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Limb contractures are associated with poor outcomes and quality of life in long-term care (LTC) residents. This study examined the rate of developing new joint contracture in the LTC residents and associated risk factors to formulate effective interventions in this critical but understudied area. This is an observational study with data obtained from the Hong Kong Longitudinal Study on LTC Residents between 2005 and 2016. Trained assessors (nurses, social workers, and therapists) used the Minimum Data Set Resident Assessment Instrument (MDS-RAI 2.0) to collect the data of the residents from 9 residential LTC facilities. Limb contractures were defined as a functional limitation in the range of motion involving the upper or lower limbs. Primary outcomes included annual prevalence of joint contractures and factors that were associated with the development of new joint contractures. We analyzed the data for 1914 older residents (674 males, mean age 83.4 years). During the first 5 years since admission, the annual prevalence of upper limb contractures increased from 29.8% to 36.5%, and lower limb contractures increased from 41.5% to 57.4%. Overall, the increment of the prevalence rate of joint contractures per year ranged from 0.7% to 3.2% for the upper limbs and 0.3% to 6.0% per year for the lower limbs. Impaired mobility, presence of neurologic diseases, and older age were the leading independent risk factors for the development of new joint contractures. Joint contractures are highly prevalent among residents admitted to the LTC facilities, and many residents develop new contractures during the first 5 years of their admission. Immobility appears to be the main modifiable risk factor. Further studies are needed to identify potential strategies to prevent new contractures in this vulnerable group. [ABSTRACT FROM AUTHOR]

To compare outcomes between minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) and anterior lumbar interbody fusion (ALIF) at L5/S1. Primary, elective, single, MIS-TLIF, or ALIF with posterior fixation at L5/S1 were identified. Patient-reported outcome measures (PROMs) were collected. Coarsened exact matching was used to control for significant differences. Achievement of minimum clinically important difference [MCID] was determined by comparing ΔPROM scores with threshold values. Demographic/perioperative characteristics were compared between MIS-TLIF and ALIF cohorts using χ2 Student t tests. Differences in mean PROM scores, MCID rates, and postoperative complications were evaluated using an unpaired t test. After coarsened exact matching, 93 patients received MIS-TLIF and 50 received ALIF. Cohorts differed in operative time, estimated blood loss, and postoperative narcotic consumption on postoperative day 0 (P < 0.034, all). Mean PROMs differed significantly on 12-Item Short-Form Physical Component Summary at 6 weeks and 1 year, Patient-Reported Outcomes Measurement Information System Physical Function at 6 weeks, Oswestry Disability Index at 6 weeks, and visual analog scale (VAS) back at 6 weeks, with the ALIF cohort showing significantly improved mean PROMs (P ≤ 0.044, all). Significantly greater rates were reported of MCID achievement for PROMs for the ALIF cohort: VAS back at 6 weeks, Oswestry Disability Index at 12 weeks, 12-Item Short-Form Physical Component Summary at 6 weeks, and Patient-Reported Outcomes Measurement Information System Physical Function at 12 weeks (P ≤ 0.047, all). A greater rate of MCID achievement for the MIS-TLIF cohort was seen for 6-week and overall VAS leg (P < 0.046, all). Postoperative fever was greater in the TLIF cohort (9.6% vs. 2.0%; P < 0.047). Patients undergoing ALIF showed significantly improved rates of MCID achievement for disability, physical function, and back pain during the early postoperative period. However, the overall MCID achievement rate for leg pain was higher for the MIS-TLIF cohort. [ABSTRACT FROM AUTHOR]

Estimating the illuminant from a color-biased image is an ill-posed problem without prior information or invariance about the surfaces of a scene. Based on the classical image formation model, we have developed a heuristic approach to obtain the illuminant color by computing the ratio of the average of all pixels over the color-biased scene to that over the roughly recovered scene obtained by local normalization in each channel. The computed ratio represents an estimated invariance across color channels (IACC), ranging between the average reflectance of surfaces and the maximum reflectance of surfaces of a scene, modulated by the illuminant color. This work builds a mathematical foundation for IACC and explains why it is suitable for illuminant estimation. The core discovery is that the magnitude relationship of the average reflectances of surfaces between any two color channels is opposite to that of the maximum reflectances of surfaces for most natural scenes. As a result, we have designed two approaches for explicitly learning IACC of an image, resulting in very accurate illuminant estimation. The first approach involves a novel shallow model based on diagonal or non-diagonal matrices, together with the learned model parameters, to improve IACC performance. The second approach applies IACC as a constraint to optimize a novel deep learning approach, which has achieved state-of-the-art performance on two benchmarks. An interesting finding is that the output of the learned network, constrained only by IACC loss, provides a coarse estimation of intrinsic images such as albedo from the input color-biased image. • Biologically inspired image invariance (IACC) with mathematical basis is developed. • IACC guided shallow illuminant estimation (IE) model obtains competitive performance. • IACC guided deep IE obtains SOTA performance and learns physical albedo. [ABSTRACT FROM AUTHOR]

• The ARTFORCE PET-Boost trial aimed to improve local control through 2 dose-escalation strategies. • HRQoL remained on average stable, despite frequently noted PRO-symptoms. • No significant differences in HRQoL/PROs were found between both groups. • A decline in physical functioning was noted in both groups. • Our results provide insights on the impact of dose-escalated RT on PROs in LA-NSCLC. The ultimate challenge in dose-escalation trials lies in finding the balance between benefit and toxicity. We examined patient-reported outcomes (PROs), including health-related quality of life (HRQoL) in patients with locally advanced non-small cell lung cancer (LA-NSCLC), treated with dose-escalated radiotherapy. The international, randomised, phase 2 ARTFORCE PET-Boost study (NCT01024829) aimed to improve 1-year freedom from local failure rates in patients with stage II-III NSCLC, with a ≥ 4 cm primary tumour. Treatment consisted of an individualised, escalated fraction dose, either to the primary tumour as a whole or to its most FDG-avid subvolume (24 x 3.0–5.4 Gy). Patients received sequential or concurrent chemoradiotherapy, or radiotherapy only. Patients were asked to complete the EORTC QLQ-C30, QLQ-LC13, and the EuroQol-5D at eight timepoints. We assessed the effect of dose-escalation on C30 sum score through mixed-modelling and evaluated clinically meaningful changes for all outcomes. Between Apr-2010 and Sep-2017, 107 patients were randomised; 102 were included in the current analysis. Compliance rates: baseline 86.3%, 3-months 85.3%, 12-months 80.3%; lowest during radiation treatment 35.0%. A linear mixed-effect (LME) model revealed no significant change in overall HRQoL over time, and no significant difference between the two treatment groups. Physical functioning showed a gradual decline in both groups during treatment and at 18-months follow-up, while clinically meaningful worsening of dyspnoea was seen mainly at 3- and 6-months. In patients with LA-NSCLC treated with two dose-escalation strategies, the average patient-reported HRQoL remained stable in both groups, despite frequent patient-reported symptoms, including dyspnoea, dysphagia, and fatigue. [ABSTRACT FROM AUTHOR]

• Baseline pulse pressure was associated with future handgrip strength, gait speed, and 6-min walking distance among older adults in this study. • Older adults with both high systolic blood pressure (≥140 mmHg) and high pulse pressure (≥60 mmHg) had a significantly increased risk of future weakness, slowness, and lower endurance. • Controlling pulse pressure could slow the age-related decline in physical function. This study examined the associations between pulse pressure, hypertension, and the decline in physical function in a prospective framework. The Healthy Aging Longitudinal Study tracked a group of Taiwanese adults aged 55 or more over an average of 6.19 years to assess pulse pressure and decline in physical function, including in handgrip strength, gait speed, and 6-min walking distance, at baseline (2009–2013) and in the second phase of assessments (2013−2020). Pulse pressure was calculated as the difference between systolic and diastolic blood pressure values. Weakness, slowness, and low endurance were defined as decreases of ≥0.23 m/s (one standard deviation) in gait speed, ≥5.08 kg in handgrip strength, and ≥ 57.73 m in a 6-min walk, as determined from baseline to the second phase of assessment. Linear and logistic regressions were employed to evaluate the associations between pulse pressure, hypertension, and decline in physical function. Baseline pulse pressure was associated with future handgrip strength (beta = −0.017, p = 0.0362), gait speed (beta = −0.001, p < 0.0001), and 6-min walking distance (beta = −0.470, p < 0001). In multivariable models, only handgrip strength (beta = −0.016, p = 0.0135) and walking speed (beta = −0.001, p = 0.0042) remained significantly associated with future pulse pressure. Older adults with high systolic blood pressure (≥140 mmHg) and elevated pulse pressure (≥60 mmHg) exhibited a significantly increased risk of weakness (odds ratio: 1.30, 95 % confidence interval: 1.08–1.58), slowness (1.29, 1.04–1.59), and diminished endurance (1.25, 1.04–1.50) compared with the reference group, who exhibited systolic blood pressure of <140 mmHg and pulse pressure of <60 mmHg. Among older adults, pulse pressure is associated with a decline in physical function, especially in terms of strength and locomotion. [ABSTRACT FROM AUTHOR]

Water temperature and ice cover are critical characteristics of the ecological, biogeochemical, and physical functioning of a lake. Site-specific observations of temperature and ice, however, are not available for most lakes in the world. Yet this information is crucial to understanding the global role of lakes in the functioning of the bio- and hydrosphere. Here, we present the LakeTEMP dataset, referring to the ∼1.4 million lakes globally of the HydroLAKES database with a surface area exceeding 0.1 km2, and consisting of two subsets: (1) an observational dataset that contains lake surface water temperatures (LSWTs), derived from Landsat 8 thermal radiance observations between 2013 and 2021 extracted at the lake center points; and (2) a dataset with monthly and yearly LSWT summary statistics and predictions of average yearly ice cover durations, interpolated from the observational dataset using seasonal trendlines. All observations underwent extensive quality control and filtering, based on outlier detection, overlapping imagery removal, and the removal of observations taken from dry lake beds. Validation of the LSWT observations was carried out with in-situ data and yielded an R2, RMSE and median of differences of 0.93, 1.71 °C and 0.42 °C, respectively. The global average yearly LSWT is 6.3 °C, assuming 0 °C during times of presumed ice cover, and 12.4 °C when only considering periods of open water. About 8% of all lakes never freeze, ∼6% have short or sporadic freezing periods, and ∼86% freeze every year, corresponding to an estimated proportion of global lake surface area of 23%, 20%, and 57%, respectively. The warmest lakes in the world (average temperatures of up to 36 °C) are all artificial lakes used in the power plant, mining, salt extraction, and aquaculture industries. LakeTEMP fills a crucial spatial data gap in large-scale limnological research, especially for the incorporation of small lakes and understudied geographies of remote regions. Moreover, easy linkage to other large-scale datasets that use the unique lake identifiers from HydroLAKES, most notably the LakeATLAS database (56 hydro-environmental variables for each lake including anthropogenic influences), allows to explore characteristics that may be correlated to or affected by LSWT and ice cover. The data are in an analysis-ready format and openly available at https://doi.org/10.6084/m9.figshare.23844660. • First global scale lake surface water temperature (observed) dataset for all lakes >0.1 km2. • First global scale ice phenology (estimated) dataset for all lakes >0.1 km2. • Global mean lake surface water temperature, assuming 0 °C during winter ice cover, is 6.3 °C. • About 8% of the lakes of the world never freeze, ∼6% have short or sporadic freezing periods, and ∼ 86% freeze every year. • These datasets enable novel investigations of large-scale thermal processes in lakes. [ABSTRACT FROM AUTHOR]

Serious games have emerged as promising tools for physiotherapy, offering an engaging way to motivate patients and improve physical functions. Stress, a common physiological response, can impede patient performance and hinder recovery in physiotherapy. However, there is limited research on stress recognition for children during physiotherapeutic serious games. This study proposes a deep and machine learning based method for stress detection from facial images of children. The contributions include the utilization of a novel dataset comprising videos of 25 children, including children with specific conditions, and the exploration of using adults' facial images for data augmentation. The proposed method employs a modified deep network architecture, VGG-Face, for facial emotion recognition and utilizes three machine learning models for stress recognition. This study represents the first attempt to recognize stress in children's facial images during physiotherapy with serious games. The findings hold the potential to optimize patient outcomes and contribute to monitoring patients during home therapy. • Emotion/Stress recognition in children during physiotherapeutic games. • First attempt to recognize stress from children's facial images. • Usage of a novel dataset of 25 children including children with specific conditions. [ABSTRACT FROM AUTHOR]

Volatile organic compound (VOC) emissions are becoming an increasingly significant issue because of the increasing demand for bitumen in road engineering. This study attempted to develop a type of fume-suppressed bitumen with good comprehensive performance. Initially, 1, 2, and 3% organic montmorillonite and 2, 3, and 4% waxy warm-mix agents were utilised to modify bitumen. Subsequently, the fume suppression and physical and construction performances of the modified bitumen were evaluated, and the modified bitumen with the best comprehensive performance was determined. On this basis, constant- and variable-temperature heating modes were designed to verify the fuel suppression performance of the modified bitumen thoroughly. Finally, the modification mechanism of modified bitumen was investigated via atomic force microscopy. The results indicate that the modifier had the greatest impact on the ductility of the modified bitumen in terms of its physical performance. Although waxy warm mixed agents increase VOC emissions, organic montmorillonite can inhibit this effect. The modified bitumen, composed of 2% organic montmorillonite and 2% waxy warm mix agent, has the best comprehensive performance, with a 40.6% emission reduction rate under constant temperature heating mode and 46.4–28% range from 200 ℃ to 120 ℃ under another mode. The waxy warm mix agents and organic montmorillonite-modified bitumen developed into continuous and dispersed phase systems, respectively, leading to variations in the modified bitumen's physical performance and VOC emission capacity. In contrast, the composite-modified bitumen exhibited a two-phase structure with the surface morphology of an 'egg tray'. This unique structure enhances the heating surface area and facilitates heat conduction, improving the bitumen performance during construction. [Display omitted] • Consideration was given to the VOC emission reduction effect caused by the decrease in viscosity of bitumen. • The efficacy of fume suppression asphalt was verified in two heating modes. • A fume suppression asphalt with commendable comprehensive performance was designed. [ABSTRACT FROM AUTHOR]

Most products today have several functions, but these are achieved by integrating different monofunctional devices and/or materials in a system. Having several functions simultaneously in one single material has many potential advantages, such as a structural material that can also store energy, have self-sensing or self-healing capability or any other physical function. This would lead mass and resource savings, being more energy efficient and thus more sustainable. This paper presents a mini review on how carbon fibres can be used for integrating several functions simultaneously in a high-performance load carrying structural material using the electrical and electrochemical properties of carbon fibres. Through this carbon fibre composites can also store energy like a lithium-ion battery, be used as a strain sensor, have electrically controlled actuation and shape-morphing, and be used as an energy harvester. [ABSTRACT FROM AUTHOR]

• We develop a novel chemical method for the surface encapsulation of hydrogel with elastic coating that can prevent hydrogel from de/hydration in air and water. • Our mothed shows multiple applicability, which is applicable not only for flat surface of hydrogels, but also various irregular shapes including tubes, spheres, and wrinkles of hydrogels. • Our mothed can improve the functionality of hydrogel sensors, making them capable of long-term sensitivity in both air and water systems. De/hydration is unavoidable for unencapsulated hydrogels, which would weaken their physical performance during applications. Herein, we report a surface-encapsulating method that can chemically make an elastic coating at the surface of hydrogel to prevent it from de/hydration in air and water. The water loss is less than 6 wt% in weight by keeping the surface-encapsulated hydrogel in air at 28 °C for 20 days, and its weight doesn't increase by immersing it in water for 60 days. The adhesion energy between hydrogel and the coating reaches 2000 J/m2, so that it can keep the structural integrity in response to repeated stretching, compression, bending, twisting, and knotting. This method doesn't require any templates and special devices, which can make surface encapsulation for hydrogels that have irregular shapes such as tubes, spheres, and wrinkles. The encapsulated elastic coating is of long-term (180 days) stability without interfacial failure in air, and in acidic, alkaline, and salt solutions, which enables the hydrogel capable of long-term sensitivity as a strain sensor in air and water systems, showing great potential for signal transmission under water. [ABSTRACT FROM AUTHOR]

This study explores the relationship between musculoskeletal conditions of ageing and life-space mobility (LSM) in 1110 community-dwelling older adults from the Hertfordshire Cohort Study. LSM is a novel measure which captures ability to mobilise within the home, locally and more widely. Among men, older age, care receipt, not driving a car, lower wellbeing, and reduced physical function were associated with lower LSM, while in women only driving status and physical function were associated with LSM. Osteoporosis, arthritis, and fractures had no significant associations with LSM in either gender. These findings provide support for sex-specificity in the determinants of LSM and inform novel approaches to improving mobility and health in older age. • Life-space mobility (LSM) is essential for engagement in activities and maintaining independence. • Mobility declines with age and is associated with adverse health outcomes. • This study investigates gender differences in the relationships between musculoskeletal factors and LSM among older adults. • Musculoskeletal conditions and fractures were not associated with LSM. • Age, receipt of care, falls wellbeing, and physical function were associated with LSM in men; only physical function was associated with LSM in women. [ABSTRACT FROM AUTHOR]

• The HMob scale showed excellent internal consistency and reliability. • The HMOB scale presents concurrent validity with the FSS and FIM scales. • The HMOB scale can be used in daily practice to measure mobility in hospital. Existing mobility scales for hospitalized patients do not include assessment of tasks for the right and left side, ability to transfer from sitting to lying and from standing to sitting, ability to climbing steps and pick up an object from the floor in the same instrument. Evaluate the reliability and validity of the hospital mobility assessment scale (HMob) according to the Consensus-based standards for the selection of health measurement instruments (COSMIN). Study conducted in three inpatient units (cardiology, neurology, and gastrohepatology) and one adult intensive care unit in a hospital. Patients of both sexes were included; age >18 years; collaborative and who obeyed commands, with different medical diagnoses and clinical release to leave their bed (provided by the doctor). Special populations such as those with burns and orthopedics were excluded. The sample consisted of 130 patients; 20 from the pilot study and 110 to assess the clinimetric properties of the HMob. Cronbach alpha coefficient was 0.949. Relative intra- (A1-A2) and inter-rater (A1-B; A2-B) reliability was excellent (A1-A2: ICC = 0.982, p-value < 0.0001; A1-B: ICC = 0.993, p-value < 0.0001; A2-B: ICC = 0.986, p-value < 0.0001.) The convergent criterion validity of HMob in relation to the ICU Functional Status Score was 0.967 (p-value < 0.0001) and for Functional Independence measure (MIF) was 0.926 (p-value < 0.0001). The HMob scale showed excellent internal consistency, intra- and inter-rater reliability, and concurrent validity in the motor domain, which suggests that it can be used in daily practice to measure mobility in hospitalized patients. [ABSTRACT FROM AUTHOR]

Chronic pain is associated with substantial impairment in physical function, which has been identified as a top concern among persons with pain. GetActive-Fitbit , a mind-body activity program, is feasible, acceptable, and associated with improvement in physical function among primarily White, sedentary individuals with pain. In preparation for a multisite efficacy trial, we must examine feasibility across multiple sites with diverse patient populations. Here we describe the protocol of a multisite, feasibility RCT comparing GetActive-Fitbit with a time- and attention-matched educational comparison (Healthy Living for Pain). We aim to 1) test multisite fidelity of clinician training; 2) evaluate multisite feasibility benchmarks, including recruitment of chronic pain patients taking <5000 steps/day and racial and ethnic minorities; and 3) optimize fidelity and study protocol in preparation for a future multisite efficacy trial. Clinician training fidelity was assessed via roleplays and mock group sessions. Feasibility (i.e., recruitment, acceptability, credibility, adherence, satisfaction), multimodal physical function (e.g., self-report, 6-Minute Walk Test, step-count), and other psychosocial outcomes are assessed at baseline, posttest, and 6 months. Protocol optimization will be assessed using exit interviews and cross-site meetings. The trial is ongoing. Clinician training is complete. 87 participants have been recruited. 54 completed baseline assessments and randomization, 44 are mid-intervention, and 9 have completed the intervention and posttest. This study addresses the critical need for feasible, acceptable mind-body-activity interventions for chronic pain that follow evidence-based guidelines and improve all aspects of physical function across diverse populations. Results will inform a future fully-powered multisite efficacy trial. Clinical Trial Registration: NCT05700383 [ABSTRACT FROM AUTHOR]

Physical Unclonable Functions (PUFs) have gained attention as a lightweight hardware security primitive. In particular, the SRAM-based PUF uses the unpredictable power-up value of the cells within an SRAM. Although these values should ideally be always the same within each SRAM to accomplish a correct PUF operation, this is often not the case, especially when factors like circuit aging are considered. While certain studies explore the effects of aging on SRAM PUFs, they often simplify the analysis. For instance, some studies assume that only Bias Temperature Instability (BTI) contributes to circuit degradation while others evaluate the overall degradation without accounting for the stochastic effects of aging on each individual cell. In this work, we first perform a detailed characterization of the nature of aging in SRAM PUFs, demonstrating that the impact of Non-Conductive Hot-Carrier Injection cannot be neglected. We also show that different cells degrade differently, highlighting the importance of accounting for the stochasticity of aging. After that, a method based on the Data Retention Voltage metric to select the cells with the most stable power-up response is introduced. Using these cells to generate the PUF identifier will result in a more stable response, and thus a better PUF performance. [ABSTRACT FROM AUTHOR]

• Aerobic + resistance exercise increased the total intrincic capacity. • Aerobic exercise alone did not effect the total intrincic capacity. • Aerobic exercise and aerobic + resistance exercise improved strength and flexibility. • Aerobic exercise and aerobic + resistance exercise improved mobility and endurance. • Aerobic exercise and aerobic + resistance exercise improved aerobic capacity. Our study determined the impact of 12-week aerobic exercise (AE) and aerobic + resistance exercises (AE + RE) within the green exercise concept, on senior fitness, aerobic capacity, and intrinsic capacity (IC). The study was a multicenter, randomized controlled study conducted at two senior living facilities with individuals aged 65 and above whose cardiorespiratory and musculoskeletal conditions are suitable for moderate exercise and who have normal cognition levels. Block randomization was applied to 96 participants in a ratio of 1:1:1 to be assigned to AE, AE + RE, and control (C) groups. Intervention groups received exercise sessions led by physiotherapists within the senior living facilitiy gardens, with a frequency of once a week for 50 min, for 12 weeks. Also, they were prescribed additional exercise sessions on two additional days of the week. At the commencement of the study and 12th week, shuttle walking test, senior fitness test (SFT), intrinsic capacity assessment (with Timed Up and Go test, Mini Mental State Examination, Geriatric Depression Scale-15, Mini Nutritional Assessment, handgrip strength test) was conducted of all participants. The primary outcome was the Z score of IC, secondary outcomes were VO 2max and SFT subparameters. The study was registered in the Protocol Registry and Results System (Clinicaltrials.gov PRS) with the registration number NCT05958745. 90 participants successfully completed the study, with 30 individuals in each of the AE, AE + RE, and C groups. By the end of the 12th week, the arm curl score was significantly higher in the AE + RE compared to the C (mean difference: 3.96, 95 % CI= 2.47 to 5.46, p = 0.01). There were significant differences in chair stand, two-minute step, 8-foot up-and-go, chair sit and reach, and back scratch tests in both AE and AE + RE compared to C. AE and AE + RE exhibited significantly higher shuttle test distances and VO 2max values compared to the C (p < 0.0001). AE + RE achieved a significantly higher total IC score than the C (mean difference: 0.59, %95 CI= -0.07 to 1.26, p = 0.025). In this study within the green exercise concept, both AE and AE + RE led to similar improvements in strength, flexibility, mobility, endurance, and aerobic capacity. Notably, AE + RE demonstrated an additional benefit by increasing the total IC, while AE alone did not exhibit the same effect. [ABSTRACT FROM AUTHOR]

Frailty describes multidimensional vulnerability to stressors. In patients with bladder cancer, frailty predicts an increased risk of treatment-related complications and mortality. A critical limitation of the frailty literature lies in the many ways frailty is measured. Relying on one frailty instrument to label a patient as "frail" risks oversimplifying a patient's vulnerability profile, failing to identify specific vulnerabilities (e.g. nutritional vs. cognitive vs. psychological vs. functional frailty) that may be clinically actionable. Current guidelines recommend using a comprehensive geriatric assessment (CGA) to quantify frailty across domains of physical function, mental health/cognition, nutrition, multimorbidity, and social supports in older and medically complex adults. However, the CGA provides so much data that it can be challenging to synthesize into a single assessment and integrate into busy clinical practice. Herein, we propose a novel CGA-derived Frailty Spider Plot. This approach synthesizes the discrete CGA-identified vulnerabilities into a single, clinically useful frailty profile. Patients with urothelial cancer were prospectively enrolled from a multidisciplinary bladder cancer clinic between 9/2020 and 7/2021. After providing informed consent, participants completed a CGA incorporating validated assessments of frailty, functional status, multimorbidity, nutrition, cognition, and mental health, augmented with computed tomography-derived assessments of muscle mass and adiposity. We quantified the interdependence and relationships of different frailty instruments and domains using Spearman Correlation Coefficients to measure the degree to which the instruments conveyed similar or discrete data regarding patients' risk factors. Frailty measures for each patient were then visualized using spider plots to discriminate individual frailty phenotypes. Each spoke represented a specific frailty instrument from the CGA, grouped by frailty domains. Nodes of the spoke were determined by predefined validated thresholds for each geriatric assessment. Outer ring values corresponded to higher degrees of frailty for each instrument (Figure). The cohort included 67 patients (median age 71 years, 16.4% female). This population was medically complex with ASA class ≥III in 55.2%, ECOG PS ≥3 in 25.4%, and Charlson Comorbidity Index;≥3 in 54%. Most patients had muscle-invasive bladder cancer (77.6%; cN+ and M1 in 20.9% and 7.6%, respectively). The CGA identified key vulnerabilities beyond a standard risk assessment with 31.4% vulnerable-to-moderately frail (Clinical Frailty Scale), 23.9% at risk for falls, 13.4% and 7.5% with mild and moderate-to-severe depression, respectively, 3% with mild/moderate dementia, 34% at risk for malnutrition, and 6% malnourished. The majority of frailty measures were weakly correlated (ρ<|0.5|) across instruments with the exception of Clinical Frailty Scale/Timed-up-and-Go (ρ=0.7, p<0.0001), Mini-Mental/Grip strength (ρ=0.61, p<0.001), and albumin/skeletal muscle index (ρ=0.51, p=0.01). To illustrate, two patients' Frailty spider plots are presented in the Figure, demonstrating the specific and unique vulnerabilities within respective domains between individuals. In this prospective observational cohort, a CGA identified key vulnerabilities. Here, we demonstrate that the different domains communicate discrete information regarding an individual's specific risk profile that would be oversimplified if we rely on the nomenclature of frail/not frail. Notably, even within a domain, different instruments demonstrated low correlations, thus contributing distinct insights regarding a patient's individual vulnerability profile. We present a novel approach to synthesize these numerous data points in a single visual depiction that demonstrates the driving components of frailty (e.g. physical function, multimorbidity, nutrition, mental health/cognition) that could be targeted by personalized prehabilitation interventions. This approach maintains the specificity of the data provided by a CGA. Future work will evaluate the most relevant risk assessment instruments to best predict salient clinical outcomes and develop more parsimonious Frailty spider plots for evaluation and validation in clinical practice. [ABSTRACT FROM AUTHOR]

To identify cognitive and health profiles of cognitively impaired older adults with the presence of prior mobility impairment, which may represent a specific pathway to the development of cognitive impairment or dementia. Retrospective longitudinal study. In adults aged ≥65 years who developed cognitive impairment or dementia, we compared cognitive and health profiles of those who did (n = 57) and did not (n = 86) experience slow gait up to 14 years before symptom onset. Measures of cognitive and biomarkers assessed longitudinally over an average of 7 years before symptom onset were compared between groups using linear mixed effects models, adjusted age, sex, race, and additionally adjusted for education for cognitive outcomes. Compared to those without prior slow gait, those with slow gait had lower Digit Symbol Substitution Test and Pegboard dominant and nondominant hand performance. The slow gait group also had greater body mass index (BMI), waist, systolic blood pressure, lower high-density lipoprotein and low-density lipoprotein, and lower lysophosphatidylcholine 18:2, a lipid associated with mitochondrial function, and showed greater increases in 2-hour glucose levels of an oral glucose tolerance test. The slow gait group was more likely to take medication for hypertension and hypercholesterolemia. During the presymptomatic stage, cognitively impaired older persons who experience prior slow gait are more likely to have deficits in psychomotor speed and manual dexterity, an unfavorable metabolic and vascular profile, and lower lipid levels related to mitochondrial function. Older persons who exhibit mobility impairment should be evaluated for metabolic and vascular dysfunction at an early stage, and successful treatment of these conditions may slow down the progression of cognitive impairment or dementia. [ABSTRACT FROM AUTHOR]

• This is the first paper describing PROMIS ability to participate in social roles in patients with an extremity fracture. • The impact of extremity fractures on physical and social health is evident. • Upper extremity fracture patients do better on social health, pain and physical function. • PROM(I)S can add valuable information to outcome information in patients with an extremity fracture. The incidence of patients with fractures is increasing and so is the impact on health care systems and society. To improve patient care, measurement of disabilities and impaired health experiences after traumatic musculoskeletal injuries are important. Next to objective clinical parameters, PROM(I)S can be used to map health domains important to patients. We aimed to objectify different aspects of (health-related) quality of life in fracture patients, including the ability to participate in social roles and activities using PROMIS among other PROMs. An observational cohort study was performed in which health-related quality of life in fracture patients was measured. Patients aged 18 year and older either treated conservatively or surgically between November 2020 and June 2022 were included. Participants were followed for a maximum of one year and completed the following PROMs: PROMIS-CAT physical function, PROMIS-CAT pain interference, PROMIS-CAT ability to participate in social roles and activities and LEFS or QDASH. We applied a univariate linear mixed model to evaluate significance of improvement. Seven hundred-forty six patients with a mean age of 54.4 years were included. Mean PROMIS scores were structurally inferior in the lower extremity (LE) fracture group in comparison with the upper extremity (UE) fracture group. For "PROMIS physical function", UE fracture patients performed better and showed physical progression earlier. For "PROMIS pain interference", UE fracture patients experienced fewer limitations, but it took longer to experience improvement in this group. For "PROMIS ability to participate in social roles", significant improvement was only seen in the UE fracture group at one year follow up. Upper -and lower extremity fractures can have a significant impact on physical function and social health. Patients with UE fractures tend to have fewer limitations compared to LE fracture patients. Physical function and pain interference is most impaired shortly after the injury in all fracture patients and show significant changes over time, social health improves less over time. Moment of measurement should be based on type of fracture and can differ between individual patients, but when generic measures and outcomes are desirable, PROMIS questionnaires can potentially be used measurement. [ABSTRACT FROM AUTHOR]

Earthen plasters have been widely used in historical buildings such as grottoes, which have high historical, artistic, scientific, social, and cultural values. In order to study the influence of the material composition of plasters on its physical performance, a total of seven different types of earthen plaster specimens were made using Dengban clay and six admixtures (quartz sand, two types of vegetal fibers, and three types of hydraulic limes), and the surface water absorption properties, hygrothermal properties, surface strength (surface hardness, surface cohesion, and surface impact resistance), color difference, and radial shrinkage of all plasters were systematically investigated and compared. The results show that the addition of sand, vegetal fibers, and hydraulic limes all changed the surface water absorption, thermal conductivity, and water vapor permeability of plaster, and inhibit the radial shrinkage during the curing process. Compared to the other admixtures, sand had the least effect on the overall performance of plasters. Both types of vegetal fibers can greatly improve the impact resistance of plaster surface, but due to the formation of microcracks on the surface of the plaster with wheat straw fibers, its water absorption is much higher than that of the plaster with hemp fibers. The addition of three types of hydraulic limes changed the surface color of the plaster to some extent, and the water repellency of the plaster surface will be enhanced due to the carbonation of hydraulic lime. • The physical performance of seven types of earthen plasters was investigated. • The carbonation process enhances the water repellency of the plasters with hydraulic lime added. • The addition of vegetal fibers has greatly improved the impact resistance of the plaster surface. • The addition of hydraulic lime has an effect on the surface color (ΔE > 3). [ABSTRACT FROM AUTHOR]

In this study, an enhanced numerical manifold method (NMM) simulator is developed to determine the combined impacts of reinforcement range and grouting timing on the effectiveness of grouting reinforcement for preventing the large deformation geo-hazard during the tunnel excavation through a fault rupture zone. To accomplish this objective, the limitations of the current two-dimensional simulation method, which lacks connection to the actual tunnel excavation process, are overcome by proposing a novel softening path function. Using this novel softening path function, each simulation step is given a specific physical meaning, establishing a connection to the actual tunnel excavation process. This improvement enables more accurate and analyzable simulation outcomes. To verify the accuracy of the proposed softening path function, a series of simulations of tunnel excavation are conducted using this softening path function. These results align closely with the results obtained by other reliable numerical methods and previous studies. After validation, several sets of numerical cases are conducted, considering 6 different geo-stress conditions, 10 different grouting reinforcement ranges, and 7 different grouting timings. Based on these simulation results, a critical value for reinforcement range, which equals to the diameter of tunnel face, is identified, and it is founded that delaying the grouting timing can increase the slurry migration range up to 94.6%. Furthermore, delaying the grouting timing can also reduce the convergence displacement of reinforced surrounding rocks after excavation up to 18.2% within a geo-stress range of 10 to 20 MPa. • A novel softening path function with clear physical meanings for tunnel excavation simulations is proposed. • A critical value of the grouting reinforcement range is identified. • Influences of grouting timing on the slurry migration range are revealed. • Influences of grouting timing on the convergence displacement of tunnels are revealed. [ABSTRACT FROM AUTHOR]

Alzheimer's disease (AD) is a very disabling disease. Pathologically, it is characterized by the presence of amyloid plaques and neurofibrillary tangles in the brain that results in neurodegeneration. Its clinical manifestations include progressive memory impairment, language decline and difficulty in carrying out activities of daily living (ADL). The disease is managed using interventions such as pharmacological interventions and aerobic exercise. Use of aerobic exercise has shown some promises in reducing the risk of developing AD, and improving cognitive function and the ability to carry out both basic and instrumental ADL. Although, the mechanisms through which aerobic exercise improves AD are poorly understood, improvement in vascular function, brain glucose metabolism and cardiorespiratory fitness, increase in antioxidant capacity and haemoglobin level, amelioration of immune-related and inflammatory responses, modulation of concentration of circulating Neurotrophins and peptides and decrease in concentration of tau protein and cortisol level among others seem to be the possible mechanisms. Therefore, understanding these mechanisms is important to help characterize the dose and the nature of the aerobic exercise to be given. In addition, they may also help in finding ways to optimize other interventions such as the pharmacological interventions. However, more quality studies are needed to verify the mechanisms. • Alzheimer's disease (AD) seriously affects cognitive and physical function. • A promising intervention in patients with AD is aerobic exercise. • The exercise modulates disease biomarkers, and improves brain glucose metabolism and vascular function. • It also increases antioxidant capacity and levels of brain-derived neurotrophic factor. • Modulation of those biomarkers helps to slow down progression of the disease. [ABSTRACT FROM AUTHOR]

Almost 75% of US adults are overweight or obese. Though intentional weight loss of as little as 3% improves physical functioning and reduces cardiometabolic risk, most adults are unsuccessful at long-term weight maintenance. Our hypothesis is that intermittent fasting (IF: short periods of intense energy restriction) will reduce weight regain. IF may combat obesity due to its effects on nutrient-sensing signaling pathways and circadian rhythm. The objective of this randomized clinical trial is to test the effectiveness of an intensive body weight management program with and without IF. In the Promotion of Successful Weight Management in Overweight and Obese Veterans (POWER-VET) trial (NCT04131647), 154 middle-aged and older adults (50–75 years) who are overweight and obese (BMI: 25–40 kg/m2) and seen at either a Baltimore, MD or San Antonio, TX Veterans Affairs Medical Center will be enrolled. Participants will undergo 12 weeks of weight loss (including a low-calorie heart healthy (HH) diet and exercise). Following weight loss, participants will be randomly assigned to one of two 24-week weight maintenance (WM) interventions: WM alone (continuation of HH diet and exercise) or WM + IF. The primary aim is to determine the effect of WM + IF compared to WM alone on body weight maintenance after intentional weight loss. Determining effective, translatable strategies that minimize weight regain following successful weight loss holds public health relevance. This POWER-VET trial introduces an innovative practice of IF to prevent weight regain after clinically significant weight reduction and could provide evidence-based recommendations to promote this type of intervention in middle aged and older adults. [ABSTRACT FROM AUTHOR]

—To address the issue of maladaptive reliability theory models in delay-based physical unclonable functions (PUF) of ring classes, this paper begins by analyzing the relationship between four key transistor parameters (channel length, channel width, threshold voltage, and gate oxide thickness) and delay sensitivity. Then establishes reliability quantification formulas for various PUF types, including ring oscillator PUF, k-out-of-1 PUF, Loop PUF, transient effect ring oscillator PUF, and duty cycle PUF. This analysis and comparison are conducted using the inverter delay model and probabilistic statistical methods to ensure fairness at the theoretical level. Finally, the proposed model is validated through simulation experiments, along with further analysis and comparison of ring-PUF. The results demonstrate that delay sensitivity can be utilized to assess the extent of delay impact when process parameters fluctuate. In terms of reliability, the ring-PUF can be ranked as follows: k-out-of-1 PUF, Loop PUF, ring oscillator PUF, transient effect ring oscillator PUF, and duty cycle PUF. This paper offers extensive technical guidance and theoretical support for ring PUF designers. [ABSTRACT FROM AUTHOR]

The use of a strong physical unclonable function (PUF) for device authentication in resource-limited settings is promising but susceptible to machine learning (ML) attacks. Several defenses have been suggested, but they often have drawbacks such as increased hardware requirements, compromised reliability, and limited effectiveness against sophisticated ML attacks. To overcome these challenges, a one-time key-based (OTK) obfuscation approach has been proposed aiming to bolster the security of robust PUFs when facing machine learning-based attacks. The main concept involves obtaining multiple stable responses from the PUF and selecting one as the initial key for challenge obfuscation. However, only the challenge input for the selected key is stored on the device side. The server stores all the stable challenge-response pairs and uses this selected key for the first authentication only. After every authentication, the input to the key is updated on both sides. For response obfuscation random number generated by the server is used. Our proposed method can effectively prevent ML attacks with minimal hardware requirements. Arbiter-PUF and Rely-PUF as case studies are analyzed. Experimental findings indicate that when applied to 64 × 64 Arbiter and Rely PUF, our method significantly reduces the effectiveness of various machine learning attacks, resulting in a prediction accuracy of approximately 50.6% and 50.96% respectively. This level of accuracy is comparable to random guessing. The 64-bit OTK-PUF boasts an impressively compact storage footprint, comprising merely 164 Look-Up Tables (LUTs), 276 flip-flops, and a 512-bit of read-only memory (ROM). The execution of the protocol on the Vitis platform takes a mere 0.02 s on the device side. • The novelty of our article is that resource-efficient challenge-response obfuscation is used to secure both challenges and responses. The freshness of every communication between the server and device is maintained by adding randomness. TRNG is used to generate the random numbers which are used on the server side to avoid extra hardware overload on the device side. • The synergy of hardware and software co-design within the suggested protocol has been realized through the implementation on Xilinx System-on-Chip (SoC) FPGA Platform. • To assess the efficacy of our proposed security approach, we subjected it to rigorous testing using well-established attack methods. In addition to leveraging prevalent modeling attacks employing machine learning algorithms, we introduced a novel deep learning algorithm for modeling attacks. These endeavors collectively contributed to a comprehensive evaluation of our approach's resilience. • Protection against replay attack is analyzed. If an attacker, acting as a fake server, uses any intercepted message sent previously, the keys will not be matching and the authentication process will abort the process. The proposed approach is compared with the recent methods in terms of resource consumption and security against modeling attacks. [ABSTRACT FROM AUTHOR]

IoT security plays a crucial role where smart devices are interconnected and one of these can give an intrusion access to the network if they are not secured. Physical unclonable function (PUF) comes in handy as an emerging lightweight hardware security primitive for key management and device authentication. In this research work, we propose a new architecture of PUF hardware based on memristor threshold voltage variation. Memristor manufacturing variations are exploited for the threshold voltage variation which makes the device unique. The selection from the proposed crossbars forms two connected memristors. The selections connect the formed voltage divider network to the input and ground. The output is probed at the middle node, which is the selected rows of the two crossbars. Voltage (challenge) is applied at selected pair of memristors through the corresponding columns and rows, and output (response) is taken from the selected rows. We believe this work will set a new direction for the researchers to explore manufacturing errors for PUF applications. [ABSTRACT FROM AUTHOR]

The aqueous zinc-ion batteries (AZIBs) exhibit promising potential as a viable solution for large energy storage. Solving dendrite growth the surface of zinc metal anode in AZIBs is of great significance for its application in energy storage field. Among the many strategies for solving the zinc anode problem, the influence of zinc anode pretreatment is often ignored. The effect of sandpaper physical polishing on the performance of zinc anode was studied in this paper. The striated grooves formed on the surface of the zinc anode after sandpaper treatment make the zinc anode have a large specific surface area and a high zinc plating/stripping kinetics. It was found that sandpaper with larger mesh count (the finer the sandpaper) could reduce roughness and had the higher the electrochemical performance of zinc anodes. Consequently, the cycle life of 2000 M-Zn symmetric battery can reach 900 h under the current density of 0.5 mA cm−2. In the application of energy storage, the full battery composed of 2000 M-Zn and sodium doped V 2 O 5 cathode (NVO) still has a specific capacity of 148.6 mAh g−1 after 500 cycles, and has a stable rate performance. The pretreatment strategy of zinc anode holds significant importance in the applications of AZIBs. [Display omitted] • The properties of Zn anodes could be optimized by sandpaper pretreatment. • The morphology of striped gullies on the surface of Zn was constructed. • Effect of the mesh number of polished sandpaper on the properties of zinc anodes. • After fine sandpaper grinding, Zn surface was more conducive to electrolyte infiltration. [ABSTRACT FROM AUTHOR]

• This study provides the latest evidence on the level of life space mobility of community elderly people. • The life space mobility of community elderly people is at a moderate level globally, with 42% of them living in a state of restricted life space. • The level of life space mobility among community elderly people gradually achieved stability after 2017. • South America, females and earlier survey years have a lower level of LSM. Multiple countries have conducted surveys on the level of life space mobility for community-dwelling elderly through the Life-Space Assessment, the results vary greatly, from 41.7 to 88.6. However, there is no meta-analysis on the current situation of community-dwelling elderly life space mobility. To systematically assess the global level of life space mobility for community-dwelling elderly, to identify potential covariates such as geographical regions, survey years, gender, and age that contribute to the heterogeneity between the studies, and to identify the dynamic trend based on survey years. Systematic review and meta-analysis. Two reviewers searched the following 8 electronic bibliographic databases from inception until May 28, 2023: PubMed, The Cochrane Library, Web of Science, Embase, Chinese Biomedical Database, China Knowledge Resource Integrated Database, WanFang, and Weipu Database. This review was conducted using the Stata 14.1 and R 4.3.1. The Cochrane's Q statistical and I2 index were used to test for heterogenicity and assess the degree of heterogenicity, respectively. Studies were appraised using the Agency for Healthcare Research and Quality tool, the Newcastle-Ottawa Scale for the quality of cross-sectional studies, cohort studies, respectively. A total of 29 studies were selected from databases and reference lists. The pooled score of Life-Space Assessment was 66.84 (95% CI: 63.30–70.39) and the prevalence of restricted life space was 42% (95% CI: 0.27–0.57). The geographical regions, survey years, gender were found to be a significant covariate of the pooled score of life space mobility estimate in the subgroup analysis. The mean score of Life-Space Assessment gradually achieved stability after 2017. The life space mobility of community-dwelling elderly in the global is at a moderate level, with 42% of them experiencing restricted life space. South America, females and earlier survey years have a lower level of life space mobility. In the future, the government should identify vulnerable groups for targeted intervention to promote the level of LSM in the community-dwelling elderly. PROSPERO [CRD42023443054]. [ABSTRACT FROM AUTHOR]

• Care independency for hygiene is a predictor for using absorbing material. • Urinary incontinence prior to admission is associated with using absorbing material. • Diagnosis dementia is not a predictor for using absorbing material. The purpose of this study is to explore the characteristics and capabilities of nursing home residents with urinary incontinence in relation to urinary incontinence interventions. A secondary data-analysis on the data from 1417 residents (65 years and above), suffering from urinary incontinence and living in nursing homes and collected by a cross-sectional multi-center point prevalence measurement, the Dutch annual independent (Inter)national Prevalence Measurement of Quality of Care of Maastricht University, was performed. In order to explore the relationship between an urinary incontinence intervention and the predictors diagnosis dementia, body posture, mobility, (un)dressing, hygiene and communication; onset urinary incontinence; frequency, time of loss and quantity urinary incontinence and fecal incontinence, a Chi-squared Automatic Interaction Detector (CHAID) analysis was performed. The level of care dependency for hygiene is the key variable in predicting the use of an urinary incontinence intervention. The ability to adopt an appropriate body posture, being urinary incontinence prior to admission into a nursing home and being diagnosed with dementia are identified as significant predictors. Residents care independent for hygiene and for adopting an appropriate body posture and urinary incontinence before admission into a nursing home are more likely to use absorbing material. In residents being care dependent for hygiene and for adopting an appropriate body posture and diagnosed with dementia, a combination of absorbing material with toileting or other interventions are mostly applied. Results reveal that residents' characteristics and capabilities determine the implementation of an urinary incontinence intervention. [ABSTRACT FROM AUTHOR]

• Seven latent statuses of physical function were identified. • Physical function decline progress in some typical stages. • Indicative limitation and transition trend are useful for developing preventive intervention and tailored care for physically limited elderly. Multiple limitations often co-occur and accumulate, leading to subsequent function decline. However, there is a scarcity of longitudinal studies examining the progression of physical function among the general population of older adults in China. This study aimed to define typical physical function status and its change, which were characterized by the coexistence and accumulation of diverse limitations targeting a Chinese sample of older adults. This study used the three recent public data waves of the Chinese Longitudinal Healthy Longevity Survey during a 6-year follow-up period. 9765 individuals who were over 65 and participated in the 2011 survey were included. Latent transition analysis was used to identify the latent physical function status and explore the transition of older adults among different latent statuses. Seven latent statuses of physical function were identified, with visual impairment and related limitations being particularly prevalent among older adults. Upper limb mobility appeared to be a differentiated indicator of physical functional status. Physical function decline mainly started with the limitations in squatting, carrying weights and walking, then to the status with intact upper limb mobility and hearing function only, or converted directly into the latter, then to complete dysfunction. Our findings suggest some indicative limitations and critical steps in the process of functional decline among older adults. These results may provide insight for researchers and policymakers to develop tailored preventive and rehabilitation care and provide support for physically limited elderly according to their latent status and course of functional decline. [ABSTRACT FROM AUTHOR]

• Chlorination increased the total relative abundance of ARGs, MGEs, and VFGs. • FLB played a prominent role in promoting antibiotic resistome during chlorination. • Chlorination significantly increased potential antibiotic resistome risk in FLB. • Shifts of host and mobility could notably impact ARGs in FLB during chlorination. • Enhancing biological function may facilitate ARG spread in FLB during chlorination. The risk associated with antibiotic resistance genes (ARGs) in size-fractionated bacterial community during drinking water chlorination remains unclear, and is of paramount importance for risk mitigation through process selection and optimization. This study employed metagenomic approaches to reveal the alterations of ARGs, their potential functions and hosts within the free-living and particle-associated fractions. The total relative abundance of ARGs, mobile genetic elements (MGEs), and virulence factor genes (VFGs) significantly increased in the free-living fraction after chlorination. The contribution of the free-living fraction to the ARG relative abundance rose from 16.40 ± 1.31 % to 93.62 ± 0.47 % after chlorination. Multidrug resistance genes (e.g. mex F and mex W) were major contributors, and their co-occurrence with MGEs in the free-living fraction was enhanced after chlorination. Considering multiple perspectives, including presence, mobility, and pathogenicity, chlorination led to a significant risk of the antibiotic resistome in the free-living fraction. Moreover, potential functions of ARGs, such as cell wall/membrane/envelope biogenesis, defense mechanisms, and transcription in the free-living fraction, were intensified following chlorination. Potential pathogens, including Pseudomonas aeruginosa, Pseudomonas alcaligenes , and Acinetobacter junii , were identified as the predominant hosts of multidrug resistance genes, with their increased abundances primarily contributing to the rise of the corresponding ARGs. Overall, alterations of hosts as well as enhancing mobility and biological functions could collectively aid the proliferation and spread of ARGs in the free-living fraction after chlorination. This study provides novel insights into antibiotic resistance evolution in size-fractionated bacteria community and offers a management strategy for microbiological safety in drinking water. [Display omitted] [ABSTRACT FROM AUTHOR]

The main challenge in the analysis of unconfined seepage flow is that the position of free surfaces is unknown a priori , which needs to be determined through a series of iterative processes. The numerical manifold method (NMM) is a promising method which uses a dual cover system consisting of both mathematical and physical covers. Compared with those traditional methods, NMM is characterized by meshing convenience, approximation accuracy, and being capable of coping with free boundary value problems. Unlike the traditional NMM where the material interface participates in cutting the mathematical cover while forming the physical cover, the physical patches in this study can contain the material interface. The new weight functions for such physical patches are constructed using the refraction law, followed by the application to the analysis of unconfined seepage flow problems. By comparing with analytical or reference solutions of some classic examples, it is validated that the proposed method can accurately locate the free surface, demonstrating its accuracy and convenience in solving unconfined seepage problems. [ABSTRACT FROM AUTHOR]

In a two-arm pilot trial, we examined the feasibility, acceptability, and preliminary efficacy of a 12-week, adaptive text message intervention (TMI) to promote health behaviors and psychological well-being in 60 individuals with multiple cardiac risk conditions (i.e., hypertension, hyperlipidemia, and/or type 2 diabetes) and suboptimal adherence to exercise or dietary guidance. Participants were allocated to receive the TMI or enhanced usual care (eUC). The TMI included daily adaptive text messages promoting health behaviors, twice-weekly messages to set goals and monitor progress, and monthly phone check-ins. Feasibility (primary outcome) and acceptability were measured by rates of successful text message delivery and daily participant ratings of message utility (0–10 Likert scale). We also assessed impact on health behavior adherence, psychological health, and functional outcomes. The TMI was feasible (99.3% of messages successfully sent) and well-accepted (mean utility = 7.4/10 [SD 2.6]). At 12 weeks, the TMI led to small-sized greater improvements in moderate to vigorous physical activity (d = 0.37), overall physical activity (d = 0.23), optimism (d = 0.20), anxiety (d = −0.36), self-efficacy (d = 0.22), and physical function (d = 0.20), compared to eUC. It did not impact other outcomes substantially at this time point. This 12-week, adaptive TMI was feasible, well-accepted, and associated with small-sized greater improvements in health behavior and psychological outcomes. Though larger studies are needed, it has the potential to be a scalable, low-intensity program that could be used in clinical practice. ClinicalTrials.gov registration: NCT04382521 • We conducted a trial of a text message intervention to promote health behaviors. • The intervention was feasible and well-accepted by participants. • The intervention led to small increases in health behaviors, compared to usual care. [ABSTRACT FROM AUTHOR]

Describe clinicians' perspectives of facilitators and barriers to eliciting physical function goals from patients with multiple chronic conditions pre- and post-surgery. Semi-structured qualitative interviews were conducted with clinicians, recruited from an academic medical center, who treat adult patients with multiple chronic conditions. Purposive sampling ensured multiple provider types were represented. Interviews were conducted in person or via web conference and were audio recorded. Findings were summarized using descriptive qualitative content analysis. Of the 12 participating clinicians, 92% were female and 83% specialized in geriatrics. Clinicians had a mean of 10.7 (min-max: 1–30) years of experience. Key facilitators to goal-setting conversations were sufficient time, familial support, and patient cognitive ability. Barriers included lack of time, lack of training, patient challenges in choosing realistic and specific actionable goals, emotional barriers, and cognitive challenges. Some facilitators and barriers are modifiable, including time, inclusion of family members in the clinical encounter, and clinician training to enable actionable goal setting. These results highlight areas for intervention to facilitate goal elicitation for physical function in clinical care settings. Clinicians should be aware of the barriers impacting eliciting goals. Healthcare organizations could consider providing effective goal elicitation training and tools to facilitate goal setting conversation. • Clinician interviews revealed facilitators and barriers of patient goal-setting • Facilitators included family support, sufficient visit time, and cognitive ability • Barriers included lack of time, inadequate clinician training, and cognitive issues • Many facilitators and barriers to goal-setting are modifiable [ABSTRACT FROM AUTHOR]

The first goal of this study was to explore associations between functional dependence levels during activities of daily living (eg, functional mobility, eating, and toileting) before COVID-19 and presence of COVID-19 symptoms (eg, fever, dehydration, lethargy, and shortness of breath) during illness. The second goal of this study was to explore associations between presence of specific COVID-19 symptoms and level of functional decline from before to after illness. Retrospective cohort study. A total of 375 residents at a single skilled nursing facility in New York City. Data were extracted from the Minimum Data Set 3.0 and chart reviews. Multiple linear regressions analyzed relationships between baseline functional dependence in eating, functional mobility, and toileting and presence of dehydration, lethargy, shortness of breath, and fever. Ordinal linear regressions analyzed associations between COVID-19 symptom presence and changes in functional dependence from before to after illness. Pre–COVID-19 eating dependence was significantly associated with dehydration during COVID-19. Dehydration during COVID-19 was significantly associated with greater functional declines in functional mobility from before to after illness. Shortness of breath was significantly associated with increased functional declines in eating and functional mobility. Patients with COVID-19 should be monitored for shortness of breath and dehydration, as these symptoms are associated with functional decline. Individuals experiencing functional decline before COVID-19 onset are especially vulnerable to these symptoms. Future research should further explore the relationship between functional status and COVID-19 symptoms. [ABSTRACT FROM AUTHOR]

People's daily movements, as aggregated in spatial units, shape mobility flows that can be modelled by geospatial networks. The structure of these networks both reflects and influences how cities are lived in, perceived and planned. In this study, location tracking data from mobile phones were used to investigate the functional and spatial structures of daily mobility networks and how these networks change as they grow in size. A case study was performed on 81 Spanish functional Urban Areas (FUAs). The results of this study show that the friction of the space and the average length of the aggregate daily mobility are constant and do not depend on the area and demographic size of the FUAs. The average length of the aggregate daily mobility is associated with the increase in complexity that occurs as mobility networks grow, which is reflected in an increase in the number of levels of interaction and the proportion of local flows that integrate adjacent spaces across different scales. The method used provides quantitative indicators that reveal the similarities and differences of daily mobility, as well as the interactions that occur in FUAs according to their size. This information is very useful in urban and mobility planning. • The average length of aggregate daily mobility is identical in all Spanish FUAs. • The mobility networks of the largest FUAs are composed of functional modules. • Modularity is a mechanism for networks to grow without increasing the average length. • Long-distance movements are less numerous and weaker than short-distance movements. • These weak ties make that daily mobility networks function as a spatial unit. [ABSTRACT FROM AUTHOR]

Physical unclonable function (PUF) is a promising hardware security primitive that can generate a unique secret key peculiar to each chip by extracting the differences of non-reproducible manufacturing variations for the same implementations. Although there are several types of PUF designs and structures, ring oscillator (RO) PUF is one of the most prominent PUFs due to its straightforward implementation and remarkable performance. However, the traditional RO-PUF does not support large sizes of input/output combinations or challenge-response pairs (CRPs), as it is called in the scope of PUFs. Consequently, RO-PUF is more vulnerable to adversary attacks which can reveal the PUFs' CRPs using a machine learning approach. Increasing the size of RO-PUF's CRPs requires a high increase in the circuit size leading to unacceptable area overhead for lightweight applications. The primary technique used to increase RO-PUF CRPs' size without increasing the size of the required hardware is to develop a configurable ring oscillator (CRO) PUF. In this paper, we propose a configurable logic unit (CLU) that can be utilized to build a low-hardware CRO-PUF. The proposed CLU consists of a 1-XOR gate and a 1-XNOR gate. Building a CRO-PUF using the proposed CLU dramatically increases the CRPs size while minimizing the required hardware. The proposed CRO-PUF achieves excellent evaluation results, with measured uniqueness of 50.1 %, uniformity of 49.45 %, and reliability of 98.33 %. These values are in close proximity to the ideal targets of 50 % for uniqueness and uniformity, and 100 % for reliability [ABSTRACT FROM AUTHOR]

Activity space in people with substance use disorders (SUDs) has been assessed for theoretical reasons and for detection/prevention of relapse. In this observational study, we relate passively obtained activity space measures to mental states and behaviors relevant to the success of treatment for opioid use disorder. Our long-term goal is to use such data to assess risk in real time and to recognize when SUD patients might benefit from a just-in-time intervention. We used GPS data from 238 urban residents in the first 16 weeks of stabilization on medication for opioid use disorder to test preregistered hypotheses about activity space (distance traveled, number of locations, time spent moving, and psychosocial-hazard levels of neighborhoods where participants spent time) in relation to certain static variables (personality, mood propensities) and time-varying treatment-relevant behaviors such as craving and use of opioids and cocaine. The most consistent findings were that 1) mobility decreased over the course of the study; 2) neuroticism was associated with overall lower mobility; 3) trait-like positive mood (averaged from momentary ratings) was associated with higher mobility; 4) participants who used cocaine more frequently had lower mobility; 5) early in treatment, participants spent less time moving (i.e., were more sedentary) on days when they were craving. Some of these findings were in the expected direction (i.e., the ones involving neuroticism and positive mood), and some were opposite to the expected direction (i.e., we expected cocaine use to be associated with higher mobility); others (e.g., changes in mobility over time or in relation to craving) involved nondirectional hypotheses. Real-time information that patients actively provide is valuable for assessing their current state, but providing this information can be burdensome. The current results indicate that certain static or passively obtained data (personality variables and GPS-derived mobility information) are relevant to time-varying, treatment-relevant mental states and drug-related behavior, and therefore might be useful when incorporated into algorithms for detecting need for intervention in real time. Further research should assess how population-specific these relationships are, and how these passive measures can best be combined with low temporal-density, actively-provided data to obtain valid, reliable assessments with minimal burden. • We assessed mobility as a function of personality, mood, craving and drug use • Mobility decreased over the first 16 weeks of buprenorphine or methadone treatment • Neuroticism and persistent cocaine use were each associated with low mobility • Trait-like positive mood was associated with high mobility • Mobility was generally related more to between-person traits than momentary states [ABSTRACT FROM AUTHOR]

• The 10-year incidence of dizziness/vertigo was relatively high in older adults. • Age and migraine were independent predictors of incident dizziness/vertigo. • Dizziness/vertigo was associated with reduced quality of life over 10 years. We used a cohort of community-dwelling adults to establish the 10-year incidence and predictors of dizziness/vertigo, and its impacts on health-related quality of life. Of the 1152 participants aged 55 + years who did not have dizziness/vertigo at baseline, 799 and 377 participants were followed up after 5 and 10 years, respectively, and had complete data and so were included in the incidence analysis. Hearing loss was determined as the pure-tone average of audiometric hearing thresholds at 500, 1000, 2000 and 4000 Hz, and any hearing loss was defined as >25 dB hearing level. Tinnitus and migraine were assessed by a positive response to a single question. Audiologists screened participants for reported dizziness using a single question. Quality of life was measured using the Short Form 36-item Health Survey (SF-36). The cumulative 10-year incidence of dizziness/vertigo, vestibular vertigo and non-vestibular vertigo were 39.8 %, 27.1 %, and 11.9 %, respectively. Age and presence of migraine were significant predictors of incident dizziness/vertigo: multivariable-adjusted hazard ratio (HR) 1.03 (95 % confidence interval, CI, 1.01–1.06) and HR 1.63 (95 % CI 1.13–2.35), respectively. A significant decrease in scores for the following SF-36 domains was observed over the 10 years among participants reporting baseline dizziness/vertigo: physical functioning (P -trend ≤ 0.0001), role limitation due to physical problems (P -trend ≤ 0.0001), general health (P -trend = 0.01), and vitality (P -trend = 0.01). Dizziness/vertigo was a frequent and detrimental symptom in this population of community-dwelling adults. Our study highlights the burden imposed by dizziness, as evidenced by a significant prospective association with poorer quality of life. [ABSTRACT FROM AUTHOR]

Exercise-induced fatigue (EF) is a common occurrence during prolonged endurance and excessive exercise and is mainly caused by energy depletion, harmful metabolite accumulation, oxidative stress, and inflammation. EF usually leads to a reduction in initiating or maintaining spontaneous activities and muscle performance and ultimately results in a decrease in the quality of life of people who engage in physical work. Therefore, the interest in investigating EF-targeting agents with minimal side effects and good long-term efficacy has substantially increased. Natural edible and medicinal polysaccharides have shown positive anti-EF effects, but the relevant reviews are rare. This review comprehensively summarizes studies on natural polysaccharides from edible and medicinal sources that can relieve EF and improve physical performance from the past decade, focusing on their sources, monosaccharide compositions, anti-EF effects, and possible molecular mechanisms. Most of these anti-EF polysaccharides are heteropolysaccharides and are mainly composed of glucose, arabinose, galactose, rhamnose, xylose, and mannose. In EF animal models, the polysaccharides exert positive EF-alleviating effects through energy supply, metabolic regulation, antioxidation, anti-inflammation, and gut microbiota remodeling. However, further studies are still needed to clarify the anti-EF effects of these polysaccharides on human beings. In summary, the present review expects to provide scientific data for the future research and development of natural polysaccharide-based anti-EF drugs, dietary supplements, and health-care products for specific fatigue groups. [Display omitted] [ABSTRACT FROM AUTHOR]

Gait and balance impairments affects approximately a quarter of people with multiple sclerosis (pwMS) at onset and increases to almost half by five years. Physical rehabilitation has been recognised as the gold standard method to restore physical function in multiple sclerosis (MS). Emerging evidence in the literature is suggesting that a remote therapy rehabilitation platform (Telerehabilitation) is cost-effective, beneficial, and satisfying for patients and health care practitioners. The overarching aim of this review is to identify and summarise the evidence on the different types of telerehabilitation interventions available to manage gait and balance. This review followed a methodological framework for conducting scoping reviews. PubMed, Science Direct and Web of Science were searched in April 2023 for relevant published literature. The inclusion criteria were peer-reviewed journal articles written in English which included telerehabilitation interventions for pwMS. Search keywords included multiple sclerosis and telerehabilitation. A reviewer screened titles and abstracts and eligible articles were fully reviewed. The included studies were categorised based on the type of intervention. Eight studies were included in this review. The participants (n = 355) had an average age of 48 years (SD = 9.9) with 50% who had relapsing remitting multiple sclerosis who were living with MS for 12 years on average. Study designs included randomised control trials (n = 3), pilot studies and feasibility studies (n = 4). Two types of interventions were identified: Exergaming (n = 5) and Web-Based Physical Therapy (n = 2) of which exergaming appeared to be optimal in improving gait and balance. This scoping review identified and summarised the evidence on telerehabilitation interventions used for gait and balance in MS. The evidence is showing that telerehabilitation could be used as an alternative to conventional rehabilitation methods for improving gait and balance. More robust trials with larger sample sizes are needed to build on the current evidence to enable telerehabilitation to be integrated into care pathways in the future. • Telerehabilitation is changing the landscape of MS rehabilitation. • Digital technology is transforming physical rehabilitation in MS. • Telerehabilitation has potential to co-exist with conventional rehabilitation. • Telerehabilitation may breakdown access barriers for people with MS. [ABSTRACT FROM AUTHOR]

Prostate specific membrane antigen (PSMA) has been the subject of several studies in recent decades as a promising molecular target for prostate cancer (PCa), in fact it is considered an excellent molecular target for both PCa imaging (both for staging and follow-up), by means of PET/CT and for radioligand therapy. Its interesting molecular features have enabled the development of a new diagnostic and therapeutic approach for PCa, called "theranostics." Considering the abundance of PSMA-based probes that have appeared so far in the literature, the present work focuses the attention on radiopharmaceuticals with increasing clinical application, highlighting advantages and disadvantages in terms of different metabolization and excretion processes, pharmacokinetic, binding affinity and variable internalization rate, tumor-to-background ratio, residence times and toxicity profile. [Display omitted] • PSMA investigated as an excellent target for prostate cancer imaging. • DCFPyl, PSMA 1007 and PSMA JK-7 as 18F labeled pharmaceuticals in clinical practice. • Comparison of the physical performance for the radionuclides Ga-68 and F-18. • PSMA radiolabels for imaging and radioligand therapy of prostate cancer. • Aluminium fluoride species with a radiometallic chelating system. [ABSTRACT FROM AUTHOR]

The prognostic significance of obesity in sarcopenic adults is controversial. This systematic review and meta-analysis aimed to investigate the effect of additional obesity on health outcomes in sarcopenia. MEDLINE, EMBASE, Scopus and CENTRAL were systematically searched for studies to compare health outcomes of adults with sarcopenic obesity (SO) to those of sarcopenic non-obese (SNO) adults. We also considered the methods of assessing obesity. Of 15060 records screened, 65 papers were included (100612 participants). Older community-dwelling SO adults had 15% lower mortality risk than the SNO group (hazard ratio, HR: 0.85, 95% confidence interval 0.76, 0.94) even when obesity was assessed by measurement of body composition. Additionally, meta-regression analysis revealed a significant negative linear correlation between the age and the HR of all-cause mortality in SO vs. SNO community-dwelling adults, but not in severely ill patients. Compared with SNO, SO patients presented lower physical performance, higher risk for metabolic syndrome, but similar cognitive function, risk of falls and cardiovascular diseases. Age-related obesity, SO and later fat loss leading to SNO represent consecutive phases of biological aging. Additional obesity could worsen the health state in sarcopenia, but above 65 years SO represents a biologically earlier phase with longer life expectancy than SNO. • Among older adults sarcopenic obesity confers better survival than sarcopenia alone. • The effect of obesity on mortality risk in sarcopenic adults depends on age. • Obesity worsens the physical function and the metabolic syndrome in sarcopenia. • Obesity does not influence the mortality risk in severely ill sarcopenic patients. [ABSTRACT FROM AUTHOR]

Perception of the full state is an essential technology to support the monitoring, analysis, and design of physical systems, one of whose challenges is to recover global field from sparse observations. Well-known for brilliant approximation ability, deep neural networks have been attractive to data-driven heat and flow field reconstruction studies for practical systems. However, limited by network structure, existing researches mostly learn the reconstruction mapping in finite-dimensional space that usually has poor transferability to the variable resolution of outputs. This paper extends the new paradigm of neural operators and proposes an end-to-end physical field reconstruction method with both excellent performance and mesh transferability named RecFNO. The proposed method aims to learn the mapping from sparse observations to flow and heat fields in infinite-dimensional space, contributing to a more powerful nonlinear fitting capacity and resolution-invariant characteristic. According to different usage scenarios, three types of embeddings are first developed to model the sparse observation inputs: MLP, mask, and Voronoi embedding. The MLP embedding is propitious to more sparse input, while the others benefit from spatial information preservation and perform better with the increase of observation data. Then, stacked Fourier layers are adopted to reconstruct physical field in Fourier space that regularizes the overall recovered field by Fourier modes superposition. Benefiting from the operator in infinite-dimensional space, the proposed method obtains remarkable accuracy and better resolution transferability among meshes. The experiments conducted on fluid mechanics and thermology problems show that the proposed method outperforms existing POD-based and CNN-based methods in most cases and has the capacity to achieve zero-shot super-resolution. • A resolution-invariant temperature and flow field reconstruction method named RecFNO is proposed. • Three types of embeddings for sparse observation are developed. • RecFNO can reconstruct the physical field in function space with excellent performance and resolution transferability. • The validity of the method is confirmed in numerical experiments and practical cases. [ABSTRACT FROM AUTHOR]

Research on natural health has identified the potential benefit of outdoor blue spaces for human health and wellbeing. However, the existing evidence has relatively limited attention to the elderly. This study aims to review the available evidence on outdoor blue spaces and health outcomes among older individuals and identify knowledge gaps. In accordance with the PRISMA guidelines, specific keywords were used to search for articles published in English from inception to October 2023. Five databases (Scopus, PubMed, Web of Science, CINAHL, and PsycINFO) were searched, and 22 studies were identified in this review. We classified articles based on elderly health as general health (e.g., self-reported, perceived health and wellbeing), physical health (e.g., physical activity, physical function index), and mental health and wellbeing (e.g., depression). The findings indicated a positive correlation between outdoor blue space and the health of the elderly. In terms of the characteristics of exposure to outdoor blue spaces, direct contact (e.g., sensory-based) has not been well documented compared to indirect contact (e.g., distance, percentage, region-based). Although encouraging, the available body of evidence is limited and lacks consistency. Future research is needed to provide complementary evidence between outdoor blue spaces and elderly health. • Outdoor blue spaces have the potential to benefit elderly health. • Direct interaction with outdoor blue spaces was understudied in comparison to indirect contact. • For the elderly, the ways to access outdoor blue spaces were distance, percentage, region, and sensory exposure. • Little but important evidence was found on the correlation between outdoor blue spaces and the health of the elderly. [ABSTRACT FROM AUTHOR]

• The built-in electric field between the Mn 3 O 4 -MnS enhances the carrier transport. • The core–shell structure enables high mechanical stability. • Mediated pseudo-capacitance is induced by the configuration of Si@Mn 3 O 4 -MnS/C. • The vacancy-enriched Si@Mn 3 O 4 -MnS/C presents excellent cyclability. A configuring vacancy-enriched Mn oxide/sulfide embedded in amorphous carbon layer with highly concentrated vacancies to encapsulate silicon was tentatively explored to overcome the long-term stabilization issues of silicon active center. Our experimental results demonstrate that the configuration of vacancy-enriched Mn 3 O 4 -MnS/carbon hybrid coating layer not only functions as a physical separation layer to prevent silicon from direct contact with electrolytes, but also works as an interesting intermediator to facilitate the structure stabilization and the deep utilization of silicon core center. The surface pseudo-capacitive effect dramatically benefits to the modification of the rate performance of silicon. The synthesized Si@Mn 3 O 4 -MnS/C anode material maintains a high reversible capacity of 830 mAh/g after undergoing 200 charge–discharge cycles at 200 mA g−1 current density. [ABSTRACT FROM AUTHOR]

Challenging children with Down syndrome to walk fast and with external ankle load has demonstrated acute adjustments, such as increased step length and decreased step width, and improved joint stability. However, it is unknown to what extent these task constraints affect gait stability. Assessing dynamic gait stability through margin-of-stability not only quantifies adjustments related to balance control, but also informs safety considerations. Twenty-four children with and without Down syndrome participated in this study. Subjects walked overground at two speed conditions: self-selected (normal) and as fast as possible (fast); and two ankle load conditions: no load and ankle load of 2% body mass. We assessed margin-of-stability in the anteroposterior and mediolateral directions, separately, at three gait events of toe-off, mid-swing, and heel strike. Children with Down syndrome walked with greater mediolateral margin-of-stability than typically developing children. Children with Down syndrome demonstrated less anteroposterior margin-of-stability than typically developing children only before heel-strike at normal speed but increased anteroposterior margin-of-stability at fast speed. The ankle load increased the mediolateral margin-of-stability in both groups but did not impact the anteroposterior margin-of-stability. In addition, children with Down syndrome took shorter and wider steps for more lateral placement of mediolateral margin-of-stability. Children with Down syndrome were capable of adjusting their margin-of-stability for fast walking and ankle-load conditions. However, children with Down syndrome walked with less mediolateral stability and anteroposterior mobility than typically developing children. Children with Down syndrome overcompensate the mediolateral foot placement to recapture their margin-of-stability and maintain gait stability. • Children with Down syndrome walked with a distinct joint pattern compared to peers. • Increased walking speed improved ankle kinematics, but challenged knee kinematics. • Ankle load improved hip and knee kinematics, but challenged ankle plantarflexion. • Intervention design can consider the manipulation of walking speed and ankle load. [ABSTRACT FROM AUTHOR]

Early-stage lung cancer survivors are a growing population. A comprehensive plan to address needs relevant to longer survival (e.g., psychological distress, persistent symptoms, physical function) and clinic capacity is necessary. How to deliver comprehensive survivorship care that meets national standards and results in improved patient outcomes is a challenge. Survivorship clinics staffed by advanced practice providers (APP) are an option to address these needs. In June 2019, Atrium Health Wake Forest Baptist Comprehensive Cancer Center (AHWFB-CCC) opened a dedicated survivorship clinic. Stakeholders from the lung cancer disease-oriented team developed a standard referral pathway for patients to survivorship. A standard workflow was developed in the electronic medical record. Eligible lung cancer survivors were referred to the Lung Cancer Survivorship Clinic for a survivorship orientation visit (SOV) with a lung cancer specific APP. Prior to the SOV, a welcome video, disease-specific questionnaire, and electronic patient reported outcome (ePRO) tools (i.e., PROMIS-29 and Distress Thermometer) were sent to the patients' electronic chart. At the SOV, the ePRO responses and survivorship care plan were reviewed. Patients were offered a post visit survey. A comparison of PROMIS-29 Scores to the United States (US) lung cancer survivor population was performed using a T-test. PROMIS-29 T-score responses based on treatment modality were also compared using T-test. Results: From January 2020 to March 2023, 315 lung cancer patients completed a SOV. Most patients were able to complete the pre-visit questions via the electronic chart. AHWFB-CCC survivors reported improved PROMIS-29 T-Scores compared to the average United States (US) early-stage lung cancer survivor, with meaningfully better scores (≥ 3 pts) in four of the seven health-related domains measured. PROMIS-29 T-Scores did not differ by treatment modality (all p values >0.05). Most patients found the SOV helpful and expressed better understanding of their cancer treatment and side effects after the SOV. Our model of an optimized electronic medical record pathway paired with an APP led survivorship visit is feasible and can address current challenges in providing survivorship care to early-stage lung cancer survivors. Survivors had similar ePROs regardless of treatment modality, indicating their survivorship care could be consolidated. Future evaluation is needed to establish if this care model improves outcomes over subsequent visits, minimizes the effect of health disparities, or enhances care capacity. [ABSTRACT FROM AUTHOR]

• Significant benefit for ONB if compared to ICUD was detected only for specific subdomains of QoL questionnaires. • No direct comparison between ICUD/ONB and TMT is available. • These data should be used in clinical practice to empower patients in deciding about local treatment choice. Radical cystectomy (RC) is considered the standard treatment for muscle invasive bladder cancer (MIBC). However, RC is often burdened by significant impact on quality of life (QoL); Continence preserving methods (e.g., continent cutaneous urinary diversion and orthotopic neobladder-ONB), have been proposed as alternatives to improve postoperative QoL. Trimodal therapy (TMT) emerged as alternative to surgery. To assess the impact of these treatments from the patients' perspective, we undertook a systematic review and meta-analysis of literature, focusing on studies reporting QoL data about each of the abovementioned approaches. A systematic review was carried out including all prospective and retrospective studies enrolling patients treated with radical intent for non-metastatic MIBC from 1999 to 2021 (either RC or TMT). All studies included specifically reported QoL for one of the main treatment approaches explored (RC followed by ileal conduit urinary diversion-ICUD, ONB or TMT). Pooled analysis for EORTC QLQ-C30 and BLM-30 questionnaires showed that ONB yielded a significant advantage only for Physical Functioning (pooled mean standardized difference −0.73 SD, p-value 0.019, I 2 = 93 %) and for Emotional Functioning (pooled mean standardized difference −0.16 SD, p-value 0.029, I 2 = 0 %). A trend in favour of higher mean reported values after TMT for Global Health Score, Physical Functioning and Role Functioning was found, if compared to both RC approaches. Significant benefit for ONB if compared to ICUD was detected only for specific subdomains of QoL questionnaires. No direct comparison with TMT is available, but data suggest advantage of this approach when compared to both reconstructive scenarios. [ABSTRACT FROM AUTHOR]

Ice slurry ingestion during prolonged exercises may improve performance in hot environments; however, the ideal amount and timing of ingestion are still uncertain. We determined whether ad libitum ice slurry ingestion influences physiological and perceptual variables and half-marathon performance while comparing the effects of the amount and moment of ingestion between ice slurry and water at 37 °C. Ten trained participants (28 ± 2 years; mean and SD) were required to run two half marathons while consuming either ice slurry (-1 °C; Ad-1) or water (37 °C; 37 CE) ad libitum. They then performed two other half marathons where, during one, they were required to ingest an amount of water equivalent to the amount consumed during the Ad-1 trial (Pro37), and in the other, to ingest ice slurry in the amount consumed during the 37 CE trial (Pro-1). During the half marathons, dry-bulb temperature and relative humidity were controlled at 33.1 ± 0.3 °C and 60 ± 3%, respectively. Ad-1 ingestion (349.6 ± 58.5 g) was 45% less than 37 CE ingestion (635.5 ± 135.8 g). Physical performance, heart rate, perceived exertion, body temperatures, and thermal perception were not influenced by the temperature or amount of beverage ingestion. However, a secondary analysis suggested that lower beverage ingestion was associated with improved performance (Ad-1 + Pro37 vs. 37 CE + Pro-1: −4.0 min, Cohen's d = 0.39), with a significant relationship between lower beverage ingestion and faster running time (b = 0.02, t = 4.01, p < 0.001). In conclusion, ice slurry ingestion does not affect performance or physiological or perceptual variables during a half marathon in a hot environment. Preliminary evidence suggests that lower beverage ingestion (ice slurry or warm water) is associated with improved performance compared to higher ingestion. • The current study controlled the temperature of beverages and ingestion behavior. • Ad libitum ice slurry does not improve half-marathon performance in the heat. • Athletes ingested less ice slurry than 37 °C water during the ad libitum trials. • 80% of athletes reported gastric discomfort and headache when ingesting ice slurry. • Half-marathon performance was 3–4% better in trials with lower beverage ingestion. [ABSTRACT FROM AUTHOR]