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Neurotrophic isoindolinones from the fruiting bodies of Hericium erinaceus.
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Jan2021, Vol. 31, pN.PAG-N.PAG. 1p. - Publication Year :
- 2021
-
Abstract
- Four compounds, hericerin (1), isohericerinol A (2), N -de-phenylethyl isohericerin (3) and corallocin A (4) were isolated from the fruiting bodies of Hericium erinaceus, a lion's mane mushroom (Hericiaceae). Among them, isohericerinol A (2) was newly reported in nature. Further investigation of the neurotrophic effect of isolated compounds demonstrated that isohericerinol A (2) strongly increased the nerve growth factor (NGF) production in C6 glioma cells followed by corallocin A (4) and hericerin (1). Increased NGF production by these compounds promoted the neurite outgrowth in N2a neuronal cells. Western blot analysis also showed the increased protein expression of NGF, brain-derived neurotrophic factor (BDNF) and synaptophysin (SYP) in C6-N2a cells. Taken together, our present study characterized the neurotrophic constituents of H. erinaceus , which may support the potential use of memory improvement. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 31
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 147583566
- Full Text :
- https://doi.org/10.1016/j.bmcl.2020.127714