1. Oral and maxillofacial desmoid-type fibromatoses in an eastern Chinese population: a report of 20 cases.
- Author
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Min R, Zun Z, Lizheng W, Minjun D, Shengwen L, Wenjun Y, and Chenping Z
- Subjects
- Adolescent, Adult, Age Factors, Alkaline Phosphatase blood, Biomarkers, Tumor blood, Cell Transformation, Neoplastic, Child, Child, Preschool, China epidemiology, Cranial Fossa, Middle pathology, Female, Follow-Up Studies, Humans, Male, Mandibular Neoplasms epidemiology, Maxillary Neoplasms epidemiology, Middle Aged, Mitotic Index, Neoplasm Recurrence, Local epidemiology, Rare Diseases epidemiology, Retrospective Studies, Sex Factors, Skull Base Neoplasms epidemiology, Young Adult, Facial Neoplasms epidemiology, Fibroma epidemiology, Fibromatosis, Aggressive epidemiology, Jaw Neoplasms epidemiology, Mouth Neoplasms epidemiology
- Abstract
Objective: Primary desmoid-type fibromatoses arising from the oral and maxillofacial region are uncommon and hold the character of local invasion and regional recurrence. The purpose of this study was to analyze the clinicoepidemiologic characteristics of this rare disease in an eastern Chinese population., Study Design: Epidemiological and clinicopathological data on 20 patients were reviewed from the hospital records and analyzed accordingly., Results: Twelve males and 8 females with a ratio of 3:2 were involved. The mandible was the most common site of presentation. Suspected malignant change was found in 6 cases and an extremely high recurrence rate was also found in up to 53%. Abnormally high blood levels of alkaline phosphatase were found in 65% of patients, which had a close relation with tumor malignant change., Conclusion: Chinese people are more susceptible to desmoid-type fibromatoses and are at an extremely high risk of regional malignant change. Elevated serum alkaline phosphatase levels may be taken as an indicator for malignant transformation., (Copyright © 2011 Mosby, Inc. All rights reserved.)
- Published
- 2011
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