New Biosilified Pd-lipase hybrid biocatalysts for dynamic resolution of amines.

Authors :: de Souza, Stefânia P.
Leão, Raquel A.C.
Bassut, Jonathan F.
Leal, Ivana C.R.
Wang, Shuai
Ding, Qiqi
Li, Yingying
Lam, Frank Leung-Yuk
de Souza, Rodrigo O.M.A.
Itabaiana Jr, Ivaldo
Source :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Dec2017, Vol. 58 Issue 52, p4849-4854. 6p.
Publication Year :: 2017
Abstract: In this work lipase CaLB was immobilized on functionalized Pd-SiO 2 nanoparticles in order to simplify the DKR of α-methylbenzylamine. Hybrid biocatalysts showed immobilization efficiencies of 82%, 80% and 76% when containing 1, 5 and 10% of Pd respectively. On DKR reaction values of ee > 99% and conversion of 82% were found with only 1% of Pd, generating a productivity of 2.21 mg of product h −1  mg of support −1 against 0.76 found by N435®. Compared to commercial N435®, the novel biocatalysts showed protein loads about 15-fold lower and higher activity, demonstrating competitive performances and high industrial applications. [ABSTRACT FROM AUTHOR]

Subjects :: *PALLADIUM catalysts
*AMINES
*ENZYMES
*RESOLUTION (Chemistry)
*SILICA nanoparticles
*CATALYTIC activity

Language :: English
ISSN :: 00404039
Volume :: 58
Issue :: 52
Database :: Academic Search Index
Journal :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
Publication Type :: Academic Journal
Accession number :: 126513717
Full Text :: https://doi.org/10.1016/j.tetlet.2017.11.031