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1. Synthesis and biological evaluation of N alpha-hydroxysulfonyl-[Nle28,31]-CCK26-33.

Author

Sugg EE, Shook JE, Serra M, Korc M, Yamamura HI, Burks TF, and Hruby VJ

Subjects
Amylases metabolism, Animals, Cerebral Cortex metabolism, Chemical Phenomena, Chemistry, Guinea Pigs, Ileum drug effects, In Vitro Techniques, Male, Pancreas enzymology, Rats, Rats, Inbred Strains, Sincalide chemical synthesis, Sincalide metabolism, Sincalide pharmacology, Gallbladder drug effects, Peptide Fragments, Sincalide analogs & derivatives
Abstract

Two analogues of [Nle28,31]-CCK26-33 containing an N-terminal acetyl or N-terminal hydroxysulfonyl moiety were prepared and characterized. Both analogues were equipotent to native CCK26-33 in four bioassays, demonstrating that N-terminal sulfation of CCK26-33 analogues is compatible with full biological activity.

Published
1986
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