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Circulating Activin A is elevated at 36 weeks' gestation preceding a diagnosis of preeclampsia.
- Source :
-
Pregnancy hypertension [Pregnancy Hypertens] 2022 Mar; Vol. 27, pp. 23-26. Date of Electronic Publication: 2021 Nov 17. - Publication Year :
- 2022
-
Abstract
- Activin A is aberrantly expressed by the preeclamptic placenta and circulating levels have been investigated as a potential biomarker for the disease. In a nested case-control study we measured Activin A levels in maternal plasma at 28- and 36-weeks' gestation preceding term preeclampsia diagnosis. At 28 weeks Activin A was not significantly altered (n = 73 destined to develop preeclampsia vs n = 191 controls). At 36 weeks' gestation Activin A was significantly increased in 40 women destined to develop preeclampsia relative to 201 controls (p < 0.0001). These findings provide further validation of Activin A as a potential biomarker for subsequent term preeclampsia.<br /> (Copyright © 2021 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 2210-7797
- Volume :
- 27
- Database :
- MEDLINE
- Journal :
- Pregnancy hypertension
- Publication Type :
- Academic Journal
- Accession number :
- 34844073
- Full Text :
- https://doi.org/10.1016/j.preghy.2021.11.006