group). All subjects had used binaural or bimodal fitting for over 6 months. Their speech perception was examined in a quiet environment using monosyllabic words. Late cortical waves were measured while subjects were engaged in an oddball task of 1kHz frequent and 2kHz rare tone stimuli. The latencies of event-related potential (N1, N2, P3) were compared for monaural, binaural, and bimodal hearing conditions. Results: Significantly (p <0.01, paired t-test) better speech perception for monosyllabic words was found for both binaural and bimodal hearing than monaural hearing. The latency of N1 did not significantly change for either binaural or bimodal hearing. On the other hand, the latency of N2 was significantly (p <0.01, paired t-test) shorter for binaural and bimodal hearing than for monaural hearing. The latency of P3 was shorter for binaural and bimodal hearing than monaural hearing in all subjects, and the difference was statistically significant in both CI/CI and CI/HA groups (p <0.01, paired t-test). Conclusions: Better speech perception was obtained for binaural and bimodal hearing than for monaural hearing in CI subjects. The results obtained in the comparison of P3 latency agreed with that of speech perception. Thus, using bilateral hearing devices is recommended for CI subjects. We also found that event-related potentials were useful as an objective tool to assess the advantage of binaural and bimodal hearing for CI subjects. [Copyright &y& Elsevier]

Abstract: Binaural temporal resolution was measured using the discrimination of brief interaural time delays (ITDs). In experiment 1, three listeners performed a 2I-2AFC, ITD-discrimination procedure. ITD changes of 8 to 1024μs were applied to brief probe noises. These probes, with durations of 16 to 362ms, were placed symmetrically in time within a 500-ms burst of otherwise interaurally uncorrelated noise. Psychometric functions were measured to obtain thresholds and temporal windows fitted to those thresholds. The best-fitting window was a symmetric roex shape (equivalent rectangular duration=197ms), an order of magnitude longer than monaural temporal windows and differed substantially from windows reported by Bernstein et al. [Bernstein, L.R., Trahiotis, C., Akeroyd, M.A., Hartung, K., 2001. Sensitivity to brief changes of interaural time and interaural intensity. J. Acoust. Soc. Am. 109, 1604–1615]. Experiment 2, replicated their main experiment, comparing their ITD-detection task with a similar discrimination procedure. Thresholds in the detection conditions were significantly better than those in the discrimination condition, particularly for short probe durations, indicating the use of an additional cue at these durations for the detection task and thus undermining the assumptions made in their window fit. [Copyright &y& Elsevier]

Abstract: Design of computationally efficient yet perceptually realistic room auralisation algorithms require a careful selection of the early reflections to be auralised. A perception-based simplification algorithm is presented for the selection of the early reflections using a criterion which depends both on the arrival time and on the angle of incidence of the early reflection with respect to the listener. Results of two subjective tests for the evaluation of the proposed algorithm are presented. The proposed algorithm is shown to provide a significant reduction in the number of early reflections without significantly affecting the tested localisational or spatial qualities of auralisation. [Copyright &y& Elsevier]

Abstract: Reflection masked thresholds (RMTs) for the simple scenario of a test reflection masked by the direct sound (200ms long broadband noise) were measured as a function of reflection delay for diotic and dichotic stimulus presentations. In order to discriminate between contributions to reflection masking from simultaneous versus forward masking, the simultaneous RMT was measured in addition to the traditional RMT. Simultaneous RM was realized by truncating the offset of the test reflection such that the test reflection and the direct sound had a common offset. By comparing the experimental results for the two RMTs, it is shown that forward masking effects only have a significant effect on reflection masking for delays above 7–10ms. Moreover, binaural mechanisms were revealed which deteriorate auditory detection of test reflections for delays below 7–10ms and enhance detection for larger delays. The monaural and binaural processes that may underlie reflection masking are discussed in terms of auditory-modelling concepts. [Copyright &y& Elsevier]

Abstract: The ability to perceive time-varying acoustic changes deteriorates with advancing age. To learn more about the mechanisms underlying such perceptual deficits, we used magnetoencephalography (MEG) to examine the physiological response to interaural phase differences (IPD) in young, middle-aged, and older adults. Stimulus onset evoked P1m–N1m–P2m cortical responses, as did the change in interaural phase. There were no significant age-related latency differences in the detection of sound “onset”; however, the ability to detect “changes” within the stimulus deteriorated with increased age. Peak latencies were prolonged for the “change” response when compared to the “onset” response, suggesting that the physiological detection of IPDs requires more time than detecting sound “onset”. These results provide physiological evidence of impaired temporal processing in the elderly that is likely unrelated to hearing loss or cognitive ability because brain activity was measured passively in response to audible low frequency stimuli. [Copyright &y& Elsevier]

Abstract: Steady-state responses were evoked by noise stimuli that alternated between two levels of interaural correlation ρ at a frequency f m. With ρ alternating between +1 and 0, responses at f m dropped steeply above 4Hz, but persisted up to 64Hz. Two time constants of 47 and 4.4ms with delays of 198 and 36ms, respectively, were obtained by fitting responses to a transfer function based on symmetric exponential windows. The longer time constant, possibly reflecting cortical integration, is consistent with perceptual binaural “sluggishness”. The shorter time constant may reflect running cross-correlation in the high brainstem or primary auditory cortex. Responses at 2f m peaked with an amplitude of 848±479nV (f m =4Hz). Investigation of this robust response revealed that: (1) changes in ρ and lateralization evoked similar responses, suggesting a common neural origin, (2) response was most dependent on stimulus frequencies below 1000Hz, but frequencies up to 4000Hz also contributed, and (3) when ρ alternated between [0.2–1] and 0, response amplitude varied linearly with ρ, and the physiological response threshold was close to the average behavioral threshold (ρ =0.31). This steady-state response may prove useful in the objective investigation of binaural hearing. [Copyright &y& Elsevier]

Data from humans and animal models provide evidence for an age-dependent impairment in the ability to localize sound. The lateral superior olive (LSO) in the ascending auditory pathway is one important center involved in processing of binaural auditory stimuli. To identify potential age-dependent changes we characterized the LSO in young (<15 months) and old (⩾3 years) gerbils with a special emphasis on the expression of GABA- and glycine-like immuno-reactivity. The dimensions of the LSO, as well as the number and density of glycine- and GABA-immuno-reactive neurons, were not significantly different between young and old gerbils. The size of glycine- and GABA-immuno-reactive neurons was significantly reduced in the high-frequency (medial) limb of the LSO. Over all, age-dependent changes in the LSO of the gerbil were small. [Copyright &y& Elsevier]

A new type of array signal processing combined with a weighted least squares algorithm to enable two-channel output with binaural information is proposed in this paper. This algorithm may be effective for use in a binaural hearing aid because the interaural relationship can be preserved after array signal processing. Retaining spatial information on specified directions while sufficiently suppressing unnecessary ambient noise coming from directions other than those of target sounds is required for this type of algorithm. In order to satisfy these two simultaneous requirements, the proposed algorithm was derived from a constraint algorithm by employing the weighted least squares algorithm. Performance in directivity patterns as well as interaural time difference (ITD) and interaural level difference (ILD) were evaluated. Computer simulations showed that this algorithm yields robust performance in various conditions compared with array signal processing based on a constraint algorithm. [Copyright &y& Elsevier]

Conductive hearing loss attenuates and delays sound passing through the middle ear. This impairs binaural hearing and other central auditory functions dependent on high fidelity sound transmission. Persistent conductive loss leads to central impairments that persist after the peripheral loss has resolved. For example, children who have had multiple episodes of otitis media with effusion (OME) in the first few years of life may have poor detection of sounds in noisy environments, evidenced by reduced binaural unmasking (BU). Recent research shows that a ‘threshold’ level of OME is required to produce impaired BU. Children who had OME in one or both ears for more than about 50% of the first 5 years had reduced BU. Animal research, using long-term ear plugging, suggests that total OME duration, rather than age at the time of having the disease, determines its effect on BU. Animals reared with bilateral (but not unilateral) ear plugs also have poor auditory temporal resolution, and reduced sensitivity to short tones in the presence of background noise, after plug removal. However, given time (6–24 months) and training, all animals regained normal temporal resolution. [Copyright &y& Elsevier]

Using dichotic signals presented by headphone, stimulus onset dominance (the precedence effect for lateralization) was investigated for six sensorineural hearing-impaired subjects. Stimuli were based on 2400-Hz lowpass-filtered 5-ms noise bursts. We used the paradigm, as described by Goverts et al. (2000, Hear. Res. 148, 88–94), in which a single noise burst is divided into leading and lagging parts, with opposite lateralization cues (viz. an interaural time delay of 0.2 ms). The occurrence of onset dominance was investigated by measuring the lateral perception of the stimulus (‘left’ or ‘right’) with fixed, equal durations of leading and lagging parts, while decreasing the absolute signal level or adding a filtered white noise. The dominance of the leading part was quantified by measuring the lateral perception of the stimulus as a function of the relative duration of the leading (and thus the lagging) part. This was done at about 40 dB sensation level (SL) in quiet and in filtered white noise, at a signal-to-noise ratio resulting in a SL of about 6 dB. Results are compared to normal hearing reference data at various SLs. Hearing-impaired data show a large variance and overall a decreased precedence effect in terms of both occurrence and quantification, which cannot be explained on basis of reduced audibility. Mean performance of the hearing-impaired subjects at 40 dB in quiet was similar to normal hearing performance in masking noise at a signal-to-noise ratio of 0 dB. [Copyright &y& Elsevier]

Enhanced speech intelligibility in realistic acoustic scenarios guarantees effective communication. Noise and reverberation degrade speech intelligibility, but the combined effect of reverberation, informational noise and position of target, listener and noise source on speech intelligibility still needs to insights. This work investigates the effect of real complex acoustic scenarios on speech intelligibility for adults. In two primary-school classrooms with reverberation time of 0.4 s and 3.1 s, receivers were located on axis with the target at increasing distances, and noise sources were both co-located and spatially separated from the target at different distances providing various degrees of energetic and informational masking. Noise level was maintained constant and set at 60 dB at the receiver's position, regardless of the noise source distance. The longer reverberation time resulted in worse speech recognition thresholds (SRT80s) by 6 dB on average. The competitive effect of informational noise resulted in increased SRT80s by 7 dB on average, in comparison to energetic noise. The SRT80 increases by ~2 dB with doubling the target-to-receiver distance when the noise source is close to the receiver, accounting for both reverberations and noise types. The spatial release from masking resulted in improved speech intelligibility by up to ~3 dB when the noise source is 1 m far from the receiver for energetic masker for low reverberation and, unexpectedly, for the informational masker in high reverberation. This may indicate that a perceptual segregation mechanism sorts out competing voices of informational masker according to their directions in least favorable listening situations. • The effect of real complex acoustic scenarios on speech intelligibility is studied. • A longer reverberation time results in significantly worse speech recognition. • Informational masking degrades speech recognition with respect to energetic masking. • Spatial release from masking results in improved speech intelligibility up to ~3 dB. • Perceptual segregation may have a critical role in complex listening situations. [ABSTRACT FROM AUTHOR]

• Psychophysics and modeling link reverberation level, loudness, and reverberance. • Normal hearing reverberance studied by scaling reverberation level at the ears. • Previous work replicated and extended with new listening conditions. • Time-varying aspects of loudness model critical for predicting reverberance. Previous work has explored novel binaural combinations of reverberation and the resulting perceived reverberation strength (reverberance). The present study examines the perceptual effects of additional binaural combinations of reverberation with the goal of explaining reverberance in terms of basic psychoacoustic principles. Stimuli were generated using virtual space techniques simulating a speech source 3 m to the listener's right in a moderately reverberant environment. Reverberant energy at the ears was varied systematically relative to the natural level for the environment (0-dB gain). The method of magnitude estimation was used to estimate reverberance. Four experiments were conducted. Experiment 1 tested monaural listening conditions for both left and right ears at reverberation gains from -21 dB to 0 dB. Experiment 2 tested a binaural listening condition where only reverberant energy at the ear farther from the source was manipulated (-21 dB to 0 dB). Experiment 3 tested two binaural conditions over a wider range of reverberation gains (-18 dB to +24 dB). In one condition, reverberant energy was manipulated for both ears equally. In the other condition, reverberant energy was manipulated only for the ear nearer the source. In Experiment 4, reverberant tails of the stimuli were removed to test whether listeners were able to use ongoing reverberant information to judge reverberance. The results from all experiments were found to be well predicted by a model of time-varying binaural loudness that focused on "glimpses" in time with relatively high reverberant sound energy and low direct sound energy. These findings suggest that the mechanisms underlying reverberance and loudness may be similar. [ABSTRACT FROM AUTHOR]

• Back-end enhancement of interaural level differences improves left/right discrimination at narrow azimuths in bilateral cochlear implant users. • Linked band selection enhances interaural level differences. • Linked band selection improves left/right discrimination at wide azimuths in bilateral cochlear implant users. • Back-end enhancement of interaural level differences besides linked band selection is desirable to improve left/right discrimination for bilateral cochlear implant users. Bilateral cochlear implant (BiCI) users do not localize sounds as well as normal hearing (NH) listeners do. NH listeners rely on two binaural cues to localize sounds in the horizontal plane, namely interaural level differences (ILDs) and interaural time differences. BiCI systems, however, convey these cues poorly. In this work, we investigated two methods to improve the coding of ILDs in BiCIs. The first method enhances ILDs by applying an artificial current-versus-angle function to the clinical levels delivered by the basal electrodes of the CI contralateral to the target sound. The second method enhances ILDs by using bilaterally linked N -of- M band selection. Results indicate that the participants were able to discriminate the location of the sound more accurately at narrow azimuths when the ILD enhancement was applied, compared to when they were using natural ILDs. Also, the results show that linking the band selection had a positive effect on left/right discrimination accuracy at larger azimuths for three out of the 10 tested participants, when compared to unlinked band selection. Based on these results, we conclude that ILD enhancement besides linked N -of- M band selection can help some BiCI participants to discriminate sound sources on the frontal horizontal plane. [ABSTRACT FROM AUTHOR]

• Inferior colliculi show substantial ITD sensitivity in absence of hearing experience. • Early deaf and hearing experienced animals have comparable ITD sensitivity. • Early deaf rats exhibit more central and less contralateral ITD tuning. • ITD sensitivity in deaf rats should suffice for good psychoacoustic performance. For deaf patients cochlear implants (CIs) can restore substantial amounts of functional hearing. However, binaural hearing, and in particular, the perception of interaural time differences (ITDs) with current CIs has been found to be notoriously poor, especially in the event of early hearing loss. One popular hypothesis for these deficits posits that a lack of early binaural experience may be a principal cause of poor ITD perception in pre-lingually deaf CI patients. This is supported by previous electrophysiological studies done in neonatally deafened, bilateral CI-stimulated animals showing reduced ITD sensitivity. However, we have recently demonstrated that neonatally deafened CI rats can quickly learn to discriminate microsecond ITDs under optimized stimulation conditions which suggests that the inability of human CI users to make use of ITDs is not due to lack of binaural hearing experience during development. In the study presented here, we characterized ITD sensitivity and tuning of inferior colliculus neurons under bilateral CI stimulation of neonatally deafened and hearing experienced rats. The hearing experienced rats were not deafened prior to implantation. Both cohorts were implanted bilaterally between postnatal days 64-77 and recorded immediately following surgery. Both groups showed comparably large proportions of ITD sensitive multi-units in the inferior colliculus (Deaf: 84.8%, Hearing: 82.5%), and the strength of ITD tuning, quantified as mutual information between response and stimulus ITD, was independent of hearing experience. However, the shapes of tuning curves differed substantially between both groups. We observed four main clusters of tuning curves – trough, contralateral, central, and ipsilateral tuning. Interestingly, over 90% of multi-units for hearing experienced rats showed predominantly contralateral tuning, whereas as many as 50% of multi-units in neonatally deafened rats were centrally tuned. However, when we computed neural d' scores to predict likely limits on performance in sound lateralization tasks, we did not find that these differences in tuning shapes predicted worse psychoacoustic performance for the neonatally deafened animals. We conclude that, at least in rats, substantial amounts of highly precise, "innate" ITD sensitivity can be found even after profound hearing loss throughout infancy. However, ITD tuning curve shapes appear to be strongly influenced by auditory experience although substantial lateralization encoding is present even in its absence. [ABSTRACT FROM AUTHOR]

• We investigate binaural unmasking in free-field conditions for normal-hearing listeners. • The noise but not the speech in the worse acoustic ear is necessary for unmasking to occur. • Binaural unmasking requires the noise stimuli at the eardrums to be binaurally coherent. • The medial olivocochlear efferent reflex does not contribute to binaural unmasking. For speech in competition with a noise source in the free field, normal-hearing (NH) listeners recognize speech better when listening binaurally than when listening monaurally with the ear that has the better acoustic signal-to-noise ratio (SNR). This benefit from listening binaurally is known as binaural unmasking and indicates that the brain combines information from the two ears to improve intelligibility. Here, we address three questions pertaining to binaural unmasking for NH listeners. First, we investigate if binaural unmasking results from combining the speech and/or the noise from the two ears. In a simulated acoustic free field with speech and noise sources at 0° and 270°azimuth, respectively, we found comparable unmasking regardless of whether the speech was present or absent in the ear with the worse SNR. This indicates that binaural unmasking probably involves combining only the noise at the two ears. Second, we investigate if having binaurally coherent location cues for the noise signal is sufficient for binaural unmasking to occur. We found no unmasking when location cues were coherent but noise signals were generated incoherent or were processed unilaterally through a hearing aid with linear, minimal amplification. This indicates that binaural unmasking requires interaurally coherent noise signals, source location cues, and processing. Third, we investigate if the hypothesized antimasking benefits of the medial olivocochlear reflex (MOCR) contribute to binaural unmasking. We found comparable unmasking regardless of whether speech tokens (words) were sufficiently delayed from the noise onset to fully activate the MOCR or not. Moreover, unmasking was absent when the noise was binaurally incoherent whereas the physiological antimasking effects of the MOCR are similar for coherent and incoherent noises. This indicates that the MOCR is unlikely involved in binaural unmasking. [ABSTRACT FROM AUTHOR]

The primary aim of this study is to investigate whether the electrical stimulation of the second ear causes a difference in electrically evoked auditory brainstem responses (eABR) between two ears over time. The study included thirteen subjects under the age of five who used cochlear implants for at least six months in the first ear prior to the sequential cochlear implantation. Postoperative eABRs were conducted on the 1st (first fitting of the second speech processor), 3rd, and 6th months of the second implantation in the basal, medial, and apical electrode positions. The recording was started with the second cochlear implant (CI2), and then the first cochlear implant (CI1) was tested. Sound field audiometry and receptive/expressive language assessments were also performed at 1 and 6 months after the second cochlear implantation. eABR results indicate that when eV wave latencies are examined for all electrodes, CI2 is significantly longer than CI1 (p < 0.05). When eV wave amplitudes are examined for all electrodes, CI1 is significantly higher than the CI2 (p < 0.05). eV latency and amplitude changes between both implants were examined up to six months after implantation. Statistically significant changes were observed in the basal, medial, apical electrode for eV wave latencies, and only in the medial electrode for eV wave amplitudes (p < 0.05). Average sound field thresholds and receptive/expressive language scores improved statistically significantly for all subjects at the end of the study (p < 0.05). The postoperative eABR test is a valuable test battery that provides the clinician with important ideas about the estimated threshold, comfortable and audible sound level, CI performance, and auditory pathways up to the brainstem. Since the maturation is still ongoing, an extended period longer than six months is needed to evaluate interaural differences. [ABSTRACT FROM AUTHOR]

• Neurons tuned to high frequency tones in E. fuscus are sensitive to onset ITDs. • ITD sensitivity is centered within the behaviorally relevant range of E. fuscus. • Minimum and maximum neuronal responses cluster across similar ITD values. • ITD sensitivity in the bat IC is similar to other mammalian midbrain structures. Many neurons in the auditory midbrain are tuned to binaural cues. Two prominent binaural cues are the interaural level difference (ILD) and the interaural time difference (ITD). The ITD cue can further be subdivided into the ongoing envelope ITD cues and transient onset ITD cues. More is known about the sensitivity of single neurons to ongoing envelope ITDs compared to transient onset ITDs in the mammalian auditory system, particularly in bats. The current study examines the response properties of single neurons in the inferior colliculus (IC) of the big brown bat, Eptesicus fuscus , to onset ITDs in response to high frequency pure tones. Measures of neurons' dynamic ITD response revealed an average change of 36% of its maximum response within the behaviorally relevant range of ITDs (±50 µs). Across all IC neurons, we measured an average time-intensity trading ratio of 30 µs/dB in the sensitivity of the ITD response function to changing ILDs. Minimum and maximum ITD responses were clustered within a narrow range of ITDs. The average peak in the ITD response function was at 268 µs, a finding that is consistent with other non-echolocating mammals. Some ITD-sensitive neurons also showed weak facilitation of maximum response during binaural stimulation, compared to monaural stimulation. These results suggest that echolocating bats possess the potential to use onset ITD cues to assist in the azimuthal sound localization of ultrasonic frequencies. [ABSTRACT FROM AUTHOR]

This study aims at building an evacuation system using audio signals. The feature of the system is the utilization of the precedence effect for a listener to easily perceive the direction of an emergency exit. Two kinds of pre-listening tests were conducted to reconfirm the basic characteristics of the precedence effect which needed consideration in the proposed system. Firstly, the influence of various kinds of background sounds to the precedence effect was investigated in a horizontal plane. The complexity of signal, that is, the difference in levels between the audio signal and background sound, and the variety of the sounds, influenced the precedence effect. Secondly, the generation and disappearance of the precedence effect were investigated in the vertical plane. We confirmed that the generation and disappearance of the precedence effect were clear in the horizontal plane and vague in the vertical plane. The results of the two pre-listening tests led us a new concept of an evacuation system with the loudspeakers set beside a wall in a passageway. In the listening tests of the proposed system, the generation and disappearance of the precedence effect of an audio signal were investigated. The configuration of the loudspeaker setting had a good effect on guidance of evacuees during an emergency. The installation angle of a loudspeaker was shown to be an important factor in the perception of stable sound localization in the direction of the emergency exit. At installation angles of 10 or 20°, the direction of sound localization became more straight ahead than in the case of other installation angles. Furthermore, at the worst listening position for the perception of sound localization, we confirmed that the difference in intensity between the loudspeakers contributed to the improvement of sound localization. Therefore, using loudspeakers with sharper directivity was suggested, which can easily improve the direction of sound localization at the worst listening position to become more straight ahead. We confirmed that the proposed evacuation system with loudspeakers set beside the wall in a passageway was a promising candidate. [ABSTRACT FROM AUTHOR]

This study aimed to characterize binaural hearing abilities with bone conduction stimulation in simulated conductive hearing loss. Bone conduction hearing devices (BCDs) are a common method of rehabilitating conductive hearing loss. However, little is known about the access these devices provide to binaural cues. To study the ability of BCDs to restore access to binaural cues in conductive loss, normal hearing listeners were plugged unilaterally and bilaterally and localization ability was assessed using a non-surgical BCD attached to the mastoid/s via an adhesive (MED-EL, Corp). The results demonstrate that 1) application of the BCD in simulated unilateral conductive hearing loss does not restore access to binaural cues, evidenced by poor localization abilities. 2) bilateral application of BCDs in simulated bilateral conductive hearing loss provides access to binaural cues, 2) unilateral application of BCDs in simulated bilateral conductive hearing loss disrupts these cues and impairs localization performance, The transcutaneous stimulation of the adhesive BCD resulted in decreased access to sound compared to the normal open ear, resulting in asymmetries in aided versus non-aided hearing thresholds. Symmetrical hearing results in improved localization abilities, while asymmetric hearing disrupts sound localization abilities. • Binaural hearing abilities can be achieved in maturated auditory systems. • Adhesive BCDs do not improve localization in unilateral plugged conditions. • Accurate sound localization with bilateral adhesive BCDs. • Sound localization abilities are disrupted by asymmetric hearing. [ABSTRACT FROM AUTHOR]

Objectives Although cochlear implantation is widely used to treat unilateral deafness in adults, very little literature exists on its use and effects on the paediatric population. This report adds to the literature showing the mid-term follow-up outcomes achieved by these children. Material and methods Three children with congenital unilateral deafness were studied after implantation. Speech perception in noise, and sound localization ability were evaluated using age-appropriate materials. Results The preliminary data of our small group of 3 children with congenital unilateral profound hearing loss revealed that up to 3 years post-implantation, congenitally deaf children who received a cochlear implant after 4 years of age do not demonstrate binaural hearing benefits. Conclusion Early intervention in the prelingual phase may be crucial for the development of binaural hearing. [ABSTRACT FROM AUTHOR]