1. Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1) is reduced with preeclampsia and small for gestational aged fetuses.
- Author
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Bartho LA, Walker SP, Cannon P, Nguyen TV, Nguyen A, Botha SM, Hannan NJ, Tong S, and Kaitu'u-Lino TJ
- Subjects
- Humans, Female, Pregnancy, Adult, Infant, Newborn, RNA, Messenger metabolism, Hypoxia metabolism, Pre-Eclampsia metabolism, Receptors, Immunologic metabolism, Receptors, Immunologic genetics, Placenta metabolism, Infant, Small for Gestational Age
- Abstract
Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1) is an inhibitory receptor expressed on immune cells. We evaluated LAIR1 in placentas from preeclamptic or small for gestational age (SGA) pregnancies, and placental explant model (1 % O
2 , IL6 and TNFα, or control). LAIR1 mRNA was reduced in placentas from preeclamptic (p < 0.0001, n = 78) and SGA (p < 0.0001, n = 32) pregnancies. LAIR1 protein expression was reduced in placentas from preeclampsia (p < 0.0001, n = 43) and SGA (p = 0.009, n = 10) pregnancies. Hypoxia (1 % O2 ) reduced LAIR1 mRNA expression in placental explants (p = 0.008). These findings suggest hypoxia modulates LAIR1 expression in the placenta., Competing Interests: Declaration of competing Interest None., (Crown Copyright © 2024. Published by Elsevier Ltd. All rights reserved.)- Published
- 2024
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