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Pathogenic bacteria are closely associated with the occurrence, development and metastasis of oral squamous cell carcinoma (OSCC). Antibacterial therapy has been considered an enhancement strategy to suppress bacteria-associated tumors and promote anti-tumor immune responses. Herein, we developed an injectable adhesive hydrogel, PNIPAM/DL@TIR, for the in situ photothermal ablation and robust stimulation of antitumor immunity against OSCC colonized by Porphyromonas gingivalis (Pg), one of the major oral pathogenic bacteria. PNIPAM/DL@TIR, composed of poly(N-isopropylacrylamide), demethylated lignin, and TAT peptide-conjugated IR820, was prepared using a simple dissolve-dry-swell solvent exchange method. Upon 808 nm laser irradiation, PNIPAM/DL@TIR exerted photothermal effects to ablate Pg-colonized OSCC and generate dual tumor and bacterial antigens. Owing to its large number of catechol groups, PNIPAM/DL@TIR efficiently captured these antigens to form an in situ antigen repository, thereby eliciting robust and durable antitumor immune responses. Proteomic analysis revealed that the captured antigens comprised both tumor neoantigens and bacterial antigens. The catechol groups endowed PNIPAM/DL@TIR with antioxidant activity, which was also conducive to stimulating antitumor immunity. Altogether, this study develops an injectable adhesive hydrogel and provides a combination strategy for treating bacteria-associated OSCC. In this study, we developed an injectable adhesive hydrogel, PNIPAM/DL@TIR, for in situ photothermal ablation and robust stimulation of antitumor immunity against OSCC colonized by Porphyromonas gingivalis , one of the major oral pathogenic bacteria. PNIPAM/DL@TIR, which consists of poly(N-isopropylacrylamide), demethylated lignin, and TAT peptide-conjugated IR820 exhibited outstanding photothermal performance. Owing to the presence of catechol groups, PNIPAM/DL@TIR has good bioadhesive properties and can capture protein antigens to form in situ antigen repository, thus initiating robust and long-term antitumor immune responses. In addition, PNIPAM/DL@TIR exhibited strong antioxidant activity that is favorable for promoting antitumor immunity. In the mouse model of OSCC with bacterial infection, PNIPAM/DL@TIR not only ablated the primary tumors upon NIR laser irradiation, but also induced tumor and bacterial vaccination in situ to suppress distant tumors and lung metastasis. [Display omitted] [ABSTRACT FROM AUTHOR]

Heterocyclic organic semiconductors have attracted significant attention as photocatalysts for hydrogen evolution due to excellent absorbency and abundant active sites. Herein, we developed a dual heterocyclic (O/S) conjugated microporous polymer Py-Th-Fu, consisting of both the furan and thiophene heterocycles, for photocatalytic H 2 evolution. Compared with the furan O-heterocycle Py-Fu and thiophene S-heterocycle Py-Th, the Py-Th-Fu with the dual heterocyclic structure is more outstanding in regulating the optoelectronic properties, morphological properties, electric charge shift kinetics, and photocatalytic H 2 evolution activity. Computational analysis also elucidates the smallest hydrogen adsorption free energy of Py-Th-Fu, which suggests it is the most advantageous for hydrogen mass transfer in this dual heterocycle polymer. As a result, the synergistic combination of two different heteroatom catalytic sites enables the dual heterocycle Py-Th-Fu to afford enhanced catalytic activity with an optimal rate of 23.28 mmol g−1 h−1, which is nearly equal to 5.06 and 1.58 times that of the corresponding O- and S-containing single heterocycles Py-Fu and Py-Th under visible lighting (λ > 420 nm). Our study demonstrates that the dual heterocyclic strategy using ternary copolymerization to tune the optoelectronic properties may open the horizon for fabricating high-performance photocatalytic water splitting via sunlight-driven hydrogen evolution. [Display omitted] • We developed a CMP photocatalyst with double heterocyclic strategy. • This strategy regulated the morphological properties and charge transfer kinetics. • Double heterocycle exhibited better HER than the single heterocycle in CMPs. [ABSTRACT FROM AUTHOR]

Photocatalytic hydrogen evolution has attracted tremendous interest as it offers a process for generation of green hydrogen based on solar radiation. But the process is extremely complex as many factors influence photocatalytic hydrogen evolution. While novel photocatalysts such as MOFs, perovskites, conjugated polymers, carbon-based materials, quantum dots, and others face challenges such as stability and scalability, semiconductor photocatalysts and cocatalysts such as TiO 2 /Pt, Ni–CdS, CdS/ZnO, CdS/ZnS have the advantages of simplicity in synthesis, stability, and scalability. Despite decades of research, challenges such as charge separation, spectrum usage, low hydrogen generation efficiency, photocatalyst stability and scalability persist. This review discusses what has been achieved so far in the domain of photocatalytic hydrogen evolution and presents a critical analysis of challenges to be addressed in developing a robust and practical photocatalytic hydrogen generation system based on efficiency of photocatalysts and their stability and the extreme importance of efficient reactor designs. [Display omitted] • Challenges associated with photocatalytic hydrogen generation systems. • Photocatalysts, cocatalysts and their stability challenges in hydrogen evolution. • Potential of semiconductor nanostructures, plasmonic nanoparticles and QDs. • Importance of reactor designs in enhancing photocatalytic hydrogen evolution. [ABSTRACT FROM AUTHOR]

[Display omitted] Two novel conjugated polymers comprised of 2,3-R 2 -di- thieno[3,2- f :2 ' ,3 ' - h ]quinoxaline, where R is 3 ' -(octyloxy)- phenyl (P1) or 2 ' -(2-ethylhexyl)thiophen-4 ' -yl (P2), and 2,1,3-benzothiadiazole have been synthesized using the Stille cross-coupling reaction. The synthesized polymers were investigated as hole transport layer (HTL) materials in perovskite solar cells. Polymer P2 as an HTL material provided improved short-circuit current and open-circuit voltage and, correspondingly, enhanced power conversion efficiency of perovskite solar cells compared to that of polymer P1. [ABSTRACT FROM AUTHOR]

Dibenzothiophene-S,S-dioxide (BTDO) is one of the cutting-edge electron-acceptor monomers for designing conjugated polymer based organic materials toward photocatalytic H 2 production from water. Normally, structure design of BTDO containing donor-acceptor (D-A) polymer photocatalyst mainly focuses on screening electron-donor motifs, the importance of modification on BTDO molecular toward improving charge carrier separation and photocatalytic performance is always ignored. Herein, a novel thienyl-fused BTDO building block (BTDO-DT) is prepared and utilized to synthesize B-BTDO-DT polymer photocatalyst by Sonogashira-Hagihara cross-coupling polycondensation using 1,4-Diethynylbenzene (B) and BTDO-DT as monomers. Experimental and density functional theory (DFT) calculation results demonstrate that modification of BTDO by thiophene not only enlarges light absorption region and promotes photogenerated e−/h+ separation, but also decreases H atom adsorption free energy (ΔG H*) on oxygen atom in the O S O group. As a result, B-BTDO-DT exhibits an outstanding visible light induced photocatalytic H 2 production rate of 156.6 μmol h−1 using 30 mg catalyst without Pt cocatalyst, which is 4.5 times higher than that of B-BTDO. And the H 2 production rate of B-BTDO-DT is further improved to be 259.8 μmol h−1 with 2.0 wt% Pt as co-catalyst. The present work may open a new direction for the design of conjugated polymer based photocatalysts with high photocatalytic activities. A novel thienyl-fused Dibenzothiophene-S,S-dioxide (BTDO) building block (BTDO-DT) is prepared and utilized to synthesize B-BTDO-DT polymer photocatalyst, which exhibits wider visible light absorption region, quicker photogenerated e−/h+ separation and smaller H atom adsorption free energy (ΔG H*) when compared with B-BDTO polymer, resulting in 4.5 times improvement on photocatalytic H 2 production performance. [Display omitted] • Dibenzothiophene-S,S-dioxide is fused by thiophene to prepare B-BTDO-DT polymer. • B-BTDO-DT exhibits narrower band-gap and quicker e−/h+ separation than B-BTDO. • Photocatalytic H 2 production rate of B-BTDO-DT is 4.5 times higher than B-BTDO. [ABSTRACT FROM AUTHOR]

Recent progress in conjugated polymer photocatalysts has opened avenues for enhancing photocatalytic hydrogen production (PHP) activity through structural design. This study highlights the impact of the acceptor-to-donor feed ratio on PHP activity in copolymers, influencing their energy level structures. Five conjugated porous polymers (CPPs) were synthesized by adjusting the acceptor-to-donor molar ratio. Notably, at a 2:1 acceptor-to-donor ratio, the polymer demonstrated a high hydrogen evolution rate (HER) of 61.9 mmol g−1 h−1 under full arc irradiation without co-catalysts and an apparent quantum yield (AQY) of 7.77% at 475 nm. However, further increasing the proportion of the donor unit in the copolymers decreases their HER. Experiments and theoretical simulation characterized that the feed ratios effectively tune the polymer's molecular structure, hydrophilicity, band gap, and the generation and transport efficiency of photo-induced charge carriers, ultimately affecting the hydrogen production kinetics and efficiency. This research demonstrates that tuning the band structure and chemical compositions of CPPs through statistical copolymerization significantly impacts their PHP activity. [Display omitted] • Conjugated porous polymers (CPPs) with donor-acceptor type were prepared as photocatalysts. • PProDOT-didecyl was used as the donor unit to tune the energy levels of the CPPs. • BS-4 shows an impressive hydrogen evolution rate of 61.9 mmol g−1 h−1 under full arc free of co-catalyst. • The optimum donor-to-acceptor ratio is crucial for improved photocatalytic activity. [ABSTRACT FROM AUTHOR]

• The thermal-fluid-structure coupling method is proposed in this study. • Thermal deformation of the structure is considered in the proposed model. • The effect of low temperature on the compressor efficiency is analyzed. • The effect of the rotor deformation on the compressor performance is studied. • The effect of operating conditions on the compressor efficiency is investigated. The boil-off gas (BOG) twin-screw compressors are widely used in the transportation of liquefied natural gas. A thermal-fluid-structure (TFS) simulation model of the screw compressor is established based on the conjugated heat transfer and weak fluid-structure coupling method. The thermal deformation of the structure at a steady state is considered in the CFD simulation to improve the calculation accuracy. The accuracy of the calculation results was verified by the experiment on a high-speed oil-free twin-screw air compressor. The thermal performance and the compressor efficiencies at different operating conditions were obtained by simulations. It was found that the volumetric efficiency increased from 67 to 78 % while the isentropic efficiency increased from 64 to 75 % with increasing the suction temperature. The volumetric efficiency reduced from 76 to 71 % with increasing the discharge pressure while the isentropic efficiency reached the maximum value of 70 % when the discharge pressure was equal to the end-of-compression pressure. Besides, when the rotational speed was lower than 6000 rpm, increasing the rotational speed had a significantly positive effect on the compressor efficiencies. The volumetric efficiency increased slowly when the speed raised from 6000 to 10,000 rpm. The isentropic efficiency reached a maximum of 73 % at the speed of 8000 rpm, which decreased to 72 % at 10,000 rpm. [ABSTRACT FROM AUTHOR]

• A 3D size-dependent sliding contact model is established within the couple stress elasticity. • The analytical FRFs are derived with considerations of couple stress effects and transverse effects. • The effects of two additional intrinsic length-related parameters induced by couple stress theory are investigated. • The role of couple stress effects in size-dependent frictional sliding contact is studied. This work investigates a three-dimensional size-dependent frictional contact problem of a rigid spherical punch sliding on an elastic half-space. The size-dependent material behaviors are governed by the couple stress theory, and the corresponding frequency response functions, which include two additional length-related elastic parameters, are obtained. Based on the conjugate gradient method and the discrete convolution-fast Fourier transform algorithm, a semi-analytical model is established to predict the frictional size-dependent contact behaviors and then the detailed parameter analysis is performed. The transverse effects of the couple stress, which are induced due to the considerations of the two additional elastic parameters in couple stress theory, are investigated in the contact problems for the first time. And the dependences of the size-dependent contact behavior on the coupling effects of the friction and the two additional elastic parameters are presented. [ABSTRACT FROM AUTHOR]

Antibody drugs play a vital role in diagnostics and therapy. However, producing antibodies from mammalian cells is challenging owing to cellular heterogeneity, which can be addressed by applying droplet-based microfluidic platforms for high-throughput screening (HTS). Here, we designed an integrated system based on disulfide-bonded redox-responsive hydrogel beads (redox-HBs), which were prepared through enzymatic hydrogelation, to compartmentalize, screen, select, retrieve, and recover selected Chinese hamster ovary (CHO) cells secreting high levels of antibodies. Moreover, redox-HBs were functionalized with protein G as an antibody-binding module to capture antibodies secreted from encapsulated cells. As proof-of-concept, cells co-producing immunoglobulin G (IgG) as the antibody and green fluorescent protein (GFP) as the reporter molecule, denoted as CHO(IgG/GFP), were encapsulated into functionalized redox-HBs. Additionally, antibody-secreting cells were labeled with protein L-conjugated horseradish peroxidase using a tyramide amplification system, enabling fluorescence staining of the antibody captured inside the beads. Redox-HBs were then applied to fluorescence-activated droplet sorting, and selected redox-HBs were degraded by reducing the disulfide bonds to recover the target cells. The results indicated the potential of the developed HTS platform for selecting a single cell viable for biopharmaceutical production. [ABSTRACT FROM AUTHOR]

Poly(ethylene glycol) (PEG) is widely utilized as a hydrophilic coating to extend the circulation time and improve the tumor accumulation of polymeric micelles. Nonetheless, PEGylated micelles often activate complement proteins, leading to accelerated blood clearance and negatively impacting drug efficacy and safety. Here, we have crafted amphiphilic block copolymers that merge hydrophilic sulfoxide-containing polymers (psulfoxides) with the hydrophobic drug 7-ethyl-10-hydroxylcamptothecin (SN38) into drug-conjugate micelles. Our findings show that the specific variant, PMSEA-PSN38 micelles, remarkably reduce protein fouling, prolong blood circulation, and improve intratumoral accumulation, culminating in significantly increased anti-cancer efficacy compared with PEG-PSN38 counterpart. Additionally, PMSEA-PSN38 micelles effectively inhibit complement activation, mitigate leukocyte uptake, and attenuate hyperactivation of inflammatory cells, diminishing their ability to stimulate tumor metastasis and cause inflammation. As a result, PMSEA-PSN38 micelles show exceptional promise in the realm of anti-metastasis and significantly abate SN38-induced intestinal toxicity. This study underscores the promising role of psulfoxides as viable PEG substitutes in the design of polymeric micelles for efficacious anti-cancer drug delivery. This study emphasizes PMSEA's potential as a sulfoxide-containing polymer for anti-cancer drug delivery, offering an alternative to PEG in constructing polymeric prodrug micelles efficiently. [Display omitted] • Sulfoxide-containing polymer PMeSEA presents a promising alternative to PEG. • Micelles grafted with PMeSEA successfully diminish complement system activation. • Reducing complement activation enhances the antitumor activity of PMeSEA-micelles. [ABSTRACT FROM AUTHOR]

The emergence of antibiotic-resistant bacteria is a serious threat to public health. Antimicrobial peptides (AMP) are a powerful alternative to antibiotics due to their low propensity to induce bacterial resistance. However, cytotoxicity and short half-lives have limited their clinical translation. To overcome these problems, AMP conjugation has gained relevance in the biomaterials field. Nevertheless, few studies describe the influence of conjugation on enzymatic protection, mechanism of action and antimicrobial efficacy. This review addresses this gap by providing a detailed comparison between conjugated and soluble AMP. Additionally, commonly employed chemical reactions and factors to consider when promoting AMP conjugation are reviewed. The overall results suggested that AMP conjugated onto biomaterials are specifically protected from degradation by trypsin and/or pepsin. However, sometimes, their antimicrobial efficacy was reduced. Due to limited conformational freedom in conjugated AMP, compared to their soluble forms, they appear to act initially by creating small protuberances on bacterial membranes that may lead to the alteration of membrane potential and/or formation of holes, triggering cell death. Overall, AMP conjugation onto biomaterials is a promising strategy to fight infection, particularly associated to the use of medical devices. Nonetheless, some details need to be addressed before conjugated AMP reach clinical practice. Covalent conjugation of antimicrobial peptides (AMP) has been one of the most widely used strategies by bioengineers, in an attempt to not only protect AMP from proteolytic degradation, but also to prolong their residence time at the target tissue. However, an explanation for the mode of action of conjugated AMP is still lacking. This review extensively gathers works on AMP conjugation and puts forward a mechanism of action for AMP when conjugated onto biomaterials. The implications of AMP conjugation on antimicrobial activity, cytotoxicity and resistance to proteases are all discussed. A thorough review of commonly employed chemical reactions for this conjugation is also provided. Finally, details that need to be addressed for conjugated AMP to reach clinical practice are discussed. [Display omitted] [ABSTRACT FROM AUTHOR]

[Display omitted] A systematic study of the UV light-induced degradation of a series of structurally similar conjugated polymers revealed important relationships between the molecular structure of the used building blocks and photostability of the resulting materials. These findings form a set of important guidelines for future rational design of new absorber materials for efficient and stable organic solar cells. [ABSTRACT FROM AUTHOR]

The viologen component with redox activity in the ionic CMP serves as an electronic pump for donating electrons to and accepting electrons from sulfur species, which can facilitate the conversion of both solid lithium sulfide and soluble polysulfides. [Display omitted] The commercialization of lithium-sulfur (Li-S) batteries has been hindered by the shuttle effect and sluggish redox kinetics of lithium polysulfides (LiPSs). Herein, we reported a viologen-based ionic conjugated mesoporous polymer (TpV-Cl), which acts as the cathode host for modifying Li-S batteries. The viologen component serves as a reversible electron conveyer, leading to a comprehensive enhancement in the adsorption of polysulfides and improved conversion rate of polysulfides during the electrochemical process. As a result, the S@TpV-PS cathode exhibits outstanding cycling performance, achieving 300 cycles at 2.0 C (1 C = 1675 mA g−1) with low decay rate of 0.032% per cycle. Even at a high sulfur loading of 4.0 mg cm−2, S@TpV-PS shows excellent cycling stability with a Coulombic efficiency of up to 98%. These results highlight the significant potential of S@TpV-PS in developing high-performance Li-S batteries. [ABSTRACT FROM AUTHOR]

Donor-acceptor conjugated polymers have received significant attention as the most promising photocatalysts for efficient photocatalytic hydrogen production (PHP). Nonetheless, achieving high photocatalytic PHP performance relies on molecular framework design and the judicious selection of different structural units. Herein, benzotrithiophene (BTT) and triazine derivatives were used as the basic units of organic polymers, and two conjugated porous polymers (CPPs) named as CP1 and CP2 were successfully synthesized by Stille coupling reaction. Compared with benzene as the linkage unit of triazine, it is evident that the incorporation of the thiophene unit in CP2 broadens its light response range, and promotes the generation of electrons/holes induced by light. Density functional theory (DFT) calculations and femtosecond transient absorption(fs-TA) spectroscopy reveal that CP2 effectively inhibits the photogenerated electron-hole pair recombination and promotes carrier transport. Remarkably, CP2 with Pt co-catalyst exhibited a notably superior PHP performance compared with that of CP1 polymer, which achieved an impressive hydrogen evolution rate (HER) of 21702.4 μmol/g/h, surpassing CP1 by approximately 3.7 times. This work provides a new tactic for enhancing the intrinsic PHP activity and reveals the underlying mechanism for the enhanced photocatalytic activity by regulating the different structural units of the donor-acceptor conjugated polymers. [Display omitted] • Two conjugated porous polymers were constructed based on benzotrithiophen and triazine derivatives. • Polymers CP1 and CP2 were prepared from benzene and thiophene linked triazine derivatives, respectively. • The different linkage units contribute to the great difference in photocatalytic performance. • CP2 exhibited an ultrahigh hydrogen evolution rate 21702.4 μmol/g/h. • The thiophene unit in CP2 suppress recombination of photo-induced charge carriers and promote transport. [ABSTRACT FROM AUTHOR]

Therapeutic proteins often require needle-based injections, which compromise medication adherence especially for those with chronic diseases. Sublingual administration provides a simple and non-invasive alternative. Herein, two novel peptides (lipid-conjugated protamine and a protamine dimer) were synthesized to enable sublingual delivery of proteins through simple physical mixing with the payloads. It was found that the novel peptides promoted intracellular delivery of proteins via increased pore formation on the cell surface. Results from in vitro models of cell spheroids and human sublingual tissue substitute indicated that the novel peptides enhanced protein penetration through multiple cell layers compared to protamine. The novel peptides were mixed with insulin or semaglutide and sublingually delivered to mice for blood glucose (BG) control. The effects of these sublingual formulations were comparable to the subcutaneous preparations and superior to protamine. In addition to peptide drugs, the novel peptides were shown to enable sublingual absorption of larger proteins with molecular weights from 22 to 150 kDa in mice, including human recombinant growth hormone (rhGH), bovine serum albumin (BSA) and Immunoglobulin G (IgG). The novel peptides given sublingually did not induce any measurable toxicities in mice. [Display omitted] • Two novel derivatives of protamine were synthesized to facilitate sublingual delivery of proteins. • These protamine derivatives enable delivery of proteins up to 150 KDa by simple mixing. • The protamine derivatives promoted transcellular delivery by forming nanopores on cell surface. • These protamine derivatives were safe in mice. [ABSTRACT FROM AUTHOR]

In this study, cobalt phosphide (CoP 2) was synthesized onto a Nickel foam (NF) support via phosphorylation under an N 2 atmosphere. The resulting material was then coated with tetrahydroxyquinone (THQ), a conjugated microporous polymer, using a hydrothermal method. The as-synthesized CoP 2 /THQ@NF showed remarkable electrocatalytic performance for the hydrogen evolution reaction and excellent durability in acidic electrolytes. This was attributed to the synergistic effect of the NF support, CoP 2 , and THQ, which led to a modified electronic structure of CoP 2 and a high electron transfer rate of THQ. A low overpotential of 137 mV was required in a 0.5 M H 2 SO 4 solution to achieve a current density of 10 mA cm−2. • Integration of electrically conjugated polymers with non-precious metal phosphates boosts HER catalytic efficiency. • The development of CoP 2 /THQ@NF hybrid electrocatalysts through systematic methodological approaches is overviewed. • Merging organic polymers with inorganic materials elevates the catalytic prowess of non-precious metal catalysts. [ABSTRACT FROM AUTHOR]

Ideally, the dressings used in the clinic have characteristics that help the wound closure process. Among several factors that affect the success of this healing process, there is debridement. It manages the wound bed components and the re-epithelialization process. Still, the property of debridement is not generally associated with dressings. Here, we show a chemically modified bacterial cellulose film conjugated to a proteolytic enzyme, papain, as a dressing with debridement properties. Bacterial cellulose films were reacted with a spacer derived from succinic acid and finally had this enzyme covalently immobilized in its structure by an amide bond. FT-IR and UV–vis showed bands typically of bioconjugated polymer. Enzymatic immobilization was very effective under the conditions applied with high yield (33% w/w), and these remained activated after the coupling reaction. The bacterial cellulose film with the enzyme papain attached to it was also very compatible with fibroblast cells, suggesting that it could be a promising wound dressing material for future research. [ABSTRACT FROM AUTHOR]

Rational design of organic semiconductors with wide visible light absorption and quick charge separation is of great significance for photocatalytic hydrogen production form water. In this work, the chemical structure of a linear conjugated polymer composed of ethynyl-linked benzene (B) and 2,1,3-benzothiadiazole (BT) is regulated by thiophene (TP) and polycyclic aromatic hydrocarbons [naphthalene (N) and anthracene (A)], and series of polymers including B-BT-TP-x, N-BT-TP-x and A-BT-TP-x (x = 0.2, 0.4, 0.6, 0.8) are synthesized. After thiophene and polycyclic aromatic hydrocarbon regulation, the polymers exhibit strong absorption in the whole visible light region of 400->650 nm and quick internal charge separation and transfer. Visible-light-driven photocatalytic hydrogen production rates of the synthesized polymers follow the order of B-BT (170.0 μmol/h) < B-BT-TP-0.6 (735.3 μmol/h) < N-BT-TP-0.4 (841.5 μmol/h) < A-BT-TP-0.6 (969.2 μmol/h) using 30 mg catalyst with 1.0 wt% Pt as cocatalyst. In addition, high apparent quantum yield (AQY) values of 8.04%, 5.58% and 0.95% under 550 nm, 650 nm and 700 nm monochromatic lights are obtained using A-BT-TP-0.6 catalyst. The present work provides new insights into design of advanced organic semiconductors for highly efficient photocatalytic solar energy conversion. The modification of thiophene and PAHs enhanced the absorption of the linear conjugated polymer in the visible region of 400–650 nm and accelerated the separation and transfer of internal charge. [Display omitted] • The prepared conjugated polymer exhibits strong absorption in the visible light range of 400∼>650 nm. • A high rate of photocatalytic H 2 evolution of 969.2 μmol/h was achieved with 30 mg of catalyst. • The polymer exhibits high quantum yields at wavelengths of 550 and 700 nm, with values of 8.04% and 0.95%, respectively. • The introduction of polycyclic aromatic hydrocarbons enhance photo-induced charge separation efficiency. • Exploring the Impact of Polymers on Hydrogen Production Efficiency from the Perspective of Electronic Density. [ABSTRACT FROM AUTHOR]

Conjugated polymers such as polypyrrole, polyaniline, and polythiophene have developed as capable candidates for scaffold fabrication due to their electrical conductivity, tunable surface properties, and ability to deliver bioactive molecules. When blended with other biomaterials and nanoparticles enables the formation of composites that leverage the advantages of both components. The main focus areas of the review include the use of conjugated polymer-based composites (CPCs) for tissue engineering e.g., neural, cardiac, bone, and skin. Within each section, specific examples are provided of conjugated polymer-biomolecule composite systems that have been explored along with a discussion of their composition, fabrication, and performance for supporting cell growth and tissue regeneration. Finally, current challenges and future perspectives are discussed in applying CPCs toward engineering clinically relevant tissues and organs. Overall, this comprehensive review covers fundamental design considerations in developing conjugated polymer composite scaffolds and their emerging applications in tissue engineering. [Display omitted] [ABSTRACT FROM AUTHOR]

• A mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) model was developed for ligand-conjugated RNA therapeutics, with a focus on small interfering RNA (siRNA) conjugated with the tris N- acetylgalactosamine (GalNAc) 3 ligand. • This model incorporates competition between parent and formed active metabolite for asialoglycoprotein receptor (ASGPR)-dependent occupancy and hepatocyte uptake, considers intracellular sequestration and slow degradation, and downstream engagement of RNA-induced silencing complex (RISC) governing target mRNA degradation. • The model integrated published experimental data for givosiran and active AS(N-1)3′ givosiran, effectively captured plasma, liver, and kidney concentration-time profiles in rats and monkeys with successful prediction of givosiran plasma pharmacokinetics in humans. • An in vivo affinity (K D) value of 27.7 nM for tris GalNAc-ASGPR binding and weight-based allometric scaling exponents of −0.27 and −0.24 for SC absorption and intracellular (endolysosomal) degradation were estimated. • Decreased liver uptake efficiency and net-shifts in liver-to-kidney distribution ratios were simulated with increasing dose following IV and, to a lesser extent, following SC administration, explained by different ASGPR occupancy profiles resulting from the different dosing routes. Triantennary N -acetyl-D galactosamine (GalNAc) 3 -conjugated small interfering RNA (siRNA) have majorly advanced the development of RNA-based therapeutics. Chemically stabilized GalNAc-siRNAs exhibit extensive albeit capacity-limited (nonlinear) distribution into hepatocytes with additional complexities in intracellular liver disposition and pharmacology. A mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) model of GalNAc-siRNA was developed to i) quantitate ASGPR-mediated disposition and downstream RNA-induced silencing complex (RISC)-dependent pharmacology following intravenous (IV) and subcutaneous (SC) dosing, ii) assess the kinetics of formed active metabolite, iii) leverage, as an example, published experimental data for givosiran, and iv) demonstrate PK translation across two preclinical species (rat and monkey) with subsequent prediction of human plasma PK. The structural model is based on competition between parent and formed active metabolite for occupancy and uptake via ASGPR into hepatocytes, intracellular sequestration and degradation, and downstream engagement of RNA-induced silencing complex (RISC) governing target mRNA degradation. The model jointly and accurately captured available concentration-time profiles of givosiran and/or AS(N-1)3′ givosiran in rat and/or monkey plasma, liver, and/or kidney following givosiran administered both IV and SC. RISC-dependent gene silencing of ALAS1 mRNA was well-characterized. The model estimated an in vivo affinity (K D) value of 27.7 nM for GalNAc-ASGPR and weight-based allometric exponents of −0.27 and −0.24 for SC absorption and intracellular (endolysosomal) degradation rate constants. The model well-predicted reported givosiran plasma PK profiles in humans. PK simulations revealed net-shifts in liver-to-kidney distribution ratios with increasing IV and SC dose. Importantly, decreases in the relative liver uptake efficiency were demonstrated following IV and, to a lesser extent, following SC dosing explained by differential ASGPR occupancy profiles over time. [ABSTRACT FROM AUTHOR]

Dermal absorption of weak electrolytes applied to skin from pharmaceutical and cosmetic compositions is an important consideration for both their efficacy and skin safety. We developed a mechanistic, physics-based framework that simulates this process for leave on applications following solvent deposition. We incorporated this framework into our finite dose computational skin permeation model previously tested with nonelectrolytes to generate quantitative predictions for weak electrolytes. To test the model, we analyzed experimental data from an in vitro human skin permeation study of a weak acid (benzoic acid) and a weak base (propranolol) and their sodium and hydrochloride salts from simple, ethanol/water vehicles as a function of dose and ionization state. Key factors controlling absorption are the pH and buffer capacity of the dose solution, the dissolution rate of precipitated solids into a lipid boundary layer and the rate of conversion of the deposited solid to its conjugate form as the nonionized component permeates and (sometimes) evaporates from the skin surface. The resulting framework not only describes the current test data but has the potential to predict the absorption of other weak electrolytes following topical application. [Display omitted] • Weak electrolytes precipitated on skin as solids redissolve and penetrate the skin. • We model absorption as a function of dissolution rate, skin load and ionization state. • Skin pH recovers exponentially post-dose with a t 1/2 related to dose buffer capacity. • The model is calibrated based on in vitro permeation data for a weak acid and base. • The framework has potential to predict absorption of a wide range of electrolytes. [ABSTRACT FROM AUTHOR]

[Display omitted] • Our current study reports an active compound, namely bavachinin (BVC), protects high fat diet-induced nonalcoholic fatty liver disease in golden hamsters. • To identify the target of BVC, we introduce click chemistry-activity‐based protein profiling (CC-ABPP) technology, which is a chemical proteomic approach that identifies potential targets interacting with probe-conjugated compounds. • With the use of CC-ABPP, we identify proliferating cell nuclear antigen (PCNA) as the target of BVC. And validation experiments including Cellular thermal shift assay (CETSA), Drug affinity responsive target stability (DARTS), Surface-plasmon resonance (SPR) are carried out to verify the direct interaction between BVC and PCNA. • With the use of molecular docking and co-immunoprecipitation, BVC is proved to bind to the pocket of PCNA, facilitating the interaction between PCNA and DNA polymerase delta, while inhibits interaction between PCNA and p21. BVC's promotion on cell proliferation is then verified by CCK-8 staining, CFSE staining, and cell cycle assay. • In NALFD golden hamsters, BVC protects hepatocytes and inhibits hepatocytes apoptosis, through promoting liver regeneration. Besides, BVC also ameliorates hyperlipemia. Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease all over the world, and no drug is approved for the treatment of NAFLD. Bavachinin (BVC) is proven to possess liver-protecting effect against NAFLD, but its mechanism is still blurry. With the use of Click Chemistry-Activity‐Based Protein Profiling (CC-ABPP) technology, this study aims to identify the target of BVC, and investigate the mechanism by which BVC exerts its liver-protecting effect. The high fat diet induced hamster NAFLD model is introduced to investigate BVC's lipid-lowering and liver-protecting effects. Then, a small molecular probe of BVC is designed and synthesized based on the CC-ABPP technology, and BVC's target is fished out. A series of experiments are performed to identify the target, including competitive inhibition assay, surface-plasmon resonance (SPR), cellular thermal shift assay (CETSA), drug affinity responsive target stability (DARTS) assay, and co-immunoprecipitation (Co-IP). Afterward, the pro-regeneration effects of BVC are validated in vitro and in vivo through flow cytometry, immunofluorescence, and the terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL). In the hamster NAFLD model, BVC shows lipid-lowing effect and improvement on the histology. PCNA is identified as the target of BVC with the method mentioned above, and BVC facilitates the interaction between PCNA and DNA polymerase delta. BVC promotes HepG2 cells proliferation which is inhibited by T2AA, an inhibitor suppresses the interaction between PCNA and DNA polymerase delta. In NAFLD hamsters, BVC enhances PCNA expression and liver regeneration, reduces hepatocyte apoptosis. This study suggests that, besides the anti-lipemic effect, BVC binds to the pocket of PCNA facilitating its interaction with DNA polymerase delta and pro-regeneration effect, thereby exerts the protective effect against HFD induced liver injury. [ABSTRACT FROM AUTHOR]

A diffuse interface-lattice Boltzmann model is proposed for modeling conjugate heat transfer problems with imperfect interfaces. According to the continuity condition of heat flux and jump condition of temperature across the imperfect interface, a unified sharp interface equation of the temperature field with a singular source term in the composite media domain is established. Then a diffuse interface equation is obtained by making a smoothed approximation of the unified sharp interface equation. The novel diffuse interface equation is restructured into a second-order heat diffusion equation with an anisotropic diffusion coefficient tensor. To numerically solve the second-order anisotropic diffusion equation, a multiple-relaxation-time (MRT) lattice Boltzmann (LB) scheme is employed. Several numerical simulations of benchmark test examples with analytical solutions are carried out to demonstrate the accuracy of the present model, including the steady-state heat diffusion in a two-layer medium with a flat interface, steady heat diffusion in a square domain with a curved interface and unsteady-state temperature diffusion with two-layer media. The numerical results show that the phenomenon of temperature jump across the imperfect interface can be successfully and correctly captured. Moreover, as an example of practical application, the new proposed diffuse interface model is utilized to predict the effective thermal conductivity of porous media with thermal contact resistance at pore scale. The variation law of the effective thermal conductivity is obtained for each parameter by studying the effects of thermal conductivity ratios of the dual-component material, the shape and volume fraction of blocks in the material, the interfacial thermal conductance coefficient, and the number of blocks on the effective thermal conductivity. Both uniform and random pore structures are considered. The previous theoretical equations strongly support the validity of the present model. [ABSTRACT FROM AUTHOR]

While a number of enteric coatings and pH-sensitive oral delivery vehicles have been developed, they lack the ability to sufficiently protect proteins from proteolytic degradation once released from the carrier. In this work, we show that H-bonded, pH-sensitive poly(methacrylic acid-grafted ethylene glycol) glycol (henceforth designated as P(MAA-g-EG) gels) exhibit great promise as protein carriers, as they utilize poly(ethylene glycol) (PEG) chains to promote mucoadhesion in the small intestine, increasing the chances that the drug is released within the villus of the absorptive intestinal wall. Importantly, PEG was also conjugated to the B29-lysine (LysB29) position of insulin in order to protect the drug from proteolytic degradation once released in the small intestine and adhere the drug to the intestinal epithelium through improved mucoadhesion. PEG-conjugated (PEGylated) molecules were found to actively participate in the carrier loading and release mechanism, with the drug conjugate hydrogen bonding to the MAA while in the collapsed state and subsequently repulse the drug above the polymer's isoelectric point. This effect was enhanced through the evaluation of PEG graft density within the carrier. Cellular transport and changes in transepithelial resistance caused by the PEGylated insulin (PI) in the presence of P(MAA-g-EG) microparticles were analyzed using a 1:1 co-culture of human colon adenocarcinoma (Caco-2) and: the mucus-secreting human colon carcinoma cell(HT-29-MTX). Finally, the in vivo absorption of insulin was measured in Sprague-Dawley rats to ensure that the PEGylated insulin conjugates are biologically active, as well as to compare the bioavailability to control insulin. Collectively, these results lead toward the development of a novel system for improved insulin delivery, with improved stability of insulin through PEGylation. [Display omitted] [ABSTRACT FROM AUTHOR]

The interactions between polymers and the immune system remains poorly controlled. In some instances, the immune system can produce antibodies specific to polymer constituents. Indeed, roughly half of pegloticase patients without immunomodulation develop high titers of anti-PEG antibodies (APA) to the PEG polymers on pegloticase, which then quickly clear the drug from circulation and render the gout treatment ineffective. Here, using pegloticase as a model drug, we show that addition of high molecular weight (MW) free (unconjugated) PEG to pegloticase allows us to control the immunogenicity and mitigates APA induction in mice. Compared to pegloticase mixed with saline, mice repeatedly dosed with pegloticase containing different MW or amount of free PEG possessed 4- to 12- fold lower anti-PEG IgG, and 6- to 10- fold lower anti-PEG IgM, after 3 rounds of pegloticase dosed every 2 weeks. The markedly reduced APA levels, together with competitive inhibition by free PEG, restored the prolonged circulation of pegloticase to levels observed in APA-naïve animals. In contrast, mice with pegloticase-induced APA eliminated nearly all pegloticase from the circulation within just four hours post-injection. These results support the growing literature demonstrating free PEG may effectively suppress drug-induced APA, which in turn may offer sustained therapeutic benefits without requiring broad immunomodulation. We also showed free PEG effectively blocked the PEGylated protein from binding with cells expressing PEG-specific B cell receptors. It provides a template of how we may be able to tune the interactions and immunogenicity of other polymer-modified therapeutics. A major challenge with engineering materials for drug delivery is their interactions with the immune system. For instance, our body can produce high levels of anti-PEG antibodies (APA). Unfortunately, the field currently lack tools to limit immunostimulation or overcome pre-existing anti-PEG antibodies, without using broad immunosuppression. Here, we showed that simply introducing free PEG into a clinical formulation of PEG-uricase can effectively limit induction of anti-PEG antibodies, and restore their prolonged circulation upon repeated dosing. Our work offers a readily translatable method to safely and effectively restore the use PEG-drugs in patients with PEG-immunity, and provides a template to use unconjugated polymers with low immunogenicity to regulate interactions with the immune system for other polymer-modified therapeutics. [Display omitted] [ABSTRACT FROM AUTHOR]

[Display omitted] The synthesis of novel thiazolo[5,4- d ]thiazole-containing conjugated polymer was performed by three alternative methods, namely, by the Stille or Suzuki cross-coupling as well as microwave-assisted condensation reaction with carbonyl precursor and dithioxamide. The latter way is straightforward and efficient for the design of novel materials with desirable optoelectronic and physicochemical characteristics providing an encouraging hole-transport properties and comparable performance of perovskite solar cells. [ABSTRACT FROM AUTHOR]

Delivery of therapeutic substances into the brain poses a significant challenge in the treatment of neurological disorders. This is primarily due to the blood–brain barrier (BBB), which restricts access, alongside the limited stability and distribution of these agents within the brain tissue. Here we demonstrate an efficient delivery of microRNA (miRNA) and antisense RNA preferentially to neurons compared to astroglia in the brain of healthy and Alzheimer's disease mice, via disulfide-linked conjugation with poly(ß-L-malic acid-trileucine)-copolymer a biodegradable, amphiphilic, and multivalent platform. By conjugating a D-configured (D3)-peptide (vector) for specific targeting, highly efficient delivery across the BBB is achieved through the Low-Density Lipoprotein Receptor-Related Protein-1 (LRP-1) transcytosis pathway, amyloid beta (Aβ) peptides. Nanodrug distribution was determined by fluorescent labeling and analyzed by microscopy in neurons, astroglia, and in extracellular amyloid plaques typical for Alzheimer's disease. Whereas D-configured BBB-vectors can efficiently target neurons, L-configured (e.g., AP2-peptide) guided vector can only cross BBB but not seem to bind neurons. An analysis of post-injection fluorescence distribution, and RNA-seq followed by real-time PCR validation, confirmed a successful in vivo delivery of morpholino-miRNA-186 nanoconjugates into mouse brain. The size and fluorescence intensity of the intracellular nanodrug particulates were analyzed and verified by a competition with non-fluorescent conjugates. Differentially expressed genes (DEGs) from RNA-seq were identified in the nanodrug injected mice, and the changes of selected DEGs related to Alzheimer's disease were further validated by western blot and real-time PCR. Collectively, these results demonstrated that D3-peptide-conjugated nanopolymer drug is able to achieve neuron-selective delivery of miRNA and can serve as an efficient brain delivery vehicle in Alzheimer's disease (AD) mouse models. Graphical abstract: D peptides are used to facilitate polymeric nanodrugs containing nucleic acids to cross the BBB and preferentially target neurons or amyloid plaques in the Alzheimer's disease mouse brain. [Display omitted] [ABSTRACT FROM AUTHOR]

The stratiform manganese deposits, hosted within the Sausar Group of rocks, in Madhya Pradesh state of India, has undergone polyphase deformation and metamorphism. The region is an enterprising geosite to understand the lithological and tectonic control on manganese mineralization. We have carried out a conjugate remote sensing based analysis using Visible, Near Infrared and Short Wave Infrared bands (VIS-NIR-SWIR) of optical imagery from multiple sensors supplemented with analysis of L-band microwave data over the Balaghat district of Madhya Pradesh to delineate prospective areas for manganese exploration, supported by the lab and field-based evidence. The enhanced image products (i.e.band ratios, principal components) and spectral anomaly map derived from Advanced Space-borne Thermal Emission and Reflection Radiometer (ASTER) and Sentinel-2B multispectral bands are used to delineate the lithological contrast of the host rock and indicate key locales of mineralization. The geological structures interpreted using the merged product of Advanced Land Observation Satellite Phased Array L-band SAR (ALOS PALSAR −1), Landsat 8 PC bands (2 & 3) and the processed Horizontal Gradient Magnitude (HGM) from advanced satellite gravity model (EIGEN-6C4), illustrates the structural control on the mineralization. The petrological details derived from the host rock samples shows microstructures like micro-folding, foliations, quartz grain elongation etc., thus representing the microscale deformations within the rock units occurring in the area.The lab-based spectral signatures of manganese-bearing host rock was resampled to image spectra and spectral anomaly map using Constrained Energy Minimization (CEM), which shows good correlation with the existing mine locations. The information from remote sensing and lab analysis has been integrated thematically using the knowledge-based Weighted Sum Method (WSM) with existing mine locations as the training dataset. The derived mineral prospect map indicates several new areas of manganese prospectivity which can serve as a guide for detailed future explorations in the region. [ABSTRACT FROM AUTHOR]

A universal drug delivery system (DDS) with brain-targeted ability is demanded to enhance antiepileptic therapeutic efficacy and reduce side effects in multiple types of epileptic seizures. In this study, we reported a micelle-based DDS possessing the brain-targeted ability and electro-responsive feature for universal delivery of antiepileptic drugs (AEDs). The system is fabricated by ferrocene (Fc)-conjugated D-a-tocopherol polyethylene glycol succinate and amphiphilic block copolymer, which improve the drug encapsulation of different AEDs. Interestingly, the intrinsic nature of TPGS-Fc including transferrin receptor-mediated transcytosis and efflux pump inhibition endows the system with high permeability across the blood-brain barrier. Based on the hydrophobic-hydrophilic transition of Fc, the micelles can respond to epileptiform discharges and thus release the loaded AEDs. Improved antiepileptic efficacy of the micelles has been demonstrated in acute, continuous, and chronic epilepsy models. In summary, we have developed a universal micelle-based DDS for various AEDs delivery, which provides a promising approach to on-demand therapy of different epileptic seizures. Electro-responsive micelles with controlled release of various anti-epileptic drugs and brain-targeted ability are designed for improving drug concentration in epileptic foci and enhancing therapeutic efficacy. [Display omitted] • Electro-responsive micelle has ability of universal anti-epileptic drugs delivery. • Transferrin-mediated transcytosis and P-gp inhibition enhance the efficacy bypass BBB. • TFP exerts electro-responsive release and improve drug concentration in epileptic foci. • TFP enhances therapeutic efficacy of anti-epileptic drugs. [ABSTRACT FROM AUTHOR]

Signal transduction downstream of growth factor and immune receptor activation relies on the production of phosphatidylinositol-(3,4,5)-trisphosphate (PI(3,4,5)P3) lipids by PI3K. Regulating the strength and duration of PI3K signaling in immune cells, Src homology 2 domain–containing inositol 5-phosphatase 1 (SHIP1) controls the dephosphorylation of PI(3,4,5)P3 to generate phosphatidylinositol-(3,4)- bisphosphate. Although SHIP1 has been shown to regulate neutrophil chemotaxis, B-cell signaling, and cortical oscillations in mast cells, the role that lipid and protein interactions serve in controlling SHIP1 membrane recruitment and activity remains unclear. Using single-molecule total internal reflection fluorescence microscopy, we directly visualized membrane recruitment and activation of SHIP1 on supported lipid bilayers and the cellular plasma membrane. We find that localization of the central catalytic domain of SHIP1 is insensitive to dynamic changes in PI(3,4,5)P3 and phosphatidylinositol-(3,4)-bisphosphate both in vitro and in vivo. Very transient SHIP1 membrane interactions were detected only when membranes contained a combination of phosphatidylserine and PI(3,4,5)P3 lipids. Molecular dissection reveals that SHIP1 is autoinhibited with the N-terminal Src homology 2 domain playing a critical role in suppressing phosphatase activity. Robust SHIP1 membrane localization and relief of autoinhibition can be achieved through interactions with immunoreceptor-derived phosphopeptides presented either in solution or conjugated to a membrane. Overall, this work provides new mechanistic details concerning the dynamic interplay between lipid-binding specificity, protein–protein interactions, and the activation of autoinhibited SHIP1. [ABSTRACT FROM AUTHOR]

Nitrogen-coordinated metal catalyst has been regarded as a promising candidate for precious platinum for oxygen reduction reaction (ORR). However, controlling the structure and composition of coordinated metals in heterogeneous catalysts remains a synthetic bottleneck. Here, we design and fabricate π-conjugated polymer/CNTs heterointerfaces by polymerizing Co-BTA on CNTs. Co-BTA contains abundant Co–N 4 moieties and provides catalytic sites for ORR. CNT acts as a support and constructs the network for electron transport. Therefore, Co-BTA/CNT exhibits outstanding catalytic activity for ORR with comparable half-wave potential to commercial Pt/C. Furthermore, Co-BTA/CNT demonstrates better durability and methanol tolerance compared with Pt/C. Importantly, zinc-air batteries with Co-BTA/CNT have a maximum discharge power of 94.5 mW cm−2 and a high energy density of 985 Wh kg−1, superior to that with commercial Pt/C (51.5 mW cm−2, 930 Wh kg−1). This work paves a new avenue for precisely controlling nitrogen-coordinated metal catalysts for electrochemical energy conversion and storage. A π-conjugated polymer (Co-BTA) coating CNTs by using 1,2,4,5-Benzenetetramine tetrahydrochloride as ligands was fabricated, which contains controllable architectures with abundant Co–N 4 moieties and provides catalytic sites for ORR. [Display omitted] • π-conjugated polymer/CNTs heterointerfaces was designed and fabricated. • Co-TBA/CNT contains controllable architectures with abundant Co–N 4 moieties. • Co-BTA/CNT exhibits outstanding catalytic performance and better durability than Pt/C for ORR. [ABSTRACT FROM AUTHOR]

[Display omitted] Owing to considerable energy constraints and global warming phenomenon, to find alternative sources of renewable and affordable energy has become a highly prerequisite in this current era. Use of sustainable technologies in this regard for renewable fuel retention applications has become more beneficial in encouraging the broad usage of clean energy. Conjugated microporous polymers (CMPs) are a distinct family of composites, that merge extensive the π-conjugation with microporous structure. The CMPs have been recognized as an essential subclass of porous composites, ever since their development in 2007. The CMPs have been developed with a number of distinct configurations and characteristics, which allows for the versatility of conjugated framework cellular implementations and mesoporous structure. The exploration of CMPs in sustainable fuel devices is crucial for the development of CMP-based composites and their use in sustainability and environmental design. Numerous network developing processes and synthesized building components provide a huge heterogeneity of CMPs with various characteristics and design patterns. As a consequence, CMPs have been employed here for cathode/anode materials for lithium ion batteries (LIBs), sodium/potassium LIBs, supercapacitors, fuel cell electrode for solar cell, hydrogen storage materials, photocatalytic hydrogen and oxygen production reaction (HER, OER), photocatalytic CO 2 reduction and so on. Due to the large surface areas of these composites, the distinctive charge storage mechanisms found in CMPs are explored, and a synopsis of how CMPs might facilitate ultrafast in desirable variety is presented. In addition, an evaluation between CMPs and linear polymers is presented, which provides further assistance for the synthesis of active materials. The most significant shortcomings experienced by CMPs in the domains of energy production have been evaluated, and potential strategies, synthetic process with reactions, physiochemical properties along with morphology have been demonstrated. Thus, this review is intended to be an entertaining and motivating study in the scientific community of the energy storage experts. [ABSTRACT FROM AUTHOR]

HCl doped-copolymer of ortho phenylene diamine, meta phenylene diamine, and pyrrole terpolymers blend was synthesized. Physical vapor deposition was used to produce the terpolymer-blended thin films, allowing the creation of the fiber structure at a low deposition rate, with a chamber pressure of 5 × 10−5 mbar and a thickness of 100 ± 2 nm. The produced thin films of terpolymers blend were examined utilizing a combination of theoretical and experimental techniques including TD-DFT/DMol3, CATSTEP, FT-IR spectrum, XRD, and optical characterizations. According to XRD computations, the terpolymers blend had an average crystallite size of 190 ± 2 nm, while SEM measurements showed that the length of the fibers was ≅ 73 ± 2 μm. The blend of terpolymers displayed an absorbance of 1.83 at 612 nm. Additionally, the blend of terpolymers' indirect/direct bandgap and absorption index was observed with noticeable alterations. The molecular structure optimization and frequency calculations for the crystal models and isolated molecules were carried out using the materials studio 7.0 tool (TDDFT/DMol3 and CASTEP). The DFT-Gaussian09W-vibration values closely matched the experimental results in terms of structure and optical characteristics. The application of thin films in polymer solar cell applications looks promising due to the noticeable improvements in optical characteristics. [ABSTRACT FROM AUTHOR]

The extended π-conjugated system in polymer semiconductors holds a great potential in tuning the delocalized electrons for promoting photocatalytic efficiency. Herein, π-conjugate pyridine rings and nitrogen defects co-decorated polymer carbon nitride nanosheet (NCN-2AP-X) was constructed and applied in solar driven hydrogen (H 2) and hydrogen peroxide (H 2 O 2) production. Benefiting from synergistic effect of pyridine rings and N vacancies, the synthesized NCN-2AP photocatalyst with rich delocalized electrons indicates the extended light absorption range and improved carrier separation capability, particularly favoring the photocatalytic reactions. The optimal NCN-2AP-10 displayed an excellent H 2 production rate of 2.55 mmol g−1 h−1 under visible-light irradiation with apparent quantum efficiency (AQE) of 9.79% at 420 nm. Moreover, a H 2 O 2 production rate of 1.39 mmol L−1 h−1 was achieved by NCN-2AP-10 under monochromatic light (365 nm) irradiation. This work would provide a new view in designing the π-conjugated system incorporating metal-free photocatalysts for efficient H 2 and H 2 O 2 production. A π-conjugate pyridine rings and nitrogen defects decorated carbon nitride was developed, and exhibited photocatalytic activities in H 2 and H 2 O 2 production. [Display omitted] [ABSTRACT FROM AUTHOR]

Despite the potential of hexagonal boron carbon nitride (h-BCN) with a unique graphite-like structure in the field of photocatalysis, the serious photocarrier recombination caused by disordered charge transfer has limited its practical application. In this work, we propose a conceptual design of in-plane heterostructures consisting of graphene sheet and non-phase-separated borocarbonitride (G sheet –BCN) with micro π-conjugated heterointerface for directional utilization of disorder charge. The obtained G 150 –BCN exhibits 10 times longer carrier decay lifetime (16.82 ns) and 3.7 times higher CO yield (51.14 μmol g−1 h−1) than pristine BCN. It was confirmed by systematical characterizations and theoretical calculations that the micro π-conjugated heterointerface enables the directional transport of photo-induced electrons from BCN to graphene domains, resulting in enhanced carrier separation and CO 2 reduction efficiency. This work developed a unique synthetic route to the design and construction of heterojunction with proper interface and rational electronic structure for efficient separation of photoexcited charges. [Display omitted] • A conceptual design of in-plane Graphene sheet –BCN heterostructure was proposed. • The different work functions of two domains generated interfacial charge gradient. • The micro π-conjugated heterointerface enables directional utilization of disorder charge. • The carrier separation and CO 2 reduction efficiency was significantly enhanced. • The mechanism of photocatalytic performance enhancement has been proposed. [ABSTRACT FROM AUTHOR]

Semiconductor materials anchored with transition metal cluster are promising photocatalysts for photocatalytic hydrogen evolution. In this paper, Co, N-co-doped graphene modified thin mesoporous carbon nitride (Co-NG/TMCN) was be synthesized through electrostatic adsorption treatment. Extensive characterization was used to explore the morphology, structures and optical properties of the as-prepared photocatalysts. The 10 wt% Co-NG/TMCN exhibited the high photocatalytic hydrogen evolution rate (2949 μmol g−1) within 4 h visible light irradiation, which was about 113 times than that of the pure TMCN (26 μmol g−1). Co-NG material with excellent electrical conductivity played a major role in accelerating charge transfer from TMCN material to cobalt atomic clusters. The photocatalytic hydrogen evolution performance of Co-NG/TMCN material was effectively improved. Consequently, a feasible approach for doping transition metal clusters to enhance photocatalytic activity was provided. • The introduction of cobalt atomic clusters provided more active sites. • The synergy between Co, N-co-doped graphene and thin mesoporous carbon nitride was beneficial to the ficient separation of photogenerated electrons. • The low content cobalt atomic clusters were efficiently utilized to increase hydrogen production rate. [ABSTRACT FROM AUTHOR]

FeN 4 single-atom catalysts are among the most promising electrocatalysts for oxygen reduction reaction (ORR), which has important roles in energy conversion systems, such as fuel cells and metal-air batteries. It has been investigated that the activity of FeN 4 single-atom catalysts is highly dependent on the density and distance of the FeN 4 active centers. However, controllable synthesis of FeN 4 single-atom catalysts with designed active center distance and density is still a remaining difficulty. In this work, a series of pyridyl conjugated microporous polymers with varying types of nitrogen are used as precursors to synthesize carbonaceous single-atom ORR catalysts with different amounts of FeN 4 active centers. The influence of the nature of the nitrogen groups in the precursors on the number of FeN 4 active sites and the ORR activity trend of the obtained FeN 4 –C catalysts was investigated. The catalyst with the highest density of FeN 4 sites showed a high efficiency for ORR, making its application in Zn-air batteries promising. FeN 4 –C catalysts with different active site densities are synthesized by a series of pyridyl conjugated microporous polymers with different amount and position of N as precursors. The FeN 4 –C single-atom catalysts carbonized from polymeric precursors show increasing ORR activity with the increasing of active site density. The optimized FeN 4 –C-4 catalysts with the highest density of FeN 4 active sites show superior ORR performance than Pt/C and having potential for applications in Zn-air battery. [Display omitted] [ABSTRACT FROM AUTHOR]

[Display omitted] • Conjugated ladder polymer (cLP) synthesized in a flow reactor for the first time. • Multi-step synthesis was conducted in a single flow system. • Soluble cLPs obtained with controlled molecular weights (M n = 9.8–54.0 kDa) • Molecular weight-dependent material properties were characterized. The coplanar backbone of conjugated ladder polymers (cLPs) enhances electron transfer and π-π interactions, making cLPs promising materials for various applications in organic electronics and optoelectronics. Nevertheless, the limited solubility and intricate synthetic processes for cLPs make it challenging to control their molecular weight and corresponding properties, and pose as significant obstacles to their widespread application. Here, an n -type cLP, PNDI-2BocL, was synthesized using a flow reactor for the first time, with controlled molecular weights. The polymerization reaction conditions to synthesize a precursor polymer, PNDI-2Boc, were first optimized in flow, followed by sequential ladderization in batch through the injection of an acid solution. The reaction time of polymerization was varied from 7.5 to 15 min, yielding soluble PNDI-2BocL with a number-averaged molecular weight (M n) ranging from 9.8 to 54.0 kg/mol with a deviation of 11 %. Additionally, 15 min of polymerization and ladderization were successfully conducted in a single flow system sequentially for the first time. In the molecular weight-dependent studies, higher optical absorption at longer wavelengths, increased degrees of crystallinity, and higher electron mobilities in organic field-effect transistors (OFETs) were observed for higher molecular weight PNDI-2BocL. Our results highlight the importance of controlling the molecular weights of cLPs and demonstrate that the flow synthesis technique provides a viable solution for synthesizing soluble cLPs in a controlled, reproducible, and rapid manner. [ABSTRACT FROM AUTHOR]

[Display omitted] • CCPs have high conductivity, stability and multisites for redox activity. • CCPs show superiority in electrochemical energy storage. • The structure–property relationship of CCPs is summarized. • The challenges and possible strategies of CCPs for energy storage are discussed. Conjugated coordination polymers (CCPs), which are considered as special conductive MOFs (cMOFs), have aroused increasing interest in electrical-related applications owing to their predictable topological structures, excellent electrical conductivity, intrinsic redox activity and high stability. In this review, we will first demonstrate the superiority of CCPs as multifunctional materials in applications for electrochemical energy storage based on a comprehensive study of their chemical and structural properties. Then, the utilization of CCPs as electroactive materials in batteries and supercapacitors is presented, with emphasis on the recent progress in the study of structure–property relationships. Additionally, the potentials to further broaden the application of CCPs in lithium-sulfur and metal-air batteries by exploiting their inherent physical and chemical properties are summarized. Finally, the challenges and possible strategies of CCPs for energy storage are addressed, which may provide valuable information and insights for future applications of CCPs in electrochemical energy storage systems. [ABSTRACT FROM AUTHOR]

[Display omitted] • A COP photocatalyst named PDIN-PyN+ was synthesized by incorporating quaternary ammonium groups. • The hydrophilicity and light absorption region of PDIN-PyN+ were improved. • PDIN-PyN+ exhibited excellent removal performance for BPA and 2,4-D under visible light irradiation. • The degradation mechanism was investigated and ·O 2 –, 1O 2 , h+ were confirmed as the ROS. Conjugated organic polymers (COPs) originating from porphyrin and perylene bisimide exhibit promising capacity as photocatalysts benefiting from their inherent semiconducting characteristics, but most of them suffer from the hydrophobic properties, which strongly hinder their surface reactions and photocatalytic performance. To solve this problem, the quaternary ammonium groups were introduced into the porous skeleton of a COP-based photocatalyst (PDIN-Py) through Friedel-Crafts alkylation & Menschutkin reactions to yield a super-hydrophilic COP, denoted as PDIN-PyN+. Apart from the hydrophilicity, such post-modification strategy also enhances the visible light utilization, boosts the photogenerated carriers transport and endows PDIN-PyN+ with more positive zeta potential (21.9 mV), thus enhancing the electrostatic interaction with target anionic model pollutants including bisphenol A (BPA) and 2,4-dichlorophenoxyacetic acid (2,4-D) and improving the photocatalytic degradation performance. The removal efficiency (η) of PDIN-PyN+ towards 2,4-D (150 ppm) and BPA (20 ppm) can reach >99 % within 30 min under the irradiation of visible light, and the PDIN-PyN+ also exhibits excellent reusability and withstands various environmental influencing factors, thereby it shows great potential in real-water treatment scenarios. [ABSTRACT FROM AUTHOR]

With more than 5,740 tons of e-waste generated each year, this large amount of e-waste holds tremendous value. However, less than 20 % of e-waste is currently recycled. Therefore, the recovery of gold from e-waste using clean and efficient photocatalytic gold reduction strategies is promising. In our study, we propose a synergistic adsorption-photocatalytic gold recovery strategy and design a green and efficient photocatalyst named BTD-TEA (thiazolium-containing unit) for photocatalytic recovery of gold from e-waste. [Display omitted] • Thiazole-functionalized D-π-A CMP is innovatively applied to photocatalytic reduction of Au(III). • The BTD-TEA has larger dipole moment, inducing a giant built-in electric field. • The BTD-TEA exhibits a breakthrough gold recovery capacity (4052.8 mg g−1) under light irradiation. From the perspectives of environmental protection and efficiency, the use of clean and efficient photocatalytic reduction technology to recover gold from e-waste not only has a high economic value, but also reduces environmental pollution. However, it remains a challenge to construct adsorbents with simultaneously high photocatalytic activity, high stability, high capacity and high selectivity. Here, we demonstrate the application of D-π-A type thiazole-functionalized conjugated microporous polymer (termed BTD-TEA) for adsorption-photocatalytic recovery of gold from e-waste. The synthesized BTD-TEA not only have a narrow optical bandgap (1.75 eV) and excellent semiconductor properties, but also have ultra-high acid stability (stable in aqua regia). Surprisingly, BTD-TEA exhibits breakthrough gold adsorption capacity (4052.83 mg g−1), ultrafast adsorption kinetics, excellent selectivity and outstanding reusability under light conditions. This work provides a promising new adsorption-photocatalytic strategy for gold recovery from e-waste. [ABSTRACT FROM AUTHOR]

Large-scale incineration of e-waste will bring about severe environmental pollution. Recovery of gold from e-waste using green, efficient, low-energy, and secondary-pollution-free photocatalytic technology is recognized as one of the most promising technologies. Two-dimensional conjugated polymers are often employed for photocatalytic systems due to their structural diversity and stability. However, the efficiency of active site utilization in 2D materials still needs to be improved because the catalytic reduction centers are located in the basal layer and it is difficult for Au(III) to access them. Here, we report the first example of one-dimensional D-π-A conjugated polymers for photoenhanced gold recovery from e-waste. [Display omitted] • D-π-A 1D linear polymers is innovatively applied for photoenhanced gold recovery from e-waste. • The BTP-DET has larger dipole moment, inducing a giant built-in electric field. • The highly conjugated BTP-DET framework provides efficient charge separation and migration efficiency. • Under light irradiation, BTP-DET exhibited ultra-high gold recovery (2580.8 mg g−1). In principle, photocatalytic Au(III) reduction from e-waste using sunlight could provide a cleaner and more efficient alternative strategy to existing processes. Two-dimensional (2D) conjugated polymers are often employed for photocatalytic systems due to their structural diversity and stability. However, the efficiency of active site utilization in 2D materials still needs to be improved because the catalytic reduction centers are located in the basal layer and it is difficult for Au(III) to access them. Herein, we demonstrate the application of D-A and D-π-A type one-dimensional (1D) conjugated polymers for the photoenhanced gold recovery from electronic waste. The two synthesized 1D conjugated polymers, named BTP-DET (D-π-A type) and BTP-TDB (D-A type), exhibit a wide light absorption range and excellent chemical stability. Benefiting from the superior charge separation and migration efficiency of the D-π-A skeleton, BTP-DET exhibits a small optical band gap of 1.60 eV, which is significantly smaller than that of BTP-TDB (1.78 eV), and thus enables the extraction of the gold with a higher capacity of BTP-DET (2580.8 mg g−1) under visible light, than the BTP-TDB (2072.7 mg g−1). This work paves the way for exploring low dimensions of conjugated polymers for photocatalysis. [ABSTRACT FROM AUTHOR]

The mechanical properties of carbon fiber (CF) reinforced high-performance thermoplastic composites are significantly compromised due to inadequate interface bonding between CF and matrix. In this study, electrochemical polymerization techniques were employed to modify CFs with polypyrrole (PPy), poly-aniline (PANI), and poly- o -phenylenediamine (PoPd), to systematically investigate the impact of conjugated polymers on the interfacial properties of CF/copoly (phthalazinone ether sulfone ketone)s (PPESK) composites through a combination of experimental and molecular dynamics (MD) approaches. The findings revealed distinct differences among these conjugated polymers in terms of their effects on both IFSS and ILSS for CF/PPESK composites. Among all tested laminates, PoPd@CF-60s/PPESK exhibited the highest IFSS, ILSS and flexural strength values of 39.8 MPa, 75.6 MPa, and 1494 MPa, respectively, 94.1 %, 20.6 %, and 47.6 % higher than those of CF-desized/PPESK, without compromising CFs strength and thermal resistance of CF/PPESK composites. MD simulations combined with fracture morphology analysis confirmed that compatibility between conjugated polymers and matrix played a pivotal role in enhancing interface properties for CF/PPESK composites. Furthermore, the AFM outcomes demonstrated that the PoPd layer could serve as the modulus transition layer between the CF phase and the PPESK phase, which effectively enhancing the load transfer efficiency between the two phases under external forces. To summarize, this work presents a straightforward yet non-destructive approach that effectively enhances the interface strength within advanced CF reinforced high performance thermoplastic polymer composites (CFRHPTPs). [Display omitted] • Comprehensive evaluation of interfacial interactions through a combination of experimental and MD approaches. • The IFSS, ILSS, and flexural strength of CF/PPESK were enhanced by 94.1 %, 20.6 %, and 47.6 % respectively. • The mechanism of conjugated polymers to improve the interfacial adhesion was revealed systematically. [ABSTRACT FROM AUTHOR]

Solar interface evaporation technology can effectively draw fresh water from the abundant seawater by utilizing green and clean solar energy. Advanced photothermal conversion materials play a crucial role in solar interface evaporation. As an emerging class of crystalline conjugated polymers, COFs (Covalent Organic Frameworks) provide an ideal molecular platform for the design of photothermal conversion materials. However, the mechanisms in which COF nano-morphologies promote photothermal conversion and the interface evaporation process remain unclear. In this work, we take advantage of the highly designable structure and functionality of COFs and develop porphyrin squaric acid-based COF membranes by controlling the nucleation and growth of COF crystal templated by porphyrin self-assemblies. These membranes feature an intramolecular donor-acceptor (D-A) heterojunction structure favorable for photothermal conversion and a unique nanosheet array structure. The arrayed COF nanosheets enhance light absorption and reduce the enthalpy of water evaporation, thereby increasing the evaporation rate. The membrane achieves an evaporation rate of 2.32 kg m−2 h−1 and an evaporation efficiency of 85.7 %. The COF membrane enables solar-driven desalination and demonstrates long-term salt resistance. This work provides a practical approach for constructing interface evaporation materials with unique micro/nanostructures. [Display omitted] • COF-based photothermal membrane is designed with TAPP-SQ nanosheet arrayed architecture. • TAPP-SQ nanosheet array reduces water evaporation enthalpy by photothermal Marangoni effect. • TAPP-SQ nanosheet array and D-A structure effectively enhance light absorption. • High evaporation rate of 2.32 kg m−2 h−1 and solar-vapor efficiency of 85.7 % are demonstrated. [ABSTRACT FROM AUTHOR]

In this study, two conjugated polymers (CPs) featuring poly(phenylene butadiynylene) (PPB) were meticulously synthesized and composited with single-walled carbon nanotubes (SWCNTs) to investigate their thermoelectric properties and fabricate wearable thermoelectric generators (TEGs). These CPs, designated as P1 and P2 , were tailored with distinct side chain configurations by incorporating 2-butyloctyloxy and 6-(methyldioctylsilyl)hexyloxy groups, respectively. Notably, P2 , characterized by longer side chains with branchpoints farther from the backbone, exhibited planar backbone structure and enhanced solubility, consequently engendering stronger π–π interaction with SWCNTs and facilitating the disperse of SWCNTs through polymer wrapping at bundle surface. Such characteristics therefore contributed to the superior thermoelectric performances of the P2 /SWCNTs nanocomposite, yielding a higher power factor (PF) of 216.5 μW m−1 K−2 for the spin-coated film. Furthermore, the corresponding wearable TEGs, which were constructed through spray-coating with 14 legs, resulted in an output power of approximately 49.6 nW under a temperature difference of 25 K, exhibiting successful harvesting of waste heat. Further applications also demonstrated operational efficacy under diverse conditions. These findings not only underscored the significance of side chain engineering in tailoring the thermoelectric properties of CP/SWCNTs nanocomposites but also demonstrated the feasibility of fabricating high-performance wearable thermoelectric devices applicable in versatile contexts. [Display omitted] [ABSTRACT FROM AUTHOR]

The polymer dots (Pdots) prepared by the conjugated polymer (PFO, poly (9,9-dihexylfluorene-2,7-diyl)) have high fluorescence intensity and are often used in biological fluorescence imaging. However, due to the chain defects, the PFO Pdots suffer from stability issues such as photoinactivation and photobleaching. To solve this problem, we drew inspiration from the preparation process of organic planar light-emitting devices and added an optimization processing after Pdots was prepared. We used illumination as the driving force to activate defects on its chain, and ascorbic acid as a reducing substance to restore the chain defects of the polymer to a more stable state. Through this method, we increased the fluorescence intensity by nearly 1.9 times, and significantly improving their long and short-term stability. In addition, it ensures other properties remain unchanged. This optimization scheme is also fully compatible with the entire biological imaging process, ensuring that other important properties such as cytotoxicity do not undergo unnecessary changes. Furthermore, we conducted material characterization and theoretical simulation, revealing that the optimization scheme mainly serves to repair C-9 alkyl defects on the polyfluorene unit. This study has improved and enhanced the fluorescence performance of PFO Pdots, and also provides a way to optimize the treatment of other similar conjugated polymer material systems. [Display omitted] • Improvement a few defects on the main chain of polyfluorene and bringing its good fluorescence emission. • Improved the cell imaging performance of polyfluorene fluorescent probe while ensuring biosafety. • Quantum efficiency and long-term stability are significant improved. • Provide a model for optimization of polyfluorene materials. [ABSTRACT FROM AUTHOR]

Tetraphenylethylene (TPE) and its derivatives with tunable structure and excellent photoelectric performance have aroused great concern in the field of electrochemiluminescence (ECL), but improving their ECL efficiency remains an enormous challenge in ECL bioanalysis. Herein, an encapsulation-manipulated aggregation-induced ECL (EM-AIECL) strategy was explored to effectively boost the ECL efficiency of TPE. Large π-conjugated polymer poly[2,5-dioctyl-1,4-phenylene] (PDP) was creatively developed as encapsulation matrix to envelop TPE molecules via hydrophobic interactions. The resulting complex TPE@PDP nanoparticles (NPs) not only restricted the molecule motion of TPE due to space limitation, but also inhibited the aggregation-caused quenching effect caused by TPE crystals featuring dense aggregation structure. Furthermore, the robust electronic coupling between PDP and TPE aggregates enabled superior charge transport within TPE@PDP NPs, thus yielding strong AIECL. As compared to TPE crystals, TPE@PDP NPs showcased 3.87-fold enhancement of ECL intensity. Impressively, TPE@PDP NPs coupled a three-dimensional DNA walker-assisted multiple rolling circle amplification strategy to construct an ECL sensing platform for malathion analysis, and a wide linear range of 5.0 fM ∼ 0.5 μM and low limit of detection of 0.9 fM were obtained. EM-AIECL strategy provides a new idea for designing organic AIECL luminophors, and opens an avenue for detecting pesticides specifically and sensitively. • A simple encapsulation-manipulated aggregation-induced ECL strategy was proposed. • TPE was enveloped in inner core of poly[2,5-dioctyl-1,4-phenylene] (PDP) through hydrophobic interactions. • TPE@PDP NPs showcased an excellent AIECL emission. • A "signal on" ECL biosensor was constructed for sensitive malathion assay. [ABSTRACT FROM AUTHOR]

[Display omitted] • Effective synthesis of bistricyclic aromatic enes in high yield. • Tandem Suzuki coupling/Heck cyclization reaction in one pot. • Expanded application in the preparation of ladder-type polymer A variety of bistricyclic aromatic enes (BAEs) and its derivatives have been prepared via the palladium-catalyzed Suzuki coupling/Heck cyclization tandem reaction in one pot. In the new proposal the expected products were obtained in exciting yields at nearly equimolar ratios of the substrates. It is very useful method for the synthesis of the fluorenylidene-based BAEs. Even the corresponding ladder-type conjugated polymer was also prepared by the tandem reaction. [ABSTRACT FROM AUTHOR]