1. New Biosilified Pd-lipase hybrid biocatalysts for dynamic resolution of amines.
- Author
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de Souza, Stefânia P., Leão, Raquel A.C., Bassut, Jonathan F., Leal, Ivana C.R., Wang, Shuai, Ding, Qiqi, Li, Yingying, Lam, Frank Leung-Yuk, de Souza, Rodrigo O.M.A., and Itabaiana Jr, Ivaldo
- Subjects
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PALLADIUM catalysts , *AMINES , *ENZYMES , *RESOLUTION (Chemistry) , *SILICA nanoparticles , *CATALYTIC activity - Abstract
In this work lipase CaLB was immobilized on functionalized Pd-SiO 2 nanoparticles in order to simplify the DKR of α-methylbenzylamine. Hybrid biocatalysts showed immobilization efficiencies of 82%, 80% and 76% when containing 1, 5 and 10% of Pd respectively. On DKR reaction values of ee > 99% and conversion of 82% were found with only 1% of Pd, generating a productivity of 2.21 mg of product h −1 mg of support −1 against 0.76 found by N435®. Compared to commercial N435®, the novel biocatalysts showed protein loads about 15-fold lower and higher activity, demonstrating competitive performances and high industrial applications. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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