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Your search keyword '"Booker, Shon K."' showing total 2 results
Start Over Author "Booker, Shon K." Publisher elsevier b.v.
2 results on '"Booker, Shon K."'

1. Effect of microwave heating on Ullmann-type heterocycle-aryl ether synthesis using chloro-heterocycles

Author

D’Angelo, Noel D., Peterson, Joseph J., Booker, Shon K., Fellows, Ingrid, Dominguez, Celia, Hungate, Randall, Reider, Paul J., and Kim, Tae-Seong

Subjects
*DIRECT energy conversion, *ELECTRIC heating, *ORGANIC compounds, *AROMATIC compounds
Abstract

Abstract: Ullmann ether synthesis was conducted on a variety of chloro-heterocycles with different phenols using optimized conditions involving copper powder and cesium carbonate. On many substrates, microwave heating afforded higher yields in significantly shorter reaction times compared to conventional heating conditions. These findings provide a facile method for aryl ether synthesis from chloropyridines, chloroquinolines, and chlorobenzothiazoles. [Copyright &y& Elsevier]

Published
2006
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2. CC chemokine receptor-3 (CCR3) antagonists: Improving the selectivity of DPC168 by reducing central ring lipophilicity

Author

Pruitt, James R., Batt, Douglas G., Wacker, Dean A., Bostrom, Lori L., Booker, Shon K., McLaughlin, Erin, Houghton, Gregory C., Varnes, Jeffrey G., Christ, David D., Covington, Maryanne, Das, Anuk M., Davies, Paul, Graden, Danielle, Kariv, Ilona, Orlovsky, Yevgeniya, Stowell, Nicole C., Vaddi, Krishna G., Wadman, Eric A., Welch, Patricia K., and Yeleswaram, Swamy

Subjects
*CYTOCHROME P-450, *METALLOENZYMES, *MONOOXYGENASES, *NITROGEN excretion
Abstract

Abstract: DPC168, a benzylpiperidine-substituted aryl urea CCR3 antagonist evaluated in clinical trials, was a relatively potent inhibitor of the 2D6 isoform of cytochrome P-450 (CYP2D6). Replacement of the cyclohexyl central ring with saturated heterocycles provided potent CCR3 antagonists with improved selectivity against CYP2D6. The favorable preclinical profile of DPC168 was maintained in an acetylpiperidine derivative, BMS-570520. [Copyright &y& Elsevier]

Published
2007
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