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Elevated levels of NEFA caused by negative energy balance in transition cows induce cellular dyshomeostasis. Ubiquitin-like modifier 1 ligating enzyme 1 (UFL1) can maintain cellular homeostasis and act as a critical regulator of stress responses besides functioning in the ubiquitin-like system. The objective of this study was to elucidate the UFL1 working mechanism on promoting cellular adaptations in bovine mammary epithelial cells (BMECs) in response to NEFA challenge, with an emphasis on the ER and mitochondrial function. The results showed that exogenous NEFA and UFL1 depletion resulted in the disorder of ER and mitochondrial homeostasis and the damage of BMEC integrity, overexpression of UFL1 effectively alleviated the NEFA-induced cellular dyshomeostasis. Mechanistically, our study found that UFL1 had a strong interaction with IRE1α and could modulate the IRE1α/XBP1 pathway of unfolded protein response in NEFA-stimulated BMECs, thereby contributing to the modulation of cellular homeostasis. These findings imply that targeting UFL1 may be a therapeutic alternative to relieve NEB-induced metabolic changes in perinatal dairy cows. [Display omitted] • NEFA and UFL1 depletion resulted in the disorder of ER and mitochondrial homeostasis. • UFL1 overexpression effectively alleviated the NEFA-induced cellular dyshomeostasis. • UFL1 could interact with IRE1α and modulate the IRE1α/XBP1 pathway of UPR in BMECs. • IRE1α functioned as a positive regulator in MAMs homeostasis of NEFA-induced BMECs. [ABSTRACT FROM AUTHOR]

• Experiences from SWH systems mandatory installation in China were summarized. • The interaction of seven stakeholders in SWH building application was analyzed. • Three key factors for the successful mandatory installation of SWH were summarized. • Recommendations were given for using the mandatory installation policy effectively. • The government should regularly evaluate the effectiveness of policy implementation. The paper summarizes the implementation experiences and lessons learned from the solar water heating (SWH) system mandatory installation policy in China. In-depth interviews, questionnaire surveys and field investigation were conducted to understand the prevailing attitudes of the stakeholders associated with the application of SWH in buildings. Scenario analysis was used to analyze the effect of expanding the coverage of mandatory installation policies. The results show that due to the strong market externalities of SWH building applications, the government must provide inducements to stakeholders through mandatory policies or fiscal incentives to create an impetus for them to use SWH extensively. For China, it is necessary to strengthen and support the utilization of renewable energy policies and extend the mandatory installation policy of SWH systems to taller buildings to fulfill the national renewable energy application goals. The most reasonable technical route, full process control, and attention to system operation and maintenance are the three key factors for the successful implementation of a mandatory installation policy for SWH systems. The policy recommendations presented in this paper can not only be applied to China but also other developing countries as well. [ABSTRACT FROM AUTHOR]

• Experience and lessons summarized on the first solar district heating system in rural Beijing. • A solar-assisted GSHP system is a reliable solution for district heating. • Solar collectors contribute to heat balance of the soil heat storage. • An optimized scenario with a reduction of overall operating cost by 10.9% proposed. • The combination of domestic hot water and space heating is worth promoting in China. Experimental and theoretical investigations have been carried out on the first large scale solar assisted ground source heat pump (SAGSHP) for heating and cooling of a village in the outskirts of Beijing. Long term performances of the system without and with solar heating were monitored. A TRNSYS model of the SAGSHP system was developed and validated against the measured data. Based on a parametrical investigation using the model, an optimized solution was proposed. It is shown that adding a domestic hot water system to the original SAGSHP system will not only help to secure thermal balance of the ground but also reduces primary energy consumption for hot water by 70%. The system COP increases by 9.4% from 2.42 to 2.65 and the annual overall operating cost decreases from 892,000 CNY to 794,000 CNY with only a small increase in equipment cost. Under the premise of ensuring thermal balance of the ground, there is an optimal match between the size of the ground heat storage, the collector area and the tank volume. Experience and lessons learned from the project are conducive to successful implementation of similar projects in the future. [ABSTRACT FROM AUTHOR]

Abstract Solar thermal has contributed little for space heating in China. In 2014, although China shared 75.8% of the total solar collector installations in the world, only less than 0.3% of the solar collectors were used for space heating. To promote solar district heating (SDH) in China, based on Danish experiences and Chinese clean heating transformation practices, a PEST (policy, economics, social, and technology) analysis and a SWOT (strengths, weaknesses, opportunities, and threats) analysis on SDH development in China were conducted. An extensive survey and on-site investigation were carried out to identify the applicability of SDH in rural areas. SDH development strategies, roadmap, and decision-making process for a SDH project are summarized. SDH has a broad application prospect in China with abundant solar resources and favorable policies. The solar heated floor area can achieve 756 million m2 with an assumption of 3% coverage of the total heat demand of buildings. Particular areas with low population density, scarce resources, and strict environmental requirements, e.g., Tibet, should be given a high priority for SDH. Rural villages and small towns with better infrastructure, e.g., district heating networks, are the best target market for SDH in the next five years. With the development of seasonal heat storage technologies and the accumulation of practical experience, SDH can be expanded to industrial parks, large residential communities in sparsely populated northwest China. Integration of solar heat with existing heating networks in big cities with central heating will be challenging in the long run. Highlights • The solar heated area can achieve 756 million m2 with an assumption of 3% coverage of the total heated area in China. • High-performance flat plate collectors will significantly increase the reliability of solar district heating systems. • A solar assisted ground source heat pump system is a reliable solution as a form of solar district heating. • Particular areas with low population density should be given high priority for solar district heating. • Land availability is a significant obstacle to the development of large-scale solar district heating. [ABSTRACT FROM AUTHOR]

China is the second-largest economy country, and the largest country worldwide in total solar energy system capacity installed. More than 70% of total solar collector capacity worldwide is installed in China. The production of solar collector in China had decreased significantly from 64 million m2 in 2012 to 37 million m2 in 2017, corresponding to a reduction of around 40% of the market in 2012. There are very limited comprehensive studies in existing literature, which have investigated the reasons on the decline of Chinese solar thermal market. This study aims to identify the reasons from both the demand and the supply sides in details. Furthermore, with the rise of emerging markets, such as the rapid development of the "Clean Heating Initiative" for space heating in North China, solar heat industrial process, and the mandatory installation of solar domestic hot water system for residential buildings below 100 m in urban area, the Chinese solar thermal market is expected to recover soon, called "U-shaped curve" in this study. The market share of flat plate collector and evacuated tube collector is predicted to change in the near future. The research and development of flat plate solar collectors will increase continually in the market other than evacuated tube solar collectors like the past 10 years. The main driver for the solar thermal market development in China in the near future will be the demand from the urban area. • The largest solar thermal market worldwide has been presented. • The market share of flat plate collector will continue to grow gradually. • Market factors from both supply and demand sides are analyzed in detail. • Scenarios is predicted in short, middle and long terms. [ABSTRACT FROM AUTHOR]

In the past decades, solar heat for industrial processes (SHIP) have been rapidly developed and applied, and also getting more and more attention all over the world. China is the largest energy consumer with industry accounting for almost 70% of its total energy consumption. Low- and medium-temperature heat takes up 45% of process heat, covering 50–70% of industrial energy consumption, which provides a favorable condition for solar application in industrial processes. China has built developed some demonstration projects to make industrial processes well integrated with solar heating systems. This paper briefly summarizes the status of China's energy consumption, integration of SHIP, as well as available matching solar technologies. Ten typical industrial sectors are selected to specifically describe their potential of SHIP. Moreover, 26 SHIP cases covering the selected 10 sectors are presented by field researches, with capacity of energy saving and emission reduction previously investigated according to their own proportion of SHIP. The potential of SHIP in the 10 sectors are further predicted by optimistically and conservatively making their proportion in SHIP 5.5% and 2% respectively during the period of 2016–2020. The results show that at least 39.40 million tons of coal equivalent and 98.22 million tons of CO 2 emission is expected to be reduced in 2020 in China's all industrial sectors although solar can meet different proportions of heat demand in different industrial sectors. [ABSTRACT FROM AUTHOR]

[Display omitted] • Steaming significantly decreased polysaccharide content in Polygonatum cyrtonema. • Steaming caused degradation, aggregation, and depolymerization of polysaccharides. • Steaming for 2–4 h greatly enhanced immunological activities of polysaccharides. • Steaming for longer time (≥6 h) had negative impacts of immunological activities. • The changes of immune activities of polysaccharides were related to their structure. Steaming significantly decreased the polysaccharide content in the rhizome of Polygonatum cyrtonema. This study aimed to reveal the effects of steaming on structural characteristics and immunomodulatory activities of Polygonatum cyrtonema polysaccharide (PCP). The results showed that steaming decreased the polysaccharide content in the rhizome by 38.41%. Structural changes of PCP by steaming included molecular degradation, aggregation, and depolymerization, which also affected its immunological activities. Steaming first degraded β-type fructofuranose in PCP from raw rhizome. However, steaming for 2 h and 4 h increased the molecular weight and particle size, and changed the monosaccharide composition of the PCPs. Additionally, PCP at 2 h and 4 h had higher immunological activities than PCP from raw rhizome. Then, a longer steaming time (6–12 h) caused excessive destruction of PCP and had negative impacts on their immunological activities. These results revealed changes in PCP during the steaming process and provided a reference for the processing of Polygonatum cyrtonema , especially for avoiding overprocessing. [ABSTRACT FROM AUTHOR]

We aim to identify the potential genes and signaling pathways associated with the nasopharyngeal carcinoma (NPC) prognosis using Weighted Gene Co-Expression Network Analysis (WGCNA). Gene Expression Omnibus (GEO) query was utilized to download two NPC mRNA microarray data. WGCNA was conducted on differentially expressed genes (DEGs) to obtain tumor-associated gene modules. Genes in core modules were intersected with DEGs for gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) functional enrichment analysis. GSE102349 dataset was devoted to identifying prognostic hub genes by survival analysis and the results were confirmed by quantitative polymerase chain reaction (qPCR). Co-expression networks were built, and we detected 12 gene modules. The Brown module and Magenta module were extremely associated with NPC samples. GO functional analysis and KEGG pathway analysis was carried out to the genes in the Brown and Magenta modules. Our data indicated that DEGs in Brown module and Magenta module were correlated with the biological regulation, metabolic process, reproduction, and cellular proliferation. Twenty-six hub genes were obtained and were considered to be closely related to NPC. GSE102349 dataset was devoted to identifying prognostic hub genes by survival analysis. The expression of IL33, MPP3 and SLC16A7 in GSE102349 dataset was significantly correlated with the progression-free survival (PFS). The results of qPCR indicated a strong correlation between SLC16A7 expression and the overall survival (OS). WGCNA contributed to the detection of gene modules and identification of hub genes and crucial genes. These crucial genes might be potential targets for pharmaceutic therapies with potential clinical significance. [ABSTRACT FROM AUTHOR]

To find an optimal economic solution for solar district heating (SDH) in China, an evaluation model based on the levelized cost of heat (LCoH) is developed. A Python program is developed to calculate the LCoH of SDH systems using the quasi-dynamic test method. Based on these calculations, the trend of LCoH with solar collector area under different heating load intensities, heating terminal units, heated areas and land rents is discussed. The optimal solar collector area and the solar fraction are determined for combinations of solar thermal with four types of auxiliary heat sources, including air source heat pumps, ground source heat pumps, gas boilers and gas boilers with seasonal heat storage. The calculations show an economic optimal solar fraction of 11%–33% for a SDH system with heat pumps. High dependency of LCoH on network temperature is found for a SDH system with gas boilers. Seasonal heat storage minimizes LCoH of a SDH system with gas boilers at 100% solar fraction. The findings can be used as a reference for local authorities, consultants and engineers in the early energy planning to determine the optimal proportion of solar energy in a district heating system with the lowest operating cost. • An optimal solar fraction of 11%–33% for a SDH system with heat pumps. • High dependency of LCoH on network temperature for a SDH system with gas boilers. • Heat storage minimizes LCoH of a SDH system with gas boilers at 100% solar fraction. • The higher the heat demand, the greater the solar contributed economic benefits are. • With biomass >1100 CNY/ton, the biomass heating system reduces LCoH by adding solar. [ABSTRACT FROM AUTHOR]

Oxidative stress is the downstream of various adverse stresses which impairs meat quality of broiler chickens. Yet, the specific molecular mechanisms of oxidative stress in meat quality of broiler thigh muscle remains unclear. This study investigated the effects and mechanisms of H 2 O 2 -induced oxidative stress on meat quality of broiler thigh muscle, with particular emphasis on apoptosis and autophagy and the ROS/NF-κB signaling pathway. The results showed that 10%H 2 O 2 -treated broilers exhibited significantly higher drip loss and shear force and lower pH 24h and muscle weight. Moreover, the ROS formation, the contents of oxidation products, the expressions of caspases (3, 6, 8, 9), Beclin1, and LC3-II/LC3-I were significantly increased, whereas the levels of antioxidation products and the expression of phosphorylation of NF-κBp65 were significantly decreased. These findings from the present study indicating that H 2 O 2 -induced oxidative stress significantly impaired the meat quality by inducing apoptosis and abnormal autophagy via ROS/NF-κB signaling pathway in the broiler thigh muscle. [ABSTRACT FROM AUTHOR]

Highlights • The largest solar district heating market worldwide has been presented. • Characters of solar district heating plants in Denmark were summarized. • Possibility of solar district heating in smart renewable energy system was shown. • Potential trend of solar district heating plants in Denmark was discussed. Abstract Large solar collector fields are very popular in district heating system in Denmark, even though the solar radiation source is not favorable at high latitudes compared to many other regions. Business models for large solar heating plants in Denmark has attracted much attention worldwide. Denmark is not only the biggest country in both total installed capacities and numbers of large solar district heating plants, but also is the first and only country with commercial market-driven solar district heating plants. By the end of 2017, more than 1.3 million m2 solar district heating plants are in operation in Denmark. Furthermore, more than 70% of the large solar district heating plants worldwide are constructed in Denmark. Based on the case of Denmark, this study reviews the development of large solar district heating plants in Denmark since 2006. Success factors for Danish experiences was summarized and discussed. Novel design concepts of large solar district heating plants are also addressed to clarify the future development trend. Potential integration of large solar district heating plants with other renewable energy technologies are discussed. This paper can provide references to potential countries that want to exploit the market for solar district heating plants. Policy-makers can evaluate the advantages and disadvantages of solar district heating systems in the national energy planning level based on the know-how and experiences from Denmark. [ABSTRACT FROM AUTHOR]

Multiple studies have demonstrated that excessive glucose utilization is a common feature of cancer cells to support malignant phenotype. Acute myeloid leukemia (AML) is recognized as a heterogeneous disorder of hematopoietic stem cells characterized by altered glucose metabolism. However, the role of glucose metabolic dysfunction in AML development remains obscure. In this study, glucose and 2-Deoxy- D -glucose (2-DG) treatment were applied to analyze the relationship between glucose metabolism and cell survival. Cell Counting Kit-8 (CCK-8) and flow cytometry (FCM) assays were used to examine the cell viability and apoptosis rate. Glucose consumption and lactate production were measured to assess the glucose metabolism pathway. The results demonstrated that abnormally increased glucose effectively promoted proliferation of leukemic cells and inhibited cell apoptosis, while 2-DG ameliorated leukemic phenotypes. Importantly, glucose exposure induced active glycolysis by increasing glucose consumption and lactate production. Furthermore, the levels of key glycolysis-related genes glucose transporter 1 (GLUT1) and monocarboxylate transporter 1 (MCT1) were upregulated. Mechanistic investigations revealed that AKT/mTOR signaling pathway was activated in glucose condition. In conclusion, our findings indicate that glucose induced-AKT/mTOR activation plays a growth-promoting role in AML, highlighting that inhibition of glycolysis would be a vital adjuvant therapy strategy for AML. [Display omitted] • Glucose treatment promotes leukemic cell growth and inhibits cell apoptosis. • Glucose treatment induces glycolysis in leukemic cells. • AKT/mTOR signaling pathway is involved in glycolysis and leukemic cell survival. [ABSTRACT FROM AUTHOR]