1,040,747 results
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2. Some weak versions of the M1-spaces
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Shou Lin and Fucai Lin
- Subjects
Pure mathematics ,General Topology (math.GN) ,s-σ-mi-spaces ,54B10, 54C05, 54D30 ,mi-spaces ,Space (mathematics) ,Combinatorics ,Monotonically normal space ,Closure-preserving ,FOS: Mathematics ,Strongly monotonically normal ,Monotonically normal ,Geometry and Topology ,s-mi-spaces ,Mathematics ,Mathematics - General Topology - Abstract
We mainly introduce some weak versions of the $M_{1}$-spaces, and study some properties about these spaces. The mainly results are that: (1) If $X$ is a compact scattered space and $i(X)\leq 3$, then $X$ is an $s$-$m_{1}$-space; (2) If $X$ is a strongly monotonically normal space, then $X$ is an $s$-$m_{2}$-space; (3) If $X$ is a $\sigma$-$m_{3}$ space, then $t(X)\leq c(X)$, which extends a result of P.M. Gartside in \cite{CP}. Moreover, some questions are posed in the paper., Comment: 8 pages
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3. Distance-hereditary graphs are clique-perfect
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Maw-Shang Chang and Chuan-Min Lee
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Combinatorics ,Discrete mathematics ,Distance-hereditary graphs ,Computer Science::Discrete Mathematics ,Applied Mathematics ,Clique-transversal number ,Discrete Mathematics and Combinatorics ,Clique-independence number ,Graphs ,Graph ,Mathematics - Abstract
In this paper, we show that the clique-transversal number @t"C(G) and the clique-independence number @a"C(G) are equal for any distance-hereditary graph G. As a byproduct of proving that @t"C(G)=@a"C(G), we give a linear-time algorithm to find a minimum clique-transversal set and a maximum clique-independent set simultaneously for distance-hereditary graphs.
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4. An algorithmic framework for network reconstruction
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Annegret Wagler, Robert Weismantel, and Markus Durzinsky
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Theoretical computer science ,General Computer Science ,Computer science ,business.industry ,Systems biology ,Petri nets ,Petri net ,Process architecture ,Theoretical Computer Science ,Task (project management) ,Computational biology ,Relevance (information retrieval) ,Integer decomposition ,Artificial intelligence ,business ,Reverse engineering ,Computer Science(all) - Abstract
Models of biological systems and phenomena are of high scientific interest and practical relevance, but not always easy to obtain due to their inherent complexity. To gain the required insight, experimental data are provided and need to be interpreted in terms of models that explain the observed phenomena. In systems biology the framework of Petri nets is often used to describe models for the regulatory mechanisms of biological systems. The aim of this paper is to provide, based on results in Marwan et al. (2008) [1] and Durzinsky et al. (2008) [2], an algorithmic framework for the challenging task of generating all possible Petri nets fitting the given experimental data.
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5. Improving the Quality of Web-based Enterprise Applications with Extended Static Checking: A Case Study
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Frédéric Rioux and Patrice Chalin
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Design by Contract ,General Computer Science ,Java ,Scala ,Computer science ,Design by contract ,computer.software_genre ,Theoretical Computer Science ,Extended Static Checking ,Real time Java ,Extended static checking ,Web application ,Web-based Enterprise Application ,Java applet ,computer.programming_language ,business.industry ,Programming language ,strictfp ,Generics in Java ,Java concurrency ,Java API for XML-based RPC ,TheoryofComputation_LOGICSANDMEANINGSOFPROGRAMS ,Java Modeling Language ,business ,Java annotation ,computer ,Computer Science(all) - Abstract
ESC/Java2 is a tool that statically detects errors in Java programs and that uses the Java Modeling Language (JML) as its annotation language. ESC/Java2 can modularly reason about the code of a Java Web-based Enterprise Application (WEA) and uncover potential errors. In this paper, we assessed the effectiveness of ESC/Java2 at helping developers increase WEA quality by detecting design and implementation issues.
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6. Identification of dual mTORC1 and mTORC2 inhibitors in melanoma cells: Prodigiosin vs.obatoclax
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Victor Guallar, Jose M. Lizcano, Ali Hosseini, Vanessa Soto-Cerrato, T. Gao, Roberto Quesada, Margarita Espona-Fiedler, Ricardo Pérez-Tomás, and Universitat de Barcelona
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Indoles ,Antineoplastic Agents ,mTORC1 ,Therapeutics ,Biology ,Mechanistic Target of Rapamycin Complex 1 ,Biochemistry ,mTORC2 ,chemistry.chemical_compound ,Phosphatidylinositol 3-Kinases ,Clinical trials ,Protein kinases ,Cell Line, Tumor ,Humans ,Pyrroles ,Protein kinase B ,Melanoma ,PI3K/AKT/mTOR pathway ,Pharmacology ,Cell growth ,Prodigiosin ,TOR Serine-Threonine Kinases ,RPTOR ,Proteins ,Ribosomal Protein S6 Kinases, 70-kDa ,Terapèutica ,Anti-Bacterial Agents ,Gene Expression Regulation, Neoplastic ,Proteïnes quinases ,chemistry ,Multiprotein Complexes ,Cancer research ,Insulin Receptor Substrate Proteins ,Proto-Oncogene Proteins c-akt ,Obatoclax ,Transcription Factors ,Assaigs clínics - Abstract
The PI3K/AKT/mTOR signaling pathway regulates cell proliferation, survival and angiogenesis. The mammalian target of rapamycin (mTOR) is a protein kinase ubiquitously expressed within cells that regulates cell growth and survival by integrating nutrient and hormonal signals. mTOR exists in two complexes, mTORC1 and mTORC2. Hyperactivation of the mTOR protein has been linked to development of cancer, raising mTOR as an attractive target for cancer therapy. Prodigiosin (PG) and obatoclax (OBX), two members of the prodiginines family, are small molecules with anticancer properties which are currently under clinical trials. In the present paper, we demonstrate that mTOR is a molecular target of both prodiginines in melanoma, a highly drug-resistant cancer model. The inhibition of mTORC1 and mTORC2 complexes by PG or OBX resulted in a loss of AKT phosphorylation at S473, preventing its full activation, with no significant effect on T308. The strongest activity inhibition (89%) was induced by PG on mTORC2. Binding assays using Surface Plasmon Resonance (SPR) provide kinetic and affinity data of the interaction of these small molecules with mTOR. In addition, in silico modeling produced a detailed atomic description of the binding modes. These results provide new data to understand the mechanism of action of these molecules, and provide new structural data that will allow the development of more specific mTOR inhibitors for cancer treatment.
7. PROGRAM.
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DERMATOLOGY , *CONFERENCES & conventions , *VIRUSES , *DNA , *SKIN infections , *ANTIGENS - Abstract
The article informs about the details of the Thirty-first Annual Meeting of the Society for Investigative Dermatology, Inc, to be held On June 20 and 21, 1970, at the Sheraton Chicago Hotel, Chicago, Illinois. Many papers will be presented at this meeting. The paper titled "Ultrastructural Autoradiographic Study of Molluscum Contagiosum Virus Maturation In Vivo," informs that tritiated thymidine when injected into lesions of molluscum contagiosum incorporates into DNA of germinative cell nuclei, as well as into cytoplasmic inclusions of infected spinous and granular cells. The paper titled "Antigens of Human Wart Tissue," informs about experimental animal tumors caused by papova viruses contain cellular antigens which relate to tumor rejection.
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- 1970
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8. ANNOUNCEMENT.
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MEETINGS , *DERMATOLOGY , *SKIN diseases , *NATURAL history , *SOCIETIES - Abstract
Applications are being invited for scientific papers to be read before the Section on Dermatology of the American Medical Association meeting on June 20-24, 1971 at Atlantic City, New Jersey. Moreover, there will be two meetings of the Society for Investigative Dermatology Inc. in the year 1971. The spring meeting will be on May 1, 1971 and the thirty-second annual meeting will be held on June 18-20, 1971. The formation of the European Society for Dermatological Research has also been announced. The objective of the society is the promotion of research related to skin and its disease through the application of methods of natural sciences.
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- 1970
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9. ANNOUNCEMENTS.
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CONFERENCES & conventions , *SOCIETIES , *SKIN diseases , *MEDICINE , *TRANSLATING & interpreting , *RESEARCH - Abstract
The article presents the announcement of a joint meeting of the Society for Investigative Dermatology and the European Society for Dermatological Research from May 17 through May 19, 1972. The purpose of this meeting will be to serve as a forum for the presentation of original dermatological research papers. Twelve minutes will be allotted per paper. All presentations must be in English. Simultaneous translation will not be provided. The program will be selected by a joint program committee of the two sponsoring Societies. The article also announces that the Third World Congress of the International Society of Tropical Dermatology will be held in Sao Paulo, Brazil, on September 13-18, 1974.
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- 1971
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10. ANNOUNCEMENT.
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MEETINGS , *DERMATOLOGY , *FORUMS , *DERMATOLOGISTS - Abstract
The Society for Investigative Dermatology and the European Society for Dermatological Research are holding a joint meeting from May 17-19, 1972 in Amsterdam, Netherlands. The purpose of this meeting will be to serve as a forum for the presentation of original dermatological research papers. All the presentations in the meeting are required to be in English. Also, the Aspen Conference for Dermatologists, being sponsored by the Rocky Mountain Dermatological Society will be held on July 22, 1971.
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- 1971
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11. ENZYMATIC BASIS FOR THE ACTIVE TRANSPORT OF SODIUM IN THE ECCRINE SWEAT GLAND.
- Author
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Sato, Kenzo, Dobson, Richard L., and Mali, J. W. H.
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ENZYME activation , *SWEAT glands , *ADENOSINE triphosphatase , *RHESUS monkeys , *STOICHIOMETRY , *LACTATES - Abstract
1. The characteristics of the Na-K-ATPase of the rhesus monkey palm eccrine sweat gland were studied. The maximal activation concentrations for Na+ and K+ were 200 mM and 40 mM respectively. 2. An attempt was made to estimate the stoichiometric relationship between Na+ flux and ATP hydrolysis by the Na-K-ATPase activity obtained in this study and ATP production estimated from CO2 and lactate production reported in our previous paper (1). Na+/ATP ratios of 3.3 and 3.0 respectively were obtained, which agree well with the usual ratio of 3 found in other transporting epithelia. 3. The distal (straight) duct was isolated and its Na-K-ATPase activity determined. The Na-K-ATPase activity in the distal duct was less than one tenth of that in the sweat gland coil (secretory coil + proximal duct) and thus the role of the distal duct as a site of active sodium transport would be relatively minor. [ABSTRACT FROM AUTHOR]
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- 1971
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12. TYROSINASE ISOLATED FROM MOUSE MELANOMA MELANOSOME.
- Author
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Miyazaki, Kazuhiro and Seiji, Makoto
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PHENOL oxidase , *MICE , *MELANOMA , *CHROMATOGRAPHIC analysis , *ELECTROPHORESIS , *POLYACRYLAMIDE , *CELLULOSE acetate - Abstract
Tyrosinase was dissolved from the melanosome fraction of Harding-Passey mouse melanoma and purified further by Sephadex G-100 gel filtration and DEAE-cellulose column chromatography. The specific activity of the purified preparation was 763 times as high as that of the original melanosome. Tyrosinase thus isolated showed only a single activity in both the electrophoresis of a polyacrylamide gel and a cellulose acetate. The Km value is the same as those of the original melanosome and the smooth-surfaced-membrane. The relationship between particle bound tyrosinase and solubilized tyrosinase is discussed in this paper. [ABSTRACT FROM AUTHOR]
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- 1971
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13. ANNOUNCEMENTS.
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DERMATOLOGY , *MEETINGS ,ABSTRACTS - Abstract
This article presents information on various public announcements on dermatology. The joint meeting of The Society for Investigative Dermatology and the European Society for Dermatological Research will be held from May 17-19, 1972 in Amsterdam, the Netherlands. The purpose of this meeting is to serve as a forum for the presentation of original dermatological research papers. The deadline for submission of abstracts will be November 30, 1971. The Fifth Annual Meeting of the Carmel Skin Club will be held on February 4, 1972 in California.
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- 1971
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14. THE PRODUCTION OF HYALURONIDASE (HYALURONATE LYASE) BY <em>CORYNEBACTERIUM ACNES</em>.
- Author
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Puhvel, S. Madli and Reisner, Ronald M.
- Subjects
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ACNE , *FATTY acids , *SEDIMENTATION & deposition , *ENZYMES , *SKIN , *PROTEINS - Abstract
This paper presents evidence of the production of hyaluronidase by Corynebacterium acnes. In a study of seven random isolates of C. acnes from lesions of cystic acne and from normal skin, hyaluronidase activity ranged from less than one turbidity reducting unit. (TRU) to 72 TRU per mg of extracellular protein. These findings raise the interesting possibility that C. acnes hyaluronidase may play a role in the development of acne by contributing to the inflammatory phase through an increased permeability of the follicular epithelium to free fatty acids and other irritants. [ABSTRACT FROM AUTHOR]
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- 1972
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15. SOME OBSERVATIONS ON THE POST-PLUCKING DEPRESSION IN TRITIATED THYMIDINE UTILIZATION IN MOUSE SKIN AND SOME TENTATIVE CELL KINETIC DETERMINATIONS.
- Author
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Potten, Christopher S.
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CELLS , *DNA synthesis , *SKIN , *GROWTH factors , *THYMIDINE , *ANESTHESIA - Abstract
Immediately after plucking the hairs from a mouse, with its skin in the resting phase of the hair growth cycle, both the labeling index and incorporation levels of ³HTdR are lowered. This depression persists until stimulated cells enter S, usually about 10 hours after plucking. These observations are confirmed using a combination of liquid scintillation and autoradiographic procedures. The dpm per punch of fixed skin, the labeling index of the basal layer, the grains per labeled basal layer cell and the proportion of labeled DNA are all reduced following plucking. The dpm per punch of fresh skin is concomitantly enlarged by plucking through an increase in the fixative-soluble pool, which may be due to the induction of vascular changes. Anesthesia apparently reduces slightly the incorporation levels into fixed unplucked skin. The vascular changes and anesthesia depression of incorporation cannot account for the depression in incorporation into fixed tissue which must be due to a more direct effect on DNA synthesis. The data could be explained on the basis of a reduction in the rate of synthesis combined with a block to entry into S or to progression through S. Using the autoradiographic and liquid scintillation techniques presented in this paper and published previously, a number of calculations were made regarding the proliferative population size in the epidermis and hair follicle. The cycle time for basal layer cells in unplucked skin is estimated to be 141 hours with an upper limit on the growth fraction of 0.92. [ABSTRACT FROM AUTHOR]
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- 1972
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16. ANNOUNCEMENT.
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CONFERENCES & conventions , *DERMATOLOGY , *ASSOCIATIONS, institutions, etc. - Abstract
This article presents information about upcoming conferences in the field of dermatology, published in the June 1, 1972 issue of the "Journal of Investigative Dermatology." The annual joint meeting of the Western Section of the American Federation for Clinical Research, the Western Society for Pediatric Research and the Western Association of Physicians will be held in Carmel, California, from January 31 through February 3, 1973. The Sixth Annual meeting of the Carmel Skin Club will be held in Carmel, California on February 2, 1973. Papers for Presentation are hereby solicited.
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- 1972
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17. ANGIOGENESIS IN PSORIASIS: THERAPEUTIC IMPLICATIONS.
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Folkman, Judah
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PSORIASIS , *NEOVASCULARIZATION , *BLOOD-vessel development , *SKIN diseases , *CANCER cells , *ENDOTHELIUM - Abstract
Within solid neoplasms. the population of tumor cells and the population of capillary endothelial cells constitute a highly integrated ecosystem. Tumor cells release an endothelial mitogen. Tumor-Angiogenesis-Factor (T.A.F.) which continually stimulates new capillaries to grow into the tumor. When T.A.F. is blocked, neovascularization is prevented and tumor nodules stop expanding at a diameter less than 2.5 mm. They enter a dormant phase because they are forced to live by simple diffusion of nutrients and wastes. Thus "anti-angiogenesis can force a population of tumor cells to become dormant at a tiny diameter. In this paper an analogy is drawn between tumor angiogenesis and the angiogenesis which accompanies psoriasis. if the relationship between psoriatic epithelium and its capillary endothelium turns out to be similar to the integration of capillaries by solid tumors, then "anti-angiogenesis' may eventually become a useful therapeutic approach in psoriasis. [ABSTRACT FROM AUTHOR]
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- 1972
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18. ANNOUNCEMENT.
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DERMATOLOGY , *CONFERENCES & conventions , *SKIN diseases , *ASSOCIATIONS, institutions, etc. , *DERMATOLOGISTS - Abstract
The Subsection of Dermatology of the Western Section of the American Federation for Clinical Research will meet as a part of the annual joint meeting of the Western Section of the American Federation for Clinical Research, the Western Society for Pediatric Research and the Western Association of Physicians, in Carmel, California, from January 31 through February 3, 1973. This Subsection of Dermatology is recognized and supported by the Society for Investigative Dermatology as a regional meeting of the Society. Papers for presentation at this meeting are hereby solicited. Dermatologists who wish to present a paper at this meeting but who are not members of one of the three parent organizations can without difficulty usually find a member to sponsor their presentation.
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- 1972
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19. ANNOUNCEMENT.
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DERMATOLOGY , *MEDICAL research , *SKIN diseases , *PHYSICIANS , *MEDICAL societies , *ASSOCIATIONS, institutions, etc. - Abstract
The subsection of Dermatology of the western section of the American Federation of Clinical Research will meet as a part of annual joint meeting of the Western Section of the American Federation for Clinical Research, the Western Society for Pediatric Research and Wester Association of Physicians in California, from January 31 to February 3, 1973. Papers for presentation at this meeting are hereby solicited. Dermatologists, who wish to present a paper at this meeting but who are not members of one of three parent organizations can usually find a member to sponsor their presentation.
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- 1972
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20. CULTURE OF DERMATOPHYTES UPON STRATUM CORNEUM.
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Knight, Arthur G.
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DERMATOPHYTES , *DERMATOMYCOSES , *ADHESIVE tape , *ANTIFUNGAL agents , *ANTI-infective agents , *BACTERIAL spores - Abstract
An in vitro method of culturing dermatophytic spores on stratum corneum alone is described. The stratum corneum is stripped onto a translucent adhesive tape and fixed to a microscope slide. Spores are applied and the tape is incubated under controlled conditions. The technique has been made semiquantitative and applied to the study of a topical anti- fungal agent. [ABSTRACT FROM AUTHOR]
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- 1972
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