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Synthesis and biological evaluation of N alpha-hydroxysulfonyl-[Nle28,31]-CCK26-33.
- Source :
-
Life sciences [Life Sci] 1986 Nov 03; Vol. 39 (18), pp. 1623-9. - Publication Year :
- 1986
-
Abstract
- Two analogues of [Nle28,31]-CCK26-33 containing an N-terminal acetyl or N-terminal hydroxysulfonyl moiety were prepared and characterized. Both analogues were equipotent to native CCK26-33 in four bioassays, demonstrating that N-terminal sulfation of CCK26-33 analogues is compatible with full biological activity.
- Subjects :
- Amylases metabolism
Animals
Cerebral Cortex metabolism
Chemical Phenomena
Chemistry
Guinea Pigs
Ileum drug effects
In Vitro Techniques
Male
Pancreas enzymology
Rats
Rats, Inbred Strains
Sincalide chemical synthesis
Sincalide metabolism
Sincalide pharmacology
Gallbladder drug effects
Peptide Fragments
Sincalide analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 0024-3205
- Volume :
- 39
- Issue :
- 18
- Database :
- MEDLINE
- Journal :
- Life sciences
- Publication Type :
- Academic Journal
- Accession number :
- 2430160
- Full Text :
- https://doi.org/10.1016/0024-3205(86)90158-x