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Novel γ-lactone derivatives from Trigonostemon heterophyllus with their potential antiproliferative activities.
- Source :
-
Bioorganic chemistry [Bioorg Chem] 2018 Sep; Vol. 79, pp. 107-110. Date of Electronic Publication: 2018 Apr 30. - Publication Year :
- 2018
-
Abstract
- Two novel γ-lactone derivatives, trigoheterophines A (1) and B (2), together with four known furan derivatives (3-6), were isolated from the stems and leaves of Trigonostemon heterophyllus. The structures of 1 and 2 were elucidated by extensive spectroscopic methods and the known compounds were identified by comparing with the data reported in literature. Among them, trigoheterophines A (1) and B (2) represent an unusual type of γ-lactone derivatives, possessing 21 carbon atoms on the carbon skeleton, and known compouds (3-6) are rare furan derivatives in the plant kingdom with diverse long-chain hydrocarbyl groups as substituents at C-4. All isolated compounds were evaluated for their antiproliferative activities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 in vitro. Compounds 1-6 showed significant antiproliferative effects against various human cancer cell lines with IC <subscript>50</subscript> values ranging from 0.28 to 12.06 μM. These findings suggest that the discoveries of these novel γ-lactone derivatives and furan derivatives with significant antiproliferative activities isolated from T. heterophyllus could be of great importance to the development of new anticancer agents.<br /> (Copyright © 2018 Elsevier Inc. All rights reserved.)
- Subjects :
- 4-Butyrolactone chemistry
4-Butyrolactone isolation & purification
Antineoplastic Agents, Phytogenic chemistry
Antineoplastic Agents, Phytogenic isolation & purification
Cell Line, Tumor
Cisplatin pharmacology
Doxorubicin pharmacology
Drug Screening Assays, Antitumor
Humans
Molecular Structure
Plant Leaves chemistry
Plant Stems chemistry
4-Butyrolactone analogs & derivatives
4-Butyrolactone pharmacology
Antineoplastic Agents, Phytogenic pharmacology
Euphorbiaceae chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1090-2120
- Volume :
- 79
- Database :
- MEDLINE
- Journal :
- Bioorganic chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 29738968
- Full Text :
- https://doi.org/10.1016/j.bioorg.2018.04.015