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Contaminants of emerging concern, including pharmaceuticals, are commonly found in wastewater from households, farms, and healthcare facilities. When active pharmaceutical ingredients enter water sources, they contaminate the waterways and cause potential hazard effects on the aquatic environment and human populations. This concern is especially critical with antibiotics, due to the development of antibiotic-resistant bacterial strains. However, Florfenicol, a bacteriostatic antibiotic widely used in veterinary medicine, poses a significant risk of water pollution when discharged into waterways. In the present study and its practical application, removal of targeted pollutant namely antibiotic florfenicol by ozonation was investigated by measuring chemical oxidation demand (COD), biochemical oxygen demand (BOD), and turbidity for pharmaceutical wastewater in the batch reactor, while optimizing feeding electro flocculation voltage, O 3 flow rate, O 3 dosage and ceramic membrane filtration. Due to the production of hydroxyl radicals with strong oxidation properties, pollutants in wastewater can be effectively degraded via heterogeneous catalytic ozonation. It was examined whether the regenerated catalyst exhibited good catalytic activity after three cycles of washing with Milli-Q water and ethanol. The results show that the effluent concentration of antibiotic Florfenicol is about 99% alongside residual values for 91%, 79%, and 89% for COD, BOD, and turbidity, respectively (Time: 30 min, pH: 7.5). Meanwhile, the wastewater's degradability capacity (BOD 5 /COD ratio) increased from 0.37 to 0.53, rendering it more readily biodegradable for further treatment. These results indicate that the process of hybrid electro flocculation and catalytic ozonation with ceramic membrane has a high treatment efficiency for veterinary antibiotics, and a continuous-flow reactor can be utilized more practically for a full-scale industrial application. [Display omitted] • The veterinary antibiotic Florfenicol (FF) was treated using a hybrid method. • Novel catalyst Mg-Fe-Co-Zeolite 5Aº was prepared and applied in hybrid treatment. • BOD 5 and COD pollutant values meet the Punjab Environment Quality Standards by applying a hybrid process. • Biodegradability, as measured by the BOD 5 /COD ratio, was enhanced from 0.37 to 0.53. [ABSTRACT FROM AUTHOR]

Disordered osteoclast activity has been implicated in the pathogenesis of gouty bone erosion. We sought to determine if the addition of denosumab (a monoclonal antibody targeting the receptor activator of nuclear factor kappa-B ligand - RANKL) to intensive urate-lowering therapy (ULT) improves gouty bone erosion. Open-label, parallel-group pilot randomized controlled trial in which 20 participants with gout with at least one confirmed conventional radiographic foot bone erosion were assigned in a 1:1 allocation to receive denosumab (60 mg subcutaneous every 6 months) added to intensive ULT (serum urate ≤5 mg/dL or 300 µmol/L at the time of randomization and continued for the duration of the study), or intensive ULT alone. The primary outcome was the change in the bilateral foot and ankle computed tomography (CT) bone erosion score from baseline to 12 months, assessed by an experienced musculoskeletal radiologist blinded to study assignment. Secondary outcomes included change in serum C-terminal telopeptide (CTX), and patient reported outcomes of pain and function. Although serum CTX declined markedly in the denosumab/ULT group compared with the ULT alone group, there was no interval change in CT erosion score in either the denosumab/ULT or ULT alone group after one year of follow-up. Other secondary outcomes did not differ between groups. There were two severe adverse events: One patient developed atrial fibrillation (on denosumab/ULT) and another atrial flutter (on ULT alone). In this pilot study, denosumab did not offer additional benefit to intensive urate lowering therapy for gouty bone erosion. [ABSTRACT FROM AUTHOR]

Dual energy computed tomography (DECT) allows direct visualization of monosodium urate crystal deposition in gout. However, DECT urate volume data are often highly skewed (mostly small volumes with the remainder considerably larger), making statistical analyses challenging in longitudinal research. The aim of this study was to explore the ability of various analysis methods to normalise DECT urate volume data and determine change in DECT urate volumes over time. Simulated datasets containing baseline and year 1 DECT urate volumes for 100 people with gout were created from two randomised controlled trials. Five methods were used to transform the DECT urate volume data prior to analysis: log-transformation, Box-Cox transformation, log(X-(min(X)-1)) transformation; inverse hyperbolic sine transformation, and rank order. Linear regression analyses were undertaken to determine the change in DECT urate volume between baseline and year 1. Cohen's d were calculated as a measure of effect size for each data treatment method. These analyses were then tested in a validation clinical trial dataset containing baseline and year 1 DECT urate volumes from 91 people with gout. No data treatment method successfully normalised the distribution of DECT urate volumes. For both simulated and validation data sets, significant reductions in DECT urate volumes were observed between baseline and Year 1 across all data treatment methods and there were no significant differences in Cohen's d effect sizes. Normalising highly skewed DECT urate volume data is challenging. Adopting commonly used transformation techniques may not significantly improve the ability to determine differences in measures of central tendency when comparing the change in DECT urate volumes over time. [ABSTRACT FROM AUTHOR]

Rationale and Objectives: To evaluate the prevalence of physiologic pineal calcification, estimate observer variability, and examine the association with choroid plexus calcification. Materials and Methods: A retrospective review of hard copy head computed tomography films of 242 patients age younger than 16 years by two independent observers. Results: Physiologic pineal calcification was present in 20% of the whole group, in 39% of those 8-14 years age, in 8% of those younger than 10 years age, and in 1% of those younger than age 6 years. Observer agreement was very good (kappa = 0.72). Choroid plexus calcification was present in 16% and was four times as common in those with pineal calcification (38% versus 10%, P = .005), with very good observer agreement (kappa = 0.74). Conclusion: Physiologic pineal calcification is more common in children than previously reported, mostly because of improving computed tomography technology. There is an association with choroid plexus calcification. [ABSTRACT FROM AUTHOR]

: Rationale and ObjectivesThe authors'' purpose was to investigate the reliability of a personal computer (PC)–based display system compared with a workstation in the evaluation of rheumatoid arthritis on computed radiographs of the hands.: Materials and MethodsTwo radiologists on two occasions independently scored randomized computed radiographs of individual joints of the hands from 23 patients with rheumatoid arthritis and 14 control subjects. Each joint was scored from 0 (definitely normal) to 30 (severe disease) for each of four variables: soft-tissue swelling, osteopenia, erosions, and joint space narrowing. The observations were replicated on a picture archiving and communication system workstation and a PC. Intraobserver and interobserver reliability were calculated, as was the difference in scores between the two systems. The null hypothesis was that there was no difference between the workstation and the PC.: ResultsThe intraobserver reliability for normal versus abnormal joints was 73% with the workstation and 79% with the PC. The intraobserver reliability for workstation versus PC was 83%. There was moderate interreader reliability for both platforms (average κ statistic, 0.46 [workstation] vs 0.45 [PC]). Small differences in scores between platforms are probably due mostly to the ordinal nature of the scoring system.: ConclusionFor evaluating computed radiographs of the hands in early rheumatoid arthritis, a PC-based system provides results similar to those obtained with a workstation, at considerably reduced cost. [Copyright &y& Elsevier]

Predicting breast tissue motion using biomechanical models can provide navigational guidance during breast cancer treatment procedures. These models typically do not account for changes in posture between procedures. Difference in shoulder position can alter the shape of the pectoral muscles and breast. A greater understanding of the differences in the shoulder orientation between prone and supine could improve the accuracy of breast biomechanical models. 19 landmarks were placed on the sternum, clavicle, scapula, and humerus of the shoulder girdle in prone and supine breast MRIs (N = 10). These landmarks were used in an optimization framework to fit subject-specific skeletal models and compare joint angles of the shoulder girdle between these positions. The mean Euclidean distance between joint locations from the fitted skeletal model and the manually identified joint locations was 15.7 mm ± 2.7 mm. Significant differences were observed between prone and supine. Compared to supine position, the shoulder girdle in the prone position had the lateral end of the clavicle in more anterior translation (i.e., scapula more protracted) (P < 0.05), the scapula in more protraction (P < 0.01), the scapula in more upward rotation (associated with humerus elevation) (P < 0.05); and the humerus more elevated (P < 0.05) for both the left and right sides. Shoulder girdle orientation was found to be different between prone and supine. These differences would affect the shape of multiple pectoral muscles, which would affect breast shape and the accuracy of biomechanical models. • Differences in shoulder girdle joint orientations between prone and supine MRI • Personalization of a multi-body skeletal model using manually identified landmarks • Significant differences were found in the clavicle, scapula, and humerus orientation. • Shoulder position needs to be accounted for when performing biomechanics simulations. [ABSTRACT FROM AUTHOR]

The influence of ankle kinematics and plantar pressure from mid-range barefoot running on T2 relaxation times of tibiotalar cartilage is unknown. This study aimed to quantitatively evaluate the T2 relaxation time of tibiotalar cartilage and ankle biomechanics following 5 km barefoot running. Twenty healthy runners (who had no 5 km barefoot running experience) underwent 3.0-Tesla magnetic resonance (MR) scans and assessment of running gait before and after 5 km barefoot running. Participants were divided into two groups consisting of marathon-experienced (n = 10) and novice (n = 10) with equal number of males and females in each group. Three musculoskeletal radiologists measured T2 relaxation times in 18 regions of the ankle cartilage: anterior zone, central zone, and posterior zone, or lateral, middle, and medial sections in the sagittal plane. Three-dimensional ankle kinetics, kinematics, and plantar pressure were all also assessed during barefoot running. In the novice group, the T2 relaxation time in the posterior zone of tibial cartilage (p = 0.001) and lateral section in both tibial (p = 0.02) and talar (p = 0.02) cartilage were significantly increased after barefoot running. Ankle kinematics exhibited significant changes in females. Plantar loading was shifted from the medial to lateral aspect after running. This included a significant reduction in the loading under the toes and the 1st, 2nd and 3rd metatarsals, with a significant increase under the 4th and 5th metatarsals and lateral midfoot. The results suggest that plantar pressure may directly lead to local increases in cartilage T2 signal, which was not associated with changes in ankle kinematics. [ABSTRACT FROM AUTHOR]