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Your search keyword '"Kyo Yeol Hwang"' showing total 2 results
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2 results on '"Kyo Yeol Hwang"'

1. Fermented soy bean extract suppresses differentiation of 3T3-L1 preadipocytes and facilitates its glucose utilization

Author

Ji Won Hwang, Hyun Ju Do, Oh Yoen Kim, Ji Hyung Chung, Jae-Yeon Lee, Young Shik Park, Kyo Yeol Hwang, Su-Il Seong, and Min-Jeong Shin

Subjects
Soy bean extract, Adipogenesis, C/EBPα, ACC, GLUT4, Nutrition. Foods and food supply, TX341-641
Abstract

Obesity is a serious health problem which may continuously increase the morbidity and mortality associated with a variety of acute and chronic diseases.This study aimed to examine the antiobesity effect of soy bean extract fermented by Bacillus subtilis MORI (BTD-1) and to elucidate the mechanisms underlying such effects using 3T3-L1 preadipocytes. Lipid accumulations were significantly inhibited by BTD-1 treatment, which were accompanied by the decreased expression of CCAAT element binding protein α (C/EBPα) and the increased phosphorylation of acetyl-CoA carboxylase (ACC) protein expression. In addition, BTD-1 treatment increased the expression of glucose transporter 4 (GLUT4) along with significantly increasing glucose uptake into the adipocytes based on results of a 2-deoxy-D-[3H] glucose uptake assay. Our findings suggest that BTD-1 may suppress the differentiation of 3T3-L1 adipocytes and greatly facilitate glucose uptake into the adipocytes. Therefore, BTD-1 has a potential as a functional food ingredient in improving obesity and related metabolic disorders.

Published
2015
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2. Fermented soy bean extract suppresses differentiation of 3T3-L1 preadipocytes and facilitates its glucose utilization

Author

Young Shik Park, Oh Yoen Kim, Min Jeong Shin, Hyun Ju Do, Ji Hyung Chung, Jae Yeon Lee, Ji Won Hwang, Kyo Yeol Hwang, and Su Il Seong

Subjects
medicine.medical_specialty, Nutrition and Dietetics, Adipogenesis, Nutrition. Foods and food supply, Glucose uptake, Glucose transporter, Medicine (miscellaneous), 3T3-L1, Biology, Pyruvate carboxylase, C/EBPα, Endocrinology, Functional food, Soy bean extract, Internal medicine, medicine, biology.protein, Phosphorylation, TX341-641, ACC, GLUT4, Food Science
Abstract

Obesity is a serious health problem which may continuously increase the morbidity and mortality associated with a variety of acute and chronic diseases.This study aimed to examine the antiobesity effect of soy bean extract fermented by Bacillus subtilis MORI (BTD-1) and to elucidate the mechanisms underlying such effects using 3T3-L1 preadipocytes. Lipid accumulations were significantly inhibited by BTD-1 treatment, which were accompanied by the decreased expression of CCAAT element binding protein α (C/EBPα) and the increased phosphorylation of acetyl-CoA carboxylase (ACC) protein expression. In addition, BTD-1 treatment increased the expression of glucose transporter 4 (GLUT4) along with significantly increasing glucose uptake into the adipocytes based on results of a 2-deoxy-D-[3H] glucose uptake assay. Our findings suggest that BTD-1 may suppress the differentiation of 3T3-L1 adipocytes and greatly facilitate glucose uptake into the adipocytes. Therefore, BTD-1 has a potential as a functional food ingredient in improving obesity and related metabolic disorders.

Published
2015

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