7 results on '"Neoplasms, Squamous Cell complications"'
Search Results
2. Management and outcome of head and neck squamous cell carcinomas in obese patients.
- Author
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Deneuve S, Tan HK, Eghiaian A, and Temam S
- Subjects
- Adult, Aged, Alcohol Drinking adverse effects, Carcinoma mortality, Carcinoma therapy, Carcinoma, Squamous Cell, Female, Head and Neck Neoplasms mortality, Head and Neck Neoplasms therapy, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Neoplasms, Squamous Cell mortality, Neoplasms, Squamous Cell therapy, Obesity therapy, Prognosis, Retrospective Studies, Risk Factors, Squamous Cell Carcinoma of Head and Neck, Treatment Outcome, Carcinoma complications, Head and Neck Neoplasms complications, Neoplasms, Squamous Cell complications, Obesity complications, Smoking adverse effects
- Abstract
Head and neck squamous cell carcinomas are common lesions, related to chronic smoking and drinking behaviors. But in contrast to other cancers, effect of obesity on occurrence, diagnosis, treatment and prognosis of these tumors remains to date unknown. This is a retrospective review of 111 obese patients (sex ratio=6.4, median age=54.5 year old), treated between 1999 and 2007. Risk factors, tumoral localization and staging (41% stage I-II) were the same as in general population. However, we found 26.1% difficult pan-endoscopies, 54% ACE-27 comorbidity scores ≥2 and 22.5% misstaged cervical lymphadenopathy. Treatment was based upon surgery (61%) or radiotherapy-chemotherapy (39%), and 37% of patients developed complications. Median follow up (38 months) and five-year overall survival (50%) are comparable to data in non obese patients. Although no direct relation between obesity and squamous cell carcinomas of the head and neck was found, obesity causes problems in tumor assessment and increases surgical complications rate. However, final good therapeutic tolerance and overall survival rate show that these patients should be managed like normal weighted ones. Receiving optimal treatments allow them to anticipate equivalent outcome as in general population., (Crown Copyright © 2011. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2011
- Full Text
- View/download PDF
3. The role of human papillomavirus infection in head and neck cancers.
- Author
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Syrjänen S
- Subjects
- Carcinoma complications, Carcinoma epidemiology, Carcinoma prevention & control, Carcinoma virology, Carcinoma, Squamous Cell, DNA, Viral isolation & purification, Genetic Testing, Head and Neck Neoplasms epidemiology, Head and Neck Neoplasms prevention & control, Head and Neck Neoplasms virology, Humans, Neoplasms, Squamous Cell complications, Neoplasms, Squamous Cell epidemiology, Neoplasms, Squamous Cell prevention & control, Neoplasms, Squamous Cell virology, Oropharyngeal Neoplasms complications, Oropharyngeal Neoplasms epidemiology, Oropharyngeal Neoplasms virology, Papillomaviridae isolation & purification, Papillomavirus Infections diagnosis, Papillomavirus Infections epidemiology, Papillomavirus Infections therapy, Papillomavirus Vaccines therapeutic use, Prognosis, Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms complications, Papillomaviridae physiology, Papillomavirus Infections complications
- Abstract
The link between head and neck squamous cell cancer (HNSCC), especially oropharyngeal cancer, and HPV has become established. HPV16 is the most common genotype in these tumours but HPV6 and HPV11 can also be found in a minority of these cancers, implying that these low-risk HPV types are not entirely benign in the head and neck region. HPV status is also associated with p16 expression and HPV+ tumours are less likely to harbour p53 mutations. HPV DNA is closely associated with poorly differentiated cancers, positive lymph nodes and late-stage disease, which all indicate poor prognosis. Contradictory to this, patients with HPV+ HNSCC seem to have significantly improved response to chemotherapy and radiotherapy as compared with HPV-negative tumours. Interestingly, the risk factors of HNSCC are the same as for HPV, including the number of sexual partners, younger age at first sexual intercourse, practice of oral sex, history of genital warts and younger age.
- Published
- 2010
- Full Text
- View/download PDF
4. Why do some lung cancer patients receive no anticancer treatment?
- Author
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Vinod SK, Sidhom MA, Gabriel GS, Lee MT, and Delaney GP
- Subjects
- Adenocarcinoma complications, Adenocarcinoma pathology, Aged, Aged, 80 and over, Australia, Carcinoma, Large Cell complications, Carcinoma, Large Cell pathology, Carcinoma, Non-Small-Cell Lung complications, Carcinoma, Non-Small-Cell Lung pathology, Comorbidity, Decision Making, Female, Humans, Ireland, Lung Neoplasms complications, Lung Neoplasms pathology, Male, Middle Aged, Neoplasm Staging, Neoplasms, Squamous Cell complications, Neoplasms, Squamous Cell pathology, Patient Preference, Prospective Studies, Scotland, Small Cell Lung Carcinoma complications, Small Cell Lung Carcinoma pathology, Survival Rate, Treatment Outcome, United States, Adenocarcinoma therapy, Carcinoma, Large Cell therapy, Carcinoma, Non-Small-Cell Lung therapy, Lung Neoplasms therapy, Neoplasms, Squamous Cell therapy, Small Cell Lung Carcinoma therapy
- Abstract
Introduction: A significant proportion of lung cancer patients receive no anticancer treatment. This varies from 19% in USA, 33% in Australia, 37% in Scotland, and 50% in Ireland. The aim of this study was to identify the reasons behind this., Methods: The Lung Cancer Multidisciplinary Meeting (MDM) in South-West Sydney prospectively collects data on all patients presented. All new lung cancer patients presented between December 1, 2005, and December 31, 2007, were reviewed. Patients were assigned optimal treatment based on evidence-based guidelines. Those patients in whom guidelines recommended no treatment (GNT) were compared with those whom the MDM recommended no treatment (MNT) and with those who actually received no treatment (ANT)., Results: There were 335 patients with a median age of 69 years. A total of 82% had non-small cell lung cancer, 14% had small cell lung cancer, and 4% had no pathologic diagnosis. Eighty-five percent had locally advanced or metastatic disease. GNT was recommended in 4% (n = 13), MNT in 10% (n = 32) but ANT comprised 20% (n = 66). The differences between GNT and MNT were mainly due to patient comorbidities and clinician decision, but the differences between MNT and ANT were due to patient preference and declining performance status. In multivariate analysis, older age, poorer Eastern Cooperative Oncology Group status, non-small cell lung cancer, and non-English language predicted for ANT., Conclusions: The proportion of patients with lung cancer receiving no treatment is greater than that predicted by guidelines or recommended by the MDM but lower than that described in population-based studies suggesting that MDMs can improve treatment utilization in lung cancer.
- Published
- 2010
- Full Text
- View/download PDF
5. Markers of human papillomavirus infection and their correlation with cervical dysplasia in human immunodeficiency virus-positive women.
- Author
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Riva E, Serraino D, Pierangeli A, Bambacioni F, Zaniratti S, Minosse C, Selleri M, Bucci M, Scagnolari C, Degener AM, Capobianchi MR, Antonelli G, and Dianzani F
- Subjects
- Adult, DNA, Viral genetics, Female, Genetic Markers genetics, Humans, Middle Aged, Papillomaviridae classification, Polymerase Chain Reaction, Species Specificity, HIV, HIV Infections complications, Neoplasms, Squamous Cell complications, Neoplasms, Squamous Cell virology, Papillomaviridae genetics, Papillomavirus Infections complications, Papillomavirus Infections virology, Uterine Cervical Dysplasia complications, Uterine Cervical Dysplasia virology
- Abstract
Human papillomavirus (HPV) genotypes and HPV DNA load were analysed in cervical smears from 76 human immunodeficiency virus (HIV)-positive and 54 HIV-negative women. The prevalence of genotypes was similar for all women, with the exception of HPV62, which was over-represented in HIV-positive samples. HIV-positive women showed a higher prevalence of multiple genotypes that correlated neither with CD4(+) T-cell counts nor with cervical dysplasia. No significant differences were observed in terms of total or single-type HPV DNA load. The HPV DNA load in both HIV-positive and HIV-negative women was significantly higher in squamous intra-epithelial lesions than in negative Pap smears.
- Published
- 2007
- Full Text
- View/download PDF
6. Primary orbital aspergilloma of the exenterated orbit in an immunocompromized patient.
- Author
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Naik MN, Vemuganti GK, and Honavar SG
- Subjects
- AIDS-Related Opportunistic Infections complications, AIDS-Related Opportunistic Infections drug therapy, Anti-Infective Agents therapeutic use, Aspergillosis drug therapy, Exudates and Transudates microbiology, Eye Enucleation, Eye Infections, Fungal drug therapy, Eye Infections, Fungal etiology, Eye Neoplasms complications, Eye Neoplasms surgery, Humans, Male, Middle Aged, Neoplasms, Squamous Cell complications, Neoplasms, Squamous Cell surgery, Orbital Diseases drug therapy, Tomography, X-Ray Computed, AIDS-Related Opportunistic Infections microbiology, Aspergillosis microbiology, Aspergillus isolation & purification, Eye Infections, Fungal microbiology, Orbital Diseases microbiology
- Abstract
Aspergilloma is a fungal ball that usually forms in a preformed stationary cavity, mostly in lung and paranasal sinuses. We report a rare case of primary orbital Aspergilloma following exenteration for an invasive ocular surface squamous neoplasia, clinically mimicking a recurrence of the tumor. The fungal ball showed the presence of conidiophores with a globular head and a complete row of uni and biserrate phialides, suggestive of Aspergillus flavus species. The exposure to air in the orbit, possibly promoted the formation of conidiophores, which are normally seen when the organism is located in air cavities.
- Published
- 2006
7. Esophageal cancer surgery in heart transplant patients.
- Author
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von Rahden BH, Stein HJ, Schmidt G, Bartels H, Overbeck M, and Siewert JR
- Subjects
- Aged, Cardiomyopathy, Dilated complications, Cardiomyopathy, Dilated surgery, Esophageal Neoplasms complications, Esophagectomy methods, Fatal Outcome, Humans, Male, Middle Aged, Neoplasms, Squamous Cell complications, Treatment Outcome, Esophageal Neoplasms surgery, Heart Transplantation, Neoplasms, Squamous Cell surgery
- Abstract
We herein report about 2 heart transplant patients undergoing surgical resection for esophageal cancer. Both were long-term survivors after orthotopic heart transplantation for dilated cardiomyopathy. One patient underwent a transthoracic esophagectomy and gastric pull-up for an early squamous cell carcinoma of the infracarinal esophagus. The second patient underwent a resection of the cervical esophagus and interposition of a free jejunal segment after neoadjuvant radiochemotherapy for a locally advanced squamous cell carcinoma in the cervical esophagus.
- Published
- 2005
- Full Text
- View/download PDF
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