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181 results on '"Valeriani, M."'

2. Ultrasound diagnosis of placental and umbilical cord anomalies in singleton pregnancies resulting from in-vitro fertilization.

Author

Larcher, L., Jauniaux, E., Lenzi, J., Ragnedda, R., Morano, D., Valeriani, M., Michelli, G., Farina, A., and Contro, E.

Abstract

placental anomalies can affect fetal and maternal outcome due to severe maternal hemorrhage potentially resulting in hysterectomy and cord accident including abruption that can determine fetal damage or death. The aims of our study are to determine if the rate of placental and umbilical cord anomalies are more common in IVF singleton pregnancies compared to spontaneous pregnancies; to evaluate the role of ultrasound in screening for these anomalies and to investigate if oocyte donor fertilization is an additional risk factor for the development of these anomalies. this was a prospective cohort study involving two tertiary centers. Patients with a singleton pregnancy conceived with IVF and patients presenting with a spontaneous conception were recruited between 1st May 2019 to 31st March 2021. A total of 634 pregnancies were enrolled in the study. All patients underwent similar antenatal care, which included ultrasound examinations at 11–14, 19–22 and 33–35 weeks. Ultrasound findings of placental and/or umbilical cord abnormalities were recorded using the same protocol for both groups and confirmed after birth. IVF pregnancies had a significantly higher risk of low-lying placenta, placenta previa, bilobed placenta and velamentous cord insertion (VCI) compared with spontaneous pregnancies. In the heterologous subgroup there was a significant increased incidence of placenta accreta spectrum (PAS) disorders than in spontaneous pregnancies. All these anomalies were identified prenatally on ultrasound imaging and confirmed at birth. IVF pregnancies in general and those resulting from donor oocyte in particular are at higher risk of placental and umbilical cord abnormalities compared to spontaneous pregnancies. These anomalies can be diagnosed accurately at the mid-trimester detailed fetal anomaly scan and our findings support the need for a targeted ultrasound screening of these anomalies in IVF pregnancies. • IVF pregnancies are at higher risk of placental abnormalities compared to spontaneous. • Heterologous IVF pregnancies are at higher risk of placenta accreta spectrum. • US has a high diagnostic accuracy in detecting placental anomalies prenatally. [ABSTRACT FROM AUTHOR]

Published
2023
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16. Diagnosis of pediatric anti-NMDAR encephalitis at the onset: A clinical challenge.

Author

Ursitti, F., Roberto, D., Papetti, L., Moavero, R., Ferilli, M.A.N., Fusco, L., Vigevano, F., Curatolo, P., and Valeriani, M.

Subjects
ANTI-NMDA receptor encephalitis, ENCEPHALITIS, MOVEMENT disorders, EPILEPSY, SYMPTOMS, ANXIETY disorders
Abstract

To investigate the clinical and instrumental features at the onset addressing to the diagnosis of anti-NMDAR encephalitis. Twenty children (age: 15 months-17 years; 7 males, 13 females) with initial suspected diagnosis of autoimmune encephalitis, observed between January 2008 and March 2018, were included. The final diagnosis was anti-NMDAR encephalitis in 7 children, other/probable autoimmune encephalitis in 7 children, and primary psychosis in the remaining 6 children. At the clinical onset, anxiety disorder was the main symptom that helped in distinguishing the group of psychotic children from children with non-infectious encephalitis (P = 0.05 OR = 0.001), while epileptic seizures strongly predicted anti-NMDAR encephalitis (P = 0.04 OR = 28.6). At the onset, anti-NMDAR encephalitis could be distinguished from other/probable autoimmune encephalitis for the presence of sleep/wake rhythm alteration (P = 0.05 OR = 15). Among the symptoms occurring during the hospitalization, movement disorders (P = 0.031 OR = 12) were predictive of non-infectious encephalitis rather than primary psychosis. More specifically, the occurrence of language impairment (P = 0.03 OR = 33), epileptic seizures (P = 0.04 OR = 28.6) and catatonia (P = 0.03, OR = 33), were predictive of anti-NMDAR encephalitis. Also at this stage, anxiety disorder (P = 0.03 OR = 0.033) was predictive of primary psychosis. Our findings suggest that at the clinical onset epileptic seizures and sleep/wake rhythm alteration represent the main features addressing to the diagnosis of anti-NMDAR encephalitis rather than primary psychosis and other/probable autoimmune encephalitis, while anxiety disorder could be a solid predictor of primary psychosis. • Clinical presentation of pediatric anti-NMDAR encephalitis and psychosis can be overlapping. • Epilepsy and sleep/wake rhythm abnormalities characterize anti-NMDAR encephalitis onset. • Anxiety disorder is a strong predictor of psychosis. • Normal brain MRI does not exclude anti-NMDAR encephalitis. • CSF oligoclonal bands are more frequent in anti-NMDAR than other autoimmune encephalitis. [ABSTRACT FROM AUTHOR]

Published
2021
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18. SC174 - Enzalutamide in patients with castration-refractory prostate cancer: Retrospective, multicenter, real life study

Author

Gacci, M., Marchioni, M., De Francesco, P., Natoli, C., Calabrò, F., Losanno, T., Cito, G., Serni, S., Doni, L., De Nunzio, C., De Tursi, M., Valeriani, M., Giacinti, S., Maestro, M. Alvarez, Scarcia, M., Ludovico, G., Del Bene, G., Simone, G., Ferriero, M., Tuderti, G., Bove, P., Laudisi, A., Carrieri, G., Cormio, L., Verze, P., La Rocca, R., Di Nicola, M., Schips, L., and Cindolo, L.

Published
2019
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