Search

While many studies have established a positive correlation between adolescents' internet addiction and mental health problems, most of these studies have overlooked the internal heterogeneity of Internet addiction. This study aims to identify latent profiles among adolescents based on their Internet addiction and to examine the differences in aggression, depression, and anxiety across these profiles. We conducted a survey involving 7422 adolescents and administered the Young's Internet Addiction Test, Aggression Behavior Questionnaire, Patient Health Questionnaire-9, and Generalized Anxiety Disorder Scale. Latent profile analysis was utilized to categorize Internet addiction profiles among adolescents. Associations between Internet addiction profiles and related factors were examined using the Bolck-Croon-Hagenaars method. Latent profile analysis suggested four profiles of Internet addiction, which were labeled: Regular , Risk , Low Internet addiction , and Internet addiction. The Internet addiction profile showed higher levels of aggression, depression, and anxiety than the Low Internet addiction profile. The Low Internet addiction profile had higher levels of aggression, depression, and anxiety than the Risk profile. The Risk profile demonstrated higher levels of aggression, depression, and anxiety when compared to the Regular profile. Limitations include the cross-sectional design and the self-report measures. The identified Internet addiction profiles offer differential predictions for aggression, depression, and anxiety. These results underscore the significance of employing latent profile analysis when exploring the associations between Internet addiction and mental health issues. • There are four profiles of Internet addiction among adolescents. • The four profiles of adolescents' Internet addiction differentially predict aggression, depression, and anxiety. • When examining the associations between Internet addiction and mental health, considering the heterogeneity is crucial. • The findings provide implications for practice. [ABSTRACT FROM AUTHOR]

Smartphone addiction is an increasingly severe issue in modern society, particularly impacting the mental health of college students during the COVID-19 pandemic. This study aims to explore the relationship between smartphone addiction and mental health issues among college students, and the mediating and moderating roles of psychological resilience and parental attachment. We employed a cross-sectional study design with 100,097 college Chinese students to examine the relationships between smartphone addiction, mental health (anxiety and depression), and the mediating role of psychological resilience. Parental attachment was assessed as a moderator within these relationships. Data were analyzed using multiple regression and mediation/moderation models, controlling for relevant covariates. Our findings revealed a significant positive correlation between smartphone addiction and both anxiety and depression. Psychological resilience mediated these relationships, suggesting that higher resilience levels can mitigate the negative psychological impacts of smartphone addiction. Additionally, parental attachment moderated the effects of smartphone addiction on psychological outcomes; stronger attachment was associated with less pronounced effects of addiction on anxiety and depression. Specifically, for students with low parental attachment, the predictive effect of smartphone addiction on anxiety and depression was more pronounced, whereas higher attachment levels were protective. • Uses a sample of 90,000+ students, improving generalizability and statistical power. • Reveals a strong link between smartphone addiction, anxiety, and depression during COVID-19. • Shows that resilience mediates, and parental attachment moderates, the mental health impacts of smartphone addiction. [ABSTRACT FROM AUTHOR]

To explore the efficacy and mechanisms of stimulating the nucleus accumbens (NAc) in heroin-addicted mice using focused ultrasound and microbubbles (MBs). The conditioned place preference (CPP) method was employed to establish a heroin-addicted mice model. Mice were randomized into control (C), heroin (H), heroin + ultrasound (H + U) and H + U + MBs. Ultrasound (2 MHz fundamental frequency, 1.34 MPa peak-negative pressure, 1 MHz pulse repetition frequency, 5% duty cycle, 15 min/d, over 2 d) was applied to stimulate the NAc in the latter 2 groups. Whereas H + U + MBs received an injection of sulfur hexafluoride MBs during the stimulation. Subsequently, CPP scores, open-field test (OFT), and elevated plus-maze test (EPMT) were conducted to assess behavioral changes in addiction memory, anxiety and exercise status. HE staining was performed to detect pathological structures. Neurotransmitters such as dopamine (DA), serotonin (5-HT) and glutamate (Glu) were detected using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). Transmission electron microscopy (TEM) was used to observe ultrastructural changes of synapses in NAc. Immunohistochemistry (IHC) was utilized to detect Cleaved Caspase-3 in the NAc region. Western blotting (WB) was used to detect the protein expression of Cleaved Caspase-3, Bax and Bcl-2 in NAc. HE staining showed small patches of erythrocyte exudation were observed in the NAc and adjacent areas in H + U + MBs. The CPP scores of H + U + MBs were lower (p < 0.05) than H. After ultrasound treatment, all indices of the OFT and EPMT in H + U + MBs were significantly higher than H (p < 0.05). UPLC-MS/MS revealed that the levels of DA, 5-HT and Glu in H + U + MBs were lower than H (p < 0.01). TEM showed decrease the number of synapses (p < 0.05), and noticeable swelling of mitochondria, membrane damage, as well as damage to the cristae. Further detection by IHC and WB showed that the pro-apoptotic proteins Cleaved Caspase-3 and Bax increased and Bcl-2 decreased as anti-apoptotic proteins after ultrasound combined with MBs (p < 0.05). Focused ultrasound combined with MBs stimulate the NAc can weaken the addictive memory and improve anxiety of heroin-related mice. The mechanical effect of ultrasound combined with the cavitation effect may be a potential treatment for addiction. [ABSTRACT FROM AUTHOR]

Previous studies have demonstrated that both family dysfunction and internet addiction (IA) are associated with a higher risk of adolescent depression. However, no study has yet investigated the mechanisms involved. This study aims to explore the mediation and interaction roles of internet addiction (IA) between family functioning and depressive symptoms among adolescents in rural China. A multi-stage, stratified cluster, and random sampling was conducted among 3343 adolescents in rural China from October 27 to November 6, 2020. Depressive symptoms, IA, and family functioning were assessed using the Epidemiologic Studies Depression Scale (CES D), the Internet Addiction Test (IAT), and the Family Adaptation Partnership Growth Affection and Resolve Index (APGAR), respectively. Correlation analysis was performed by binary logistic regression. The study employed a four-way decomposition method to explore the potential mechanisms of family functioning on depressive symptoms. The results indicated that family functioning and IA were associated with adolescents' depressive symptoms. The interaction between family functioning and IA accounted for 74 % of the association between family functioning and depression symptoms, while direct effects accounted for 24 %. The "proportion eliminated" (76.11 %) was substantially larger than "proportion mediated" (7.36 %). The cross-sectional design limited to identify the causal relationship among the variables. We found that family dysfunction synergizes with IA to contribute to the high risk of adolescent depression. Prioritizing at preventing IA in adolescence could be an effective way to mitigate the adverse effects of family dysfunction on depression. • This is the first study to simultaneously examine the mediation and interaction between family functioning, internet addiction and depressive symptoms. • A multi-stage, stratified cluster, and random sampling was conducted among 3343 adolescents in rural China. • The interaction between family functioning and IA accounted for 74% of the association between family functioning and depression symptoms. • Intervening with IA can reduce family dysfunction's adverse effects on depressive symptoms by 76.11%. [ABSTRACT FROM AUTHOR]

Airline pilots are members of a unique occupational group that is often confronted with sleep routine disruptions, yet relatively few studies have examined their mental health status. This study assessed the prevalence and network structure of internet addiction, depression and sleep quality problems in commercial airline pilots. A total of 7055 airline pilots were included in analyses. Internet addiction and depression were measured with the Internet Addiction Test (IAT) and 9-item Patient Health Questionnaire (PHQ-9), respectively. Sleep quality was evaluated using the Pittsburgh Sleep Quality Index (PSQI). The network model was constructed based on an Ising model and its association with sleep quality was evaluated using a flow procedure. Internet addiction, depression and sleep quality were common among airline pilots. The prevalence of internet addiction was 8.0 % (95 % CI: 7.3–8.6 %), while the rates of depression and poor sleep quality were 23.3 % (95 % CI: 22.3–24.2 %) and 33.0 % (95 % CI: 31.9–34.1 %), respectively. In the depression and internet addiction network model, "Fatigue" (PHQ4; Expected Influence (EI): 2.04) and "Depressed/moody/nervous only while being offline" (IAT20; EI: 1.76) were most central symptoms while "Fatigue" (PHQ4; Bridge EI: 1.30) was also the most important bridge symptom. The flow network model of sleep quality with internet addiction and depression showed that "Appetite" (PHQ5) had the strongest positive association with poor sleep quality. Internet addiction, depression and sleep quality were common among airline pilots and warrant regular screening and timely treatment. Strategies to improve sleep hygiene may be useful in preventing onsets or exacerbations in depression and internet addiction among airline pilots. • The prevalence of internet addiction was 8.0% (95% CI: 7.3–8.6%), while the prevalence of depression and poor sleep quality were 23.3% (95% CI: 22.3–24.2%) and 33.0% (95% CI: 31.9–34.1%), respectively. • "Fatigue" (PHQ4) and "Depressed/moody/nervous only while being offline" (IAT20) were central symptoms. • "Appetite" (PHQ5) had the strongest positive associations with poor sleep quality. [ABSTRACT FROM AUTHOR]

It has been suggested that alexithymia plays a significant role in substance and behavioral addictions. However, only a handful of studies investigated this construct in relation to gaming addiction, and no study analyzed its differential effect on gaming engagement and addiction. A total of u adult gamers (M age = 26.04, SD = 5.78, 94 % male) completed a questionnaire that included the Toronto Alexithymia Scale (and its subscales of difficulty identifying feelings, difficulty describing feelings, and externally oriented thinking), the Addiction-Engagement Questionnaire, and additional questions about gender, age, and time spent gaming. Structural equation modeling was used as the main analytical strategy. Difficulty identifying feelings (β = 0.28) and externally oriented thinking (β = 0.19) showed a significant positive effect on gaming addiction. Contrary to addiction, externally oriented thinking showed a significant negative effect (β = −0.21) on gaming engagement. No other alexithymia subscales were significant. The model with alexithymia explained 32.7 % of the variance in gaming addiction while only 10.4 % of gaming engagement. Alexithymia is a strong predictor of gaming addiction. Gaming engagement seems to be a qualitatively different phenomenon that shows an opposite association with alexithymia than gaming addiction. However, both are related to increased time spent gaming. This suggests a need to distinguish between problematic vs. non-problematic excessive gaming as they have different associations with affect dysregulation. • Alexithymia is a strong predictor of gaming addiction. • The difficulty identifying feelings and externally oriented thinking played a role. • Alexithymia has a weaker and opposite association with gaming engagement. • Alexithymia differentiates between addictive and non-problematic gaming. • Gaming addiction and engagement are similarly related to gaming intensity. [ABSTRACT FROM AUTHOR]

Drugs like opioids are potent reinforcers thought to co-opt value-based decisions by overshadowing other rewarding outcomes, but how this happens at a neurocomputational level remains elusive. Range adaptation is a canonical process of fine-tuning representations of value based on reward context. Here, we tested whether recent opioid exposure impacts range adaptation in opioid use disorder, potentially explaining why shifting decision making away from drug taking during this vulnerable period is so difficult. Participants who had recently (<90 days) used opioids (n = 34) or who had abstained from opioid use for ≥ 90 days (n = 20) and comparison control participants (n = 44) completed a reinforcement learning task designed to induce robust contextual modulation of value. Two models were used to assess the latent process that participants engaged while making their decisions: 1) a Range model that dynamically tracks context and 2) a standard Absolute model that assumes stationary, objective encoding of value. Control participants and ≥90-days-abstinent participants with opioid use disorder exhibited choice patterns consistent with range-adapted valuation. In contrast, participants with recent opioid use were more prone to learn and encode value on an absolute scale. Computational modeling confirmed the behavior of most control participants and ≥90-days-abstinent participants with opioid use disorder (75%), but a minority in the recent use group (38%), was better fit by the Range model than the Absolute model. Furthermore, the degree to which participants relied on range adaptation correlated with duration of continuous abstinence and subjective craving/withdrawal. Reduced context adaptation to available rewards could explain difficulty deciding about smaller (typically nondrug) rewards in the aftermath of drug exposure. [ABSTRACT FROM AUTHOR]

Cannabis use may be a modifiable risk factor for mental health problems; however, the role of cannabis use frequency in population seeking mental health and addiction services remains unclear. This study aimed to: 1) compare the prevalence and functional impact of psychiatric symptoms among frequent, infrequent, and non-users of cannabis; and 2) evaluate the associations between cannabis use frequency and functional impact of psychiatric symptoms in help-seeking individuals. Data from the Mental Health and Addictions (MHA) Central Intake system in Nova Scotia, Canada was used. Participants aged 19–64 who received MHA Intake assessments from September 2019 to December 2021 with complete information about substance use were included (N = 20,611). Cannabis use frequency over past 30 days was categorized into frequent (>4 times a month), infrequent (≤4 times a month), and non-use. Psychiatric symptomatology consists of five domains: mood, anxiety, psychosis, cognition, and externalizing behaviors. Multivariate ordinal logistic regression was used to examine the associations between cannabis use frequency and functional impact of psychiatric symptoms. Frequent and infrequent cannabis users had a higher prevalence of psychiatric symptoms in each domain than non-users, while no significant differences were found between frequent and infrequent users. Frequent cannabis use was associated with greater functional impact of psychiatric symptoms in each domain compared to non-users, while infrequent use was only associated with greater functional impact of externalizing behaviors. Frequent cannabis use is associated with increased prevalence and functional impact of psychiatric symptoms among adults seeking mental health services. • The association between frequency of cannabis use with different psychiatric symptom domains is not well understood. • Studies of people with mental health needs can provide evidence to regulate harmful cannabis misuse. • Frequent cannabis use was associated with greater functional impact of each psychiatric domain compared to non-users. • Infrequent cannabis use was associated with greater functional impact of externalizing behaviors compared to non-users. [ABSTRACT FROM AUTHOR]

Although the development and application of mobile phones have changed various aspects of people's lives, excessive use of mobile phones has also raised physical and mental health concerns. However, the relationship between mobile phone addiction (MPA) and non-suicidal self-injury (NSSI) is unclear. A cross-sectional study was conducted (2022) among students from six universities to assess the relationship between MPA and NSSI. A Mobile Phone Addiction Tendency Scale (MPATS) was used to assess MPA, while NSSI was assessed via The Ottawa Self-Injury Inventory. Binary logistic regression models were used to assess the relationship between MPA and NSSI. A total of 18,723 college students (6531 males [34.9 %] and 12,192 females [65.1 %]) were included in the final analyses. The prevalence of NSSI during the past 12 months was 6.5 %. Furthermore, 5553 participants (29.7 %) met the MPA criteria (MPATS score ≥ 48), and the average MPATS score was 39.5 ± 13.0. MPA was associated with increased odds of NSSI after adjusting for socio-demographic characteristics, health-related characteristics, and relevant psychosocial variables (OR , 1.29; 95 % CI , 1.13–1.46). Moreover, gender did not affect the association of MPA and MPATS score with NSSI (P for interaction>0.05). The restricted cubic splines regression showed that a monotonically increasing risk of NSSI was associated with increasing MPATS score (P for non-linearity = 0.474). MPA is associated with increased odds of NSSI among college students, indicating that early examination, prevention, and intervention for MPA may prevent and control NSSI. • MPA was positively associated with increased odds of NSSI among college students. • No gender-specific differences was found in the association of MPA with NSSI. • A significant linear dose-response relationship between MPA and NSSI was observed in this study. [ABSTRACT FROM AUTHOR]

Facing long-term separation from their parents, left-behind children are at risk of the co-occurrence of internalizing and externalizing problems. Although previous research has gained substantial information examining the relationship between anxiety, depression, and internet addiction at the aggregate level of variables, little is known about the heterogeneity and interactions between these components at the symptom level with a large-scale purposive sample. Adopting the network approach, two network pathways, depression and anxiety, and associations between these variables and internet addiction were constructed. Our sample included 5367 left-behind children (M age = 13.57; SD age = 1.37; 50.07% females). Relevant bridging, central symptoms, and network stability were identified. Two relatively stable networks were obtained. For the network of anxiety and depression, sleep problems and tachycardia were vital bridging symptoms. Central symptoms, including tachycardia, restlessness, fatigue, and emptiness, were symptoms of depression. For the network of symptoms of anxiety, depression, and internet addiction, the bridging symptoms remained the same, and the central symptoms included tachycardia, restlessness, loss of control, and emptiness. By identifying relevant bridging and central symptoms, those with higher levels of these symptoms could be regarded as intervention targets, providing a reference for the current issue of valuing diagnosis over prevention in left-behind children. [ABSTRACT FROM AUTHOR]

This study was conducted to determine adolescents' nomophobia behaviors, eHealth literacy levels, and their predictive factors. A cross-sectional design was used. The population consisted of ninth, 10th, and 11th-grade adolescents (aged 14–17) in a high school in Turkiye (N = 1013). The study was completed with 719 voluntary adolescents. A questionnaire, the eHealth Literacy Scale, and the Nomophobia Questionnaire were used to collect data. Multiple linear regression was run for data analysis. Of the adolescents, 44.9% were found to have moderate, and 14.8% had severe nomophobia behaviors. Adolescents who were girls, the ninth and 10th graders, who used smartphone two hours or more daily, social media users, who watched videos on the smartphone and surfed on the Internet had higher nomophobia behaviors. Adolescents who were boys, who searched for health information online, found health information on the Internet helpful, and found accessing health resources on the Internet important had higher eHealth literacy levels. Adolescents should be educated about rational smartphone and Internet usage to comprehend the accuracy of health-related information. School nurses could design activities to increase eHealth literacy to encourage adolescents. Nurses could help proactively prepare nomophobia severity map and an eHealth literacy enhancement curriculum for adolescents to form functional preventive interventions. Nurse leaders can contribute to developing policies and strategies to prevent nomophobia behaviors among adolescents. • Most of the adolescents were found to have nomophobia behaviors. • Daily smartphone usage duration and following social media were predicted nomophobia behaviors. • Following social media, surfing on the Internet, and watching videos may lead to nomophobia behaviors. [ABSTRACT FROM AUTHOR]

Mobile phone addiction (MPA) has been extensively researched as an important factor for students' procrastination. However, the direction and magnitudes of the correlation between MPA and procrastination remain unclear. This meta-analysis, thus, aims to explore the relationship between MPA and procrastination in students, as well as the moderating effects of participant's individual characteristics (education level and sex), measurement tools, and social situational factors (publication year and culture). Qualified studies were obtained through a systematic search of PubMed, Web of Science, Embase, PsycINFO, China National Knowledge Infrastructure (CNKI), Wanfang, and Weipu. Meta-analysis was conducted in the CMA 3.0 software, and meta-analysis of variance (ANOVA) was used to test the moderating effect. A total of 75 studies, including 48,031 participants, were obtained. The combined effect size of the random effects model showed a significant positive correlation between MPA and procrastination in students (r = 0.376, 95 % CI [0.345, 0.406]). Education level, sex, culture, and MPA measurement tools significantly moderated the correlation between MPA and procrastination. However, the correlation was not moderated by the year of publication and the measurement tools of procrastination. MPA is positively correlated with procrastination in students. Given the high incidence of MPA in students and its potential risk factors for procrastination, attention should be paid to the identification and intervention of MPA to prevent students from procrastination. • It has been proposed that mobile phone addiction (MPA) is associated with procrastination amongst students. • The result of the meta-analysis showed a moderate positive correlation between MPA and procrastination in students. • The strength of the relationship between MPA and procrastination was moderated by education level, sex. • Culture and MPA measurement tools also significantly moderated the correlation between MPA and procrastination. [ABSTRACT FROM AUTHOR]

A large and increasing body of evidence has demonstrated that hosts often need microbial symbionts to perform essential functions. Deficiencies of microbe-free hosts are usually attributed to the lack of microbial benefits, but the field has neglected evolutionary addiction, where dependencies evolve without benefits. Evolutionary addiction is a general process that could operate in any host system evolving in the continual presence of symbionts, from the human gut to plant roots to microbial hosts of other microbes. Evolutionary addiction helps explain the broad extent to which microbes impact host biology. Microbes are widely recognized to be vital to host health. This new consensus rests, in part, on experiments showing how hosts malfunction when microbes are removed. More and more microbial dependencies are being discovered, even in fundamental processes such as development, immunity, physiology, and behavior. But why do they exist? The default explanation is that microbes are beneficial; when hosts lose microbes, they also lose benefits. Here I call attention to evolutionary addiction, whereby a host trait evolves a need for microbes without having been improved by them. Evolutionary addiction should be considered when interpreting microbe-removal experiments, as it is a distinct and potentially common process. Further, it may have unique implications for the evolution and stability of host–microbe interactions. [ABSTRACT FROM AUTHOR]

Evidence has suggested that addiction and memory systems are related, but the signaling cascades underlying this interaction have not been completelyealed yet. The importance of calcium-calmodulin-dependent protein kinase II (CaMKII) and brain-derived neurotrophic factor (BDNF) in the memory processes and also in drug addiction has been previously established. In this present investigation, we examined the effects of repeated morphine pretreatment on impairment of spatial learning and memory acquisition induced by systemic ethanol administration in adult male rats. Also, we assessed how these drug exposures influence the expression level of CaMKII and BDNF in the hippocampus and amygdala. Animals were trained by a single training session of 8 trials, and a probe test containing a 60-s free-swim without a platform was administered 24 h later. Before training trials, rats were treated with a once-daily subcutaneous morphine injection for 3 days followed by a 5-day washout period. The results showed that pre-training ethanol (1 g/kg) impaired spatial learning and memory acquisition and down-regulated the mRNA expression of CaMKII and BDNF. The amnesic effect of ethanol was suppressed in morphine- (15 mg/kg/day) pretreated animals. Furthermore, the mRNA expression level of CaMKII and BDNF increased significantly following ethanol administration in morphine-pretreated rats. Conversely, this improvement in spatial memory acquisition was prevented by daily subcutaneous administration of naloxone (2 mg/kg) 15 min prior to morphine administration. Our findings suggest that sub-chronic morphine treatment reverses ethanol-induced spatial memory impairment, which could be explained by modulating CaMKII and BDNF mRNA expressions in the hippocampus and amygdala. [Display omitted] • Pre-training acute administration of ethanol impaired spatial memory. • Amnesia induced by ethanol was decreased by morphine pre-exposure. • Ethanol increased CaMKII in the hippocampus and amygdala in morphine-pretreated rats. • Ethanol increased BDNF in the hippocampus and amygdala in morphine-pretreated rats. [ABSTRACT FROM AUTHOR]

Cross-sectional studies show that habitual use of alcohol is associated with severity of alcohol dependence reflected across a range of domains and lower number of detoxifications in multiple settings. In this study, we investigated whether alcohol use disorder (AUD) patients with greater habitual use of alcohol at baseline showed worse outcomes after one year of follow-up. A sample of inpatients with Diagnostic and Statistical Manual of Mental Disorders , Fourth Edition (DSM-IV) alcohol use disorder (AUD) was assessed at baseline (n = 50) and after one year (n = 30). The Habit, Reward, and Fear Scale (HRFS) was employed to quantify affective (fear or reward) and non-affective (habitual) drives for alcohol use, the Alcohol Dependence Scale (ADS) was used to assess clinical outcomes, and the Depression, Anxiety and Stress Scale (DASS-21) was used to quantify and control for associated affective symptoms. There was a significant reduction in the three HRFS scores at the follow-up. Regression analyses demonstrated that greater habit- and fear-related drives at baseline predicted greater decreases in the ADS scores at the endpoint. However, after controlling for age, sex and affective symptoms, only reward and fear were associated with reductions in ADS scores at the end of one year. Prescriptions of naltrexone and antidepressants/benzodiazepines did not predict decreases in reward and fear-related motivations. Although we were unable to confirm that habitual subscores at baseline predict worse long-term outcomes among inpatients with AUD, we found that a greater fear and reward motives for the use of alcohol predicted a greater magnitude of improvement in the AUD symptoms after one year. We hope that these findings will help develop new approaches toward AUD treatment and inform models of addiction research. [ABSTRACT FROM AUTHOR]

Milk tea has experienced tremendous growth in popularity in China, especially among youths. The primary objective of this study is to investigate whether milk tea addiction may have a detrimental impact on youths' mental health, such as anxiety, depression, and suicidal ideation. Additionally, we aim to explore its potential role in influencing various mental health outcomes. A large-scale, cross-sectional study was conducted from 5281 college students in Beijing, China. Participants self-reported depressive, anxiety symptoms, suicidal ideation, and milk tea addiction symptoms including milk tea consumption, dependence, guilty feelings, withdrawal, tolerance, unable to stop, craving, and intention to stop. Nearly 77 % of participants consumed milk tea at least 6–11 cups in the last year. The confirmatory factor analysis (CFA) supported the one-factor structure of the milk tea addiction scale, developed according to DSM-5 substance use guidelines. Moreover, we found that a higher level of milk tea addiction was significantly associated with a higher risk of depression (b = 0.24, p < 0.001), anxiety (b = 0.21, p < 0.001), and suicidal ideation (b = 0.06, p < 0.001), respectively, after controlling confounding variables, among youths consuming milk tea. The possible mediating role of milk tea addiction between loneliness feelings and mental health outcomes was further addressed. Our findings highlighted that milk tea consumption might lead to addiction, and it is associated with depression, anxiety, and suicidal ideation. Current findings can assist policymakers in developing regulations such as restricting advertising, providing psycho-education, establishing food hygiene standards for such a prosperous youth-dominant consumption industry while protecting their mental health. • This study provides novel insights into milk tea addiction among youths and introduces a milk tea addiction scale. • Milk tea addiction, used as a compensatory strategy for loneliness, links to depression, anxiety, and suicidal ideation. • Policymakers should tackle youth milk tea addiction through public health strategies and regulatory measures. [ABSTRACT FROM AUTHOR]

Motivational desires usually match predictions of outcome gain. The match is so close that some define desire as nothing more than the prediction of gain. Opposing evidence is presented here that desire is psychologically distinct from prediction and has different underlying neural mechanisms. Consequently, desire as incentive salience can separate completely from learned predictions, and can even create desires for outcomes that are remembered and predicted to be bad. The operating rules of incentive salience that power such desires emerge from brain mesolimbic dopamine-related systems. Two laboratory examples are described here to show how desire can separate from learned predictions of value: (i) 'wanting what is remembered to be disgusting', and (ii) 'wanting what is predicted to hurt'. In people, similar separations of motivational desire from outcome prediction can occur in addiction and related clinical conditions. Individuals typically want what they expect to like, often based on memories of previous positive experiences. However, in some situations desire can decouple completely from memories and from learned predictions of outcome value. The potential for desire to separate from prediction arises from independent operating rules that control motivational incentive salience. Incentive salience, or 'wanting', is a type of mesolimbic desire that evolved for adaptive goals, but can also generate maladaptive addictions. Two proof-of-principle examples are presented here to show how motivational 'wanting' can soar above memory-based predictions of outcome value: (i) 'wanting what is remembered to be disgusting', and (ii) 'wanting what is predicted to hurt'. Consequently, even outcomes remembered and predicted to be negatively aversive can become positively 'wanted'. Similarly, in human addictions, people may experience powerful cue-triggered cravings for outcomes that are not predicted to be enjoyable. [ABSTRACT FROM AUTHOR]

The disease theory of alcoholism, and by extension, of addiction, forms the theoretical basis of an expansive scientific industry, one which musters tremendous resources in the service of research, rehab clinics, and government programs. Revisiting the early work on the disease theory of alcoholism, this paper analyzes the apperance of the disease theory of alcoholism in the eighteenth/nineteenth century works of Rush, Trotter, and Brühl-Cramer as emergent of a theoretical tension within the Brunonian system of medicine, that of stimulus dependence. Establishing both the shared Brunonianism of these figures and the concept of stimulus dependence, I argue it is here that one finds the nascent formulation of the modern dependence model of addiction, pushing out alternative models, such as Hufeland's toxin theory. [ABSTRACT FROM AUTHOR]

A central goal of computational psychiatry is to identify systematic relationships between transdiagnostic dimensions of psychiatric symptomatology and the latent learning and decision-making computations that inform individuals' thoughts, feelings, and choices. Most psychiatric disorders emerge prior to adulthood, yet little work has extended these computational approaches to study the development of psychopathology. Here, we lay out a roadmap for future studies implementing this approach by developing empirically and theoretically informed hypotheses about how developmental changes in model-based control of action and Pavlovian learning processes may modulate vulnerability to anxiety and addiction. We highlight how insights from studies leveraging computational approaches to characterize the normative developmental trajectories of clinically relevant learning and decision-making processes may suggest promising avenues for future developmental computational psychiatry research. [ABSTRACT FROM AUTHOR]

Although bariatric surgery results in a significant weight reduction and an improvement in the quality of life in most people who undergo surgery, there are inter-individual differences in terms of postoperative results. Psychological, psychiatric and addictive disorders contribute substantially to these difficulties. Between 20% and 50% of bariatric surgery candidates have a current psychiatric/addictive disorder and approximately 30-75% have a history of a psychiatric/addictive disorder within their lifetime. Surgery is accompanied in the short-term by an improvement in depressive symptoms and binge eating, but these symptoms tend to increase again beyond the 3rd postoperative year. Over the long-term, only the improvement in depression remains durable, whilepostoperative anxiety and disordered eating symptoms do not differ significantly from the preoperative levels. There is a two to four fold increased risk of post-surgical suicide and suicide attempts (from the 1st postoperative year onward), as well as an increased risk of alcohol-abuse (beyond two years after surgery). Psychological support must therefore continue long-term. Several psychotherapeutic and pharmacological treatments have demonstrated their effectiveness in improving the postoperative prognosis of patients with psychological/psychiatric disorders. The early integration of psychological/psychiatric/addiction evaluation and support into multidisciplinary management makes it easier to identify these difficulties and to optimize the postoperative prognosis, both in terms of weight and quality of life. Prior to surgery, patients should be systematically evaluated by a psychologist or psychiatrist in order to identify and to manage disorders that could negatively impact the postoperative prognosis. After surgery, this assessment and support can be carried out in a programmed and systematic way for those patients who were identified preoperatively as the most vulnerable, but support can also be offered during follow-up in the event of specific symptoms (i.e., loss of control over food intake, failure in terms of weight or quality of life, suicidal ideation, loss of control over alcohol use, significant depression or anxiety symptoms). [ABSTRACT FROM AUTHOR]

Background: After >2 years of the Coronavirus Disease-19 (COVID-19) pandemic, it is well established how sleep symptoms are rising, especially among healthcare workers (HCW). The aim of this study is to evaluate what features are associated with sleep disturbances in the HCW population.Methods: Cross-sectional and longitudinal analysis of social and clinical variables associated with sleep problems and insomnia incidence in HCW in a large, national-level cohort. The measurement of sleep problems was assessed by self-report using Jenkins Sleep Scale (JSS). A multivariate analysis was used in the cross-sectional design and generalized linear models were used in the longitudinal design.Results: 10,467 HCW were analyzed in the cross-sectional analysis, 3313 participants were analyzed in the three timepoints of the study. Sex, previously diagnosed mental illness and frontline work with COVID-19 were associated with higher scores in JSS in the univariate analysis. In the multivariate analysis, only previous diagnosis of mental illness was related with sleep difficulties, especially previously diagnosed insomnia. The longitudinal analysis concluded that previous diagnosis of mental illnesses was associated with higher levels of insomnia development (OR = 11.62). The self-reported disorders found to be major risk factors were addiction (OR = 7.69), generalized anxiety disorder (OR = 3.67), social anxiety (OR = 2.21) and bipolar disorder (OR = 2.21).Limitations: Attrition bias.Conclusions: Previous diagnosis of mental illness was strongly related to insomnia development in HCW during the COVID-19 pandemic. Strategies that focus on this population are advised. [ABSTRACT FROM AUTHOR]

Methamphetamine (METH) is a potent and highly addictive psychostimulant and one of the most widely used illicit drugs, the abuse of which has become a severe public health problem worldwide. A growing amount of evidence has indicated potential connections between gut microbiota and mental disorders induced by METH and associations with neural and metabolic pathways. The present study aimed to explore the relationship between fecal microbial alterations and neuropsychiatric diseases in METH addictions. Thus, mental disorders and gut microbial alterations were analyzed by self-rating depression (SDS) and anxiety (SAS) scales and 16 S rRNA gene sequencing, respectively. Our results showed that increased SDS and SAS indices and decreased alpha diversity indicated more serious mental disorders and lower bacterial diversity in METH users than in the age-matched healthy control group. The gut microbial composition in female METH users was also significantly altered, with reductions in hydrogen-producing bacteria, including Bacteroides and Roseburia. Molecular hydrogen (H 2) is spontaneously produced by intestinal bacteria in the process of anaerobic metabolism, which is the main pathway for H 2 production in vivo. Numerous studies have shown that hydrogen intervention can significantly improve neuropsychiatric diseases, including Alzheimer's disease and Parkinson's disease. Our results showed that hydrogen intervention, including drinking and inhaling, significantly alleviated mental disorders induced by METH abuse, and the inhalation of hydrogen also altered gut microbiota profiles in the METH abusers. These results suggest that hydrogen intervention has potential therapeutic applicability in the treatment of mental disorders in METH abusers. • Anxiety and depression symptoms caused by methamphetamine addiction. • Gut microbiota profiles altered in methamphetamine abusers with mental disorders. • Gut microbial composition in female methamphetamine users with reductions of Bacteroides and Roseburia. • Hydrogen intervention can significantly improve methamphetamine addiction. • Hydrogen intervention alleviated mental disorders induced by methamphetamine abuse [ABSTRACT FROM AUTHOR]

1. Describe the current landscape of learning opportunities on substance use, misuse, and use disorder integrated into Hospice and Palliative medicine fellowship training across the country. 2. Examine high priority gaps in educational resources that support teaching relevant primary addiction medicine knowledge and skills to specialty Hospice and Palliative medicine fellows. Primary addiction medicine skills training is critical for the modern practice of hospice and palliative medicine (HPM). This national survey of HPM program directors reveals wide variation, gaps in training opportunities, and limited resources. Results highlight the need to support the design and wide dissemination of educational curricula on critical and relevant primary AM skills for HPM trainees. Patients with opioid use disorder (OUD) have high rates of serious illness, co-existing pain, and risk for substandard medical care. Over half of HPM specialists report regular management of opioid misuse/OUD, yet the overwhelming majority do not feel comfortable or well-trained in managing OUD or concurrent pain. Teaching core primary addiction medicine (AM) skills has been shown to increase fellows' self-reported competency and satisfaction in caring for patients with addiction. ACGME requires fellowship training on 'recognizing the signs of addiction,' however there is little guidance on what this entails. Thus, little is known about the national variation in primary AM education for HPM specialty fellows, and which topics would be prioritized for curricular development if resources were available. To describe current training opportunities, educational implementation challenges, and curricular gaps in core primary AM skills for HPM fellows nationwide. Anonymous Qualtrics surveys were sent to program directors (PD) at all 163 HPM ACGME accredited fellowships. 84 (52%) of HPM PDs responded, representing adult/ pediatric physician (83%), nurse practitioner (8%), social work (4%), and pharmacy (3%) trainees. A mean of 3.6 hours was spent on formal education around OUD and misuse. 39% felt their trainees were 'not so confident' or 'not at all confident' in caring for patients with OUD. Three priority learning objectives for curricular development include: identifying appropriate patients and plans for buprenorphine (17%), managing pain and OUD (16%), and managing prescription medication misuse (9%). The most common challenges include lack of faculty with addiction training (22%), limited faculty with experience using buprenorphine (20%), and lack of available curricula (19%) or faculty to deliver training (19%). Wide gaps in training highlight the need to support the design and dissemination of educational curricula on critical and relevant primary AM skills for HPM trainees. Workforce / Career Development / Scientific Research [ABSTRACT FROM AUTHOR]

Misinformation, or the spread of false information, can affect policy and individual health behaviors. Harm reduction practitioners and researchers have seen their work misrepresented in the media to the detriment of people in their community. Media coverage affects both public opinion and policy, which necessitates that it be informed by the current science and carefully platforms people who can speak to the science. Reporting on Addiction was formed to understand issues with media coverage and the consequences of this uninformed media coverage and propose solutions to these issues. Our “three-legged stool” approach defines this work (academic experts, researchers, community members, and the media) by identifying the problems and guiding our solutions. By working collaboratively with the media to improve their knowledge about addiction science, we aim to reduce misinformation and improve the lives of people with an addiction, in treatment, and during recovery. [ABSTRACT FROM AUTHOR]

Background: The comorbidity between substance use disorder and major depressive disorder is a typical dual diagnosis in the field of substance addiction. However, the prevalence and correlates of depression in methamphetamine addicts and whether it is associated with drug craving and alexithymia have been rarely reported in the Chinese population.Methods: We recruited 585 methamphetamine-dependent males from a drug rehabilitation center in China and 203 healthy controls. Demographic and drug use data were collected. Depression was assessed using the Mini International Neuropsychiatric Interview (M.I.N·I.). Methamphetamine cravings and alexithymia were assessed using the Desire for Drugs Questionnaire (DDQ) and the Toronto Alexithymia Scale (TAS).Results: The prevalence rate of depression in methamphetamine-dependent men was 16.58 % (97/585). The scores of DDQ desire and intention, DDQ negative reinforcement, total DDQ, difficulty identifying feelings (DIF), difficulty describing feelings (DDF), and total TAS score of depressed patients were higher than those of non-depressed patients. However, only DDQ negative reinforcement score, DIF, DDF, and total TAS score remained significant after Bonferroni correction. Additionally, logistic regression analysis found that age, DIF score, and DDQ negative reinforcement score were significant factors contributing to depression in methamphetamine-dependent men.Conclusion: Our findings suggest that the prevalence of depression is significantly higher in methamphetamine-dependent men than in the healthy Chinese population. Furthermore, age, components of alexithymia and drug craving are risk factors for depression in methamphetamine addicts. [ABSTRACT FROM AUTHOR]

In 2014, we proposed that orexin signaling transformed motivationally relevant states into adaptive behavior directed toward exploiting an opportunity or managing a threat, a process we referred to as motivational activation. Advancements in animal models since then have permitted higher-resolution measurements of motivational states; in particular, the behavioral economics approach for studying drug demand characterizes conditions that lead to the enhanced motivation that underlies addiction. This motivational plasticity is paralleled by persistently increased orexin expression in a topographically specific manner—a finding confirmed across species, including in humans. Normalization of orexin levels also reduces drug motivation in addiction models. These new advancements lead us to update our proposed framework for the orexin function. We now propose that the capacity of orexin neurons to exhibit dynamic shifts in peptide production contributes to their role in adaptive motivational regulation and that this is achieved via a pool of reserve orexin neurons. This reserve is normally bidirectionally recruited to permit motivational plasticity that promotes flexible, adaptive behavior. In pathological states such as addiction, however, we propose that the orexin system loses capacity to adaptively adjust peptide production, resulting in focused hypermotivation for drug, driven by aberrantly and persistently high expression in the orexin reserve pool. This mechanistic framework has implications for the understanding and treatment of several psychiatric disorders beyond addiction, particularly those characterized by motivational dysfunction. [ABSTRACT FROM AUTHOR]

Addiction is a disease of brain-reward circuitry whereby attention, motivation, memory and emotional systems become enslaved to the goal of seeking and acquiring drug, instead of responding to the natural rewards for which these systems evolved. At the intersection of reward/limbic structures, the medial prefrontal cortex (mPFC) receives and consolidates signals regarding environment and orchestrates the most appropriate response (i.e., decision-making and attention). As such, mPFC function plays a critical role in the vulnerability or resilience to drug addiction. In our model of drug-induced reward devaluation, an outbred group of Sprague-Dawley rats parsed into two distinct drug-taking phenotypes: those, referred to as small suppressors (SS) that readily ingest a heroin-paired sweet cue and then take little drug, and those, referred to large suppressors (LS), that avoid the heroin-paired cue, but then respond greatly for the drug of abuse. In the present study, we analyzed the mPFC transcriptome of rats from these divergent groups to discover differences in gene expression that underlie these distinct phenotypes. Genes found to be differentially expressed were those associated with schizophrenia and dopamine signaling, signal transduction, development and synaptic plasticity. These genes may underlie the circumstance whereby some individuals succumb to addiction, while others do not, and may reveal new pharmacological targets for the treatment of drug addiction. [ABSTRACT FROM AUTHOR]

The dorsal striatum integrates prior and current information to guide appropriate decision-making. Chronic stress and stimulant exposure interferes with decision-making, and can confer similar cognitive and behavioral inflexibilities. This review examines the literature on acute and chronic regulation of the epigenome by stress and stimulants. Recent evidence suggests that exposures to stress and stimulants share similarities in the manners in which they regulate the dorsal striatum epigenome through DNA methylation, transposable element activity, and histone post-translational modifications. These findings suggest that chronic stress and stimulant exposure leads to the accumulation of epigenetic modifications that impair immediate and future neuron function and activity. Such epigenetic mechanisms represent potential therapeutic targets for ameliorating convergent symptoms of stress and addiction. Stress and stimulant exposure can predispose similar behaviors, including impaired decision-making, cognitive inflexibility, and resilience to updating information; these are governed in part by the dorsal striatum. Epigenetic changes – such as DNA methylation, transposable element activity, and histone post-translational modifications – accumulate as stress or stimulant exposure is maintained from an acute to a chronic condition. Stress or stimulant-induced accumulation of epigenetic changes can potentiate differential gene regulation, altering immediate and future neuronal functions that include exposure-induced synaptic plasticity. Chronic epigenetic dysregulation of regulatory genes in the dorsal striatum may contribute to compulsivity and cognitive inflexibility phenotypes, which are among the hallmarks of anxiety and addiction. [ABSTRACT FROM AUTHOR]

Avatars serve as the virtual embodiment of users, facilitating their online interaction, with potential positive and negative effects. These effects range from enhancing social and personal development to facilitating disordered gaming patterns. As past literature has identified different disorder gaming patterns based on the connection an individual has with their avatar (referred to as the User-Avatar Bond [UAB]), the present study explored the gaming disorder risk based on a gamer's UAB profile. To investigate this, the present study comprised 565 online role-playing gamers (M age = 29.3, SD = 10.6). Participants completed the User-Avatar Bond Questionnaire and the Internet Gaming Disorder Scale-Short-Form over two waves, six months apart. Latent profile analysis was employed which identified four distinct UAB profiles: Identified Gamers, Compensated Gamers, Detached Gamers, and Differentiated Gamers. ANOVAs were conducted to assess differences in IGD behaviours within the profiles across the two waves. The findings suggested a significant difference between the profiles and IGD, where heightened avatar identification and compensation levels may act as risk factors for IGD behaviours. These findings provide crucial insight regarding the role of UAB in IGD development, treatment, and prevention. • A study on 565 gamers analyses the user avatar bonds' (UAB) role in internet gaming disorder. • Latent Profile Analysis reveals four distinct UAB profiles. • Avatar identification and compensation linked to heightened IGD risk. • Introduction of the " Detached Gamer" profile expands the typology of gamer-avatar interaction. • Insights on avatar bonds offer valuable directions for interventions in gaming disorder. [ABSTRACT FROM AUTHOR]

• Neural abnormalities of behavioral addiction caused by technological development. • The fronto-cingulate region may serve as common biomarker of behavioral addiction. • The reward circuit is closely related to behavioral addiction. • The visual network appears abnormal and can be treated with images. • Behavioral addiction has gender susceptibility. The incidence of behavioral addictions (BAs) associated with scientific and technological advances has been increasing steadily. Unfortunately, a large number of studies on the structural and functional abnormalities have shown poor reproducibility, and it remains unclear whether different addictive behaviors share common underlying abnormalities. Therefore, our objective was to conduct a quantitative meta -analysis of different behavioral addictions to provide evidence-based evidence of common structural and functional changes. We conducted systematic searches in PubMed, Web of Science and Scopus from January 2010 to December 2023, supplementing reference lists of high-quality relevant meta -analyses and reviews, to identify eligible voxel-based morphometry (VBM) and functional magnetic resonance imaging (fMRI) studies. Using anisotropic seed-based D-Mapping (AES-SDM) meta -analysis methods, we compared brain abnormalities between BAs and healthy controls (HCs). There were 11 GMV studies (287 BAs and 292 HCs) and 26 fMRI studies (577 BAs and 545 HCs) that met inclusion criteria. Compared with HCs, BAs demonstrated significant reductions in gray matter volume (GMV) in (1) right anterior cingulate gyri extending into the adjacent superior frontal gyrus, as well as in the left inferior frontal gyrus and right striatum. (2) the bilateral precuneus, right supramarginal gyrus, and right fusiform gyrus were hyperfunction; (3) the left medial cingulate gyrus extended to the superior frontal gyrus, the left inferior frontal gyrus, and right middle temporal gyrus had hypofunction. Our study identified structural and functional impairments in brain regions involved in executive control, cognitive function, visual memory, and reward-driven behavior in BAs. Notably, fronto-cingulate regions may serve as common biomarkers of BAs. [ABSTRACT FROM AUTHOR]

Online shopping addiction (OSA) is defined as a behavioral addiction where an individual exhibits an unhealthy and excessive attachment to shopping on the Internet. Since the OSA shown its adverse impacts on individuals' daily life and social functions, it is important to examine the neurobiological underpinnings of OSA that could be used in clinical practice to identify individuals with OSA. The present study addressed this question by employing a connectome-based prediction model approach to predict the OSA tendency of healthy subjects from whole-brain resting-state functional connectivity. The OSA connectome - a set of connections across multiple brain networks that contributed to predict individuals' OSA tendency was identified, including the functional connectivity between the frontal-parietal network (FPN) and cingulo-opercular network (CON) (i.e., positive network), as well as the functional connectivity within default mode network (DMN) and that between FPN and DMN (i.e., negative network). Key nodes that contributed to the prediction model included the middle frontal gyrus, inferior frontal gyrus, anterior cingulate cortex, and inferior temporal gyrus, which have been associated with impulsivity and emotional processing. Notably, this connectome has shown its specific role in predicting OSA by controlling for the influence of general Internet addiction. Moreover, the strength of the negative network mediated the relationship between OSA and impulsivity, highlighting that the negative network underlies the impulsivity characteristic of OSA. Together, these findings advanced our understanding of the neural correlates of OSA and provided a promising framework for diagnosing OSA. • The connectome-based prediction modelling was applied to predict individuals' online shopping addiction (OSA) tendency. • An OSA connectome that mainly consisted of connections across DMN, FPN, and CON contributed to the prediction of OSA. • This connectome has shown its specific role in predicting OSA by controlling for the influence of general Internet addiction. • The connections within DMN and between DMN and FPN mediated the relationship between OSA and impulsivity. [ABSTRACT FROM AUTHOR]

The gut-brain axis mediates the interaction pathway between microbiota and opioid addiction. In recent years, many studies have shown that molecular hydrogen has therapeutic and preventive effects on various diseases. This study aimed to investigate whether molecular hydrogen could serve as pharmacological intervention agent to reduce risks of reinstatement of opioid seeking and explore the mechanism of gut microbiota base on animal experiments and human studies. Morphine-induced conditioned place preference (CPP) was constructed to establish acquisition, extinction, and reinstatement stage, and the potential impact of H 2 on the behaviors related to morphine-induced drug extinction was determined using both free accessible and confined CPP extinction paradigms. The effects of morphine on microbial diversity and composition of microbiota, as well as the subsequent changes after H 2 intervention, were assessed using 16 S rRNA gene sequencing. Short-Chain Fatty Acids (SCFAs) in mice serum were detected by gas chromatography-mass spectrometry (GC-MS). Meanwhile, we also conducted molecular hydrogen intervention and gut microbiota testing in opioid-addicted individuals. Our results revealed that molecular hydrogen could enhance the extinction of morphine-related behavior, reducing morphine reinstatement. Gut microbes may be a potential mechanism behind the therapeutic effects of molecular hydrogen on morphine addiction. Additionally, molecular hydrogen improved symptoms of depression and anxiety, as well as gut microbial features, in individuals with opioid addiction. This study supports molecular hydrogen as a novel and effective intervention for morphine-induced addiction and reveals the mechanism of gut microbiota. [Display omitted] • Molecular hydrogen facilitates the extinction of morphine CPP in mice. • Molecular hydrogen improves anxiety and depression symptoms of opioid addicts. • Opioids alter gut microbial diversity and composition in mice and human. • Gut microbiota play a role in the intervention of molecular hydrogen. • Molecular hydrogen could be a novel intervention for addiction caused by opioid. [ABSTRACT FROM AUTHOR]

Online communities are becoming increasingly important in everyday life, providing opportunities for leisure habits and social organization. Some online communities are also considered risky for participants, but longitudinal studies on the potential negative consequences are needed. This social psychological study was grounded in theories of group behavior and social identification. We examined the longitudinal associations between participation in gambling and gaming online communities and excessive gambling and gaming. The role of social media identity bubbles was also considered. We used linear hybrid models and longitudinal data comprising five time points (T1–T5) to analyze within- and between-person associations. Nationally representative data were collected from Finnish respondents aged 18–75 (N = 1530) between 2021 and 2023. The Problem Gambling Severity Index (PGSI) was used to measure gambling problems, and the Internet Gaming Disorder Test (IGDT) was used to measure gaming problems. The Identity Bubble Reinforcement Scale (IBRS) measured involvement in social media identity bubbles. The results indicated that participating in online communities was associated with both gambling and gaming problems at the within- and between-person levels. Interaction analyses showed that these problems were increased among active online community users who were also involved in online identity bubbles. Online identity bubbles play a significant role in the process by which non-problematic leisure activities can become addictive behaviors. • A longitudinal study (N = 1530) of the role of online communities in gambling and gaming problems. • Online gambling community participation had positive within and between-person associations with gambling problems. • Online gaming community participation had positive within- and between-person associations with gaming problems. • Gambling and gaming problems were heightened for those concurrently involved in online identity bubbles. [ABSTRACT FROM AUTHOR]

Similar to addictive substances, addictive behaviours such as gambling and gaming are associated with maladaptive modulation of key brain areas and functional networks implicated in learning and memory. Therefore, this review sought to understand how different learning and memory processes relate to behavioural addictions and to unravel their underlying neural mechanisms. Adhering to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we systematically searched four databases – PsycINFO, PubMed, Scopus, and Web of Science using the agreed-upon search string. Findings suggest altered executive function-dependent learning processes and enhanced habit learning in behavioural addiction. Whereas the relationship between working memory and behavioural addiction is influenced by addiction type, working memory aspect, and task nature. Additionally, long-term memory is incoherent in individuals with addictive behaviours. Consistently, neurophysiological evidence indicates alterations in brain areas and networks implicated in learning and memory processes in behavioural addictions. Overall, the present review argues that, like substance use disorders, alteration in learning and memory processes may underlie the development and maintenance of behavioural addictions. • Addiction involves the acquisition of bad habits and automatic behaviours. • Behavioural addictions are associated with maladaptive neural activity related to learning and memory. • Learning and memory in behavioural addictions are complex and multifaceted. • Complex span performance is altered in behavioural addictions. • Learning processes reliant on the executive function are reduced in behavioural addictions. [ABSTRACT FROM AUTHOR]

• TMS is a promising intervention in the area of addiction medicine capable of individualized treatments within a neurocircuitry approach. • The neurocircuitry model of addiction has defined three different stages corresponding to three different areas in the brain. • The published clinical trials using TMS for MUD have focused on the neurocircuitry effects of the PFC stimulation, either the dorsal or ventral networks. • Some studies now suggest that the frontopolar cortex or the salience network could also be susceptible to intervention. • Certain patients with MUD might need a combination of different interventions depending on the pathological predominance of certain stages. The use of methamphetamine in the United States is increasing, contributing now to the "fourth wave" in the national opioid epidemic crisis. People who suffer from methamphetamine use disorder (MUD) have a higher risk of death. No pharmacological interventions are approved by the FDA and psychosocial interventions are only moderately effective. Transcranial Magnetic Stimulation (TMS) is a relatively novel FDA-cleared intervention for the treatment of Major Depressive Disorder (MDD) and other neuropsychiatric conditions. Several lines of research suggest that TMS could be useful for the treatment of addictive disorders, including MUD. We will review those published clinical trials that show potential effects on craving reduction of TMS when applied over the dorsolateral prefrontal cortex (DLPFC) also highlighting some limitations that affect their generalizability and applicability. We propose the use of the Koob and Volkow's neurocircuitry model of addiction as a frame to explain the brain effects of TMS in patients with MUD. We will finally discuss new venues that could lead to a more individualized and effective treatment of this complex disorder including the use of neuroimaging, the exploration of different areas of the brain such as the frontopolar cortex or the salience network and the use of biomarkers. [ABSTRACT FROM AUTHOR]

Background: Internet addiction has been a topic of discussion in the academic literature for many years. As of April 2020, about 60 % of the world's population (nearly 4.6 billion people) were active internet user in their early adulthood. The prevalence among adolescent and college students ranged from 0.9 % to 33 %. The current study aimed to explore internet addiction's prevalence and correlates among undergraduate medical students at an Egyptian university. Also, to assess the relationship between internet addiction, depression symptoms, and socioeconomic status.Methods: A cross-sectional study of 321 undergraduate medical students at Assiut University using the Internet Addiction Scale, Patient Health Questionnaire, and Family Affluence Scale.Results: About 9 % of the study participants screened positive for internet addiction. The most important determinants among medical students were sex, mother's employment status, family affluence, depressive symptoms, and unmonitored internet access.Limitations: We did not investigate another psychiatric disease, daily time of internet usage, most frequent time of usage, type of internet usage, and cost of use.Conclusions: Internet Addiction is an important psychological problem affecting about 9 % of Assiut university medical students during their undergraduate stage, which may interfere with their lives and studies. Students with lower Internet addiction rates were female students whose mothers were employed, lived in a low affluence family, had fewer depressive symptoms, and had unmonitored internet privacy. [ABSTRACT FROM AUTHOR]

• Centrally administered oxytocin impaired inhibitory avoidance performance of mice. • Centrally administered oxytocin antagonist had the opposite effect on performance. • Increase of evoked acetylcholine release reversed the impairment by oxytocin. • Central-acting anticholinesterases inhibitor reversed the impairment by oxytocin. • Acetylcholine receptor antagonists prevented the oxytocin antagonist effect in CNS. Oxytocin (OT) and vasopressin (AVP) are two closely related neuropeptides implicated in learning and memory processes, anxiety, nociception, addiction, feeding behavior and social information processing. Regarding learning and memory, OT has induced long-lasting impairment in different behaviors, while the opposite was observed with AVP. We have previously evaluated the effect of peripheral administration of OT or its antagonist (AOT) on the inhibitory avoidance response of mice and on the modulation of cholinergic mechanisms. Here, we replicate and validate those results, but this time through central administration of neuropeptides, considering their poor passage through the blood–brain barrier (BBB). When we delivered OT (0.10 ng/mouse) and its antagonist (0.10 ng/mouse) through intracerebroventricular (ICV) injections, the neuropeptide impaired and AOT enhanced the behavioral performance on an inhibitory avoidance response evaluated 48 h after training in a dose-dependent manner. On top of that, we investigated a possible central interaction between OT and the cholinergic system. Administration of anticholinesterases inhibitors with access to the central nervous system (CNS), the activation of muscarinic acetylcholine (Ach) receptors and the increase of evoked ACh release using linopirdine (Lino) (3–10 µg/kg, IP), reversed the impairment of retention performance induced by OT. Besides, either muscarinic or nicotinic antagonists with unrestricted access to the CNS reduced the magnitude of the performance-facilitating effect of AOT's central infusion. We suggest that OT might induce a cholinergic hypofunction state, resulting in an impairment of IA memory formation, a process for which the cholinergic system is crucially necessary. [ABSTRACT FROM AUTHOR]

Impaired behavioral inhibition is a critical factor in drug addiction and relapse. Repetitive transcranial magnetic stimulation (rTMS) reduces the craving of heroin-addicted individuals for drug-related cues. However, it is unclear whether this technique also improves impaired behavioral inhibition and how improved behavioral inhibition affects craving. The intermittent theta-burst stimulation (iTBS) has been recently shown to be non-inferior relative to rTMS for depression. Here, we aim to investigate the effect of iTBS on heroin-addicted individuals' behavioral inhibition and cue-induced craving and the relationship between the alteration of behavioral inhibition and craving. 42 of 56 initially recruited individuals with the heroin-use disorder in the abstinent-course treatment were randomized to undergo active or sham iTBS to the left dorsolateral prefrontal cortex and received three daily iTBS treatments for 10 consecutive days. We measured participants' performance during a two-choice oddball task (80% standard and 20% deviant trials) and heroin-related cue-induced craving before and immediately after treatment. The group that received active iTBS showed significantly improved two-choice oddball task performance after 10 days of intervention compared to both pre-intervention and the group who received sham iTBS. Similarly, a significant reduction in cue-induced craving was observed after following the intervention in the active iTBS group but not the sham iTBS group. The moderation model indicated that iTBS categories play a significant moderating role in the relationship between accuracy cost changing and altered cue-induced craving. The iTBS treatment protocol positively affects behavioral inhibition in patients with heroin addiction. Improvements in behavioral inhibition can substantially reduce craving. • iTBS treatment protocol can enhance behavioral inhibition of heroin use disorder. • iTBS targeting prefrontal cortex reduce cue-induced craving in heroin use disorder. • Improvements in behavioral inhibition can be a predictive factor of treatment outcome. • Improving cognitive control functions could have therapeutic implications in drug addiction. [ABSTRACT FROM AUTHOR]

Background: Adolescent smartphone addiction (ASA) has fueled concerns worldwide regarding the negative health effects. This study aimed to examine whether parental smartphone addiction (PSA) affected ASA, and evaluated the mediating role of the parent-child relationship and the moderating role of parental bonding in the effect from PSA to ASA, among a Chinese sample of parent-child pairs.Methods: A large-scale cross-sectional survey was conducted among 10- to 15-year-old students and their parents. ASA and PSA were assessed by Mobile Phone Addiction Index (MPAI). The parent-child relationship was evaluated by Child-Parent Relationship Scale-Short Form (CPRS-SF), and parental bonding was estimated by Parental Bonding Instrument (PBI). Conditional process model was used to examine the relationship between PSA and ASA, as well as the mediating effect of parent-child relationship and the moderating effect of parental bonding.Results: A total of 9515 adolescents and their parents completed the online survey. PSA significantly positively predicted ASA (B = 0.488, p < 0.001). The parent-child relationship negatively mediated the association from PSA to ASA (B = -0.321, p < 0.001). Parental overprotection moderated the indirect path from PSA to ASA through the parent-child relationship (B = -0.016, p < 0.001), but parental care had not any moderation (B = -0.005, p > 0.05). Specifically, parental overprotection had a positive moderating effect on the second half mediation path. The indirect effect of PSA on ASA through parent-child relationship was greater in higher overprotection than in lower.Limitations: Cross-sectional study of self-administrated questionnaires.Conclusions: Adolescents had a higher tendency toward smartphone addiction when their parents excessively used smartphones. The findings highlighted the essential role of parent-child relationship and parental bonding in the association from PSA to ASA. [ABSTRACT FROM AUTHOR]

Background: To conduct a meta-analysis to quantitatively assess the association between mobile phone addiction (MPA) and sleep disorder (SD) by reviewing current evidence from observational studies.Methods: The meta-analysis was conducted by searching Pubmed, Embase, Scopus, and Web of science using a retrieval strategy related to MPA and SD. Pooled Odds ratios and Pearson's correlation coefficients were calculated by R software using a random effects model.Results: 29 studies including a total of 20041 participants were identified. We found that MPA was significantly associated with an increased risk of adolescents having SD (OR = 2.25, 95%CI= 1.72-2.94). Additionally, the findings also demonstrated that weak-to-moderate positive correlations were found between MPA and SD (summary r = 0.30, 95%CI= 0.25-0.34). The meta-regression analysis and subgroup analysis suggested that the geographic location and the measurement of MPA might be the sources of heterogeneity, and the robustness of the findings was confirmed by sensitivity analysis.Limitations: The information collected was self-reported, and the recall bias was inevitable.Conclusions: This study updated the findings of the association between MPA and SD from the previous reviews and was also the first meta-analysis to assess the association between MPA and SD using Odds Radios and correlation coefficients concurrently. The result of this study re-emphasized that paying more attention to the public health concerns of MPA and SD is needed in the future, whether implementation more relevant researches or developing targeted policies. [ABSTRACT FROM AUTHOR]

Concerns surrounding electronic addictions, an umbrella term including any clinically significant technology-based addictive problem, have increased as technology has advanced. Although researchers and clinicians have observed detrimental effects associated with excessive technology use, there is no agreed-on definition or set of criteria for these problems. The lack of a consistent understanding of electronic addictions has led to a lack of consistency in both assessment and treatment studies, precluding strong recommendations for effective screening and clinical intervention. This meta-review integrates findings from 22 systematic reviews and meta-analyses of electronic addictions to determine which measures and interventions may effectively measure and treat electronic addictions. We conducted a meta-review using Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Findings suggest that although some measures may have good internal consistency and reliability among college students, there was a general lack of consistency in how measures were used across studies, making comparison difficult. Psychological and exercise-based interventions were shown to reduce symptoms of electronic addictions short-term, but no treatment was superior to others in overall symptom reduction. Most included reviews raise serious concerns about the lack of consensus on what constitutes an electronic addiction. Consequently, it was not possible to draw conclusions about the overall efficacy of any measurement tools or interventions. We provide suggestions for next steps to establish the phenomenology of electronic addictions before additional research on assessment and intervention is conducted. • Electronic addictions, broadly defined, are an area of increasing interest with no unifying definition. • Without standardization of terms and symptoms, it is not possible to judge assessment tool adequacy or treatment efficacy. • Foundational work is needed to determine if electronic addictions are primary disorders before conducting future research. [ABSTRACT FROM AUTHOR]