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Several studies suggest a relation between repeated exposure to extremely thin bodies in media and the perceptual and emotional disturbances of body representation in anorexia nervosa (AN). In this study, we utilized an exposure paradigm to investigate how perceptual experience modulates body appreciation in adolescents with AN as compared to healthy adolescents. Twenty AN patients and 20 healthy controls were exposed to pictures of thin or round models and were then required to express liking judgments about bodies of variable weight. Brief exposure to round models increased the liking judgments of round bodies but not those of thin bodies in healthy adolescents. Furthermore, exposure to round models increased the liking judgments of both thin and round bodies in adolescents with AN. Patients did not show any change of liking judgments after exposure to thin models. These results point to weak norm-based reshaping of body appreciation in AN patients. [ABSTRACT FROM AUTHOR]

The assessment of schizotypy allows to identify people at risk to develop psychosis. For this purpose, psychometric tools have been developed, such as the Magical Ideation Scale (MIS). This scale investigates attenuated forms of thought transmission experiences, thought withdrawal and aberrant beliefs, related to positive schizotypy. This study aims at providing an Italian version of the MIS and its normative data in the general population from childhood to adulthood, being the first study evaluating subjects under 17 year-old. The Italian MIS version was translated by three independent operators and administered to 1378 non-clinical participants, stratified into four age groups (i.e., 8–13, 14–17, 18–24 and 25–34). The unidimensionality of the scale was supported, and its internal consistency was satisfactory (i.e., ordinal Cronbach's α s ranging from 0.86 to 0.90 in different age groups), as well as test–retest reliability (i.e., 1-month ICC of 0.82 in a retested sub-sample). Normative data for the age groups were provided. Specific gender and age-related differences in MIS score were found, i.e. females scored higher than males in the 25–34 age group, which in general, as a group, scored lower than all the other age groups. This study provided evidence of reliability for the Italian version of the MIS in childhood and adolescence, for the first time, as well as in adulthood, showing specific gender and age effects in the early adult cohort. [ABSTRACT FROM AUTHOR]

This fMRI study investigated the functional mechanisms related to mental simulation of abstract- and action-related words and measured the effect of the type of stimulus (Abstract vs. action verbs) and the type of task (imagery vs. control task) to explore how conceptual representations interact with processing demands. A significant task by stimuli interaction showed that action-related words activated the left sensorimotor cortex during explicit imagery (as compared to the control task), whereas abstract-related verbs did not automatically activate this area. Rather, as we made sure that Abstract verbs were not associated with motor states (as tested in a rating study of our stimulus list), imagery elicited by abstract verb processing (as compared to Action verbs, and controlled for letter detection) differentially activated a right hemisphere neural network including the right supramarginal (SMG) gyrus and the precuneus which might be related to mental imagery of emotion-related scenes and not to the semantics of the stimuli per se. Our results confirmed the view that the activation of the sensorimotor cortex during language processing of abstract- and action-related words is strategy-dependent. [ABSTRACT FROM AUTHOR]

Previous studies have shown that mindfulness meditation may improve well-being in healthy individuals and be effective in the treatment of mental and neurological disorders. Here, we investigated the effects of an 8-week mindfulness-mediation program on the personality profiles of three groups of healthy individuals with no previous experience with meditation as compared to a control group not enrolled in any training. Personality profiles were obtained through the Temperament and Character Inventory (Cloninger et al., 1993). In the experimental groups, significant increments after the training were obtained in all the three character scales describing the levels of self maturity at the intrapersonal (Self-Directedness), interpersonal (Cooperativeness), and transpersonal (Self-Transcendence) levels. No changes were found in the control group. Strikingly, these effects were significant only in those groups who were engaged in consistent daily meditation practice but not in the group who attended the meditation training but were less consistent in home practice. Since higher scores in the character scales are associated to a lower risk of personality disorder, we propose that the increase of self maturity after the training may be an important mechanism for the effectiveness of mindfulness-oriented meditation in psychotherapeutic contexts. [ABSTRACT FROM AUTHOR]

Highlights: [•] We analyzed navigation and exploration of an urban virtual environment by children with autism compared to children with typical development. [•] When the navigation was in an unfamiliar urban environment we found that children with autism spent significantly less time in freely exploration and explored fewer zones than controls. [•] By repeating the exploration with a game-like goal no differences are instead found between the two groups. [Copyright &y& Elsevier]

Abstract: Background: Developmental studies of temperament and character dimensions are crucial for a better understanding of how genetic and environmental factors interact in shaping individual personality. However, although several studies have been conducted in adults, a few studies have addressed the evaluation of temperament and character in children. Here, we tested the suitability of self-report evaluation and the developmental trend of temperament and character dimensions among school-aged children using an Italian version of the junior Temperament and Character Inventory (jTCI). Methods: The jTCI was completed by 572 Italian children (292 girls and 280 boys) aged 8 to 12 years. We evaluated the internal consistency of the 7 jTCI scales at each age, the intercorrelations between the scales, and the factorial model of the questionnaires. Furthermore, we tested the differences between the development of the temperament and character dimensions in girls and boys. Results: Although the data from 8-year children showed unacceptably low internal consistency, better reliability was observed for older children. Intercorrelations and factor analysis partially confirmed the hypothesized structure of the jTCI items, with problems observed for some items of the Novelty Seeking, Harm Avoidance, Reward Dependence (RD), and Self-Directedness scales. Furthermore, in keeping with previous studies, girls presented lower scores in Novelty Seeking and higher RD, Self-Directedness, and Cooperativeness scales than did boys, with the between-sex difference in RD becoming larger at older ages. Conclusions: Although the use of the self-administered jTCI in clinical settings should be cautious, it may serve as a useful complementary instrument to describe the development of personality in childhood. [Copyright &y& Elsevier]

Twenty-two control children (aged 6–12 years) and forty-three children with developmental language disorder (DLD) (aged 7–12 years) received a test of callosal transfer of tactile information. Among the children with dysphasia, 30 had a diagnosis of receptive dysphasia and 13 of expressive dysphasia. Both control children and children with DLD made a significantly larger number of errors in the crossed localization condition (implying callosal transfer of tactile information) versus the uncrossed localization condition. In the crossed localization condition, children with DLD made a significantly larger number of errors than controls, while no differences were found in the two groups of children with DLD. These data suggest that the corpus callosum may be involved in the pathogenesis of DLD. [Copyright &y& Elsevier]

Adaptive interoceptive awareness has been revealed to be an important factor for mental health. Touch is one of the modalities through which we perceive bodily feelings. In this pilot study, self touch's role in enhancing interoceptive awareness was investigated. It was tested by means of a Self Body Brushing (SBB) procedure, which entails self-administered brushing of the entire body. A pre vs. post three-arm design was used, with 49 healthy adult participants. The SBB training was delivered to a first group (N = 13) and a Mindfulness-Oriented Meditation (MOM) training to a second group (N = 15), considered as a reference intervention for promoting interoceptive awareness; a third group of inactive control participants (N = 14) was also included. Assessment included two self-report questionnaires: the Multidimensional Assessment of Interoceptive Awareness (MAIA) and the Perceived Stress Scale (PSS). In several MAIA scales significant changes were observed: for Noticing, Attention regulation and Body listening, an overall improvement was observed, which was particularly due to changes in the active groups (SBB and MOM); Emotional awareness and Self-regulation scores increased more in the SBB group than in the other two groups. In the PSS measure, the changes in the active groups did not produce a statistically significant effect relative to the control group. SBB led to improvements in several aspects of self-reported interoceptive awareness at least as well as mindfulness meditation training. Further studies could investigate the potential effectiveness of SBB for promoting individual psychophysical health and well-being, in particular in the case of body image disturbances. [ABSTRACT FROM AUTHOR]

Although religiousness and spirituality (RS) are considered two fundamental constituents of human life, neuroscientific investigation has long avoided the study of their neurocognitive basis. Nevertheless, recent investigations with brain imaging and brain damaged patients, and more recently with brain stimulation methods, have documented important associations between RS beliefs and experiences and frontoparietal neural activity. In this study, we further investigated how individuals' implicit RS self-representations can be modulated by changes in right inferior parietal lobe (IPL) excitability, a key region associated to RS. To this end, we combined continuous theta burst stimulation (cTBS), intermittent TBS (iTBS), and sham TBS with RS-related, Implicit Association Test (IAT) and with a control self-esteem (SE) IAT in a group of fourteen healthy adult individuals. A specific decrease of implicit RS, as measured with the IAT effect, was induced by increasing IPL excitability with iTBS; conversely cTBS, which is supposedly inhibitory, left participants' implicit RS unchanged. The performance in the control SE-IAT was left unchanged by any TBS stimulation. These data showed the causative role of right IPL functional state in mediating plastic changes of implicit RS. Implications of these results are also discussed in the light of the variability of behavioral effects associated with TBS. [ABSTRACT FROM AUTHOR]

Over 80% of the global population consider themselves religious, with even more identifying as spiritual, but the neural substrates of spirituality and religiosity remain unresolved. In two independent brain lesion datasets (N 1 = 88; N 2 = 105), we applied lesion network mapping to test whether lesion locations associated with spiritual and religious belief map to a specific human brain circuit. We found that brain lesions associated with self-reported spirituality map to a brain circuit centered on the periaqueductal gray. Intersection of lesion locations with this same circuit aligned with self-reported religiosity in an independent dataset and previous reports of lesions associated with hyper-religiosity. Lesion locations causing delusions and alien limb syndrome also intersected this circuit. These findings suggest that spirituality and religiosity map to a common brain circuit centered on the periaqueductal gray, a brainstem region previously implicated in fear conditioning, pain modulation, and altruistic behavior. [ABSTRACT FROM AUTHOR]

Abstract: This study aims to describe in detail the linguistic skills of a large group of SLI participants. Particular attention is paid to the analysis of age-related effects on their linguistic performance and to whether a linguistic assessment of a narrative task can capture language impairments that might not be adequately pointed out by standardized neuropsychological tests assessing linguistic functions. The narratives produced by 62 children diagnosed with SLI with mixed expressive–receptive disorders were compared to those provided by a group of 195 children with Typical Language Development matched for chronological age and level of formal education. Furthermore, an age-related groups’ performance analysis has been performed in order to determine possible correlations between patients’ ages and types of language impairment. The SLI participants produced an amount of words comparable to that produced by the control group, albeit in a simpler fashion, as their narratives were teeming with omissions and/or substitutions of bound and free morphemes. These data suggest that the domains of morphosyntax and syntax were particularly impaired. [Copyright &y& Elsevier]

• Systematic review of the impact of mindfulness meditation on the wandering mind. • Reviewed studies consider both first-person and behavioural/physiological measures of mind wandering. • Mindfulness-based trainings reduce mind wandering episodes. • Expert meditators self-report less task-unrelated thoughts than non-meditators. • Expert meditators show decreased Default Mode Network activity. Through the practice of Mindfulness Meditation (MM), meditators become familiar with the observation of ongoing spontaneous thoughts, while maintaining an attitude of openness and equanimity. The aim of this systematic review is to present a synthesis of available findings of the short and long-term effects of MM on mind wandering (MW). We included studies that considered both first-person and behavioral/physiological measures of MW. The search resulted in 2035 papers, 24 of which were eligible. Reviewed studies revealed a high heterogeneity in designs, outcome measures and interventions. Most of the pre-post intervention studies showed that a protracted practice of MM (at least 2 weeks) reduced MW, limiting its negative effects on different cognitive tasks. Cross-sectional studies highlighted differences between expert meditators and naïve individuals: meditators self-reported less MW and showed decreased Default Mode Network activity, during meditation and resting-state. Further studies are needed to replicate available findings and to more deeply explore how MW is influenced by meditation, also considering its qualitative characteristics that remain largely unexplored. [ABSTRACT FROM AUTHOR]

Background: The neuropsychological literature on preterm-born children with spastic diplegia due to periventricular leukomalacia is convergent in reporting deficits in non-verbal intelligence and in visuo-spatial abilities. Nevertheless, other cognitive functions have found to be impaired, but data are scant and not correlated with neuroimaging findings.Aims: This study analyzes the neuropsychological strengths and weaknesses in preterm-born children with spastic diplegia (pSD) and their relationships with neuroanatomical findings, investigated by a novel scale for MRI classification.Methods and Procedures: Nineteen children with pSD, mild to moderate upper limb impairment and Verbal IQ>80, and 38 normal controls were evaluated with a comprehensive neuropsychological battery (NEPSY-II), assessing Attention/Executive Functioning, Language, Memory, Sensorimotor, Social Perception and Visuospatial Processing domains. The MRIs were quantitatively scored for lesion severity.Outcomes and Results: The results showed that, beyond core visuo-spatial and sensory-motor deficits, impairments in attention and executive functions were present in more than half of the sample, particularly in children with damage to the anterior corpus callosum.Conclusions and Implications: The findings are discussed in terms of clinical and rehabilitative implications tailored for pSD subgroups diversified for neuropsychological and neuroanatomical characteristics. [ABSTRACT FROM AUTHOR]

Several studies in the literature have shown positive psychophysical effects during or immediately after mindfulness meditation. However, the extent to which such positive effects are maintained in real-life, stressful contexts, remains unclear. This paper investigates the effects of an 8-week mindfulness-oriented meditation (MOM) program on the psychological and physiological responses evoked by immersive virtual environments (IVEs) that simulate emergency situations that may occur in life. Before and after the 8-week period, healthy MOM participants and a group of controls not involved in any meditation course were administered self-report measures of mindfulness and anxiety, and acted in the IVEs while a set of physiological parameters were recorded. Responses of MOM participants to the immersive virtual experiences were different from those of controls. MOM participants showed increased mindfulness and decreased anxiety levels. They also showed decreased heart rate and corrugator muscle activity while facing IVEs. We explain these results in terms of the awareness and acceptance components of mindfulness. More generally, the present experimental methods could also open up new lines of research that combine psychological and physiological indices with ecologically valid stimuli provided by IVEs in an effort to increase understanding of the impact of mindfulness meditation on realistic life situations. [ABSTRACT FROM AUTHOR]

The present study explores the functional neuroanatomy of the phonological production system in an Italian aphasic patient (SP) who developed conduction aphasia of the reproduction type following brain surgery. SP presented with two peculiar features: (1) his lesion was localized in the superior temporal gyrus, just posterior to the primary auditory cortex and anterior/inferior to and neighboring the Sylvian parietal temporal (Spt) area, and (2) he presented with severely impaired repetition and spelling from dictation of words and pseudowords but spared reading-aloud of words and pseudowords. Structural, functional, fiber tracking and intraoperative findings were combined to analyze SP's pattern of performance within a widely used sensorimotor control scheme of speech production. We found a dissociation between an interrupted sector of the arcuate fasciculus terminating in STG, known to be involved in phonological processing, and a part of the arcuate fasciculus terminating in MTG, which is held to be involved in lexical-semantic processing. We argue that this phonological deficit should be interpreted as a disorder of the feedback system, in particular of the auditory and somatosensory target maps, which are assumed to be located along the Spt area. In patient SP, the spared part of the left arcuate fasciculus originating in MTG may support an unimpaired reading performance, while the damaged part of the left arcuate fasciculus originating in STG may be responsible for his impaired repetition and spelling from dictation. [ABSTRACT FROM AUTHOR]

Deficits in verbal working memory (vWM) have often been reported in children with Specific Language Impairments (SLIs) and might significantly contribute to their linguistic difficulties. The linguistic and narrative skills of a group of children with diagnosis of SLI were compared to those of a group of children with typical development. The linguistic assessment included a comprehensive analysis of their lexical, grammatical and narrative abilities. Overall, the participants with SLI had difficulties at all three levels of linguistic processing. The effect of vWM was marginal on lexical processing, significant on grammatical structuring, and null on narrative construction. [ABSTRACT FROM AUTHOR]

We describe involuntary language switching from L2 to L1 evoked by electro-stimulation in the superior temporal gyrus in a 30-year-old right-handed Serbian (L1) speaker who was also a late Italian learner (L2). The patient underwent awake brain surgery. Stimulation of other portions of the exposed cortex did not cause language switching as did not stimulation of the left inferior frontal gyrus, where we evoked a speech arrest. Stimulation effects on language switching were selective, namely, interfered with counting behaviour but not with object naming. The coordinates of the positive site were combined with functional and fibre tracking (DTI) data. Results showed that the language switching site belonged to a significant fMRI cluster in the left superior temporal gyrus/supramarginal gyrus found activated for both L1 and L2, and for both the patient and controls, and did not overlap with the inferior fronto-occipital fasciculus (IFOF), the inferior longitudinal fasciculus (ILF) and the superior longitudinal fasciculus (SLF). This area, also known as Stp, has a role in phonological processing. Language switching phenomenon we observed can be partly explained by transient dysfunction of the feed-forward control mechanism hypothesized by the DIVA (Directions Into Velocities of Articulators) model (Golfinopoulos, E., Tourville, J. A., & Guenther, F. H. (2010). The integration of large-scale neural network modeling and functional brain imaging in speech motor control. NeuroImage, 52, 862–874). [ABSTRACT FROM AUTHOR]

We explored implicit motor simulation processes in Parkinson's Disease (PD) patients with ON-OFF subthalamic deep brain stimulation (DBS) of the sub-thalamic nucleus (STN). Participants made lexical decisions about hand action-related verbs, abstract verbs, and pseudowords presented either within a positive (e.g., "Do …") or a negative (e.g., "Don't …") sentence context. Healthy controls showed significantly slower responses for hand-action verbs (vs. abstract verbs) in the negative (vs. positive) context, which suggests that negative contexts may suppress motor simulation or preparation processes. The STN-DBS improves cortical motor functions, thus patients are expected to perform at the same level as unimpaired subjects in the ON condition. By contrast, the 50% reduced DBS is expected to result in a reduced activation for motor information, which in turn might cause a reduced, if not absent, context modulation. PD patients exhibited the same pattern as controls when their DBS was at 100% ON; however, reducing the DBS to 50% had a deleterious outcome on the positive faster than negative context effect, suggesting that the altered inhibition mechanism in PD could be responsible for the missed effect. In addition, our results confirm the view that implicit motor simulation mechanisms behind action-related verb processing are flexible and context-dependent. [ABSTRACT FROM AUTHOR]

Abstract: The Iowa Gambling Task (IGT) analyzes the ability of participants to sacrifice immediate rewards in view of a long term gain. Anorexia Nervosa (AN) in addition to weight loss and body image disturbances is also characterized by the tendency to make decisions that may result in long-term negative outcomes. Studies that analyzed IGT performance in patients with AN were not consistent with each other. Fifteen adolescents with AN and 15 matched controls carried out IGT after being clinically and neuropsychologically evaluated. An interesting generalized estimating equation approach showed that four independent clinical variables, and not the group, explained IGT performances, such as blocks repetition, anxiety, psychogenic eating disorders and self transcendence. The impairment of decision making is not related to the diagnosis of AN, but it is driven by high levels of anxiety and self transcendence. Instead, some psychogenic eating disorders traits, related to illness severity, positively affected IGT performance in the whole sample. IGT impairment in AN found by prior studies could be related to these clinical features which are not always taken into account. [Copyright &y& Elsevier]

Abstract: Expertise offers a unique insight into how our brain functions. The purpose of this experiment was to determine if motor system activity and functional connectivity between the cognitive system and sensorimotor system is differentially modulated by an individual's level of expertise. This goal was achieved through the acquisition of functional neuroimaging data in 10 expert volleyball players and 10 novice individuals who were presented with a series of sentences describing possible technical volleyball-specific motor acts and acts that cannot be performed as positive (“Do …!”) or negative (“Don't …”) commands, while they were silently reading them and deciding whether the actions were technically feasible or not. Compared with novices, experts' activity in the left primary motor cortex hand area (M1) and in the left premotor cortex (Pm) was decreased by impossible actions presented as positive commands. Sensorimotor activation in response to action-related stimuli is not that automatic as held since we found that these areas were deactivated during the task, and their functional connectivity to the primary visual cortex was strengthened for possible actions presented as positive commands, reflecting the neural processes underlying the interaction between motor and visual imagery. These results suggest that the neural activity within the key areas implicitly triggered by motor simulation is a function of the expertise, action feasibility, and context. [Copyright &y& Elsevier]

Abstract: Thirteen bilingual patients with Parkinson''s disease and thirteen bilingual healthy controls matched for age, sex, formal education, and cognitive functioning were administered three linguistic tests of sentence comprehension and grammatical judgment in both native Azari (L1) and Farsi (L2) languages. Both groups had acquired L2 late (formal learning at primary school) and presented with mild cognitive impairment. Parkinson''s patients had greater linguistic impairments in L1 than L2, and they had greater L1 and L2 impairments than healthy controls. These findings strongly replicate previous ones (Zanini et al., 2004) and suggest that L1 grammar processing mainly recruits cortical-subcortical language networks in agreement with the Declarative/Procedural model of language acquisition (Paradis, 1994; Ullman, 2001) and that general cognitive functioning ought to be carefully investigated with respect to linguistic impairments in bilingual subjects, especially in the case of adult subjects with neurodegenerative disorders. [Copyright &y& Elsevier]

Abstract: Background: Extremely low birth weight (ELBW) infants, even those not presenting severe neuromotor sequelae, continue to be at risk of developing multiple, complex disorders involving the cognitive, emotional and behavioural domains. Follow-up protocols are able, in the short term, to identify subjects at risk of developing major sequelae, however they fail to identify all children at risk of developing disorders. Aims: To investigate the cognitive, neuropsychological and behavioural outcomes of a sample of ELBW children at the age of four years in order to identify characteristic profiles. Study design: Longitudinal study. Subjects: 16 healthy ELBW children born in 2005 and followed up until the age of four. Outcome measure: Performances on standardised tests evaluating intelligence, memory, cognitive visual functions, attention, and executive functions. Results: General intelligence was within normal range. Cognitive profile showed mild or moderate deficits with different levels of involvement in many of the examined functions, in particular executive functions, attention and naming. Conclusion: There emerged a wide-ranging spectrum of weaknesses and deficits involving all the functions examined, which together give rise to a dysexecutive syndrome. Analysis of cognitive profiles showed that the sample could be divided into two subgroups of subjects that differ in the quality of their global cognitive and behavioural functioning. Our results confirm the need to continue follow up of ELBW children until school age, as this will allow early detection of at-risk children and the planning of timely preventive interventions. [Copyright &y& Elsevier]

Abstract: Background: A combined protocol of voxel-based morphometry (VBM) and diffusion-weighted imaging (DWI) was applied to investigate the neurodevelopment of gray and white matter in autism. Methods: Twenty children with autism (mean age=7±2.75 years old; age range: 4–14; 2 girls) and 22 matched normally developing children (mean age=7.68±2.03 years old; age range: 4–11; 2 girls) underwent magnetic resonance imaging (MRI). VBM was employed by applying the Template-o-Matic toolbox (TOM), a new approach which constructs the age-matched customized template for tissue segmentation. Also, the apparent diffusion coefficients (ADC) of water molecules were obtained from the analysis of DWI. Regions of interests (ROIs), standardized at 5 pixels, were placed in cortical lobes and corpus callosum on the non-diffusion weighted echo-planar images (b =0) and were then automatically transferred to the corresponding maps to obtain the ADC values. Results: Compared to normal children, individuals with autism had significantly: (1) increased white matter volumes in the right inferior frontal gyrus, the right fusiform gyrus, the left precentral and supplementary motor area and the left hippocampus, (2) increased gray matter volumes in the inferior temporal gyri bilaterally, the right inferior parietal cortex, the right superior occipital lobe and the left superior parietal lobule, and (3) decreased gray matter volumes in the right inferior frontal gyrus and the left supplementary motor area. Abnormally increased ADC values in the bilateral frontal cortex and in the left side of the genu of the corpus callosum were also reported in autism. Finally, age correlated negatively with lobar and callosal ADC measurements in individuals with autism, but not in children with normal development. Conclusions: These findings suggest cerebral dysconnectivity in the early phases of autism coupled with an altered white matter maturation trajectory during childhood potentially taking place in the frontal and parietal lobes, which may represent a neurodevelopmental marker of the disorder, possibly accounting for the cognitive and social deficits. [Copyright &y& Elsevier]

Abstract: The cognitive profile of individuals with Williams'' Syndrome (WS) shows peaks and troughs, with fairly good linguistic performance and a well described weakness in visual-spatial abilities. This study aims to describe in detail the narrative abilities of a group of 9 WS participants who underwent careful cognitive evaluation to assess their visual-spatial abilities, sustained attention, phonological short-term memory and lexical as well as grammatical skills in tests of expressive and receptive language. Furthermore, they performed a picture-description task in order to elicit more fluid and communicative speech samples, which were then compared with those provided by a group of 29 children with typically developing language (TD) matched for mental age. The WS participants showed visual-spatial deficits but scored within the normal range, according to their mental age, in the linguistic assessment. For the narrative task, they showed good phonological, lexical and syntactic skills, but their story descriptions were less effective than those produced by the TD group on measures assessing global coherence and lexical informativeness, showing dissociation between macro and microlinguistic abilities. These impairments were not correlated to the visual-spatial disturbances. These data suggest that the domain of discourse processing is a relative weakness in WS individuals. [Copyright &y& Elsevier]

Cognitive reserve (CR) theory suggests that individual differences in general intelligence (IQ), occupational attainment or participation in leisure/recreational activities protect against cognitive decline. However the relationship between CR and cognitive functioning in patients with brain tumours has been very rarely investigated in past research. The present study systematically assesses whether CR concept can also be applied to cognitive functions of neurosurgical patients affected by brain tumours. We investigated the role of different CR proxies (education level, premorbid IQ, current IQ, working and leisure activity) in protecting language against brain tumours and surgery effects, considering interactions with demographic (sex/age), anatomical (hemisphere/lobe location of lesion) and clinical/biological variables (tumour type: High/Low Grade Glioma or Meningioma; lesion volume; lesion aggressiveness). One-hundred patients undergoing neuropsychological assessment before and immediately after surgery participated. A "Language Score" summarizing performance on all language tests was derived with Principal Component Analysis. Data were then analyzed with Multiple Regression and Classification and Regression Tree analyses to investigate possible relationships between predictors (CR proxies and clinical variables) and Language Score. We found that premorbid IQ was the best predictor of pre-operatory language integrity, above and beyond all clinical variables considered, also moderating lesion volume effects. Moreover, patients with lower pre-operatory language integrity and low-to-moderately aggressive tumours showed a mitigating effect of current IQ over surgery consequences. Results thus suggest that different CR proxies play a role in moderating cognitive decline following brain tumours and surgery. • CR best predicted pre-operatory language integrity beyond all clinical factors considered. • CR mitigates the impact of tumour volume over language functions. • CR seems to show also some mitigating effect over surgery impact. [ABSTRACT FROM AUTHOR]

Objective The aim of this work is to provide an in-depth investigation of the impact of low-grade gliomas (LGG) and their surgery on patients' cognitive and emotional functioning and well-being, carried out via a comprehensive and multiple-measure psychological and neuropsychological assessment. Patients and Methods Fifty surgically treated patients with LGG were evaluated 40 months after surgery on their functioning over 6 different cognitive domains, 3 core affective/emotional aspects, and 3 different psychological well-being measures to obtain a clearer picture of the long-term impact of illness and surgery on their psychological and relational world. Close relatives were also involved to obtain an independent measure of the psychological dimensions investigated. Results Cognitive status was satisfactory, with only mild short-term memory difficulties. The affective and well-being profile was characterized by mild signs of depression, good satisfaction with life and psychological well-being, and good personality development, with patients perceiving themselves as stronger and better persons after illness. However, patients showed higher emotional reactivity, and psychological well-being measures were negatively affected by epileptic burden. Well-being was related to positive affective/emotional functioning and unrelated to cognitive functioning. Good agreement between patients and relatives was found. Conclusions In the long-term, patients operated on for LGG showed good cognitive functioning, with no significant long-term cognitive sequelae for the extensive surgical approach. Psychologically, patients appear to experience a deep psychological change and maturation, closely resembling that of so-called posttraumatic growth, which, to our knowledge, is for the first time described and quantified in patients with LGG. [ABSTRACT FROM AUTHOR]