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Self-compassion has been identified as a trait that correlates with robust mental health; specifically, less anxiety, depression and stress in both adolescents and adults. However, little is known about the parental and family factors that are associated with adolescent self-compassion that may promote or enhance the development of this stress-buffering trait. In this study, 1057 adolescents in grades 7-12 from two different school settings answered questions in an online survey that related to their parents' education level and their own self-compassion. Results indicated that fathers' education, but not mothers', was associated with adolescent self-compassion. Specifically, adolescents whose fathers had a college education only had the highest level of self-compassion; a significant difference was found between self-compassion of adolescents of fathers' with a college degree and those with a doctorate/professional degree. Adolescents whose fathers had less than a college education (some college, high school graduate) or more than a college education (masters or doctorate/professional degree) reported lower self-compassion. As parent education level may be a proxy for other factors such as socioeconomic status, parenting style, or parent-adolescent relationship closeness, further research is necessary that will measure these factors and parse out that which specifically is associated with self-compassion in adolescents. [ABSTRACT FROM AUTHOR]

• Traumatic rupture of a non-parasitic simple hepatic cyst is very unusual. • Open or laparoscopic cyst deroofing is a safe and effective treatment for non-parasitic simple hepatic cysts. • Rupture of a non-parasitic simple hepatic cyst could be included in the differential diagnosis of acute abdomen. Non-parasitic simple hepatic cyst is a very common type of benign liver disease, occurring in approximately 1–5% of the general population. These cysts are usually asymptomatic and are conservatively followed up without treatment. Some of these cysts, however, are associated with complications, including infection, hemorrhage, obstructive jaundice, portal hypertension, and rupture. A 74-year-old woman was transferred to our trauma center with epigastric pain after being knocked down by a cultivator. An abdominal computed tomography (CT) scan showed fluid collection and cystic lesion around the caudate lobe of the liver. Operative exploration showed that she had a ruptured hepatic cyst that originated from the caudate lobe of the liver. The cyst was deroofed to the margins of the liver parenchyma, and the internal surfaces of the cyst walls was subjected to electrocoagulator ablation. Open or laparoscopic cyst deroofing is a safe and effective treatment for non-parasitic simple hepatic cysts. Laparoscopic deroofing may also be difficult following rupture of non-parasitic simple hepatic cysts associated with infection or hemorrhage, as these cysts may collapse and the line of resection may be unclear. Laparoscopic ultrasound is a useful adjunct to delineate the boundaries of the cyst. Traumatic rupture of a non-parasitic simple hepatic cyst is a very rare complication, but can lead to acute abdomen. In patients who are known to have non-parasitic simple hepatic cyst, rupture of cyst could be included in the differential diagnosis of acute abdomen. [ABSTRACT FROM AUTHOR]

• BS012 reduces Th2-related immune response in DNCB-induced mice (in vivo AD model). • BS012 suppresses immune activation in TNF-α/IFN-γ-stimulated keratinocytes. • In serum, inflammation-related fatty acid metabolism is mainly altered by BS012. • In keratinocytes, BS012 alleviates abnormal lipid metabolism including sphingolipid. • BS012 regulates inflammation and skin barrier defect caused by atopic dermatitis. Atopic dermatitis (AD) is a chronic, relapsing skin disease accompanied by itchy and dry skin. AD is caused by complex interactions between innate and adaptive immune response. AD treatment include glucocorticoids and immunosuppressants. However, long-term treatment can have serious side effects. Thus, an effective AD treatment with fewer side effects is required. Natural materials, including herbal medicines, have potential applications. This study evaluated the in vivo and in vitro therapeutic effects of BS012, a mixture of Asarum sieboldii, Platycodon grandiflorum , and Cinnamomum cassia extracts, on AD and investigated the underlying metabolic mechanisms. The anti-inflammatory effects of BS012 were assessed using a mouse model of AD induced by 1‑chloro-2,4-dinitrobenzene (DNCB) and in tumor necrosis factor-alpha/interferon-gamma (TNF-α/IFN-γ) stimulated normal human epidermal keratinocytes (NHEKs). In DNCB-induced mice, total dermatitis score, histopathological analysis, and immune cell factors were assessed to evaluate the anti-atopic activity. In TNF-α/IFN-γ-stimulated NHEKs, pro-inflammatory cytokines, chemokines, and related signaling pathways were investigated. Serum and intracellular metabolomics were performed to identify the metabolic mechanism underlying the therapeutic effects of BS012 treatment. In DNCB-induced mice, BS012 showed potent anti-atopic activity, including reducing AD-like skin lesions and inhibiting the expression of Th2 cytokines and thymic stromal lymphopoietin. In TNF-α/IFN-γ-stimulated keratinocytes, BS012 dose-dependently inhibited the expression of pro-inflammatory cytokines and chemokines by blocking nuclear factor-kappa B and signal transducer and activator of transcription signaling pathways. Serum metabolic profiles of mice revealed significant changes in lipid metabolism related to inflammation in AD. Intracellular metabolome analysis revealed that BS012 treatment affected the metabolism associated with inflammation, skin barrier function, and lipid organization of the stratum corneum. BS012 exerts anti-atopic activity by reducing the Th2-specific inflammatory response and improving skin barrier function in AD in vivo and in vitro. These effects are mainly related to the inhibition of inflammation and recovery of metabolic imbalance in lipid organization. BS012, a novel combination with strong activity in suppressing the Th2-immune response, could be a potential alternative for AD treatment. Furthermore, the metabolic mechanism in vivo and in vitro using a metabolomics approach will provide crucial information for the development of natural products for AD treatment. [Display omitted] [ABSTRACT FROM AUTHOR]

Introduction Isolated renal arterial perforation is a rare consequence of blunt abdominal trauma. Meticulous surgical control of retroperitoneal active bleeding is difficult due to oozing of soft connective tissue, the deep position of operative field, and the presence of friable vascular tissue. Therefore, endovascular treatment is often preferred. Presentation of case An 83-year-old man was transferred to our trauma center due to retroperitoneal active bleeding after a car accident, in which his right upper abdomen struck the steering wheel. Contrast-enhanced abdominal computed tomography (CT) showed a retroperitoneal hematoma behind the inferior vena cava and contrast medium extravasation on the medial side of the right kidney. Selective right renal arteriography confirmed a perforation in the proximal right main renal artery, approximately 3 cm from the ostium. We successfully placed a covered stent across the perforation site. Discussion Endovascular management may reduce the likelihood of extensive abdominal surgery, surrounding organ damage, risk of bleeding, and postoperative morbidity. We regarded embolization as inappropriate for kidney salvage in our patient, and therefore used a self-expanding covered stent to treat the perforation. Conclusion Endovascular management of a traumatic renal arterial injury is the best approach to preserve renal function in hemodynamically stable patients who cannot tolerate laparotomy, due to risks associated with general anesthesia, and who can tolerate anticoagulation therapy. [ABSTRACT FROM AUTHOR]

Lymphangiomas are benign tumors that results from congenital malformation of lymphatic vessels. They are generally found in the neck and axilla. When they involve multiple locations, they present as lymphangiomatosis syndrome. Generalized lymphangiomatosis associated with mucinous cystadenoma of the ovary is a very rare condition. This study describes a 13-year-old girl with lymphangiomatosis of spleen, right fallopian tube and abdominal wall associated with mucinous cystadenoma of the right ovary. Contrast-enhanced abdominopelvic computed tomography scan and magnetic resonance image showed a multiple cystic splenic mass and huge abdominopelvic cystic mass. Splenectomy, excision of right ovary and fallopian tube mass, and excision of abdominal wall mass were performed without any complications. • Lymphangiomas are benign tumors that results from congenital malformation of the lymphatic vessels. • The treatment of choice for large or symptomatic splenic lymphangiomas is complete surgical resection. • Although splenic lymphangiomas are very rare, they should be considered in the differential diagnosis of splenic tumors. [ABSTRACT FROM AUTHOR]

Laboratory experiments were performed to investigate the property change of sandstones, resulting from scCO 2 -rock-groundwater reaction for 150 days under CO 2 sequestration conditions. The average surface roughness value ( SR rms ) increased more than 3.5 times during early 90 days, suggesting that the weathering process of sandstone occurs in the early reaction time after CO 2 injection. The average porosity of sandstones increased by 8.8% and P wave velocity decreased by 5.7%. The trend of rock property change and SR rms change showed in a logarithmic manner, indicating that the physical property change of reservoir rocks directly comes from CO 2 related geochemical reaction. [ABSTRACT FROM AUTHOR]

This report describes an extremely rare case of anal canal duplication associated with presacral teratoma in a 5-year-old girl who presented with perineal pain and constipation. Abdominopelvic computed tomography (CT) revealed a multiloculated heterogeneous mass measuring 5 cm in the presacral area. T2-weighted magnetic resonance imaging (MRI) showed a 4.5-cm sized multilocular cystic lesion with high signal intensity. The mass was surgically removed with coccyx. Histologically, the tumor showed components of bronchial and gastrointestinal mucosa, squamous epithelium, cartilage, fibrofatty tissue, and some exocrine glands. The histopathological diagnosis was mature teratoma. Eight months after surgery, the patient is doing well, with no recurrence of tumor. [ABSTRACT FROM AUTHOR]

Mesenteric teratoma is a rare tumor, with few cases reported in the literature. Because mesenteric teratomas have no specific signs or symptoms, their clinical manifestations depend on their size and location. This report describes a mesenteric teratoma associated with acute perforated appendicitis in a 2-year-old girl who presented with abdominal pain and high grade fever. [ABSTRACT FROM AUTHOR]

The co-occurrence of colonic atresia and Hirschsprung's disease is extremely rare and presents a diagnostic and therapeutic challenge. Although colonic atresia is usually recognized shortly after birth, the diagnosis of co-existent Hirschsprung's disease is usually made following anastomotic failure or intestinal obstruction subsequent to restoration of intestinal continuity. This report describes a female infant born with colonic atresia and Hirschsprung's disease associated with multiple anomalies. Previously reported cases are also reviewed, with an emphasis on the importance of coexistent Hirschsprung's disease in any infant born with colonic atresia. [ABSTRACT FROM AUTHOR]

This report describes an extremely rare case of extrarenal Wilms' tumor in a 4 year-old girl who presented with abdominal mass and pain. Computed tomography (CT) scanning revealed a well-defined mass lesion measuring 10 cm on the right side of her lower abdomen and pelvic cavity. The mass was surgically removed. Histologically, the tumor showed a triphasic pattern, consisting of stromal, epithelial and blastemal components. Immunohistochemistry showed that the tumor was positive for cytokeratin, vimentin and CD99. The histopathological diagnosis was extrarenal Wilms' tumor arising in the retroperitoneum and inguinal canal. The patient was administered adjuvant chemoradiotherapy due to subsequent pulmonary and peritoneal metastases. Follow-up 4 years later showed that she was doing well, with no recurrence of the tumor. [ABSTRACT FROM AUTHOR]

Most cervical teratomas are benign. However, because of their location and size, these neoplasms cause airway obstruction, and the prognosis of patients is poor if left untreated. Early diagnosis by antenatal ultrasound, airway management, and a multidisciplinary team approach to treatment are therefore necessary. This report describes a 7-day-old male neonate who presented at our institution with a huge neck mass that was treated by surgical excision. [ABSTRACT FROM AUTHOR]

B Introduction: b Pylorus preserving pancreaticoduodenectomy (PPPD) is a treatment for the resectable tumor or cancer in pancreaticoduodenal system. We therefore suggest electrical twitch obtaining intramuscular stimulation (ETOIMS) as a new treatment modality for pain control after PPPD. Through the course of pain relieving, the pain scores were significantly lower in Group 2 after PPPD (P = 0.01). [Extracted from the article]

Laboratory scale sorption and desorption experiments were performed to investigate the cesium (Cs) removal efficiency of a bead-shaped polysulfone carrier containing HNO 3 -treated bamboo charcoal (BC). The average Cs removal efficiency of BC only and of polysulfone carrier without BC after 1 h sorption reaction was 53 and 18%, respectively. However, the Cs removal efficiency for the polysulfone carrier with 5% HNO 3 -treated BC (P-5N-BC) after 1 h and 24 h reaction was 66 and 98%, respectively. The Cs removal efficiency after 24 h reaction remained >85% over a wide range of pH and temperature conditions, suggesting that using P-5N-BC as the Cs adsorbent is feasible in a variety of aquatic environments. The maximum Cs sorption capacity (q m) of P-5N-BC, as calculated from a Langmuir isotherm model, was 60.9 mg/g, which is much higher than those of other adsorbents from previous studies for 1 h of sorption time. The Cs desorption rate of P-5N-BC for 24 h desorption time was <17%, showing that the Cs was stably enough attached to the HNO 3 -treated BC for long-term use. The results of continuous column experiments showed that the total amount of treated water from the column packed with P-5N-BC increased more than nine times when compared with that from the only BC-granule-packed column. The P-5N-BC maintained more than 68% Cs removal efficiency after 90 pore volumes of flushing, suggesting that only 15 g of P-5N-BC (with only 0.75 g of HNO 3 -treated BC) could clean 5 L of Cs-contaminated water (initial Cs concentration: 1.0 mg/L; effluent concentration: < 0.09 mg/L). The present results demonstrate that P-5N-BC has remarkable potential for removal of Cs from diverse water systems. Image 1 • Using bamboo charcoal in a polysulfone carrier to remove Cs is a novel approach. • The polysulfone carrier with HNO 3 treated bamboo charcoal was used for Cs removal. • It had the highest Cs removal efficiency (>90%) under diverse water conditions. • Its Cs sorption capacity and field feasibility were proven by column experiments. • The Cs sorption mechanism was revealed by imagery techniques and isotherm models. [ABSTRACT FROM AUTHOR]

Intrathoracic ectopic kidney is an uncommon congenital anomaly, accounting for approximately 5% of all ectopic kidneys. An intrathoracic ectopic kidney and pulmonary sequestration associated with a congenital diaphragmatic hernia is a very rare condition. This study describes a patient with a right intrathoracic ectopic kidney and pulmonary sequestration associated with right sided congenital diaphragmatic hernia. Contrast-enhanced chest computed tomography showed a right intrathoracic ectopic kidney and lung mass with herniation of the right lobe of the liver through the right diaphragmatic defect. The herniated intestine, the right lobe of the liver and the right intrathoracic ectopic kidney were relocated into the abdomen, followed by excision of the pulmonary mass and closure of the diaphragmatic defect with Permacol. • An intrathoracic ectopic kidney is an extremely rare congenital anomaly. • The presence of an intrathoracic mass, together with absence of a kidney from the ipsilateral renal fossa, is suggestive of intrathoracic ectopic kidney. • Several methods are available for treatment of intrathoracic ectopic kidneys. [ABSTRACT FROM AUTHOR]

Electrical stimulation (ES) induces wound healing and skin regeneration. Combining ES with the tissue-engineering approach, which relies on biomaterials to construct a replacement tissue graft, could offer a self-stimulated scaffold to heal skin-wounds without using potentially toxic growth factors and exogenous cells. Unfortunately, current ES technologies are either ineffective (external stimulations) or unsafe (implanted electrical devices using toxic batteries). Hence, we propose a novel wound-healing strategy that integrates ES with tissue engineering techniques by utilizing a biodegradable self-charged piezoelectric PLLA (Poly (l -lactic acid)) nanofiber matrix. This unique, safe, and stable piezoelectric scaffold can be activated by an external ultrasound (US) to produce well-controlled surface-charges with different polarities, thus serving multiple functions to suppress bacterial growth (negative surface charge) and promote skin regeneration (positive surface charge) at the same time. We demonstrate that the scaffold activated by low intensity/low frequency US can facilitate the proliferation of fibroblast/epithelial cells, enhance expression of genes (collagen I, III, and fibronectin) typical for the wound healing process, and suppress the growth of S. aureus and P. aeruginosa bacteria in vitro simultaneously. This approach induces rapid skin regeneration in a critical-sized skin wound mouse model in vivo. The piezoelectric PLLA skin scaffold thus assumes the role of a multi-tasking, biodegradable, battery-free electrical stimulator which is important for skin-wound healing and bacterial infection prevention simultaneuosly. [ABSTRACT FROM AUTHOR]

Diabetic foot ulcers represent one of the major and rising health issues, as the number of diabetic patients is increasing. MicroRNAs (miRNAs) are among various bioactive molecules under investigation for diabetic wound healing. The prolonged pro-inflammatory phase in diabetic wounds partly attributes to its non-healing nature. Therefore, we hypothesized that miRNA-497, known for its regulation of inflammatory responses, would enhance diabetic wound healing. We screened miRNA candidates, including miRNA-497 in the wounded skin of streptozotocin-induced type 1 diabetic mice. The therapeutic potential of miRNA-497 mimic was studied by intradermal injection around the wound in diabetic mice. In addition, the effects of miRNA-497 on pro-inflammatory cytokines were analyzed in the wound lesion of diabetic mice, and in human dermal fibroblasts cells exposed to high glucose and lipopolysaccharide.We found a significant reduction of miRNA-497 expression in the dermal wounds of the diabetic mice relative to normal mice. Intradermal injection of miRNA-497 around the full-thickness dermal wounds in diabetic mice accelerated wound closure effectively compared to the control miRNA. miRNA-497 treatment in vivo and in vitro decreased representative pro-inflammatory cytokines such as IL-1β, IL-6, and TNF-α. Such anti-inflammatory effects of miRNA-497 shed light on its role in accelerating diabetic wound healing. In conclusion, miRNA-497, with its down-regulation activity for pro-inflammatory cytokines, is proposed as a potential therapeutic agent for diabetic wound healing. [ABSTRACT FROM AUTHOR]