1. Novel γ-lactone derivatives from Trigonostemon heterophyllus with their potential antiproliferative activities.
- Author
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Liu YP, Hu S, Wen Q, Ma YL, Jiang ZH, Tang JY, and Fu YH
- Subjects
- 4-Butyrolactone chemistry, 4-Butyrolactone isolation & purification, Antineoplastic Agents, Phytogenic chemistry, Antineoplastic Agents, Phytogenic isolation & purification, Cell Line, Tumor, Cisplatin pharmacology, Doxorubicin pharmacology, Drug Screening Assays, Antitumor, Humans, Molecular Structure, Plant Leaves chemistry, Plant Stems chemistry, 4-Butyrolactone analogs & derivatives, 4-Butyrolactone pharmacology, Antineoplastic Agents, Phytogenic pharmacology, Euphorbiaceae chemistry
- Abstract
Two novel γ-lactone derivatives, trigoheterophines A (1) and B (2), together with four known furan derivatives (3-6), were isolated from the stems and leaves of Trigonostemon heterophyllus. The structures of 1 and 2 were elucidated by extensive spectroscopic methods and the known compounds were identified by comparing with the data reported in literature. Among them, trigoheterophines A (1) and B (2) represent an unusual type of γ-lactone derivatives, possessing 21 carbon atoms on the carbon skeleton, and known compouds (3-6) are rare furan derivatives in the plant kingdom with diverse long-chain hydrocarbyl groups as substituents at C-4. All isolated compounds were evaluated for their antiproliferative activities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 in vitro. Compounds 1-6 showed significant antiproliferative effects against various human cancer cell lines with IC
50 values ranging from 0.28 to 12.06 μM. These findings suggest that the discoveries of these novel γ-lactone derivatives and furan derivatives with significant antiproliferative activities isolated from T. heterophyllus could be of great importance to the development of new anticancer agents., (Copyright © 2018 Elsevier Inc. All rights reserved.)- Published
- 2018
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