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19. Gene variants at FTO, 9p21, and 2q36.3 are age-independently associated with myocardial infarction in Czech men.

Author

Hubacek, J.A., Vrablik, M., Dlouha, D., Stanek, V., Gebauerova, M., Adamkova, V., Ceska, R., Dostálová, G., Linhart, A., Vitek, L., and Pitha, J.

Subjects
*MYOCARDIAL infarction, *GENETIC polymorphisms, *OBESITY, *MEDICAL research, CARDIOVASCULAR disease related mortality
Abstract

Aim Cardiovascular disease (CVD) is a major cause of morbidity and mortality in developed countries. This study aimed to confirm the effect of common putative CVD-associated gene variants ( FTO rs17817449, KIF6 rs20455, 9p21 rs10757274 and 2q36.3 rs2943634) on CVD manifestation, and determine whether this effect differs between younger (< 50 years) and older CVD patients. Methods 1191 controls and 1889 MI patients were analyzed. All participants were Caucasian Czech males aged < 65 years (532 were < 50 years) who were examined at cardiology clinics in Prague, Czech Republic. Variants of FTO , 9p21 , 2q36.3 , and KIF-6 were genotyped using PCR-RFLP or TaqMan assay. Results Variants of FTO (OR 1.48; 95% CI, 1.19–1.84 in a TT vs. GG comparison, p = 0.0005); 9p21 (OR 1.74; 95% CI, 1.41–2.14 in an AA vs. GG comparison, p = 0.0001); and 2q36.3 (OR 1.34; 95%CI, 1.09–1.65 in an AA vs. + C comparison, p = 0.006) were significantly associated with MI in the male Czech population. In contrast, genotype frequencies of KIF-6 (rs20455) were the same in patients and controls (P = 1.00). Nearly identical results were observed when a subset of young MI patients (N = 532, aged < 50 years) was analyzed. Conclusion We confirmed the importance of determining FTO , 9p21 , and 2q36.3 variants as part of the genetic determination of MI risk in the Czech male population. [ABSTRACT FROM AUTHOR]

Published
2016
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20. FTO and MC4R gene variants determine BMI changes in children after intensive lifestyle intervention

Author

Zlatohlavek, L., Vrablik, M., Motykova, E., Ceska, R., Vasickova, L., Dlouha, D., and Hubacek, J.A.

Subjects
*MELANOCORTIN receptors, *CRITICAL care medicine, *BODY mass index, *WEIGHT loss, *ANTHROPOMETRY, *APOLIPOPROTEIN B, *HIGH density lipoproteins, *TRIGLYCERIDES
Abstract

Abstract: Objectives: This study aimed to determine whether there is a relationship between common FTO (rs17817449) and MC4R (rs17782313) gene variants and body mass reduction or weight loss after a one-month lifestyle intervention in overweight/obese children. Design and methods: We genotyped 357 unrelated non-diabetic Czech children (age 13.7±4.9years, average BMI at baseline 30.8±4.6kg/m2). Biochemical and anthropometrical measurements were performed before and after 4weeks of lifestyle interventions (comprising a reduction in energy intake to the age-matched optimum and a supervised exercise program consisting of 5 exercise units per day, 50min each). Results: The mean weight loss achieved was 6.2±2.1kg (P<0.001). Significant associations were found between a BMI decrease and the FTO and MC4R variants. Carriers of the FTO GG genotype and/or MC4R CC genotype lost significantly more body weight compared to noncarriers (P<0.0009 for BMI and P<0.002 for body weight). These differences remained significant following adjustment for sex, age and baseline values (P=0.004 for BMI and P=0.01 for body weight). Conclusions: FTO and MC4R gene variants modify the impact of an intensive lifestyle intervention on BMI decrease in overweight/obese children. Carriers of the FTO GG genotype and MC4R CC genotype benefit significantly more from the lifestyle intervention. [Copyright &y& Elsevier]

Published
2013
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