1. Glucose attenuates the long-term adverse neurodevelopment effect of neonate pain stimulus via CRF/GR in rats.
- Author
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Xu J, Jie J, Feng C, Sun Q, Fan J, and Li D
- Subjects
- Animals, Rats, Male, Pain Threshold drug effects, Hypothalamo-Hypophyseal System metabolism, Hypothalamo-Hypophyseal System drug effects, Pituitary-Adrenal System metabolism, Pituitary-Adrenal System drug effects, Female, Glucose metabolism, Corticotropin-Releasing Hormone metabolism, Animals, Newborn, Receptors, Glucocorticoid metabolism, Rats, Sprague-Dawley, Pain metabolism, Pain etiology, Hippocampus metabolism, Hippocampus drug effects
- Abstract
Background: Neonates undergo numerous painful procedures throughout their hospitalization. Repeated procedural pain may cause adverse long-term effects. Glucose as a non-pharmacological analgesia, is used for neonate pain management. In this study, potential mechanism of attenuate pain induced by glucose in neurodevelopment effect of neonate pain stimulus was investigated., Methods: Neonatal rats to perform a repetitive injury model and glucose intervention model in the postnatal day 0-7(P0-7). Pain thresholds were measured by von Frey test weekly. The puberty behavioral outcome, tissue loss and protein expression in hippocampus were analyzed., Results: Oral administration of glucose after repeated pain stimulation can maintain the hippocampal structure in, and reduce the expressions of corticotropin releasing factor (CFR) and glucocorticoid receptor (GR), therefore, resulted in long-term threshold of pain and cognitive improvement., Conclusion: Exposure to neonatal repeated procedural pain causes persistent mechanical hypersensitivity and the dysfunction of spatial memory retention at puberty. In addition, glucose can relieve these adverse effects, possibly via decreasing CRF/GR levels to change the hypothalamus-pituitary-adrenal (HPA) axis., Competing Interests: Declaration of competing interest The authors declare no competing interests., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
- Published
- 2024
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