Ryu, Se Hwan, Hong, Seong Min, Khan, Zahra, Lee, Seul Ki, Vishwanath, Manjunatha, Turk, Ayman, Yeon, Sang Won, Jo, Yang Hee, Lee, Dae Hee, Lee, Jae Kang, Hwang, Bang Yeon, Jung, Jae-Kyung, Kim, Sun Yeou, and Lee, Mi Kyeong
Four compounds, hericerin (1), isohericerinol A (2), N -de-phenylethyl isohericerin (3) and corallocin A (4) were isolated from the fruiting bodies of Hericium erinaceus, a lion's mane mushroom (Hericiaceae). Among them, isohericerinol A (2) was newly reported in nature. Further investigation of the neurotrophic effect of isolated compounds demonstrated that isohericerinol A (2) strongly increased the nerve growth factor (NGF) production in C6 glioma cells followed by corallocin A (4) and hericerin (1). Increased NGF production by these compounds promoted the neurite outgrowth in N2a neuronal cells. Western blot analysis also showed the increased protein expression of NGF, brain-derived neurotrophic factor (BDNF) and synaptophysin (SYP) in C6-N2a cells. Taken together, our present study characterized the neurotrophic constituents of H. erinaceus , which may support the potential use of memory improvement. [ABSTRACT FROM AUTHOR]